摘要:
This is directed to providing a cosmetic finish on a component constructed by connecting several elements. A single manufacturing process, such as machining or grinding, can be applied to the connected elements to remove material from some or all of the elements and to form a smooth and continuous surface across interfaces between the individual elements of the component. In some cases, settings of the material removal process can be adjusted based on the material of the component elements. For example, the settings can be adjusted based on the manufacturing or mechanical properties of each element material.
摘要:
Provided are compounds, pharmaceutical compositions and methods of treatment or prophylaxis of disorders associated with NMDA receptor activity, including neuropathic pain, stroke, traumatic brain injury, epilepsy, and related neurologic events or neurodegeneration. Compounds are of the general Formula I, or a pharmaceutically acceptable salt, ester, prodrug or derivative thereof are provided: wherein: each (L)k-Ar1 is a substituted or unsubstituted, mono or bicyclic aryl or heteroaryl; W is a bond, alkyl, or alkenyl; X is a bond, NR1 or O and each R1 and R2 is independently H, alkyl, alkenyl or aralkyl or R1 and R2 taken together form a 5-8 membered ring; R3−-R6 are selected from certain specific substituents or a carbonyl; Y is a bond, O, S, SO, SO2, CH2, NH, N(alkyl), or NHC(═O); and Z is OH, NR6R7, NR8SO2(alkyl), NR8C(O)NR6R7, NR8C(O)O(alkyl), NR8-dihydrothiazole, or NR8-dihydroimidazole or wherein Z can fuse with Ar2 to form selected heterocycles.
摘要翻译:提供了治疗或预防与NMDA受体活性相关的病症的化合物,药物组合物和方法,包括神经性疼痛,中风,创伤性脑损伤,癫痫以及相关的神经系统事件或神经变性。 化合物为通式I,或其药学上可接受的盐,酯,前药或衍生物:其中:(L)k-Ar1为取代或未取代的单或双环芳基或杂芳基; W是键,烷基或烯基; X是键,NR 1或O,并且每个R 1和R 2独立地是H,烷基,烯基或芳烷基,或者R 1和R 2一起形成5-8元环; R 3 -R 6选自某些具体取代基或羰基; Y是键,O,S,SO,SO 2,CH 2,NH,N(烷基)或NHC(= O); 并且Z是OH,NR 6 R 7,NR 8 SO 2(烷基),NR 8 C(O)NR 6 R 7,NR 8 C(O)O(烷基),NR 8 - 二氢噻唑或NR 8 - 二氢咪唑,或其中Z可与Ar 2融合形成选定的杂环。
摘要:
An electromagnetic interference shield system, is provided. Each EMI shield may include a frame providing the structure around the electronic device components to be shielded, and a cover operative to be placed over the frame to prevent electromagnetic radiation from passing over the frame. Each frame may be coupled to a circuit board, and enclose electronic components in need of shielding. Each cover may be coupled to its corresponding frame using at least one snap that extends from the periphery of the cover towards the frame and circuit board. To minimize the space taken by the EMI shields, the snaps of adjacent covers may be offset or staggered so that opposing snaps engage voids left between snaps of the opposing cover, thus reducing the space needed between adjacent EMI shields by up to the width of a snap.
摘要:
A battery assembly for use in an electronic device is provided. The battery assembly may include a battery cell (e.g., a rechargeable battery cell), a battery connector for providing power from the battery cell to the electronic device, and a flex circuit electrically coupling the battery cell to the electronic device. The battery connector may be located adjacent the battery cell, and may include one or more alignment mechanisms for ensuring that conductive pads of the battery connector align properly with corresponding conductive elements of the electronic device. The battery cell may be fixed to the electronic device using an adhesive layer (e.g., double sided tape) placed between the cell and the electronic device. A tab may extend beyond the periphery of the battery cell to allow a user to pull or peal the battery cell from the electronic device for replacement or repair. In some embodiments, a tool may be used to grasp the tab.
摘要:
Electronic devices are provided with ejectable component assemblies. The ejectable component assembly may include a tray that can be loaded with one or more removable modules, wafers coupled to circuit boards, cages and retaining plates to assist in retaining the tray within the assembly. The ejectable component assembly may include springs operative to engage detents in the tray to retain the tray in the assembly. The ejectable component assembly may include a tray ejector mechanism for ejecting the tray from the assembly.
摘要:
Provided are compounds, pharmaceutical compositions and methods of treatment or prophylaxis of disorders associated with NMDA receptor activity, including neuropathic pain, stroke, traumatic brain injury, epilepsy, and related neurologic events or neurodegeneration. Compounds are of the general Formula I, or a pharmaceutically acceptable salt, ester, prodrug or derivative thereof are provided: wherein: each (L)k-Ar1 is a substituted or unsubstituted, mono or bicyclic aryl or heteroaryl; W is a bond, alkyl, or alkenyl; X is a bond, NR1 or O and each R1 and R2 is independently H, alkyl, alkenyl or aralkyl or R1 and R2 taken together form a 5-8 membered ring; R3−R6 are selected from certain specific substituents or a carbonyl; Y is a bond, O, S, SO, SO2, CH2, NH, N(alkyl), or NHC(═O); and Z is OH, NR6R7, NR8SO2(alkyl), NR8C(O)NR6R7, NR8C(O)O(alkyl), NR8-dihydrothiazole, or NR8-dihydroimidazole or wherein Z can fuse with Ar2 to form selected heterocycles.
摘要翻译:提供了治疗或预防与NMDA受体活性相关的病症的化合物,药物组合物和方法,包括神经性疼痛,中风,创伤性脑损伤,癫痫以及相关的神经系统事件或神经变性。 化合物为通式I,或其药学上可接受的盐,酯,前药或衍生物:其中:(L)k-Ar1为取代或未取代的单或双环芳基或杂芳基; W是键,烷基或烯基; X是键,NR 1或O,并且每个R 1和R 2独立地是H,烷基,烯基或芳烷基,或者R 1和R 2一起形成5-8元环; R 3 -R 6选自某些具体取代基或羰基; Y是键,O,S,SO,SO 2,CH 2,NH,N(烷基)或NHC(-O); 并且Z是OH,NR 6 R 7,NR 8 SO 2(烷基),NR 8 C(O)NR 6 R 7,NR 8 C(O)O(烷基),NR 8 - 二氢噻唑或NR 8 - 二氢咪唑,或其中Z可与Ar 2融合形成选定的杂环。
摘要:
A float system for use in cementing a casing in a wellbore. The wellbore is drilled with a drill bit attached to the casing. The drill bit is removed after the wellbore is drilled. The float system is lowered into the casing after the drill bit is removed. The float system includes a packer apparatus with a float apparatus, preferably a float shoe, attached to the end thereof. The packer apparatus is set in the casing to hold the float shoe in position. A bottom cementing plug is placed in the casing and is urged downwardly until it engages the upper end of the packer apparatus. The cement will flow through the packer apparatus and the float apparatus to fill the annulus between the casing and the wellbore.
摘要:
Method for enhancing a food item by apply a hypoallergenic, plant-based vegan dressing by combining water with a hypoallergenic-substrate, and at least one or more of sunflower seed butter and/or coconut cream. The resulting dressing is then subjected to a preservation process. In an alternative method, the resulting dressing is also inoculated in order to reduce its pH.
摘要:
Method for enhancing a food item by apply a hypoallergenic, plant-based vegan dressing by combining water with a hypoallergenic-substrate, and at least one or more of sunflower seed butter and/or coconut cream. The resulting dressing is then subjected to a preservation process. In an alternative method, the resulting dressing is also inoculated in order to reduce its pH.
摘要:
This is directed to an EMI shield constructed from a conformal coating. A circuit board can include electronic components for which EMI shielding is required. To provide such shielding in a space-efficient manner, a first non-conductive conformal coating can be placed over the circuit board and the electronic components. A second conductive conformal coating can then be placed over the first such that at least portions of the second coating around the periphery of the electronic components are electrically coupled to the circuit board.