摘要:
Compounds of formula I in which R1, R2, R3, each X, L, Y, Cy, Lp, D and n have the meanings as set out in the specification, and corresponding compounds in which the unsubstituted or substituted amidine group is replaced with an unsubstituted or substituted aminomethyl group, are useful as serine protease inhibitors.
摘要:
Compounds of formula (I) in which R, R1, R2, n and X1 have the meanings given in the specification are Factor Xa inhibitors useful in the treatment of thrombotic disorders.
摘要:
The system controls the frequency of an ultrasonic signal to be applied to a waveguide, such that the frequency corresponds to a preferred resonance mode of the waveguide and not to adjacent undesirable resonance modes. The system operates by carrying out a first scan of a predetermined portion of the generated signal, determining the number of resonance modes of the waveguide within this portion and selecting from these resonance modes either that one mode which is at a central frequency or that one mode which is at a frequency nearest thereto. The system may also set limits on each side of the selected resonance mode and carry out a second scan within these limits each time that the generator is activated to check whether the selected resonance mode is drifting.
摘要:
A filtration plate includes an upper plate having one or more wells formed therein, a lower plate having one or more wells corresponding to the wells of the upper plate, a filter media separating the upper plate wells from the lower plate wells, and a seal formed at an interface between the upper plate and the lower plate. A method of assembling the filtration plate comprises applying a seal-promoting material to a component of the filtration plate and curing the seal-promoting material to form the seal at an interface between the upper plate and the lower plate.
摘要:
A method is provided. The method comprises a computer embedding a first database primitive in a first entry of a distributed ledger. The method also comprises the computer embedding a second database primitive in a second entry of the distributed ledger. The method also comprises the computer extracting at least one of the first and second database primitives from the distributed ledger.
摘要:
The present invention relates to pyrazine and pyridine compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors.The compounds of this invention have formula I: wherein the variables are as defined herein.
摘要:
The present invention relates to compounds useful as inhibitors of Aurora protein kinases. The invention also provides pharmaceutically acceptable compositions comprising those compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, and disorders. The invention also provides processes for preparing compounds of the invention.
摘要:
The present invention relates to pyrazine compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors.The compounds of this invention have formula I: wherein the variables are as defined herein.
摘要:
A system and method for providing warnings of a suicide attempt provides monitoring of specific hardware, fixtures, or objects, or structure supporting or associated with same, within an isolation room by way of sensors to provide notice exterior the room that a monitored condition has changed. The sensor can be a load sensor, proximity sensor, contact sensor, or the like. More particularly, an object in an isolation room that provides an attachment potential for hanging is monitored such as by monitoring the load of said object, detecting changes in the load, and providing an alarm of the change in condition. Doors and associated hardware are particularly suitable for such monitoring.
摘要:
A method of forming a nodular insulation material suitable for installation in a cavity, comprising: propelling fibrous nodules at a substrate, wherein the fibrous nodules are formed from inorganic fibers, wherein the majority of the nodules have a maximum dimension of about one-half inch, and contacting the nodules while the nodules are being propelled, with a solution comprising water and a water soluble binder to produce coated nodules, wherein the coated nodules form an insulation on the substrate.