公开(公告)号：US07756584B2

公开(公告)日：2010-07-13

申请号：US10260720

申请日：2002-09-27

申请人： W. Douglas Sheffield ,  Andrew D. Firlik ,  Katrina S. Firlik

发明人： W. Douglas Sheffield ,  Andrew D. Firlik ,  Katrina S. Firlik

IPC分类号： A61N1/08

CPC分类号： A61N1/36014 ,  A61N1/0531 ,  A61N1/0534 ,  A61N1/0539 ,  A61N1/36017 ,  A61N1/36025 ,  A61N1/36082 ,  A61N1/361 ,  A61N1/375 ,  A61N1/3756

摘要： The following disclosure is drawn to methods of electrically stimulating areas of the brain in which neuroplasticity are occurring. The stimulation site may be different than the region in the brain where neural activity is typically present to perform the particular neural function according to the functional organization of the brain. The disclosure provides methods of identify the location in which neuroplasticity is occurring, not occurring or expected to occur.

摘要翻译： 下面的公开内容涉及电刺激其中发生神经可塑性的脑区域的方法。 刺激部位可能不同于大脑中通常存在神经活动的区域，以根据脑的功能组织来执行特定的神经功能。 本公开提供了识别发生神经可塑性的位置，不发生或预期发生的位置的方法。

公开(公告)号：US07577481B2

公开(公告)日：2009-08-18

申请号：US11355038

申请日：2006-02-15

申请人： Andrew D. Firlik ,  Jeffrey Balzer ,  Bradford Evan Gliner ,  Alan J. Levy ,  Carlton B. Morgan ,  Katrina S. Firlik

发明人： Andrew D. Firlik ,  Jeffrey Balzer ,  Bradford Evan Gliner ,  Alan J. Levy ,  Carlton B. Morgan ,  Katrina S. Firlik

IPC分类号： A61N1/18

CPC分类号： A61N1/375 ,  A61N1/0531 ,  A61N1/0534 ,  A61N1/0539 ,  A61N1/36017 ,  A61N1/36025 ,  A61N1/36082 ,  A61N1/36103 ,  A61N1/3756

摘要： The following disclosure describes a method for intracranial electrical stimulation to treat or otherwise effectuate a change in neural-functions of a patient. Several embodiments are directed toward enhancing or otherwise inducing a lasting change in neural activity to effectuate a particular neural-function. Such lasting change in neural activity is defined as “neuroplasticity.” The methods can be used to treat brain damage (e.g., stroke, trauma, etc.), brain disease (e.g., Alzheimer's, Pick's, Parkinson's, etc.), and/or brain disorders (e.g., epilepsy, depression, etc.). The methods can also be used to enhance neural-function of normal, healthy brains (e.g., learning, memory, etc.), or to control sensory functions (e.g., pain).

摘要翻译： 以下公开描述了一种用于颅内电刺激治疗或以其他方式实现患者神经功能变化的方法。 几个实施例旨在增强或以其他方式诱导神经活动的持续变化以实现特定的神经功能。 这种神经活动的持续变化被定义为“神经可塑性”。 这些方法可用于治疗脑损伤（例如卒中，创伤等），脑部疾病（如阿尔茨海默病，皮克病，帕金森病等）和/或脑部疾病（例如癫痫，抑郁症等） 。 该方法还可以用于增强正常，健康的大脑（例如学习，记忆等）的神经功能，或控制感觉功能（例如疼痛）。

公开(公告)号：US20090093862A1

公开(公告)日：2009-04-09

申请号：US12244610

申请日：2008-10-02

申请人： Bradford Evan Gliner ,  Jeffrey Balzer ,  Andrew D. Firlik

发明人： Bradford Evan Gliner ,  Jeffrey Balzer ,  Andrew D. Firlik

IPC分类号： A61N1/00

CPC分类号： A61N1/36021 ,  A61N1/0531 ,  A61N1/0534 ,  A61N1/0551 ,  A61N1/0553 ,  A61N1/36025 ,  A61N1/36071 ,  A61N1/36082 ,  A61N1/36185 ,  A61N1/375 ,  A61N1/3756 ,  G06F19/00

摘要： Methods and devices for automatically optimizing the stimulus parameters and/or the configuration of electrodes to provide neural stimulation to a patient. In one embodiment, a system includes an electrode array having an implantable support member configured to be implanted into a patient and a plurality of therapy electrodes carried by the support member. The system can also have a pulse system operatively coupled to the therapy electrodes to deliver a stimulus to the therapy electrodes, and a sensing device configured to be attached to a sensing location of the patient. The sensing device generates response signals in response to the stimulus. The system can also include a controller operatively, coupled to the pulse system and to the sensing device. The controller includes a computer operable medium that generates command signals that define the stimulus delivered by the pulse system, evaluates the response signals from the sensing device, and determines a desired configuration for the therapy electrodes and/or a desired stimulus to be delivered to the therapy electrodes.

摘要翻译： 用于自动优化刺激参数和/或电极配置以向患者提供神经刺激的方法和装置。 在一个实施例中，系统包括电极阵列，其具有被配置为植入病人的可植入支撑构件和由支撑构件承载的多个治疗电极。 系统还可以具有可操作地耦合到治疗电极的脉冲系统以将刺激传递到治疗电极，以及被配置为附接到患者的感测位置的感测装置。 感测装置响应于刺激产生响应信号。 该系统还可以包括可操作地耦合到脉冲系统和感测装置的控制器。 控制器包括计算机可操作介质，其产生定义由脉冲系统传递的刺激的命令信号，评估来自感测装置的响应信号，并且确定用于治疗电极的期望配置和/或要传送到 治疗电极。

公开(公告)号：US20080161882A1

公开(公告)日：2008-07-03

申请号：US11834660

申请日：2007-08-06

申请人： Andrew D. Firlik ,  Jeffrey Balzer ,  Bradford Evan Gliner ,  Alan J. Levy ,  Katrina S. Firlik

发明人： Andrew D. Firlik ,  Jeffrey Balzer ,  Bradford Evan Gliner ,  Alan J. Levy ,  Katrina S. Firlik

IPC分类号： A61N1/05

CPC分类号： A61N1/36017 ,  A61N1/0531 ,  A61N1/0534 ,  A61N1/0539 ,  A61N1/08 ,  A61N1/36021 ,  A61N1/36025 ,  A61N1/36071 ,  A61N1/36082 ,  A61N1/36103 ,  A61N1/3756

摘要： Methods and apparatus for treating an impaired neural function in a brain of a patient. In one embodiment, a method for treating a neural function in a brain of a patient includes determining a therapy period during which a plurality of therapy sessions are to be performed to recover functional ability corresponding to the neural function. The method continues by identifying a stimulation site in or on the brain of the patient associated with the neural function, and positioning an electrode at least proximate to the identified stimulation site. The patient is then treated by providing electrical stimulation treatments to the stimulation site. The treatment can comprise delivering electrical stimulation signals to the electrode during the therapy sessions. After expiration of the therapy period, the method includes preventing electrical stimulation signals from being delivered to the stimulation site.

摘要翻译： 用于治疗患者脑部受损的神经功能的方法和装置。 在一个实施方案中，用于治疗患者脑部神经功能的方法包括确定要执行多个治疗期间以恢复与神经功能相对应的功能能力的治疗期。 该方法通过识别与神经功能相关联的患者的脑中或其上的刺激部位，并且将电极定位至少接近所识别的刺激部位来继续。 然后通过向刺激部位提供电刺激治疗来治疗患者。 治疗可以包括在治疗期间向电极传送电刺激信号。 在治疗期满后，该方法包括防止电刺激信号传递到刺激部位。

公开(公告)号：US08412335B2

公开(公告)日：2013-04-02

申请号：US13487472

申请日：2012-06-04

申请人： Bradford Evan Gliner ,  Jeffrey Balzer ,  Andrew D. Firlik

发明人： Bradford Evan Gliner ,  Jeffrey Balzer ,  Andrew D. Firlik

IPC分类号： A61N1/36

CPC分类号： A61N1/36021 ,  A61N1/0531 ,  A61N1/0534 ,  A61N1/0551 ,  A61N1/0553 ,  A61N1/36025 ,  A61N1/36071 ,  A61N1/36082 ,  A61N1/36185 ,  A61N1/375 ,  A61N1/3756 ,  G06F19/00

摘要： System and method for automatically optimizing the stimulus parameters and/or the configuration of electrodes to provide neural stimulation to a patient, the system includes an electrode array having a support member configured to be implanted into the patient and a plurality of therapy electrodes carried by the support member. The system can also have a pulse system operatively coupled to the therapy electrodes to deliver a stimulus to the therapy electrodes, and a sensing device configured to be attached to a sensing location of the patient. The sensing device generates response signals in response to the stimulus. The system can also include a controller that generates command signals that define the stimulus delivered by the pulse system, evaluates the response signals from the sensing device, and determines a desired configuration for the therapy electrodes and/or a desired stimulus to be delivered to the therapy electrodes.

摘要翻译： 用于自动优化刺激参数和/或电极配置以向患者提供神经刺激的系统和方法，所述系统包括电极阵列，其具有被配置为植入患者体内的支撑构件，以及多个治疗电极 支持会员 系统还可以具有可操作地耦合到治疗电极的脉冲系统以将刺激传递到治疗电极，以及被配置为附接到患者的感测位置的感测装置。 感测装置响应于刺激产生响应信号。 该系统还可以包括产生命令信号的控制器，该命令信号定义由脉冲系统传递的刺激，评估来自感测装置的响应信号，并且确定治疗电极的期望配置和/或要传送给 治疗电极。

公开(公告)号：US20120253442A1

公开(公告)日：2012-10-04

申请号：US13438513

申请日：2012-04-03

申请人： Bradford Evan Gliner ,  Brad Fowler ,  Andrew D. Firlik ,  Jeffrey Balzer ,  Alan J. Levy ,  Kent Leyde

发明人： Bradford Evan Gliner ,  Brad Fowler ,  Andrew D. Firlik ,  Jeffrey Balzer ,  Alan J. Levy ,  Kent Leyde

IPC分类号： A61N1/05

CPC分类号： A61N1/32 ,  A61N1/0531 ,  A61N1/0534 ,  A61N1/0539 ,  A61N1/36017 ,  A61N1/36025 ,  A61N1/36082 ,  A61N1/375 ,  A61N1/3756 ,  A61N1/40

摘要： A device and method for intracranial electrical stimulation to effectuate a change in neural-functions of a patient, by electrical stimulating the brain at a site where neuroplasticity is occurring or is expected to occur, where the stimulation site may be different than the region in the brain where neural activity is typically present to perform the particular neural function according to the functional organization of the brain. In one embodiment in which neuroplasticity is related to the neural-function occurs in the brain, identifying the location where such neuroplasticity is present or expected to occur. Where neuroplasticity is not occurring in the brain, an alternative aspect is to induce neuroplasticity at a stimulation site where it is expected to occur. The methods can use electrical pulses that increase the resting membrane potential of neurons at the stimulation site to a subthreshold level.

摘要翻译： 用于颅内电刺激的装置和方法，通过在发生或预期发生神经可塑性的部位电刺激脑，刺激部位可能不同于 神经活动通常存在以根据脑的功能组织执行特定神经功能的脑。 在脑中发生神经功能与神经功能相关的一个实施方案中，鉴定存在或预期发生这种神经可塑性的位置。 在脑中不发生神经可塑性的情况下，另一方面是在预期发生的刺激部位诱导神经可塑性。 这些方法可以使用电脉冲，其将刺激部位的神经元的静息膜电位增加到亚阈值水平。

公开(公告)号：US20120253421A1

公开(公告)日：2012-10-04

申请号：US13487472

申请日：2012-06-04

申请人： Bradford Evan Gliner ,  Jeffrey Balzer ,  Andrew D. Firlik

发明人： Bradford Evan Gliner ,  Jeffrey Balzer ,  Andrew D. Firlik

IPC分类号： A61N1/36

CPC分类号： A61N1/36021 ,  A61N1/0531 ,  A61N1/0534 ,  A61N1/0551 ,  A61N1/0553 ,  A61N1/36025 ,  A61N1/36071 ,  A61N1/36082 ,  A61N1/36185 ,  A61N1/375 ,  A61N1/3756 ,  G06F19/00

摘要： System and method for automatically optimizing the stimulus parameters and/or the configuration of electrodes to provide neural stimulation to a patient, the system includes an electrode array having a support member configured to be implanted into the patient and a plurality of therapy electrodes carried by the support member. The system can also have a pulse system operatively coupled to the therapy electrodes to deliver a stimulus to the therapy electrodes, and a sensing device configured to be attached to a sensing location of the patient. The sensing device generates response signals in response to the stimulus. The system can also include a controller that generates command signals that define the stimulus delivered by the pulse system, evaluates the response signals from the sensing device, and determines a desired configuration for the therapy electrodes and/or a desired stimulus to be delivered to the therapy electrodes.

摘要翻译： 用于自动优化刺激参数和/或电极配置以向患者提供神经刺激的系统和方法，所述系统包括电极阵列，其具有被配置为植入患者体内的支撑构件，以及多个治疗电极 支持会员 系统还可以具有可操作地耦合到治疗电极的脉冲系统以将刺激传递到治疗电极，以及被配置为附接到患者的感测位置的感测装置。 感测装置响应于刺激产生响应信号。 该系统还可以包括产生命令信号的控制器，该命令信号定义由脉冲系统传递的刺激，评估来自感测装置的响应信号，并且确定治疗电极的期望配置和/或要传送给 治疗电极。

公开(公告)号：US08195300B2

公开(公告)日：2012-06-05

申请号：US13101306

申请日：2011-05-05

申请人： Bradford Evan Gliner ,  Jeffrey Balzer ,  Andrew D. Firlik

发明人： Bradford Evan Gliner ,  Jeffrey Balzer ,  Andrew D. Firlik

IPC分类号： A61N1/36

CPC分类号： A61N1/36021 ,  A61N1/0531 ,  A61N1/0534 ,  A61N1/0551 ,  A61N1/0553 ,  A61N1/36025 ,  A61N1/36071 ,  A61N1/36082 ,  A61N1/36185 ,  A61N1/375 ,  A61N1/3756 ,  G06F19/00

摘要： Methods and devices for automatically optimizing the stimulus parameters and/or the configuration of electrodes to provide neural stimulation to a patient. In one embodiment, a system includes an electrode array having an implantable support member configured to be implanted into the patient and a plurality of therapy electrodes carried by the support member. The system can also have a pulse system operatively coupled to the therapy electrodes to deliver a stimulus to the therapy electrodes, and a sensing device configured to be attached to a sensing location of the patient. The sensing device generates response signals in response to the stimulus. The system can also include a controller operatively coupled to the pulse system and to the sensing device. The controller includes a computer operable medium that generates command signals that define the stimulus delivered by the pulse system, evaluates the response signals from the sensing device, and determines a desired configuration for the therapy electrodes and/or a desired stimulus to be delivered to the therapy electrodes.

摘要翻译： 用于自动优化刺激参数和/或电极配置以向患者提供神经刺激的方法和装置。 在一个实施例中，系统包括电极阵列，其具有被配置为植入患者体内的可植入支撑构件和由支撑构件承载的多个治疗电极。 系统还可以具有可操作地耦合到治疗电极的脉冲系统以将刺激传递到治疗电极，以及被配置为附接到患者的感测位置的感测装置。 感测装置响应于刺激产生响应信号。 该系统还可以包括可操作地耦合到脉冲系统和感测装置的控制器。 控制器包括计算机可操作介质，其产生定义由脉冲系统传递的刺激的命令信号，评估来自感测装置的响应信号，并且确定用于治疗电极的期望配置和/或期望的刺激以被传送到 治疗电极。

公开(公告)号：US08073546B2

公开(公告)日：2011-12-06

申请号：US12834711

申请日：2010-07-12

申请人： W. Douglas Sheffield ,  Andrew D. Firlik

发明人： W. Douglas Sheffield ,  Andrew D. Firlik

IPC分类号： A61N1/36

CPC分类号： A61N1/36014 ,  A61N1/0531 ,  A61N1/0534 ,  A61N1/0539 ,  A61N1/36017 ,  A61N1/36025 ,  A61N1/36082 ,  A61N1/361 ,  A61N1/375 ,  A61N1/3756

摘要： The following disclosure describes several methods and apparatus for electrical stimulation to treat or otherwise effectuate a change in neural-functions of a patient. For example, the method can include selecting a stimulation site by generating an intended neural activity by triggering a neural signal in or from the impaired body part and detecting a region of the brain in which a response neural activity occurs in reaction to the neural signal.

摘要翻译： 以下公开内容描述了用于电刺激治疗或以其他方式实现患者神经功能变化的几种方法和装置。 例如，该方法可以包括通过在受损的身体部位触发神经信号或从受损的身体部位触发神经信号并检测在神经信号的反应中发生反应神经活动的脑区域来产生预期神经活动来选择刺激部位。

公开(公告)号：US20110092882A1

公开(公告)日：2011-04-21

申请号：US12973471

申请日：2010-12-20

申请人： Andrew D. Firlik ,  Bradford Evan Gliner ,  W. Douglas Sheffield ,  Leif R. Sloan

发明人： Andrew D. Firlik ,  Bradford Evan Gliner ,  W. Douglas Sheffield ,  Leif R. Sloan

IPC分类号： A61N5/00 ,  A61M5/00

CPC分类号： A61N1/36067 ,  A61B5/16 ,  A61B5/18 ,  A61B5/7275 ,  A61F2002/704 ,  A61M5/14276 ,  A61M5/1723 ,  A61M2205/05 ,  A61M2205/50 ,  A61M2230/63 ,  A61N1/0531 ,  A61N1/36003 ,  A61N1/36014 ,  A61N1/36017 ,  A61N1/36025 ,  A61N1/36082 ,  A61N1/361 ,  A61N1/36103 ,  A61N1/36139 ,  A61N1/372 ,  G06F19/00 ,  G06F19/3481

摘要： Systems and methods for patient interactive neural stimulation and/or chemical substance delivery are disclosed. A method in accordance with one embodiment of the invention includes affecting a target neural population of the patient by providing to the patient at least one of an electromagnetic signal and a chemical substance. The method can further include detecting at least one characteristic of the patient, with the characteristic at least correlated with the patient's performance of an adjunctive therapy task that is performed in association with affecting the target neural population. The method can still further include controlling at least one parameter in accordance with which the target neural population is affected, based at least in part on the detected characteristic.

摘要翻译： 公开了用于患者交互神经刺激和/或化学物质递送的系统和方法。 根据本发明的一个实施例的方法包括通过向患者提供电磁信号和化学物质中的至少一个来影响患者的目标神经群体。 该方法还可以包括检测患者的至少一个特征，其特征至少与患者与影响目标神经群体相关联的辅助治疗任务的性能相关。 该方法还可以进一步包括至少部分地基于检测到的特征来控制至少一个参数，根据目标神经群体受到影响。