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公开(公告)号：US20210052613A1
公开(公告)日：2021-02-25
申请号：US16881419
申请日：2020-05-22
Applicant: GILEAD SCIENCES, INC.
Inventor： Byoung Kwon Chun , Michael O' Neil Hanrahan Clarke , Edward Doerffler , Hon Chung Hui , Robert Jordan , Richard L. Mackman , Jay P. Parrish , Adrian S. Ray , Dustin Siegel
IPC: A61K31/685 , A61K31/706 , A61K31/7056 , A61K31/53 , C07H1/00 , C07H1/02 , C07H11/00 , C07H15/18 , A61K31/6615 , A61K31/665 , A61K31/683 , C07D487/04 , C07D519/00 , C07F9/24 , C07F9/6561 , A61K31/675 , A61K45/06 , A61K31/00
Abstract: Provided are compounds, methods, and pharmaceutical compositions for treating Filoviridae virus infections by administering ribosides, riboside phosphates and prodrugs thereof, of Formula IV: The compounds, compositions, and methods provided are particularly useful for the treatment of Marburg virus, Ebola virus and Cueva virus infections.
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公开(公告)号：US20190321366A1
公开(公告)日：2019-10-24
申请号：US16201221
申请日：2018-11-27
Applicant: Gilead Sciences, Inc.
Inventor： Manoj C. Desai , Randall L. Halcomb , Paul Hrvatin , Hon Chung Hui , Ryan McFadden , Paul A. Roethle , Hong Yang
IPC: A61K31/519 , A61K38/21 , C07D475/06 , A61K38/16 , A61K31/708 , A61K31/7072 , A61K31/7056 , A61K31/683 , A61K31/573 , A61K31/5377 , A61K45/06 , A61K31/551 , A61K31/527 , C07D475/08 , C07D475/12 , C07D487/04 , C07D475/10 , C07D403/12
Abstract: Provided are modulators of TLRs of Formula II: pharmaceutically acceptable salts thereof, compositions containing such compounds, and therapeutic methods that include the administration of such compounds.
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公开(公告)号：US20190275063A1
公开(公告)日：2019-09-12
申请号：US16274049
申请日：2019-02-12
Applicant: GILEAD SCIENCES, INC.
Inventor： Byoung Kwon Chun , Michael O' Neil Hanrahan Clarke , Edward Doerffler , Hon Chung Hui , Robert Jordan , Richard L. Mackman , Jay P. Parrish , Adrian S. Ray , Dustin Siegel
IPC: A61K31/685 , A61K31/683 , A61K31/706 , A61K31/6615 , C07H15/18 , C07H11/00 , C07H1/02 , C07H1/00 , A61K31/53 , A61K31/675 , C07F9/6561 , C07F9/24 , C07D519/00 , C07D487/04 , A61K31/00 , A61K45/06 , A61K31/7056 , A61K31/665
Abstract: Provided are compounds, methods, and pharmaceutical compositions for treating Filoviridae virus infections by administering ribosides, riboside phosphates and prodrugs thereof, of Formula IV: The compounds, compositions, and methods provided are particularly useful for the treatment of Marburg virus, Ebola virus and Cueva virus infections.
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![PYRAZOLO[1,5-A]PYRIMIDINES FOR ANTIVIRAL TREATMENT](/abs-image/US/2018/10/18/US20180298011A1/abs.jpg.150x150.jpg)
公开(公告)号：US20180298011A1
公开(公告)日：2018-10-18
申请号：US15923726
申请日：2018-03-16
Applicant: Gilead Sciences, Inc.
Inventor： Kerim Babaoglu , Constantine G. Boojamra , Eugene J. Eisenberg , Hon Chung Hui , Richard L. Mackman , Jay P. Parrish , Michael Sangi , Oliver L. Saunders , Dustin Siegel , David Sperandio , Hai Yang
IPC: C07D487/04 , A61K45/06 , C07F9/6561 , C07D519/00 , A61K31/519 , C07D495/04 , A61K31/5377 , A61K31/55 , A61K31/551 , A61K31/675 , C07D513/04
Abstract: The invention provides compounds of Formula I or Formula II: or a pharmaceutically acceptable salt or ester, thereof, as described herein. The compounds and compositions thereof are useful for treating Pneumovirinae virus infections. The compounds, compositions, and methods provided are particularly useful for the treatment of Human respiratory syncytial virus infections.
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公开(公告)号：US20180085370A1
公开(公告)日：2018-03-29
申请号：US15659526
申请日：2017-07-25
Applicant: Gilead Sciences, Inc.
Inventor： Manoj C. Desai , Randall L. Halcomb , Paul Hrvatin , Hon Chung Hui , Ryan McFadden , Paul A. Roethle , Hong Yang
IPC: A61K31/519 , A61K38/21 , C07D475/06 , A61K38/16 , A61K31/708 , A61K31/7072 , A61K31/7056 , A61K31/683 , A61K31/573 , A61K31/5377 , A61K45/06 , A61K31/551 , A61K31/527 , C07D403/12 , C07D475/10 , C07D487/04 , C07D475/12 , C07D475/08
CPC classification number: A61K31/519 , A61K31/527 , A61K31/5377 , A61K31/551 , A61K31/573 , A61K31/683 , A61K31/7056 , A61K31/7072 , A61K31/708 , A61K38/16 , A61K38/21 , A61K38/212 , A61K45/06 , C07D403/12 , C07D475/06 , C07D475/08 , C07D475/10 , C07D475/12 , C07D487/04 , Y02A50/385 , Y02A50/387 , Y02A50/389 , Y02A50/391 , Y02A50/393 , Y02A50/395
Abstract: Provided are modulators of TLRs of Formula II: pharmaceutically acceptable salts thereof, compositions containing such compounds, and therapeutic methods that include the administration of such compounds.
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Patent Agency Ranking
公开(公告)号：US09504689B2
公开(公告)日：2016-11-29
申请号：US14635830
申请日：2015-03-02
Applicant: Gilead Sciences, Inc.
Inventor： Dustin Siegel , David Sperandio , Hai Yang , Michael Sangi , Jay P. Parrish , Hon Chung Hui
IPC: A61K31/519 , A61K31/5377 , C07D487/04 , C07D519/00 , C07D471/04 , A61K45/06 , A61K31/4545 , A61K31/5025 , A61K31/53
CPC classification number: C07D487/04 , A61K31/4545 , A61K31/5025 , A61K31/519 , A61K31/53 , A61K31/5377 , A61K45/06 , C07D471/04 , C07D519/00
Abstract: Compounds and pharmaceutically acceptable salts and esters and compositions thereof, for treating viral infections are provided. The compounds and compositions are useful for treating Pneumovirinae virus infections. The compounds, compositions, and methods provided are particularly useful for the treatment of Human respiratory syncytial virus infections.
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公开(公告)号：US08980878B2
公开(公告)日：2015-03-17
申请号：US13865069
申请日：2013-04-17
Applicant: Gilead Sciences, Inc.
Inventor： Dustin Siegel , David Sperandio , Hai Yang , Michael Sangi , Jay P. Parrish , Hon Chung Hui
IPC: A61K31/00 , C07D413/00
CPC classification number: C07D487/04 , A61K31/4545 , A61K31/5025 , A61K31/519 , A61K31/53 , A61K31/5377 , A61K45/06 , C07D471/04 , C07D519/00
Abstract: Compounds and pharmaceutically acceptable salts and esters and compositions thereof, for treating viral infections are provided. The compounds and compositions are useful for treating Pneumovirinae virus infections. The compounds, compositions, and methods provided are particularly useful for the treatment of Human respiratory syncytial virus infections.
Abstract translation: 提供了用于治疗病毒感染的化合物及其药学上可接受的盐和酯及其组合物。 化合物和组合物可用于治疗肺炎链球菌病毒感染。 提供的化合物，组合物和方法特别可用于治疗人呼吸道合胞病毒感染。
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公开(公告)号：US20140316132A1
公开(公告)日：2014-10-23
申请号：US14321689
申请日：2014-07-01
Applicant: Gilead Sciences, Inc.
Inventor： Manoj C. Desai , Randal L. Halcomb , Paul Hrvatin , Hon Chung Hui , Ryan McFadden , Paul A. Roethle , Hong Yang
IPC: C07D475/12 , C07D475/08 , C07D475/10 , C07D475/06
CPC classification number: A61K31/519 , A61K31/527 , A61K31/5377 , A61K31/551 , A61K31/573 , A61K31/683 , A61K31/7056 , A61K31/7072 , A61K31/708 , A61K38/16 , A61K38/21 , A61K38/212 , A61K45/06 , C07D403/12 , C07D475/06 , C07D475/08 , C07D475/10 , C07D475/12 , C07D487/04 , Y02A50/385 , Y02A50/387 , Y02A50/389 , Y02A50/391 , Y02A50/393 , Y02A50/395
Abstract: Provided are modulators of TLRs of Formula II: pharmaceutically acceptable salts thereof, compositions containing such compounds, and therapeutic methods that include the administration of such compounds.
Abstract translation: 提供了式II的TLR的调节剂：其药学上可接受的盐，含有这些化合物的组合物和包括施用这些化合物的治疗方法。
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![Pyrazolo[1,5-A]pyrimidines for antiviral treatment](/abs-image/US/2014/08/19/US08809330B2/abs.jpg.150x150.jpg)
公开(公告)号：US08809330B2
公开(公告)日：2014-08-19
申请号：US14069685
申请日：2013-11-01
Applicant: Gilead Sciences, Inc.
Inventor： Kerim Babaoglu , Constantine G. Boojamra , Eugene J. Eisenberg , Hon Chung Hui , Richard L. Mackman , Jay P. Parrish , Michael Sangi , Oliver L. Saunders , Dustin Siegel , David Sperandio , Hai Yang
IPC: A61P31/14
CPC classification number: C07D487/04 , A61K31/519 , A61K31/5377 , A61K31/55 , A61K31/551 , A61K31/675 , A61K45/06 , C07D495/04 , C07D513/04 , C07D519/00 , C07F9/65616
Abstract: The invention provides compounds of Formula I or Formula II: or a pharmaceutically acceptable salt or ester, thereof, as described herein. The compounds and compositions thereof are useful for treating Pneumovirinae virus infections. The compounds, compositions, and methods provided are particularly useful for the treatment of Human respiratory syncytial virus infections.
Abstract translation: 本发明提供了本文所述的式I或式II化合物或其药学上可接受的盐或酯。 其化合物及其组合物可用于治疗肺炎链球菌病毒感染。 提供的化合物，组合物和方法特别可用于治疗人呼吸道合胞病毒感染。
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公开(公告)号：US10172860B2
公开(公告)日：2019-01-08
申请号：US15659526
申请日：2017-07-25
Applicant: Gilead Sciences, Inc.
Inventor： Manoj C. Desai , Randall L. Halcomb , Paul Hrvatin , Hon Chung Hui , Ryan McFadden , Paul A. Roethle , Hong Yang
IPC: C07D403/12 , A61K31/519 , C07D475/06 , C07D475/08 , C07D475/12 , C07D487/04 , A61K31/5377 , A61K31/573 , A61K31/683 , A61K31/7056 , A61K31/7072 , A61K31/708 , A61K38/16 , A61K38/21 , C07D475/10 , A61K31/527 , A61K31/551 , A61K45/06
Abstract: Provided are modulators of TLRs of Formula II: pharmaceutically acceptable salts thereof, compositions containing such compounds, and therapeutic methods that include the administration of such compounds.
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