公开(公告)号：US20190350499A1

公开(公告)日：2019-11-21

申请号：US16527865

申请日：2019-07-31

Applicant: DexCom, Inc.

Inventor： Sebastian Böhm ,  Daiting Rong ,  Peter C. Simpson

IPC: A61B5/1495 ,  G01N33/49 ,  A61B5/1486 ,  A61B5/145 ,  A61B5/00 ,  A61B5/1473 ,  G01N27/02 ,  G01N27/327 ,  G01D18/00

Abstract: Systems and methods for processing sensor data and self-calibration are provided. In some embodiments, systems and methods are provided which are capable of calibrating a continuous analyte sensor based on an initial sensitivity, and then continuously performing self-calibration without using, or with reduced use of, reference measurements. In certain embodiments, a sensitivity of the analyte sensor is determined by applying an estimative algorithm that is a function of certain parameters. Also described herein are systems and methods for determining a property of an analyte sensor using a stimulus signal. The sensor property can be used to compensate sensor data for sensitivity drift, or determine another property associated with the sensor, such as temperature, sensor membrane damage, moisture ingress in sensor electronics, and scaling factors.

公开(公告)号：US10448873B2

公开(公告)日：2019-10-22

申请号：US14956192

申请日：2015-12-01

Applicant: DexCom, Inc.

Inventor： Sebastian Böhm ,  Daiting Rong ,  Peter C. Simpson

IPC: A61B5/1495 ,  G01N27/327 ,  A61B5/145 ,  A61B5/1486 ,  A61B5/00 ,  G01D18/00 ,  G01N27/02 ,  G01N33/49 ,  A61B5/1473

Abstract: Systems and methods for processing sensor data and self-calibration are provided. In some embodiments, systems and methods are provided which are capable of calibrating a continuous analyte sensor based on an initial sensitivity, and then continuously performing self-calibration without using, or with reduced use of, reference measurements. In certain embodiments, a sensitivity of the analyte sensor is determined by applying an estimative algorithm that is a function of certain parameters. Also described herein are systems and methods for determining a property of an analyte sensor using a stimulus signal. The sensor property can be used to compensate sensor data for sensitivity drift, or determine another property associated with the sensor, such as temperature, sensor membrane damage, moisture ingress in sensor electronics, and scaling factors.

公开(公告)号：US20190223766A1

公开(公告)日：2019-07-25

申请号：US16254213

申请日：2019-01-22

Applicant: DexCom, Inc.

Inventor： Anna Claire Harley-Trochimczyk ,  Sebastian Böhm ,  Rui Ma ,  Disha B. Sheth ,  Minglian Shi ,  Kamuran Turksoy

IPC: A61B5/1495 ,  A61B5/01 ,  A61B5/145 ,  A61B5/1486 ,  A61B5/00 ,  A61B5/0205

Abstract: This document discusses, among other things, systems and methods to compensate for the effects of temperature on sensors, such as analyte sensor. An example method may include determining a temperature-compensated glucose concentration level by receiving a temperature signal indicative of a temperature parameter of an external component, receiving a glucose signal indicative of an in vivo glucose concentration level, and determining a compensated glucose concentration level based on the glucose signal, the temperature signal, and a delay parameter.

公开(公告)号：US20190223765A1

公开(公告)日：2019-07-25

申请号：US16254210

申请日：2019-01-22

Applicant: DexCom, Inc.

Inventor： Anna Claire Harley-Trochimczyk ,  Sebastian Böhm ,  Rui Ma ,  Disha B. Sheth ,  Minglian Shi ,  Kamuran Turksoy

IPC: A61B5/1495 ,  A61B5/01 ,  A61B5/0205 ,  A61B5/145 ,  A61B5/1486 ,  A61B5/00

Abstract: This document discusses, among other things, systems and methods to compensate for the effects of temperature on sensors, such as analyte sensor. An example method may include determining a temperature-compensated glucose concentration level by receiving a temperature signal indicative of a temperature parameter of an external component, receiving a glucose signal indicative of an in vivo glucose concentration level, and determining a compensated glucose concentration level based on the glucose signal, the temperature signal, and a delay parameter.

公开(公告)号：US20190150803A1

公开(公告)日：2019-05-23

申请号：US16261339

申请日：2019-01-29

Applicant: DexCom, Inc.

Inventor： Stephen J. Vanslyke ,  Naresh C. Bhavaraju ,  Sebastian Böhm ,  Leif N. Bowman ,  Michael J. Estes ,  Arturo Garcia ,  Apurv Ullas Kamath ,  Andrew Attila Pal ,  Thomas A. Peyser ,  Anna Leigh Davis ,  Daiting Rong ,  Disha B. Sheth ,  Peter C. Simpson ,  Dmytro Sokolovsky

IPC: A61B5/1495 ,  A61B5/00 ,  A61B5/145 ,  A61B5/01 ,  A61B5/11 ,  A61B5/053 ,  A61M5/172 ,  A61B5/1473 ,  A61B5/1486

Abstract: Systems and methods disclosed here provide ways to discriminate fault types encountered in analyte sensors and systems and further provide ways to process such discriminated faults responsively based on sensor data, clinical context information, and other data about the patient or patient's environment. The systems and methods thus employ clinical context in detecting and/or responding to errors or faults associated with an analyte sensor system, and discriminating the type of fault, and its root cause, particularly as fault dynamics can appear similar to the dynamics of physiological systems, emphasizing the importance of discriminating the fault and providing appropriate responsive processing. Thus, the disclosed systems and methods consider the context of the patient's health condition or state in determining how to respond to the fault.

公开(公告)号：US10231659B2

公开(公告)日：2019-03-19

申请号：US14717965

申请日：2015-05-20

Applicant: DexCom, Inc.

Inventor： Stephen J. Vanslyke ,  Naresh C. Bhavaraju ,  Sebastian Böhm ,  Leif N. Bowman ,  Michael J. Estes ,  Arturo Garcia ,  Apurv Ullas Kamath ,  Andrew Attila Pal ,  Thomas A. Peyser ,  Anna Leigh Rack-Gomer ,  Daiting Rong ,  Disha B. Sheth ,  Peter C. Simpson ,  Dmytro Sokolovsky

IPC: A61B5/00 ,  A61B5/1495 ,  A61B5/01 ,  A61B5/11 ,  A61B5/053 ,  A61B5/145 ,  A61B5/1486 ,  A61B5/1473 ,  A61M5/172 ,  G06F19/00

Abstract: Systems and methods disclosed here provide ways to discriminate fault types encountered in analyte sensors and systems and further provide ways to process such discriminated faults responsively based on sensor data, clinical context information, and other data about the patient or patient's environment. The systems and methods thus employ clinical context in detecting and/or responding to errors or faults associated with an analyte sensor system, and discriminating the type of fault, and its root cause, particularly as fault dynamics can appear similar to the dynamics of physiological systems, emphasizing the importance of discriminating the fault and providing appropriate responsive processing. Thus, the disclosed systems and methods consider the context of the patient's health condition or state in determining how to respond to the fault.

公开(公告)号：US09517025B2

公开(公告)日：2016-12-13

申请号：US15153586

申请日：2016-05-12

Applicant: DexCom, Inc.

Inventor： Daiting Rong ,  Sebastian Böhm ,  Matthew D. Wightlin

IPC: G01N33/483 ,  G01N33/50 ,  A61B5/1486 ,  A61B5/145

CPC classification number: A61B5/14532 ,  A61B5/14865 ,  A61B2560/0223 ,  A61B2562/0209 ,  A61B2562/043 ,  A61B2562/125

Abstract: Systems and methods of use for continuous analyte measurement of a host's vascular system are provided. In some embodiments, a continuous glucose measurement system includes an electrochemical sensor incorporating a silver/silver chloride reference electrode, wherein a capacity of the reference electrode is controlled.

Abstract translation: 提供了用于宿主血管系统的连续分析物测量的系统和方法。 在一些实施方案中，连续葡萄糖测量系统包括结合有银/氯化银参考电极的电化学传感器，其中控制参比电极的容量。

公开(公告)号：US20160157758A1

公开(公告)日：2016-06-09

申请号：US14956192

申请日：2015-12-01

Applicant: DexCom, Inc.

Inventor： Sebastian Böhm ,  Daiting Rong ,  Peter C. Simpson

IPC: A61B5/1495 ,  A61B5/145 ,  A61B5/00

Abstract: Systems and methods for processing sensor data and self-calibration are provided. In some embodiments, systems and methods are provided which are capable of calibrating a continuous analyte sensor based on an initial sensitivity, and then continuously performing self-calibration without using, or with reduced use of, reference measurements. In certain embodiments, a sensitivity of the analyte sensor is determined by applying an estimative algorithm that is a function of certain parameters. Also described herein are systems and methods for determining a property of an analyte sensor using a stimulus signal. The sensor property can be used to compensate sensor data for sensitivity drift, or determine another property associated with the sensor, such as temperature, sensor membrane damage, moisture ingress in sensor electronics, and scaling factors.

公开(公告)号：US20160089065A1

公开(公告)日：2016-03-31

申请号：US14963065

申请日：2015-12-08

Applicant: DexCom, Inc.

Inventor： Peter C. Simpson ,  Jennifer Blackwell ,  Sebastian Böhm

IPC: A61B5/1473 ,  A61B5/00 ,  A61B17/34 ,  A61B5/145

CPC classification number: A61B5/1473 ,  A61B5/14503 ,  A61B5/14532 ,  A61B5/14865 ,  A61B5/4839 ,  A61B5/6848 ,  A61B17/3468 ,  A61B2017/00004

Abstract: Sensor devices including dissolvable tissue-piercing tips are provided. The sensor devices can be used in conjunction with dissolvable needles configured for inserting the sensor devices into a host. Hardening agents for strengthening membranes on sensor devices are also provided. Methods of using and fabricating sensor devices are also provided.

公开(公告)号：US20240252074A1

公开(公告)日：2024-08-01

申请号：US18425940

申请日：2024-01-29

Applicant: Dexcom, Inc.

Inventor： Sebastian Böhm ,  Anna Harley-Trochimczyk ,  Daiting Rong ,  Rui Ma ,  Wenjie Lan ,  Minglian Shi ,  Disha Sheth ,  Nicholas Kalfas ,  Vincent Crabtree ,  Kamuran Turksoy

IPC: A61B5/1495 ,  A61B5/00 ,  A61B5/0537 ,  A61B5/145 ,  A61B5/1473 ,  A61B5/1486 ,  G01N27/02 ,  G01N27/22 ,  G01N27/24 ,  G01N33/487

CPC classification number: A61B5/1495 ,  A61B5/0537 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1473 ,  A61B5/1486 ,  A61B5/14865 ,  A61B5/6844 ,  G01N27/221 ,  G01N27/24 ,  G01N33/48707 ,  A61B5/0004 ,  A61B5/0031 ,  A61B2560/0223 ,  A61B2560/0252 ,  A61B2560/0276 ,  G01N27/026

Abstract: Various examples are directed to systems and methods of and using analyte sensors. An example analyte sensor system comprises an analyte sensor and a hardware device in communication with the analyte sensor. The hardware device may be configured to perform operations comprising applying a first bias voltage to the analyte sensor, the first bias voltage less than an operational bias voltage of the analyte sensor, measuring a first current at the analyte sensor when the first bias voltage is applied, and applying a second bias voltage to the analyte sensor. The operations may further comprise measuring a second current at the analyte sensor when the second bias voltage is applied, detecting a plateau bias voltage using the first current and the second current, determining that the plateau bias voltage is less than a plateau bias voltage threshold, and executing a responsive action at the analyte sensor.