公开(公告)号：US20250034182A1

公开(公告)日：2025-01-30

申请号：US18750925

申请日：2024-06-21

Applicant: Gilead Sciences, Inc.

Inventor： Byoung-Kwon Chun ,  Michael O. Clarke ,  Deeba Ensan ,  Rao V. Kalla ,  Richard L. Mackman ,  Jagadeesh N. Manda ,  Devan Naduthambi ,  Dustin S. Siegel

IPC: C07F9/09 ,  A61P31/14

Abstract: Phospholipid compounds and methods of using the same, singly or in combination with additional agents, and pharmaceutical formulations of said compounds for the treatment of viral infections are disclosed.

公开(公告)号：US12110294B2

公开(公告)日：2024-10-08

申请号：US17243911

申请日：2021-04-29

Applicant: Gilead Sciences, Inc.

Inventor： Mark J. Bartlett ,  Gregory F. Chin ,  Michael O. Clarke ,  Jennifer L. Cosman ,  Deeba Ensan ,  Bindu Goyal ,  Stephen Ho ,  Hon C. Hui ,  Richard L. Mackman ,  Michael R. Mish ,  Scott D. Schroeder ,  Nathan D. Shapiro ,  Dustin S. Siegel ,  Doris T. Tang ,  Hai Yang

IPC: C07D487/04 ,  A61K45/06 ,  C07D519/00 ,  C07K16/28

CPC classification number: C07D487/04 ,  A61K45/06 ,  C07D519/00 ,  C07K16/2818 ,  C07K16/2827

Abstract: The present disclosure provides pyrimidine dione compounds of Formula I






and pharmaceutical compositions thereof, for treating cancer, including solid tumors either-used alone or in combination with other anti-cancer agents.

公开(公告)号：US20240246986A1

公开(公告)日：2024-07-25

申请号：US18601528

申请日：2024-03-11

Applicant: Gilead Sciences, Inc.

Inventor： Mark J. Bartlett ,  Daniel H. Byun ,  Yifan Deng ,  Jennifer L. Cosman Ellis ,  Rao V. Kalla ,  Richard L. Mackman ,  Dustin S. Siegel ,  Xianhuang Zeng

IPC: C07D487/04 ,  A61K9/00 ,  A61K45/06 ,  A61P31/14 ,  C07D519/00 ,  C07F9/6561

CPC classification number: C07D487/04 ,  A61K9/0053 ,  A61K45/06 ,  A61P31/14 ,  C07D519/00 ,  C07F9/6561

Abstract: Compounds and methods of using said compounds, singly or in combination with additional agents, and salts or pharmaceutical compositions of said compounds for the treatment of viral infections are disclosed.

公开(公告)号：US11939347B2

公开(公告)日：2024-03-26

申请号：US17355813

申请日：2021-06-23

Applicant: Gilead Sciences, Inc.

Inventor： Daniel H. Byun ,  Byoung-Kwon Chun ,  Michael O. Clarke ,  Petr Jansa ,  Rao V. Kalla ,  Dmitry Koltun ,  Richard L. Mackman ,  Thao D. Perry ,  Dustin S. Siegel ,  Scott P. Simonovich

IPC: A61K31/675 ,  A61K45/06 ,  A61P31/12 ,  C07F9/6561

CPC classification number: C07F9/6561 ,  A61K45/06

Abstract: Compounds and methods of using said compounds, singly or in combination with additional agents, and pharmaceutical compositions of said compounds for the treatment of viral infections are disclosed.

公开(公告)号：US11851438B2

公开(公告)日：2023-12-26

申请号：US18117878

申请日：2023-03-06

Applicant: Gilead Sciences, Inc.

Inventor： Mark J. Bartlett ,  Daniel H. Byun ,  Yifan Deng ,  Jennifer L. Cosman Ellis ,  Rao V. Kalla ,  Richard L. Mackman ,  Dustin S. Siegel ,  Xianhuang Zeng

IPC: A61K31/341 ,  C07D307/20 ,  C07D487/04 ,  A61P31/14

CPC classification number: C07D487/04 ,  A61P31/14

Abstract: 1′-Cyano nucleoside analogs of Formula I and methods of using said compounds, singly or in combination with additional agents, and salts or pharmaceutical compositions of said compounds for the treatment of viral infections are disclosed.

公开(公告)号：US20230295172A1

公开(公告)日：2023-09-21

申请号：US18115955

申请日：2023-03-01

Applicant: Gilead Sciences, Inc.

Inventor： Mark J. Bartlett ,  Daniel H. Byun ,  Yifan Deng ,  Jennifer L. Cosman Ellis ,  Rao V. Kalla ,  Richard L. Mackman ,  Dustin S. Siegel ,  Xianhuang Zeng

IPC: C07D487/04 ,  C07D519/00 ,  C07F9/6561 ,  A61P31/14

CPC classification number: C07D487/04 ,  C07D519/00 ,  C07F9/6561 ,  A61P31/14

Abstract: Compounds and methods of using said compounds, singly or in combination with additional agents, and salts or pharmaceutical compositions of said compounds for the treatment of viral infections are disclosed.

公开(公告)号：US20230039553A1

公开(公告)日：2023-02-09

申请号：US17243911

申请日：2021-04-29

Applicant: Gilead Sciences, Inc.

Inventor： Mark J. Bartlett ,  Gregory F. Chin ,  Michael O. Clarke ,  Jennifer L. Cosman ,  Deeba Ensan ,  Bindu Goyal ,  Stephen Ho ,  Hon C. Hui ,  Richard L. Mackman ,  Michael R. Mish ,  Scott D. Schroeder ,  Nathan D. Shapiro ,  Dustin S. Siegel ,  Doris T. Tang ,  Hai Yang

IPC: C07D487/04 ,  C07D519/00 ,  A61K45/06 ,  C07K16/28

Abstract: The present disclosure provides pyrimidine dione compounds, and pharmaceutical compositions thereof, for treating cancer, including solid tumors. The compounds can be used alone or in combination with other anti-cancer agents.

公开(公告)号：US20210292348A1

公开(公告)日：2021-09-23

申请号：US17178115

申请日：2021-02-17

Applicant: Gilead Sciences, Inc.

Inventor： Daniel H. Byun ,  Gregory F. Chin ,  Michael O. Clarke ,  Bindu Goyal ,  Petr Jansa ,  Richard L. Mackman ,  Michael R. Mish ,  Dustin S. Siegel

IPC: C07F9/6561 ,  A61K45/06

Abstract: The present disclosure describes 4′-fluoromethyl nucleosides for treating viral infections, including Dengue.

公开(公告)号：US20210284670A1

公开(公告)日：2021-09-16

申请号：US17178463

申请日：2021-02-18

Applicant: Gilead Sciences, Inc.

Inventor： Gregory F. Chin ,  Byoung-Kwon Chun ,  Michael O. Clarke ,  Bindu Goyal ,  Hon C. Hui ,  Petr Jansa ,  Richard L. Mackman ,  Dustin S. Siegel ,  Hai Yang

IPC: C07F9/6561 ,  A61P31/14

Abstract: The present disclosure provides compounds for treating a variety of diseases, such as respiratory syncytial virus (RSV), HRV, hMPV, Ebola, Zika, West Nile, Dengue, and HCV.

公开(公告)号：US20250084088A1

公开(公告)日：2025-03-13

申请号：US18816988

申请日：2024-08-27

Applicant: Gilead Sciences, Inc.

Inventor： Deeba Ensan ,  Rao V. Kalla ,  Dustin S. Siegel

IPC: C07D487/04 ,  A61K31/53 ,  A61P31/14

Abstract: Antiviral compounds and methods of using the same, singly or in combination with additional agents, and pharmaceutical compositions of said compounds for the treatment of viral infections are disclosed.