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    Posterior Segment Drug Delivery
    23.
    发明申请
    Posterior Segment Drug Delivery 有权
    后期药物递送

    公开(公告)号：US20100255061A1

    公开(公告)日：2010-10-07

    申请号：US12696678

    申请日：2010-01-29

    申请人： Eugene de Juan, JR. ,  Yair Alster ,  Steven M. Chamow ,  Kathleen Cogan Farinas ,  Hanson S. Gifford, III ,  K. Angela MacFarlane ,  Cary J. Reich ,  Michael Barrett ,  Randolph E. Campbell ,  Robert George ,  Douglas Sutton

    发明人： Eugene de Juan, JR. ,  Yair Alster ,  Steven M. Chamow ,  Kathleen Cogan Farinas ,  Hanson S. Gifford, III ,  K. Angela MacFarlane ,  Cary J. Reich ,  Michael Barrett ,  Randolph E. Campbell ,  Robert George ,  Douglas Sutton

    IPC分类号： A61F9/00 ,  A61K39/395 ,  A61P27/02 ,  A61K31/5575 ,  A61K31/58 ,  A61F2/14 ,  B23P17/04

    CPC分类号： G01N33/558 ,  A61F9/0017 ,  A61K9/0048 ,  A61K9/0051 ,  A61K31/57 ,  A61K31/573 ,  A61K31/58 ,  A61K38/385 ,  A61K47/32 ,  A61K47/34 ,  A61K47/38 ,  A61K2039/505 ,  C07K16/22 ,  C07K2317/24 ,  C07K2317/55 ,  Y10T29/49826

    摘要： A therapeutic device to release a therapeutic agent comprises a porous structure coupled to a container comprising a reservoir. The reservoir comprises a volume sized to release therapeutic amounts of the therapeutic agent for an extended time when coupled to the porous structure and implanted in the patient. The porous structure may comprise a first side coupled to the reservoir and a second side to couple to the patient to release the therapeutic agent. A plurality of interconnecting channels can extend from the first side to the second side so as to connect a first a plurality of openings on the first side with a second plurality of openings on the second side. Each of the openings on the first side can be connected to each of the openings on the second side with the plurality of interconnecting channels, such that the rate of release of the therapeutic agent can be substantially maintained when one or more of the openings is blocked, for example with particles, cells, bacteria or tissue when the device is implanted for an extended time. The length of the channels extending from the first side to the second side may comprise an effective length greater than a distance across the porous structure from the first side to the second side. The therapeutic device many comprise an expandable retention structure and an expandable reservoir, such that the device can be delivered from a lumen of a delivery device and expand when positioned in the patient. The therapeutic device may comprises a penetrable barrier to inject therapeutic agent into the device when implanted in the patient.

    摘要翻译： 用于释放治疗剂的治疗装置包括联接到包括储存器的容器的多孔结构。 储存器包括体积大小，当耦合到多孔结构并且植入患者体内时，释放治疗剂量的治疗剂延长的时间。 所述多孔结构可以包括联接到所述储存器的第一侧和与所述患者联接以释放所述治疗剂的第二侧。 多个互连通道可以从第一侧延伸到第二侧，以便将第一侧上的第一多个开口与第二侧上的第二多个开口连接。 第一侧的每个开口可以与多个互连通道连接到第二侧的每个开口，使得当一个或多个开口被阻塞时可以基本上保持治疗剂的释放速度 ，例如当器件长时间植入时，可以使用颗粒，细胞，细菌或组织。 从第一侧延伸到第二侧的通道的长度可以包括大于多孔结构从第一侧到第二侧的距离的有效长度。 治疗装置许多包括可扩张的保留结构和可扩张的储存器，使得该装置可以从输送装置的内腔输送，并且在定位在患者体内时膨胀。 治疗装置可以包括当植入患者时将治疗剂注入装置中的可穿透屏障。

    Ocular insert apparatus and methods
    24.
    发明授权
    Ocular insert apparatus and methods 有权
    眼插装置和方法

    公开(公告)号：US08715712B2

    公开(公告)日：2014-05-06

    申请号：US13688019

    申请日：2012-11-28

    申请人： Eugene de Juan, Jr. ,  Yair Alster ,  Cary J. Reich ,  K. Angela MacFarlane ,  Janelle Chang ,  Jose D. Alejandro

    发明人： Eugene de Juan, Jr. ,  Yair Alster ,  Cary J. Reich ,  K. Angela MacFarlane ,  Janelle Chang ,  Jose D. Alejandro

    IPC分类号： A61F2/00

    CPC分类号： A61F9/0017 ,  A61B17/00234 ,  A61K9/0051 ,  A61K47/34 ,  A61L27/025 ,  A61L27/16

    摘要： A comfortable insert comprises a retention structure sized for placement under the eyelids and along at least a portion of conjunctival sac of the upper and lower lids of the eye. The retention structure resists deflection when placed in the conjunctival sac of the eye and to guide the insert along the sac when the eye moves. The retention structure can be configured in many ways to provide the resistance to deflection and may comprise a hoop strength so as to urge the retention structure outward and inhibit movement of the retention structure toward the cornea. The insert may move rotationally with deflection along the conjunctival sac, and may comprise a retention structure having a cross sectional dimension sized to fit within folds of the conjunctiva. The insert may comprise a release mechanism and therapeutic agent to release therapeutic amounts of the therapeutic agent for an extended time.

    摘要翻译： 舒适的插入物包括保持结构，其尺寸适于放置在眼睑下方并且沿着眼睛的上盖和下盖的结膜囊的至少一部分。 保留结构在放置在眼结膜囊中时抵抗偏转，并且当眼睛移动时沿着囊引导插入物。 保持结构可以以许多方式构造以提供对偏转的抵抗力，并且可以包括环箍强度，以便向外推动保持结构并阻止保持结构朝向角膜的移动。 插入件可以沿着结膜囊的偏转而旋转移动，并且可以包括保持结构，该保持结构具有尺寸适合于结膜折叠的横截面尺寸。 插入物可以包含释放机制和治疗剂以释放长期治疗剂的治疗剂量。

    SUBCONJUCTIVAL IMPLANT FOR POSTERIOR SEGMENT DRUG DELIVERY
    25.
    发明申请
    SUBCONJUCTIVAL IMPLANT FOR POSTERIOR SEGMENT DRUG DELIVERY 审中-公开
    用于分支部门药物递送的分支植入物

    公开(公告)号：US20130274692A1

    公开(公告)日：2013-10-17

    申请号：US13814470

    申请日：2011-08-04

    申请人： Yair Alster ,  Eugene De Juan, JR. ,  Kathleen Cogan Farinas ,  K. Angela MacFarlane ,  Cary J. Reich ,  Randolph E. Campbell ,  Signe Erickson

    发明人： Yair Alster ,  Eugene De Juan, JR. ,  Kathleen Cogan Farinas ,  K. Angela MacFarlane ,  Cary J. Reich ,  Randolph E. Campbell ,  Signe Erickson

    IPC分类号： A61F9/00

    CPC分类号： A61F9/0017 ,  A61K9/0051 ,  A61K31/00 ,  A61K31/573 ,  A61K31/58

    摘要： A therapeutic device can be configured to place the reservoir substantially between the conjunctiva and the scleral such that the size of the reservoir can be increased and the size of the scleral penetration decreased so as to decrease invasiveness. The device may comprise a substantially constant reservoir volume and drug release mechanism, in which the volume of the reservoir and mechanism are tuned to receive a quantity of therapeutic agent with a volume of injected formulation and release the therapeutic agent for an extended time with a release rate profile. The porous structure may comprise a first side coupled to the reservoir and a second side to couple to the patient to release the therapeutic agent, and a plurality of interconnecting channels can extend from the first side to the second side.

    摘要翻译： 治疗装置可以被配置为将储存器基本上放置在结膜和巩膜之间，使得储存器的尺寸可以增加并且巩膜穿透的尺寸减小以降低侵入性。 该装置可以包括基本上恒定的储存器体积和药物释放机构，其中储存器和机构的体积被调谐以接收一定量的具有注射制剂体积的治疗剂，并释放治疗剂延长的时间 费率简介。 多孔结构可以包括联接到储存器的第一侧和耦合到患者以释放治疗剂的第二侧，并且多个互连通道可以从第一侧延伸到第二侧。

    Eye covering and refractive correction methods and apparatus having improved tear flow, comfort, and/or applicability
    29.
    发明授权
    Eye covering and refractive correction methods and apparatus having improved tear flow, comfort, and/or applicability 有权
    具有改善的泪液流动性，舒适性和/或适用性的眼罩和屈光矫正方法和装置

    公开(公告)号：US08864306B2

    公开(公告)日：2014-10-21

    申请号：US13456168

    申请日：2012-04-25

    申请人： Eugene de Juan, Jr. ,  Cary J. Reich ,  Yair Alster ,  Matt Clark ,  Kunagmon Ashley Tuan ,  Brian Levy

    发明人： Eugene de Juan, Jr. ,  Cary J. Reich ,  Yair Alster ,  Matt Clark ,  Kunagmon Ashley Tuan ,  Brian Levy

    IPC分类号： G02C7/04 ,  G02C7/02

    CPC分类号： G02C7/049 ,  G02C7/022 ,  G02C7/024 ,  G02C7/04 ,  G02C7/047

    摘要： An eye covering such as a contact lens may comprise one or more structures to pump tear liquid under the covering such that the covering can remain in the eye and correct vision for an extended amount of time. In many embodiments, the covering comprises a material having fenestrations to draw tear liquid under the covering and an outer portion shaped to contact the conjunctiva over the sclera, such that when the eye closes pressure of one or more eyelids urges tear liquid through one or more fenestrations and under the outer portion shaped to contact the conjunctiva. When the eye blinks, the pressure of the one or more eyelids can urge the covering toward the cornea such that tear liquid can pass through the fenestrations.

    摘要翻译： 诸如隐形眼镜的眼睛覆盖物可以包括一个或多个结构，以将覆盖物下方的泪液泵送，使得覆盖物可以保留在眼睛中并且将视力延长一段时间。 在许多实施例中，覆盖物包括具有开窗以吸收覆盖物下方的泪液的材料和形状为在巩膜上接触结膜的外部部分，使得当眼睛闭合一个或多个眼睑的压力时，促使泪液通过一个或多个 开窗和在外部形状以接触结膜。 当眼睛眨眼时，一个或多个眼睑的压力可以促使覆盖物朝向角膜，使得泪液可以通过开窗。

    Implantable therapeutic device
    30.
    发明授权
    Implantable therapeutic device 有权
    植入式治疗装置

    公开(公告)号：US08623395B2

    公开(公告)日：2014-01-07

    申请号：US13204638

    申请日：2011-08-05

    申请人： Eugene de Juan, Jr. ,  Yair Alster ,  Kathleen Cogan Farinas ,  K. Angela MacFarlane ,  Cary J. Reich ,  Randolph E. Campbell

    发明人： Eugene de Juan, Jr. ,  Yair Alster ,  Kathleen Cogan Farinas ,  K. Angela MacFarlane ,  Cary J. Reich ,  Randolph E. Campbell

    IPC分类号： A61M37/00 ,  A61M31/00

    CPC分类号： A61F9/0017 ,  A61K9/0051 ,  A61K38/179 ,  A61K39/395 ,  A61K45/06 ,  A61M37/00 ,  C07K16/22 ,  C07K2317/94 ,  A61K2300/00

    摘要： A therapeutic device to release a therapeutic agent comprises a porous structure coupled to a container comprising a reservoir. The reservoir comprises a volume sized to release therapeutic amounts of the therapeutic agent for an extended time when coupled to the porous structure and implanted in the patient. The porous structure may comprise a first side coupled to the reservoir and a second side to couple to the patient to release the therapeutic agent. The length of the channels extending from the first side to the second side may comprise an effective length greater than a distance across the porous structure from the first side to the second side. The therapeutic device may comprise a penetrable barrier to inject therapeutic agent into the device when implanted in the patient.

    摘要翻译： 用于释放治疗剂的治疗装置包括联接到包括储存器的容器的多孔结构。 储存器包括体积大小，当耦合到多孔结构并且植入患者体内时，释放治疗剂量的治疗剂延长的时间。 所述多孔结构可以包括联接到所述储存器的第一侧和与所述患者联接以释放所述治疗剂的第二侧。 从第一侧延伸到第二侧的通道的长度可以包括大于多孔结构从第一侧到第二侧的距离的有效长度。 治疗装置可以包括当植入患者时将治疗剂注射到装置中的可穿透屏障。