Patent search ap:("Foundation Medicine Page Inc.") AND inv:"Matthew J. Hawryluk"

21.

发明授权
System and method for managing genomic information 有权

公开(公告)号：US11158425B2

公开(公告)日：2021-10-26

申请号：US14463068

申请日：2014-08-19

Applicant: FOUNDATION MEDICINE, INC.

Inventor： Helena Futscher de Deus , Rachel Lauren Erbach , Ronald David Collette , Alexander N. Parker , Michael Pellini , Gary Palmer , Mary Pat Lancelotta , Matthew J. Hawryluk , Philip James Stephens , Eric Karl Neumann

IPC: G16H50/20 , G16H10/60 , G16C99/00 , G16H10/20 , G16H10/40 , G16H70/60 , G16H15/00

Abstract: Various embodiments provide interfaces to access genomic testing information and incorporate it into daily physician practice. According to one aspect, a graph-based data model is used that may be used to organizes and revise precision medicine knowledge. In one example structure, gene states are abstracted into alteration groups, where alteration groups are built using reverse engineering actionable information and storing that information within the graph-based data structure. Volumes of genomic alterations and associated information (e.g., journal articles, clinical trial information, therapies, etc.) are analyzed and synthesized into actionable information items viewable on an alteration system in a graph-based data format. According to one embodiment, the system can be configured to focus practitioners on discrete portions of the alteration information on which they can act. According to other aspects, curated information is provided on the system to enable practitioners to make informed decisions regarding the implications of the presence of specific genomic alterations.

22.

发明授权
Human papilloma virus as predictor of cancer prognosis 有权

公开(公告)号：US11058687B2

公开(公告)日：2021-07-13

申请号：US16654582

申请日：2019-10-16

Applicant: FOUNDATION MEDICINE, INC. , UCL BUSINESS LTD

Inventor： Chris Hendrik Boshoff , Timothy Robert Fenton , Matthias Alexander Lechner , Philip James Stephens , Matthew J. Hawryluk , Garrett Michael Frampton , Roman Yelensky

IPC: A61K31/551 , A61K31/505 , A61P35/00 , A61K31/519 , C12Q1/70 , A61K31/506 , A61K31/454 , A61K31/52 , A61K31/404 , A61K31/4196 , A61K33/24 , A61K31/282 , A61K31/337 , A61K31/513 , A61K39/395 , A61K31/436 , A61K31/05 , A61K31/4709 , A61K31/496 , A61K31/5377 , A61K31/352 , A61N5/00 , C12Q1/6886 , A61K31/366 , A61K31/555 , A61K31/439 , A61K31/4745 , C07K16/28 , C12Q1/6883 , G01N33/571 , A61N5/10 , A61K39/00

Abstract: Methods of treating a head and neck cancer are disclosed.

23.

发明申请
NOVEL NTRK1 FUSION MOLECULES AND USES THEREOF 审中-公开

公开(公告)号：US20200299775A1

公开(公告)日：2020-09-24

申请号：US16683575

申请日：2019-11-14

Applicant: FOUNDATION MEDICINE, INC.

Inventor： Matthew J. Hawryluk , Doron Lipson , Vincent A. Miller , Philip James Stephens

IPC: C12Q1/6886 , C12N15/113 , C12N9/12 , C07K14/47 , A61K31/519 , A61K31/553 , A61K45/06

Abstract: Novel NTRK1 fusion molecules, detection reagents, and uses and kits for evaluating, identifying, assessing and/or treating a subject having a cancer are disclosed.

24.

发明申请
SYSTEM AND METHOD FOR MANAGING GENOMIC INFORMATION 审中-公开

公开(公告)号：US20200020430A1

公开(公告)日：2020-01-16

申请号：US16579500

申请日：2019-09-23

Applicant: FOUNDATION MEDICINE, INC.

Inventor： Helena Futscher de Deus , Rachel Lauren Erlich , Ronald David Collette , Alexander Nevin Parker , Michael Pellini , Gary Palmer , Mary Patricia Lancelotta , Matthew J. Hawryluk , Philip James Stephens , Eric Karl Neumann

IPC: G16H10/60

Abstract: A system for managing genomic information includes a processor to collect and store biomarker data, receive and store patient-specific pathology information, generate a graph-based data structure of complex data elements arranged into a walkable graph representation that includes at least one of a disease alteration group association (DAGA) element representing a relationship between a disease and an alteration group (AG), at least one of a disease therapy association (DTA) element representing a relationship between a disease and a therapy for treating the disease, and a therapy genomic effect (TGE) element representing a relationship between a gene and a known effect of a therapy on the gene. The processor follows links in the walkable graph representation to determine at least one inferred path, generates inferential matches to actionable items based on an accumulated trust score of the at least one inferred path, and determines a treatment decision for a cancer patient.

25.

发明授权
Methods of treating head and neck cancer 有权

公开(公告)号：US09907798B2

公开(公告)日：2018-03-06

申请号：US15200088

申请日：2016-07-01

Applicant: FOUNDATION MEDICINE, INC. , UCL Business PLC

Inventor： Chris Hendrik Boshoff , Timothy Robert Fenton , Matthias Alexander Lechner , Philip James Stephens , Matthew J. Hawryluk , Garrett Michael Frampton , Roman Yelensky

IPC: A61K31/55 , A61K31/497 , A61K31/52 , A61K31/505 , A61K31/445 , A61K31/40 , A61K38/48 , A61K39/00 , C12Q1/68 , A61K31/519 , C12Q1/70 , A61K31/506 , A61K31/454 , A61K31/404 , A61K31/4196 , A61K33/24 , A61K31/282 , A61K31/337 , A61K31/513 , A61K39/395 , A61K31/436 , A61K31/05 , A61K31/4709 , A61K31/496 , A61K31/5377 , A61K31/352 , A61N5/00 , A61K31/366 , A61K31/555 , A61K31/439 , A61K31/4745 , C07K16/28 , G01N33/571 , A61N5/10

CPC classification number: A61K31/519 , A61K31/05 , A61K31/282 , A61K31/337 , A61K31/352 , A61K31/366 , A61K31/404 , A61K31/4196 , A61K31/436 , A61K31/439 , A61K31/454 , A61K31/4709 , A61K31/4745 , A61K31/496 , A61K31/505 , A61K31/506 , A61K31/513 , A61K31/52 , A61K31/5377 , A61K31/555 , A61K33/24 , A61K39/39558 , A61K2039/505 , A61N5/00 , A61N5/10 , C07K16/2863 , C12Q1/6883 , C12Q1/6886 , C12Q1/708 , C12Q2600/106 , C12Q2600/118 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , G01N33/571 , A61K2300/00

Abstract: Methods of treating a head and neck cancer are disclosed.

26.

发明申请
NOVEL NTRK1 FUSION MOLECULES AND USES THEREOF 审中-公开
Title translation: 新型NTRK1融合分子及其用途

公开(公告)号：US20150073036A1

公开(公告)日：2015-03-12

申请号：US14473508

申请日：2014-08-29

Applicant: FOUNDATION MEDICINE, INC.

Inventor： Matthew J. Hawryluk , Doron Lipson , Vincent A. Miller , Philip James Stephens

IPC: C12Q1/68 , A61K45/06 , C12N15/113 , A61K31/553 , A61K31/519

CPC classification number: C12Q1/6886 , A61K31/519 , A61K31/553 , A61K45/06 , C07K14/47 , C12N9/12 , C12N15/1138 , C12N2310/14 , C12Q2600/106 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158

Abstract: Novel NTRK1 fusion molecules, detection reagents, and uses and kits for evaluating, identifying, assessing and/or treating a subject having a cancer are disclosed.

Abstract translation: 公开了用于评估，鉴定，评估和/或治疗患有癌症的受试者的新型NTRK1融合分子，检测试剂和用途和试剂盒。

27.

发明申请
SYSTEM AND METHOD FOR MANAGING GENOMIC TESTING RESULTS 审中-公开
Title translation: 用于管理基因测试结果的系统和方法

公开(公告)号：US20140336943A1

公开(公告)日：2014-11-13

申请号：US14146743

申请日：2014-01-03

Applicant: FOUNDATION MEDICINE, INC.

Inventor： Michael Pellini , Gary Palmer , Mary P. Lancelotta , Matthew J. Hawryluk , Philip J. Stephens

IPC: G06F19/00 , G06F19/22

CPC classification number: G06F19/3456 , G06F19/32 , G06Q50/24 , G16B30/00 , G16H10/60 , G16H15/00

Abstract: Various embodiments provide interfaces to access genomic testing information and incorporate it into daily physician practice. In some embodiments, presentation of genomic alteration data is simplified and/or coupled with contextual applications. Volumes of genomic alterations and associated information (e.g., journal articles, clinical trial information, therapies, etc.) are analyzed and synthesized into actionable information items viewable on an alteration system. According to one embodiment, the system can be configured to focus practitioners on discrete portions of the alteration information on which they can act. According to other aspects, curated information is provided on the system to enable practitioners to make informed decisions regarding the implications of the presence of specific genomic alterations.

Abstract translation: 各种实施方案提供了接口以访问基因组测试信息并将其并入日常医师实践中。在一些实施方案中，基因组改变数据的呈现被简化和/或与上下文应用相结合。将基因组变化和相关信息（例如，期刊文章，临床试验信息，治疗等）的卷分析并合成为可变更的信息项目。根据一个实施例，系统可以被配置为将从业者聚焦在它们可以作用于其上的变更信息的离散部分上。根据其他方面，在系统上提供了策划的信息，以使从业者就具体基因组改变的存在的含义做出明智的决定。

28.

发明授权
System and method for outcome tracking and analysis 有权

公开(公告)号：US12087453B2

公开(公告)日：2024-09-10

申请号：US17885412

申请日：2022-08-10

Applicant: Foundation Medicine, Inc.

Inventor： Michael Pellini , Gary Palmer , Mary Patricia Lancelotta , Matthew J. Hawryluk , Vincent A. Miller

IPC: G16H70/60 , G16B30/00 , G16H10/20 , G16H10/60 , G16H15/00 , G16H20/10 , G16H50/20

CPC classification number: G16H70/60 , G16B30/00 , G16H10/20 , G16H10/60 , G16H15/00 , G16H20/10 , G16H50/20

Abstract: Provided are systems and methods for capturing outcome information associated with various cancer treatments. The system facilitates capture and analysis of cancer treatment information and associated outcome information. The treatment and outcome information can include genomic analysis and information on treatment of different cancers. The system can store and analyze any one or more of: tumor type, genomic alterations (e.g., genes and associated alterations, gene sequence mutations, alterations, amplifications, deletions, etc.), and treatment data (including, for example, treatments targeted to specific genes and/or genomic alterations). Users of the outcome system can supply and use the treatment and outcome information to facilitate diagnosis and therapy decisions. User interfaces within the system can be configured to allow users to easily locate outcome information associated with particular treatments of tumors having certain genomic alterations.

29.

发明授权
NTRK1 fusion molecules and uses thereof 有权

公开(公告)号：US11578372B2

公开(公告)日：2023-02-14

申请号：US16683575

申请日：2019-11-14

Applicant: FOUNDATION MEDICINE, INC.

Inventor： Matthew J. Hawryluk , Doron Lipson , Vincent A. Miller , Philip James Stephens

IPC: C12Q1/6886 , C12N15/113 , C12N9/12 , C07K14/47 , A61K31/519 , A61K31/553 , A61K45/06

Abstract: Novel NTRK1 fusion molecules, detection reagents, and uses and kits for evaluating, identifying, assessing and/or treating a subject having a cancer are disclosed.