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21.发明授权Absorbable bimodal polymeric blend compositions, processing methods, and medical devices 有权可吸收的双峰聚合物共混组合物，加工方法和医疗装置公开(公告)号：US09181427B2
公开(公告)日：2015-11-10
申请号：US14533274
申请日：2014-11-05
Applicant: Ethicon, Inc.
Inventor： Dennis D. Jamiolkowski , Sasa Andjelic , Brian M. Kelly , Christopher DeFelice
IPC: C08G63/91 , C08L67/04 , A61L31/04 , A61L31/14 , A61L27/18 , A61L29/06 , A61L31/06 , A61B17/064 , A61L17/12 , C08G63/664 , C08G65/32
CPC classification number: C08L67/04 , A61B17/06166 , A61B17/064 , A61B2017/00004 , A61B2017/00831 , A61L17/12 , A61L27/18 , A61L29/06 , A61L31/041 , A61L31/06 , A61L31/148 , C08G63/664 , C08L2201/06 , C08L2203/02 , C08L2205/02 , C08L2205/025
Abstract: Novel absorbable polymeric blends having bimodal molecular weight distribution are disclosed. The bimodal blends have a first component that is a polylactide polymer or a copolymer of lactide and glycolide having a bimodal molecular weight distribution, and a second component that is a poly(p-dioxanone) polymer of unimodal or bimodal molecular weight distribution. Alternately, the bimodal blends have a first component that is a polylactide polymer or a copolymer of lactide and glycolide having a unimodal molecular weight distribution, and a second component that is a poly(p-dioxanone) polymer of bimodal molecular weight distribution. The novel polymeric bimodal molecular weight blends provide medical devices having improved dimensional stability. Also disclosed are novel absorbable medical devices made from these novel bimodal polymer blends, as well as novel methods of manufacture.
Abstract translation: 公开了具有双峰分子量分布的新型可吸收聚合物共混物。 双峰共混物具有第一组分，其是聚丙交酯聚合物或具有双峰分子量分布的丙交酯和乙交酯的共聚物，以及作为单峰或双峰分子量分布的聚（对二恶烷酮）聚合物的第二组分。 或者，双峰共混物具有第一组分，其是具有单峰分子量分布的聚丙交酯聚合物或丙交酯和乙交酯的共聚物，以及作为双峰分子量分布的聚（对二恶烷酮）聚合物的第二组分。 新型聚合双峰分子量共混物提供具有改进的尺寸稳定性的医疗装置。 还公开了由这些新型双峰聚合物共混物制成的新型可吸收医疗装置，以及新颖的制造方法。
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22.发明申请Absorbable Poly (p-dioxanone-co-glycolide) Monofilament Fibers Pocessing Mid-Term Strength Retention Post-Implantation 审中-公开可吸收聚（对二恶烷酮 - 共 - 乙交酯）单丝纤维补偿中期强度保留植入后公开(公告)号：US20150266221A1
公开(公告)日：2015-09-24
申请号：US14725196
申请日：2015-05-29
Applicant: Ethicon, Inc.
Inventor： Sasa Andjelic , Kenneth Keilman , Dennis D. Jamiolkowski
CPC classification number: B29C48/05 , A61B17/04 , A61B17/06166 , A61L17/12 , B29C48/002 , B29C48/0021 , B29C48/0022 , B29C48/022 , B29C48/147 , B29C48/865 , B29C48/91 , B29C48/919 , B29K2073/00 , B29K2995/0056 , B29K2995/006 , B29L2031/726 , B29L2031/731 , B29L2031/753 , D01D5/098
Abstract: Novel absorbable monofilament sutures and fibers having unique and improved properties are disclosed including mid-term strength retention post-implantation. Also disclosed is a novel method of manufacturing absorbable monofilament sutures and fibers. The sutures and fibers are extruded from poly(p-dioxanone-co-glycolide) copolymers.
Abstract translation: 公开了新颖的可吸收单丝缝合线和具有独特且改善的性质的纤维，包括植入后的中期强度保留。 还公开了制造可吸收的单丝缝合线和纤维的新方法。 缝合线和纤维从聚（对二恶烷酮 - 共 - 乙交酯）共聚物挤出。
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23.发明申请Absorbable Polymeric Blend Compositions with Precisely Controllable Absorption Rates, Processing Methods, and Dimensionally Stable Medical Devices Therefrom 审中-公开可吸收的具有精确控制吸收率的聚合物混合组合物，加工方法和尺寸稳定的医疗器械公开(公告)号：US20150148496A1
公开(公告)日：2015-05-28
申请号：US14548536
申请日：2014-11-20
Applicant: Ethicon, Inc.
Inventor： Dennis D. Jamiolkowski , Daniel Steiger , Brian M. Kelly , Christopher DeFelice , Sasa Andjelic , Modesto Erneta
CPC classification number: A61L31/041 , A61B17/06166 , A61B17/064 , A61B2017/00004 , A61L17/105 , A61L27/26 , A61L27/58 , A61L31/148 , C08L67/04 , C08L2205/03 , C08L2666/18
Abstract: Novel absorbable polymeric blends are disclosed. The blends have a first absorbable polymer type that is a polylactide polymer or a copolymer of lactide and glycolide and a second absorbable polymer type that is poly(p-dioxanone), wherein the first absorbable polymer type or the second absorbable polymer type or the first absorbable polymer type and the second absorbable polymer type additionally comprise a first polymeric component and a second polymeric component. The first polymeric component has a higher weight average molecular weight than the second polymeric component and at least one of said components is at least partially end-capped by a carboxylic acid. The novel polymeric blends are useful for manufacturing medical devices having dimensional stability, having engineered degradation and breaking strength retention in vivo. Also disclosed are novel absorbable medical devices made from these novel polymer blends, as well as novel methods of manufacture.
Abstract translation: 公开了新颖的可吸收聚合物共混物。 共混物具有第一可吸收聚合物类型，其是聚丙交酯聚合物或丙交酯和乙交酯的共聚物，以及聚（对二恶烷酮）的第二可吸收聚合物类型，其中第一可吸收聚合物类型或第二可吸收聚合物类型或第一可吸收聚合物类型 可吸收聚合物类型和第二可吸收聚合物类型另外包含第一聚合物组分和第二聚合物组分。 第一聚合物组分具有比第二聚合物组分更高的重均分子量，并且至少一种所述组分至少部分地被羧酸封端。 新型聚合物共混物可用于制造具有尺寸稳定性，具有工程化降解和体内断裂强度保持性的医疗装置。 还公开了由这些新型聚合物共混物制成的新型可吸收医疗器件以及新颖的制造方法。
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24.发明申请公开(公告)号：US20250033248A1
公开(公告)日：2025-01-30
申请号：US18358071
申请日：2023-07-25
Applicant: Ethicon, Inc. , Cilag GmbH International
Inventor： Sasa Andjelic , Jitendra Patel , Marc Wisnudel , Luke Orzechowski
Abstract: The present invention is directed to methods for processing absorbable, slow-to-crystallize poly(p-dioxanone) ground resin and its fines utilizing a twin-screw extruder apparatus to produce uniform pellets. Advantageously, the ground resin materials resulting from solid-state polymerization do not undergo processing, such as sieving, to remove fines from the feedstock for an extrusion and pelletizing system that has been configured with an inverted temperature profile along the extrusion barrel. The resulting PDS pellets have improved resin uniformity and greater polymer yield for improved operational efficiencies and production of extruded filaments.
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公开(公告)号：US11629222B2
公开(公告)日：2023-04-18
申请号：US16458377
申请日：2019-07-01
Applicant: Ethicon, Inc.
Inventor： Sasa Andjelic
Abstract: The present invention is directed to devices and methods for monitoring the purity of monomers, adjusting the polymerization conditions, and consequently improving a polymerization reaction process. In one method, monomer purity is estimated using an on-line evaluation by raising the temperature of the monomer formulation having a defined melting point to a first elevated temperature at least 20° C. above a preset melting point for a selected monomer formulation; cooling the monomer formulation at a controlled cooling rate in the range from about 0.5 to 50° C. per minute; measuring at least one critical property selected from the group consisting of a) crystallization peak temperature at the onset of crystallization, b) an area under the crystallization peak, which represents the heat or enthalpy of crystallization, ΔHc and combinations thereof, comparing the at least one of the selected critical properties measures relative to such properties for standard setting monomer formulations.
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Patent Agency Ranking
公开(公告)号：US11596709B2
公开(公告)日：2023-03-07
申请号：US17349535
申请日：2021-06-16
Applicant: Ethicon, Inc.
Inventor： Dennis D. Jamiolkowski , Christopher DeFelice , Sasa Andjelic , Brian M. Kelly , Marc Wisnudel , Daniel Steiger , Gaoyuan Gavin Chen
Abstract: Novel surgical sutures and novel medical devices made from novel semi-crystalline, glycolide-rich A-B-A triblock copolymers of glycolide and lactide, wherein said B-segment is a fully amorphous random copolymer of glycolide and lactide, for long term medical applications are disclosed. The novel polymer compositions are useful for long term absorbable surgical sutures, meshes and other medical devices, especially for patients with compromised healing. The novel sutures have improved properties and improved breaking strength retention, while still substantially absorbing within about a 120-day period post-implantation.
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公开(公告)号：US11135823B2
公开(公告)日：2021-10-05
申请号：US16275664
申请日：2019-02-14
Applicant: Ethicon, Inc.
Inventor： Sasa Andjelic , Dominick Egidio
IPC: B32B37/10 , B29C48/08 , B29C48/00 , B32B27/00 , B32B37/15 , A61K9/70 , A61L31/14 , B29C48/92 , A61L31/04 , A61L31/10 , B29C55/30 , B32B5/02 , B32B27/12 , B32B37/06 , B32B37/00 , A61F2/00 , B29L31/00
Abstract: The invention relates to novel processes for the lamination of semi-crystalline, high-melting point, low glass transition polymeric films, which are extruded and subsequently laminated on various thermally sensitive substrates to form laminated medical device constructs in a specific time interval to allow low processing temperatures to avoid polymer film and/or substrate degradation or heat-related distortions. Also disclosed are laminated medical device constructs made from such processes.
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28.发明申请公开(公告)号：US20200165380A1
公开(公告)日：2020-05-28
申请号：US16202454
申请日：2018-11-28
Applicant: Ethicon, Inc.
Inventor： Sasa Andjelic , Brian M. Kelly , Marc Wisnudel
Abstract: The present invention is directed methods of making absorbable poly(p-dioxanone) pellets by melt polymerization of p-dioxanone conducted in a single reactor with a temperature regulator by charging a melt reactor with a mixture of p-dioxanone (PDO) monomer, initiator, catalyst, and optionally a dye; melt polymerizing the mixture in the melt reactor with sufficient agitation of the mixture to allow complete mixing of the monomer and for sufficient time to form a PDO polymer product having an unreacted PDO monomer content of at least 65 mole percent; placing the PDO polymer product under a vacuum to remove at least portion of unreacted PDO; discharging the PDO polymer product from the melt reactor directly into an in-line, underwater pelletizer to produce undried PDO pellets, collecting the undried PDO pellets, and storing the collected PDO pellets in the freezer or a vacuum chamber prior to drying.
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公开(公告)号：US10058637B2
公开(公告)日：2018-08-28
申请号：US14548536
申请日：2014-11-20
Applicant: Ethicon, Inc.
Inventor： Dennis D. Jamiolkowski , Daniel Steiger , Brian M. Kelly , Christopher DeFelice , Sasa Andjelic , Modesto Erneta
IPC: A61L27/26 , A61L27/58 , C08L67/04 , A61L31/04 , A61L31/14 , A61B17/064 , A61L17/10 , A61B17/06 , A61B17/00
CPC classification number: A61L31/041 , A61B17/06166 , A61B17/064 , A61B2017/00004 , A61L17/105 , A61L27/26 , A61L27/58 , A61L31/148 , C08L67/04 , C08L2205/03 , C08L2666/18
Abstract: Novel absorbable polymeric blends are disclosed. The blends have a first absorbable polymer type that is a polylactide polymer or a copolymer of lactide and glycolide and a second absorbable polymer type that is poly(p-dioxanone), wherein the first absorbable polymer type or the second absorbable polymer type or the first absorbable polymer type and the second absorbable polymer type additionally comprise a first polymeric component and a second polymeric component. The first polymeric component has a higher weight average molecular weight than the second polymeric component and at least one of said components is at least partially end-capped by a carboxylic acid. The novel polymeric blends are useful for manufacturing medical devices having dimensional stability, having engineered degradation and breaking strength retention in vivo. Also disclosed are novel absorbable medical devices made from these novel polymer blends, as well as novel methods of manufacture.
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30.发明申请公开(公告)号：US20170202996A1
公开(公告)日：2017-07-20
申请号：US15001313
申请日：2016-01-20
Applicant: Ethicon, Inc.
Inventor： Sasa Andjelic , Kenneth Keilman
CPC classification number: A61L17/105 , A61L17/005 , A61L31/06 , A61L2300/404 , C08G63/664 , C08G81/00 , C08L67/04
Abstract: Novel semi-crystalline, p-dioxanone-rich ABA triblock copolymers of p-dioxanone and epsilon-caprolactone, where “B” block is a random copolymer of p-dioxanone and epsilon-caprolactone, and absorbable devices for long term medical applications are disclosed. The novel polymer compositions are useful for long term absorbable surgical sutures, and other medical devices.
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