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    Specific binding assay with a prosthetic group as a label component
    21.
    发明授权
    Specific binding assay with a prosthetic group as a label component 失效
    用假基团作为标记组分的特异性结合测定

    公开(公告)号：US4238565A

    公开(公告)日：1980-12-09

    申请号：US45423

    申请日：1979-06-04

    申请人： William E. Hornby ,  David L. Morris

    发明人： William E. Hornby ,  David L. Morris

    IPC分类号： C12N9/96 ,  G01N33/542 ,  G01N33/78 ,  C12Q1/66 ,  C12N11/02

    CPC分类号： G01N33/542 ,  C12N9/96 ,  G01N33/78 ,  Y10S435/975

    摘要： A specific binding assay for determining a ligand in a liquid medium employing an organic prosthetic group residue, such as a residue of flavin adenine dinucleotide, flavin mononucleotide, or heme, as a label component in the labeled conjugate. Preferably, the label component is the prosthetic group residue alone or is a holoenzyme residue comprising such prosthetic group residue combined with an apoenzyme in the form of a holoenzyme complex. In the former case, the label component preferably is monitored in the assay by adding an apoenzyme after the binding reaction has been initiated and measuring the resultant holoenzyme activity. In the latter case, the label component is monitored simply by measuring holoenzyme activity. The assay method may follow conventional homogeneous and heterogeneous schemes. Preferred apoenzymes for use in the assay are apoglucose oxidase and apoperoxidase. The assay offers the advantages of colorimetric read-out and of being readily adaptable to automated techniques. Also disclosed are prosthetic group-labeled and enzyme-labeled conjugates for use in the assay, as well as a method for preparing the latter conjugates.

    摘要翻译： 使用有机修饰基团残基（例如黄素腺嘌呤二核苷酸残基，黄素单核苷酸或血红素）作为标记缀合物中的标记成分来测定液体培养基中配体的特异性结合测定。 优选地，标记组分是单独的修饰基团残基，或者是包含与全酶复合物形式的脱辅基酶组合的这种假基团残基的全酶残基。 在前一种情况下，优选在测定中通过在结合反应开始后加入脱辅基酶并测量所得的全酶活性来监测标记组分。 在后一种情况下，通过测量全酶活性来简单地监测标签组分。 测定方法可以遵循常规的均相和异构方案。 用于测定的优选的脱辅基酶是糖苷氧化酶和过氧化物酶。 该测定提供比色读出的优点并且易于适应于自动化技术。 还公开了用于测定中的假体基团标记和酶标记的缀合物，以及制备后缀合物的方法。

    Device and method for thermal ablation of biological tissue using spherical ablation patterns
    22.
    发明授权
    Device and method for thermal ablation of biological tissue using spherical ablation patterns 有权
    使用球形消融图案对生物组织进行热消融的装置和方法

    公开(公告)号：US08845635B2

    公开(公告)日：2014-09-30

    申请号：US11335301

    申请日：2006-01-18

    申请人： Steven A. Daniel ,  David L. Morris ,  Kee Sein Lee

    发明人： Steven A. Daniel ,  David L. Morris ,  Kee Sein Lee

    IPC分类号： A61B18/14 ,  A61B18/00

    CPC分类号： A61B18/148 ,  A61B18/1477 ,  A61B2018/0016 ,  A61B2018/00267 ,  A61B2018/1425 ,  A61B2018/143 ,  A61B2018/1432 ,  A61B2018/1475

    摘要： A tissue ablation device and method for tissue ablation are described. The tissue ablation device comprises an energy source and an introducer coupled to the energy source, the introducer having a body, a proximal end, and a distal end. The introducer carries an electrode array that comprises a plurality of electrodes, each electrode of the plurality of electrodes is configured to extend from the body of the introducer when moved from a retracted state to a deployed state. The electrode array is designed to encircle a portion of a target tissue when the electrodes are extended into the deployed state and to form a relatively spherical shaped ablation pattern in a tissue volume surrounding the target tissue when energized by the energy source.

    摘要翻译： 描述了用于组织消融的组织消融装置和方法。 组织消融装置包括能量源和耦合到能量源的导引器，导入器具有主体，近端和远端。 引导器携带包括多个电极的电极阵列，多个电极中的每个电极构造成当从缩回状态移动到展开状态时，从引导器的主体延伸。 当电极延伸到展开状态时，电极阵列被设计成环绕目标组织的一部分，并且在被能量源激励时围绕目标组织的组织体积中形成相对球形的消融图案。

    Tissue surface treatment apparatus and method
    23.
    发明授权
    Tissue surface treatment apparatus and method 失效
    组织表面处理装置及方法

    公开(公告)号：US07625371B2

    公开(公告)日：2009-12-01

    申请号：US11034435

    申请日：2005-01-11

    申请人： David L. Morris ,  Steven A. Daniel ,  Daniel J. Balbierz

    发明人： David L. Morris ,  Steven A. Daniel ,  Daniel J. Balbierz

    IPC分类号： A61B18/18

    CPC分类号： A61M25/1002 ,  A61B18/1477 ,  A61B2018/00011 ,  A61B2018/00017 ,  A61B2018/00029 ,  A61B2018/00291 ,  A61B2018/143 ,  A61B2018/1475 ,  A61M2025/0085

    摘要： A tissue surface treatment apparatus includes a housing having a proximal end, a distal end including a tissue contacting surface, an interior defined by the housing and a handpiece coupled to the housing. The contactinc surface has a plurality of apertures. An energy delivery device including an electrode is positionable in the housing interior. The electrode includes a tissue penetrating distal end in substantial alignment with an aperture. The electrode is configured to be advanced from the housing interior through the aperture and into a target tissue site to define an ablation volume at least partly bounded by a tissue surface. An advancement device is coupled to the energy delivery device and is at least partly positionable within at least one of the housing or the handpiece. The advancement device is configured to advance the electrode from the housing interior into the target tissue site and withdrawal the electrode into the housing interior. A cable is coupled to the housing or the energy delivery device and is configured to be coupled to an energy source.

    摘要翻译： 组织表面处理设备包括具有近端，远端包括组织接触表面的壳体，由壳体限定的内部和联接到壳体的手持件。 触点表面具有多个孔。 包括电极的能量输送装置可定位在壳体内部。 电极包括与孔基本对准的穿透远端的组织。 电极被配置为从壳体内部通过孔推进到目标组织部位以限定至少部分地由组织表面限定的消融体积。 进给装置联接到能量输送装置，并且至少部分地可定位在壳体或手持件中的至少一个中。 推进装置被配置为将电极从壳体内部推进到目标组织部位并将电极抽出到壳体内部。 电缆耦合到壳体或能量输送装置，并且被配置为耦合到能量源。

    Combination panline and utility drilling or bolting unit
    25.
    发明授权
    Combination panline and utility drilling or bolting unit 有权
    组合泛用和公用事业钻孔或螺栓连接单元

    公开(公告)号：US07350876B2

    公开(公告)日：2008-04-01

    申请号：US10949981

    申请日：2004-09-24

    申请人： Timothy D. Burgess ,  William G. Kendall, Jr. ,  David L. Morris ,  Steven Payne

    发明人： Timothy D. Burgess ,  William G. Kendall, Jr. ,  David L. Morris ,  Steven Payne

    IPC分类号： E21D20/00

    CPC分类号： E21C27/02 ,  E21D20/003

    摘要： A drilling or bolting unit for selective use with either a vehicle or a panline of a face conveyor associated with a longwall miner or mining machine is disclosed. In one embodiment, the unit comprises a base adapted for engaging the panline and a plurality of receivers. Each receiver may be adapted for receiving one of the pair of forks of the vehicle, such that the unit may be used as either a panline drilling or bolting unit or as a utility drilling or bolting unit with the vehicle apart from the panline. Related methods are also described.

    摘要翻译： 公开了一种用于与长壁采矿机或采矿机相关联的面部输送机的车辆或平面线选择性使用的钻孔或螺栓连接单元。 在一个实施例中，该单元包括适于接合平移线和多个接收器的基座。 每个接收器可以适于接收车辆的一对叉中的一个，使得该单元可以用作泛线钻孔或螺栓连接单元，或者可以用作车辆远离平移线的公用事业钻井或螺栓单元。 还描述了相关方法。

    Method and system for invoking simultaneous ringing
    26.
    发明授权
    Method and system for invoking simultaneous ringing 有权
    调用同时振铃的方法和系统

    公开(公告)号：US07277735B1

    公开(公告)日：2007-10-02

    申请号：US10829740

    申请日：2004-04-22

    申请人： Dae-Sik Oh ,  Mark L. Yarkosky ,  David L. Morris ,  Vicki L. Walton

    发明人： Dae-Sik Oh ,  Mark L. Yarkosky ,  David L. Morris ,  Vicki L. Walton

    IPC分类号： H04Q7/20 ,  H04M1/00 ,  H04B1/38

    CPC分类号： H04W4/08 ,  H04W68/00

    摘要： A method and system for simultaneous ringing in a wireless communication system. Upon receipt of a request to connect a call to a given wireless communication device (WCD), a switch or other entity will determine that the given WCD subscribes to a simultaneous ringing service and will identify one or more other WCDs to simultaneously ring. The switch or other entity will then determine which of those one or more WCDs, if any, are currently operating in the same wireless coverage area as the given WCD and will then simultaneously ring the given WCD and each of the other WCDs, if any, that is determined to be operating in the same wireless coverage area.

    摘要翻译： 一种用于在无线通信系统中同时振铃的方法和系统。 在接收到将呼叫连接到给定无线通信设备（WCD）的请求时，交换机或其他实体将确定给定的WCD订阅同时振铃服务并且将识别一个或多个其他WCD以同时振铃。 交换机或其他实体随后将确定那些一个或多个WCD中的哪一个（如果有的话）当前正在与给定的WCD相同的无线覆盖区域中操作，然后将同时振铃给定的WCD和每个其他WCD（如果有的话） 确定其在相同的无线覆盖区域中操作。

    Antimicrobial fluoroelastomer rubber articles and compositions
    27.
    发明授权
    Antimicrobial fluoroelastomer rubber articles and compositions 失效
    抗微生物含氟弹性体橡胶制品及组合物

    公开(公告)号：US07060739B2

    公开(公告)日：2006-06-13

    申请号：US10424024

    申请日：2003-04-25

    申请人： Bhawan Patel ,  David L. Morris

    发明人： Bhawan Patel ,  David L. Morris

    IPC分类号： C08K3/08 ,  C08K3/10 ,  C08K3/34 ,  C08K5/09

    CPC分类号： C08K5/0025 ,  A01N59/16 ,  C08K3/013 ,  C08K3/015 ,  A01N25/10 ,  A01N2300/00 ,  C08L27/12

    摘要： Fluoroelastomer (FKM) rubber-containing articles that exhibit highly desirable long-term effective antimicrobial characteristics are provided. Such articles are in either solid or blown (foam or sponge) state (or combinations of both in multilayered forms) and can be utilized in a variety of applications. This invention utilizes the presence of non-sulfur-based curing systems and agents, such as bisphenols, that permit vulcanization and do not irreversibly bind silver ions thereto, thereby resulting in long-term antimicrobial performance of the rubber article. This invention further provides a simple method of producing such an antimicrobial vulcanized fluoroelastomer rubber-containing article. This invention also encompasses certain non-silicone pre-vulcanized raw rubber formulations made from at least a majority by weight of FKM rubber that include silver-based components to provide highly desirable long-term antimicrobial characteristics within the ultimate cured FKM articles made therefrom.

    摘要翻译： 提供了显示出非常期望的长期有效抗微生物特性的含氟弹性体（FKM）橡胶制品。 这样的制品是固体或吹制（泡沫或海绵）状态（或多层形式的两者的组合），并且可以用于各种应用中。 本发明利用了非硫基固化体系和诸如双酚的试剂，其允许硫化并且不会不可逆地结合银离子，从而导致橡胶制品的长期抗菌性能。 本发明还提供了一种制备这种抗微生物硫化含氟弹性体橡胶的制品的简单方法。 本发明还包括由至少大部分重量比的FKM橡胶制成的某些非硅氧烷预硫化生橡胶配方，其包括银基组分，以在由其制成的最终固化的FKM制品中提供高度期望的长期抗微生物特性。

    Flat-panel display with intensity control to reduce light-centroid shifting
    28.
    发明授权
    Flat-panel display with intensity control to reduce light-centroid shifting 有权
    平板显示屏具有强度控制，减少轻质心跳

    公开(公告)号：US06414428B1

    公开(公告)日：2002-07-02

    申请号：US09302698

    申请日：1999-04-30

    申请人： Donald R. Schropp, Jr. ,  John E. Field ,  James C. Dunphy ,  Lawrence S. Pan ,  David L. Morris ,  Ronald S. Besser ,  Christopher J. Spindt

    发明人： Donald R. Schropp, Jr. ,  John E. Field ,  James C. Dunphy ,  Lawrence S. Pan ,  David L. Morris ,  Ronald S. Besser ,  Christopher J. Spindt

    IPC分类号： H01J162

    CPC分类号： H01J29/028 ,  H01J29/467 ,  H01J29/481 ,  H01J31/127 ,  H01J2201/025 ,  H01J2329/8625

    摘要： The intensity at which electrons emitted by a first plate structure (10) in a flat-panel display strike a second plate structure (12) for causing it to emit light is controlled so as to reduce image degradation that could otherwise arise from undesired electron-trajectory changes caused by effects such as the presence of a spacer system (14) between the plate structures. An electron-emissive region (20) in the first plate structure typically contains multiple laterally separated electron-emissive portions (201 and 202) for selectively emitting electrons. An electron-focusing system in the first plate structure has corresponding focus openings (42P1 and 42P2) through which electrons emitted by the electron-emissive portions respectively pass. Upon being struck by the so-emitted electrons, a light-emissive region (22) in the second plate structure emits light to produce at least part of a dot of the display's image.

    摘要翻译： 控制由平板显示器中的第一板结构（10）发射的电子撞击用于使其发光的第二板结构（12）的强度，以便减少否则可能由不期望的电子发射引起的图像劣化， 由诸如板结构之间的隔离系统（14）的影响引起的轨迹变化。 第一板结构中的电子发射区（20）通常包含用于选择性地发射电子的多个横向分离的电子发射部分（201和202）。 第一板结构中的电子聚焦系统具有相应的聚焦开口（42P1和42P2），电子发射部分发射的电子分别通过该开口。 在被所发射的电子撞击时，第二板结构中的发光区域（22）发光，以产生显示器图像的至少一部分点。