公开(公告)号：US20180193469A1

公开(公告)日：2018-07-12

申请号：US15915386

申请日：2018-03-08

申请人： Foamix Pharmaceuticals Ltd.

发明人： Dov TAMARKIN ,  Elana Gazal ,  lrakliy Papiashvili ,  Yohan Hazot ,  David Schuz ,  Rita Keynan

IPC分类号： A61K47/44 ,  A61K47/06 ,  A61K9/00 ,  A61K9/12 ,  A61K47/24 ,  A61K45/06 ,  A61K47/10 ,  A61K8/36 ,  A61K8/34 ,  A61Q19/10 ,  A61Q19/00 ,  A61Q17/04 ,  A61K8/31 ,  A61K47/02 ,  A61K31/192 ,  A61K31/137 ,  A61K47/12 ,  A61K31/593 ,  A61K31/573 ,  A61K31/57 ,  A61K31/4164 ,  A61K31/65

CPC分类号： A61K47/44 ,  A61K8/31 ,  A61K8/342 ,  A61K8/361 ,  A61K9/0014 ,  A61K9/0048 ,  A61K9/12 ,  A61K9/122 ,  A61K9/124 ,  A61K31/137 ,  A61K31/192 ,  A61K31/4164 ,  A61K31/57 ,  A61K31/573 ,  A61K31/593 ,  A61K31/65 ,  A61K45/06 ,  A61K47/02 ,  A61K47/06 ,  A61K47/10 ,  A61K47/12 ,  A61K47/24 ,  A61K2800/31 ,  A61K2800/33 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/10

摘要： A substantially surface active agent free composition which includes a hydrophobic solvent, and/or a petrolatum, a paraffin wax and/or a fatty alcohol, a fatty acid and/or a wax and/or shea butter, with and without a propellant. A substantially surface active agent free composition, further comprising, a tetracycline antibiotic, or a vitamin D derivative, or one or more other active agents. A method of treatment using a substantially surface active agent free composition.

公开(公告)号：US20180193468A1

公开(公告)日：2018-07-12

申请号：US15913574

申请日：2018-03-06

申请人： Foamix Pharmaceuticals Ltd.

发明人： Dov Tamarkin ,  Elana Gazal ,  Irakliy Papiashvili ,  Yohan Hazot ,  David Schuz ,  Rita Keynan

IPC分类号： A61K47/44 ,  A61Q19/10 ,  A61Q17/04 ,  A61K47/24 ,  A61K47/12 ,  A61K47/10 ,  A61K47/06 ,  A61K47/02 ,  A61K45/06 ,  A61K31/65 ,  A61K31/593 ,  A61K31/573 ,  A61K31/57 ,  A61K31/4164 ,  A61K31/192 ,  A61K31/137 ,  A61K9/12 ,  A61K9/00 ,  A61K8/36 ,  A61K8/34 ,  A61K8/31 ,  A61Q19/00

CPC分类号： A61K47/44 ,  A61K8/31 ,  A61K8/342 ,  A61K8/361 ,  A61K9/0014 ,  A61K9/0048 ,  A61K9/12 ,  A61K9/122 ,  A61K9/124 ,  A61K31/137 ,  A61K31/192 ,  A61K31/4164 ,  A61K31/57 ,  A61K31/573 ,  A61K31/593 ,  A61K31/65 ,  A61K45/06 ,  A61K47/02 ,  A61K47/06 ,  A61K47/10 ,  A61K47/12 ,  A61K47/24 ,  A61K2800/31 ,  A61K2800/33 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/10

摘要： A topical therapeutic hydrophobic breakable composition includes a carrier comprising (a) about 60% to about 90% by weight of at least one hydrophobic oil; (b) at least one viscosity-modifying agents selected from the group consisting of a fatty alcohol, a fatty acid and a wax; and (c) a tetracycline antibiotic, characterized in that at least part of the tetracycline antibiotic is suspended in the composition; the viscosity of the composition is at least about 30% higher than the viscosity of the carrier without the tetracycline antibiotic; and is higher than the viscosity of the hydrophobic oil and the tetracycline antibiotic without the viscosity modifying agents. The tetracycline is chemically stable to the composition for at least six months; wherein more than about 90% of the tetracycline has not broken down. The composition is packaged as a breakable foam that breaks easily upon application of shear force.

公开(公告)号：US09849142B2

公开(公告)日：2017-12-26

申请号：US13831396

申请日：2013-03-14

申请人： Foamix Pharmaceuticals Ltd.

发明人： Dov Tamarkin ,  Elana Gazal ,  Rita Keynan ,  Meir Eini ,  David Schuz

IPC分类号： A61K31/65 ,  A61K9/00 ,  A61K47/10 ,  A61K47/44 ,  A61K9/12 ,  A61K47/12 ,  A61K9/06 ,  A61K47/06 ,  A61K47/24

CPC分类号： A61K31/65 ,  A61K8/31 ,  A61K8/342 ,  A61K8/361 ,  A61K9/0014 ,  A61K9/0048 ,  A61K9/06 ,  A61K9/12 ,  A61K9/122 ,  A61K9/124 ,  A61K31/137 ,  A61K31/192 ,  A61K31/4164 ,  A61K31/57 ,  A61K31/573 ,  A61K31/593 ,  A61K47/02 ,  A61K47/06 ,  A61K47/10 ,  A61K47/12 ,  A61K47/24 ,  A61K47/44 ,  A61K2800/31 ,  A61K2800/33 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/10

摘要： Methods of treatment and dosage regimes using hydrophobic gel or foam compositions comprising a tetracycline antibiotic for accelerating the return of skin integrity and or in treating or alleviating a disorder including impetigo, acne, rosacea, a skin disease caused by a bacteria or a tetracycline antibiotic responsive disease, wherein the foam composition or gel is administered topically to a target area on a subject having the disorder and wherein the target area comprises an area of skin, or mucosa or an eye.

公开(公告)号：US09675700B2

公开(公告)日：2017-06-13

申请号：US14595882

申请日：2015-01-13

申请人： Foamix Pharmaceuticals Ltd.

发明人： Dov Tamarkin ,  Elana Gazal ,  Irakliy Papiashvili ,  Yohan Hazot ,  David Schuz ,  Rita Keynan

IPC分类号： A61K8/18 ,  A61K35/50 ,  A61K31/65 ,  C07C50/36 ,  C07C237/26 ,  A61K47/44 ,  A61K47/06 ,  A61K9/00 ,  A61K9/12 ,  A61K31/4164 ,  A61K31/57 ,  A61K31/573 ,  A61K31/593 ,  A61K8/34 ,  A61K8/36 ,  A61K47/10 ,  A61K47/12 ,  A61K31/137 ,  A61K31/192 ,  A61K45/06 ,  A61K47/02 ,  A61K47/24 ,  A61K8/31 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/10

CPC分类号： A61K47/44 ,  A61K8/31 ,  A61K8/342 ,  A61K8/361 ,  A61K9/0014 ,  A61K9/0048 ,  A61K9/12 ,  A61K9/122 ,  A61K9/124 ,  A61K31/137 ,  A61K31/192 ,  A61K31/4164 ,  A61K31/57 ,  A61K31/573 ,  A61K31/593 ,  A61K31/65 ,  A61K45/06 ,  A61K47/02 ,  A61K47/06 ,  A61K47/10 ,  A61K47/12 ,  A61K47/24 ,  A61K2800/31 ,  A61K2800/33 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/10

摘要： A topical therapeutic hydrophobic breakable composition includes a carrier comprising, (a) about 60% to about 99% by weight of at least one hydrophobic oil; (b) at least one viscosity-modifying agents selected from the group consisting of a fatty alcohol, a fatty acid and a wax; and (c) a tetracycline antibiotic, characterized in that at least part of the tetracycline antibiotic is suspended in the composition; the viscosity of the composition is at least about 30% higher than the viscosity of the carrier without the tetracycline antibiotic; and is higher than the viscosity of the hydrophobic oil and the tetracycline antibiotic without the viscosity modifying agents. The tetracycline is chemically stable in the composition for at least six months; wherein more than about 90% of the tetracycline has not broken down. The composition is packaged as a breakable foam that breaks easily upon application of shear force.

公开(公告)号：US20170014517A1

公开(公告)日：2017-01-19

申请号：US14858388

申请日：2015-09-18

申请人： Foamix Pharmaceuticals Ltd.

发明人： Dov Tamarkin ,  Elana Gazal ,  Rita Keynan ,  Meir Eini ,  David Schuz

IPC分类号： A61K47/44 ,  A61K47/12 ,  A61K47/10

CPC分类号： A61K47/44 ,  A61K9/0014 ,  A61K9/06 ,  A61K9/122 ,  A61K31/65 ,  A61K47/06 ,  A61K47/10 ,  A61K47/12 ,  A61K47/24

摘要： The present invention related to the use of a pharmaceutical composition which is essentially free of pharmaceutically active agents for the treatment of human skin, especially in the treatment of acne, acne related symptoms, a tetracycline antibiotic responsive acne related disorder, skin disorder caused by a bacteria, and a tetracycline antibiotic responsive sebaceous gland disease, P. acne bacteria associated disorders, and other superficial infections, including skin infections.

摘要翻译： 本发明涉及药物组合物的使用，其基本上不含药学活性剂用于治疗人体皮肤，特别是治疗痤疮，痤疮相关症状，四环素抗生素反应性痤疮相关病症，由 细菌，以及四环素类抗生素反应性皮脂腺病，痤疮痤疮细菌相关疾病和其他表面感染，包括皮肤感染。

公开(公告)号：US09101662B2

公开(公告)日：2015-08-11

申请号：US14045528

申请日：2013-10-03

申请人： Foamix Pharmaceuticals Ltd.

发明人： Dov Tamarkin ,  Meir Eini ,  Doron Friedman ,  Tal Berman ,  David Schuz

IPC分类号： A61K9/00 ,  A61K47/00 ,  A61K47/12 ,  A61K31/573 ,  A61K31/593 ,  A61K31/341 ,  A61K31/167 ,  A61K47/18 ,  A61K9/12 ,  A61K31/375 ,  A61K47/26 ,  A61K47/32

CPC分类号： A61K47/12 ,  A61K9/0014 ,  A61K9/0031 ,  A61K9/0034 ,  A61K9/0043 ,  A61K9/0046 ,  A61K9/0048 ,  A61K9/0056 ,  A61K9/122 ,  A61K31/167 ,  A61K31/341 ,  A61K31/375 ,  A61K31/56 ,  A61K31/573 ,  A61K31/593 ,  A61K47/18 ,  A61K47/183 ,  A61K47/26 ,  A61K47/32

摘要： The present invention relates to a waterless composition and foam as a vehicle in which an active pharmaceutical or cosmetic agent, when added is stable or stabilized by or its destabilization is impeded by the presence of a modulating agent. The pharmaceutical or cosmetic composition and foam, includes: a waterless solvent, a modulating agent and one or more active pharmaceutical or cosmetic agents. The present invention also relates to a method of treatment administering the waterless composition and foam.

摘要翻译： 本发明涉及作为载体的无水组合物和泡沫，其中活性药物或化妆品在添加时稳定或稳定化或其不稳定性受到调节剂的存在的阻碍。 药物或化妆品组合物和泡沫体包括：无水溶剂，调节剂和一种或多种活性药物或化妆品。 本发明还涉及给予无水组合物和泡沫的治疗方法。

公开(公告)号：US20150118164A1

公开(公告)日：2015-04-30

申请号：US14504942

申请日：2014-10-02

申请人： Foamix Pharmaceuticals Ltd.

发明人： Dov Tamarkin ,  Helena Shifrin ,  Rita Keynan ,  Enbal Ziv ,  Tal Berman ,  David Schuz ,  Elana Gazal

IPC分类号： A61K9/12 ,  A61K45/06 ,  A61K47/24 ,  A61K31/65

CPC分类号： A61K9/12 ,  A61K8/046 ,  A61K9/0014 ,  A61K9/122 ,  A61K31/20 ,  A61K31/355 ,  A61K31/522 ,  A61K31/59 ,  A61K31/65 ,  A61K31/7056 ,  A61K45/06 ,  A61K47/06 ,  A61K47/14 ,  A61K47/24 ,  A61K47/34 ,  A61K47/44 ,  Y10S514/871 ,  Y10S514/945

摘要： A waterless foamable pharmaceutical composition suitable for external administration is disclosed. The composition includes a foamable carrier least one liquefied or compressed gas propellant. The foamable carrier includes at least one liquid oil; at least one silicone and at least one least one stabilizing agent; wherein the stabilizing agent selected from the group consisting of about 0.01% to about 25% by weight of at least one surface-active agent alone or on combination with a foam adjuvant; and about 0% to about 5% by weight of at least one polymeric agent alone or on combination with a foam adjuvant; and mixtures thereof. Pharmaceutical compositions comprising active agents, methods for their preparation, propellants suitable for use with the carriers and uses thereof are further described.

摘要翻译： 公开了一种适用于外用的无水可发泡药物组合物。 组合物包括可发泡载体至少一种液化或压缩气体推进剂。 可发泡载体包括至少一种液体油; 至少一种硅氧烷和至少一种至少一种稳定剂; 其中所述稳定剂选自约0.01％至约25％重量的至少一种表面活性剂单独或与泡沫佐剂组合; 和约0％至约5％重量的至少一种聚合物单体或与泡沫佐剂组合; 及其混合物。 进一步描述包含活性剂的药物组合物，其制备方法，适用于载体的推进剂及其用途。

公开(公告)号：US20150056149A1

公开(公告)日：2015-02-26

申请号：US14469792

申请日：2014-08-27

申请人： Foamix Pharmaceuticals Ltd.

发明人： Dov Tamarkin ,  Elana Gazal ,  Irakliy Papiashvili ,  Yohan Hazot ,  David Schuz ,  Rita Keynan

IPC分类号： A61K31/65 ,  A61K9/12 ,  A61K45/06 ,  A61K9/00

CPC分类号： A61K47/44 ,  A61K8/31 ,  A61K8/342 ,  A61K8/361 ,  A61K9/0014 ,  A61K9/0048 ,  A61K9/12 ,  A61K9/122 ,  A61K9/124 ,  A61K31/137 ,  A61K31/192 ,  A61K31/4164 ,  A61K31/57 ,  A61K31/573 ,  A61K31/593 ,  A61K31/65 ,  A61K45/06 ,  A61K47/02 ,  A61K47/06 ,  A61K47/10 ,  A61K47/12 ,  A61K47/24 ,  A61K2800/31 ,  A61K2800/33 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/10

摘要： A topical therapeutic hydrophobic breakable composition includes a carrier comprising (a) about 60% to about 99% by weight of at least one hydrophobic oil; (b) at least one viscosity-modifying agents selected from the group consisting of a fatty alcohol, a fatty acid and a wax; and (c) a tetracycline antibiotic, characterized in that at least part of the tetracycline antibiotic is suspended in the composition; the viscosity of the composition is at least about 30% higher than the viscosity of the carrier without the tetracycline antibiotic; and is higher than the viscosity of the hydrophobic oil and the tetracycline antibiotic without the viscosity modifying agents. The tetracycline is chemically stable in the composition for at least six months; wherein more than about 90% of the tetracycline has not broken down. The composition is packaged as a breakable foam that breaks easily upon application of shear force.

摘要翻译： 一种局部治疗疏水性可破坏组合物包括载体，其包含（a）约60％至约99％重量的至少一种疏水性油; （b）至少一种选自脂肪醇，脂肪酸和蜡的粘度调节剂; 和（c）四环素抗生素，其特征在于至少部分四环素抗生素悬浮于组合物中; 组合物的粘度比没有四环素抗生素的载体的粘度高至少约30％; 并且高于没有粘度改性剂的疏水性油和四环素类抗生素的粘度。 四环素在组合物中化学稳定至少六个月; 其中大于约90％的四环素未分解。 该组合物包装成易碎泡沫，在施加剪切力时容易破裂。

公开(公告)号：US20140328770A1

公开(公告)日：2014-11-06

申请号：US14327040

申请日：2014-07-09

申请人： Foamix Pharmaceuticals Ltd.

发明人： Dov Tamarkin ,  Elana Gazal ,  Irakliy Papiashvili ,  Yohan Hazot ,  David Schuz ,  Rita Keynan

IPC分类号： A61K47/44 ,  A61K9/12 ,  A61K47/02 ,  A61K47/24 ,  A61K47/10 ,  A61K47/12 ,  A61K31/65 ,  A61K45/06

CPC分类号： A61K47/44 ,  A61K8/31 ,  A61K8/342 ,  A61K8/361 ,  A61K9/0014 ,  A61K9/0048 ,  A61K9/12 ,  A61K9/122 ,  A61K9/124 ,  A61K31/137 ,  A61K31/192 ,  A61K31/4164 ,  A61K31/57 ,  A61K31/573 ,  A61K31/593 ,  A61K31/65 ,  A61K45/06 ,  A61K47/02 ,  A61K47/06 ,  A61K47/10 ,  A61K47/12 ,  A61K47/24 ,  A61K2800/31 ,  A61K2800/33 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/10

摘要： A topical therapeutic hydrophobic breakable composition includes a carrier comprising (a) about 60% to about 99% by weight of at least one hydrophobic oil; (b) at least one viscosity-modifying agents selected from the group consisting of a fatty alcohol, a fatty acid and a wax; and (c) a tetracycline antibiotic, characterized in that at least part of the tetracycline antibiotic is suspended in the composition; the viscosity of the composition is at least about 30% higher than the viscosity of the carrier without the tetracycline antibiotic; and is higher than the viscosity of the hydrophobic oil and the tetracycline antibiotic without the viscosity modifying agents. The tetracycline is chemically stable in the composition for at least six months; wherein more than about 90% of the tetracycline has not broken down. The composition is packaged as a breakable foam that breaks easily upon application of shear force.

摘要翻译： 一种局部治疗疏水性可破坏组合物包括载体，其包含（a）约60％至约99％重量的至少一种疏水性油; （b）至少一种选自脂肪醇，脂肪酸和蜡的粘度调节剂; 和（c）四环素抗生素，其特征在于至少部分四环素抗生素悬浮于组合物中; 组合物的粘度比没有四环素抗生素的载体的粘度高至少约30％; 并且高于没有粘度改性剂的疏水性油和四环素类抗生素的粘度。 四环素在组合物中化学稳定至少六个月; 其中大于约90％的四环素未分解。 该组合物包装成易碎泡沫，在施加剪切力时容易破裂。

公开(公告)号：US11219631B2

公开(公告)日：2022-01-11

申请号：US16108799

申请日：2018-08-22

申请人： Foamix Pharmaceuticals Ltd.

发明人： Dov Tamarkin ,  Enbal Ziv ,  Yohan Hazot ,  David Schuz

IPC分类号： A61K31/7056 ,  A01N25/16 ,  A61K9/12 ,  A61K47/10 ,  A61K47/38 ,  A61K31/196 ,  A61K31/327 ,  A61K31/573 ,  A61K31/58 ,  A61K9/00

摘要： A substantially surface active agent-free foamable composition which includes short-chain alcohol, water, polymer, fatty alcohol or fatty acid or a combination of fatty alcohol and fatty acid and propellant. A substantially surface active agent-free foamable composition which includes, water, polymer, fatty alcohol or fatty acid and propellant. A method of treatment using a substantially surface active agent-free foamable compositions.