公开(公告)号：US07025980B1

公开(公告)日：2006-04-11

申请号：US09661773

申请日：2000-09-14

申请人： Simon F. Williams ,  David P. Martin

发明人： Simon F. Williams ,  David P. Martin

IPC分类号： A61F2/02

CPC分类号： C12P7/625 ,  A61L27/18 ,  C08L67/04

摘要： Polyhydroxyalkanoate materials are provided which are suitable for repair of soft tissue, augmentation, and as viscosupplements in animals, particularly humans. The materials comprise liquid polyhydroxyalkanoate polymer compositions or polyhydroxyalkanoate microdispersions. Devices also are provided for storage and delivery of the polyhydroxyalkanoate compositions in vivo. Methods are provided for repairing or augmenting soft tissue in animals using the materials. In a preferred embodiment, the method include the steps of (a) selecting the animal soft tissue to be repaired or augmented; and (b) placing an injectable, liquid polyhydroxyalkanoate polymer or a polyhydroxyalkanoate microdispersion into the animal soft tissue, preferably using a minimally-invasive method such as injection. In another embodiment, the liquid polyhydroxyalkanoate polymer compositions or polyhydroxyalkanoate microdispersions are used as viscosupplements.

公开(公告)号：US06623730B1

公开(公告)日：2003-09-23

申请号：US09661948

申请日：2000-09-14

申请人： Simon F. Williams ,  David P. Martin

发明人： Simon F. Williams ,  David P. Martin

IPC分类号： A61K31765

CPC分类号： A61K31/19 ,  A61K31/765

摘要： Oligomers and polymer compositions are provided which comprise GHB and produce GHB after administration in vivo. Devices for the storage and delivery of these polymers and oligomers are also provided. These oligomers and polymer compositions are useful in a variety of applications. The compositions can be used therapeutically, for example, in the treatment of patients with narcolepsy, chronic schizophrenia, catatonic schizophrenia, atypical psychoses, chronic brain syndrome, neurosis, alcoholism, drug addiction and withdrawal, Parkinson's disease and other neuropharmacological illnesses, hypertension, ischemia, circulatory collapse, radiation exposure, cancer, and myocardial infarction. Other uses for the compositions include anesthesia induction, sedation, growth hormone production, heightened sexual desire, anorectic effects, euphoria, smooth muscle relaxation, muscle mass production, and sleep, including rapid eye movement sleep. In a still further embodiment, the oligomers and polymers may be used to produce absence seizures.

摘要翻译： 提供含有GHB并在体内施用后产生GHB的低聚物和聚合物组合物。 还提供了用于储存和递送这些聚合物和低聚物的装置。 这些低聚物和聚合物组合物可用于各种应用中。 组合物可用于治疗例如发作性睡病，慢性精神分裂症，紧张性精神分裂症，非典型精神病，慢性脑综合征，神经症，酒精中毒，药物成瘾和戒断，帕金森病和其他神经药理学疾病，高血压，缺血的患者的治疗 ，循环衰竭，放射线暴露，癌症和心肌梗死。 组合物的其它用途包括麻醉诱导，镇静，生长激素生成，性欲升高，厌食症，欣快，平滑肌松弛，肌肉量产和睡眠，​​包括快速眼动睡眠。 在另一个实施方案中，低聚物和聚合物可以用于产生不发作的发作。

公开(公告)号：US06245537B1

公开(公告)日：2001-06-12

申请号：US09076198

申请日：1998-05-12

申请人： Simon F. Williams ,  David P. Martin ,  Tillman Gerngross ,  Daniel M. Horowitz

发明人： Simon F. Williams ,  David P. Martin ,  Tillman Gerngross ,  Daniel M. Horowitz

IPC分类号： C12P762

CPC分类号： C12P7/625 ,  A61B17/06166 ,  A61B42/00 ,  A61K47/593 ,  A61K47/6957 ,  A61L15/26 ,  A61L17/10 ,  A61L27/18 ,  A61L27/34 ,  A61L29/06 ,  A61L31/06 ,  C08G63/06 ,  C08G63/6852 ,  C08G63/6882 ,  C08G63/912 ,  C12N5/0068 ,  C12N2533/30 ,  Y10S977/775 ,  Y10T428/139 ,  C08L67/04

摘要： Polyhydroxyalkanoate (PHA) that contains a pyrogen such as endotoxin due to a process of producing the PHA is treated to remove the pyrogen by a process that does not affect the inherent chemical and physical properties of the PHA to obtain a biocompatible PHA. PHA produced by fermentation with a Gram negative bacteria can be treated with an oxidizing agent such as hydrogen peroxide or benzoyl peroxide to reduce the endotoxin content to less than 20 endotoxin units/gram of PHA to produce PHA that does not elicit an acute inflammatory response when implanted in an animal. The PHA may have a melting point or glass transition temperature less than 136° C., and can be chemically modified or derivatized such as by covalently coupling an attachment or targeting molecule. The PHA may be used to form various medical devices, and can be used for in vivo applications including tissue coatings, stents, sutures, tubing, bone and other prostheses, bone and tissue cements, tissue regenerating devices, wound dressings, drug delivery, and for diagnostic and prophylactic uses.

摘要翻译： 处理由于产生PHA的过程而含有热原如内毒素的聚羟基链烷酸酯（PHA），以通过不影响PHA固有的化学和物理性能以获得生物相容性PHA的方法除去热原。 通过用革兰氏阴性细菌发酵产生的PHA可以用氧化剂如过氧化氢或过氧化苯甲酰处理以将内毒素含量降低到小于20个内毒素单位/克的PHA，以产生不引起急性炎症反应的PHA 植入动物。 PHA可以具有低于136℃的熔点或玻璃化转变温度，并且可以通过共价偶联附着物或靶向分子进行化学修饰或衍生化。 PHA可以用于形成各种医疗装置，并且可以用于体内应用，包括组织涂层，支架，缝线，管，骨和其他假体，骨和组织水泥，组织再生装置，伤口敷料，药物递送和 用于诊断和预防用途。

公开(公告)号：US08753555B2

公开(公告)日：2014-06-17

申请号：US13084388

申请日：2011-04-11

申请人： Said Rizk ,  David P. Martin ,  Kicherl Ho ,  Simon F. Williams

发明人： Said Rizk ,  David P. Martin ,  Kicherl Ho ,  Simon F. Williams

IPC分类号： B29C55/04 ,  B29C55/12 ,  A61L27/18 ,  A61L27/58 ,  C08L67/04 ,  C08G63/08

CPC分类号： A61L27/34 ,  A61L27/18 ,  A61L31/10 ,  B29C55/005 ,  B29C55/04 ,  B29C55/12 ,  B29K2067/00 ,  B29K2067/046 ,  B29K2995/006 ,  C08L67/04

摘要： Continuous processing methods for making absorbable polymeric films with one or more of the following properties: high toughness, low modulus, high tensile strength, and thickness less than 10 mm, more preferably less than 1 mm, and more preferably less than 100 μm, have been developed. In the preferred embodiment, the polymer is a polyhydroxyalkanoate, and in the most preferred embodiment, the polymer comprises 4-hydroxybutyrate. A particularly preferred embodiment is a film of poly-4-hydroxybutyrate or copolymer thereof, wherein the film has a tensile strength greater than 5.5 kgf/mm2, tensile modulus less than 181 kgf/mm2, and elongation at break from 10-500%, wherein the film is derived by a continuous process such as melt extrusion or solvent casting, followed by orientation to more than 25% of the film's original length in one or more directions. These can be used for a variety of purposes including fabrication of medical devices.

摘要翻译： 用于制造具有以下特性中的一种或多种的可吸收聚合物膜的连续加工方法：高韧性，低模量，高拉伸强度和小于10mm，更优选小于1mm，更优选小于100μm的厚度具有 已经开发 在优选的实施方案中，聚合物是聚羟基链烷酸酯，并且在最优选的实施方案中，聚合物包含4-羟基丁酸酯。 特别优选的实施方案是聚-4-羟基丁酸酯或其共聚物的膜，其中所述膜的拉伸强度大于5.5kgf / mm 2，拉伸模量小于181kgf / mm 2，断裂伸长率为10-500％ 其中所述膜通过连续方法如熔体挤出或溶剂浇铸得到，然后在一个或多个方向上定向至超过膜的原始长度的25％。 这些可以用于各种目的，包括制造医疗器械。

公开(公告)号：US08626951B2

公开(公告)日：2014-01-07

申请号：US11739023

申请日：2007-04-23

申请人： Tamara L. Casey ,  David P. Martin

发明人： Tamara L. Casey ,  David P. Martin

IPC分类号： G06F15/16

CPC分类号： H04L12/66 ,  H04L67/28 ,  H04L67/2804 ,  H04L67/2819 ,  H04L67/2823 ,  H04L67/2876 ,  H04L69/08

摘要： An interoperability system abstracts the protocols used by multiple network applications into an interoperability framework, thereby allowing the network applications to interoperate with each other and/or with modules for providing enhanced functionalities. The interoperability framework includes a number of adapters that modularize the components needed for interoperation and abstracts content from the underlying protocols and procedures used by the network applications. The interoperability framework includes a resource control that enables the network applications to access shared resources, such as data and content used by the network applications, thus allowing the applications to interoperate and for functionality enhancements to be added.

摘要翻译： 互操作性系统将多个网络应用程序使用的协议抽象为互操作性框架，从而允许网络应用程序彼此互操作和/或与模块进行互操作，以提供增强的功能。 互操作性框架包括许多适配器，用于模块化互操作所需的组件，并从网络应用程序使用的底层协议和过程中抽取内容。 互操作性框架包括一个资源控制，使网络应用程序能够访问诸如网络应用程序使用的数据和内容之类的共享资源，从而允许应用程序进行互操作并增加功能。

公开(公告)号：US20120150285A1

公开(公告)日：2012-06-14

申请号：US13160942

申请日：2011-06-15

申请人： Ryan Cahil ,  Kai Guo ,  David P. Martin ,  Said Rizk

发明人： Ryan Cahil ,  Kai Guo ,  David P. Martin ,  Said Rizk

IPC分类号： A61F2/06 ,  D04H13/00

CPC分类号： D04H1/4382 ,  A61L27/18 ,  A61L27/54 ,  A61L29/06 ,  A61L29/16 ,  A61L31/06 ,  A61L31/16 ,  A61L2300/00 ,  D04H1/42 ,  D04H1/435 ,  D04H1/56 ,  D04H3/16 ,  Y10T442/608 ,  C08L67/04

摘要： Continuous processing methods for making absorbable polymeric dry spun non-wovens with one or more of the following properties: high burst strength, fine fibers of average diameter from 0.01 μm to 50 μm, and thickness from 10 μm to 10 mm, have been developed. Improved fiber cohesion is made possible by controlling the tackiness of the fibers of the non-woven during web collection. The polymer is preferably a polyhydroxyalkanoate, more preferably, a 4-hydroxybutyrate polymer or copolymer. A non-woven of poly-4-hydroxybutyrate is most preferred. The non-wovens have fine fibers with average diameters ranging from 0.01 μm to 50 μm, and are derived by dry spun processing, during which a solution of polymer(s) is injected into a stream of high velocity air with a pressure of 1 to 500 psi for solvent stripping and polymer strand attenuation. The non-wovens can be used for a variety of purposes including fabrication of medical devices.

摘要翻译： 已经开发了用于制造具有以下性质的一种或多种的可吸收聚合干纺非织造物的连续加工方法：高破裂强度，平均直径为0.01μm至50μm的细纤维，以及10μm至10mm的厚度。 通过在卷材收集过程中控制无纺布纤维的粘性，可以改善纤维内聚力。 聚合物优选为聚羟基链烷酸酯，更优选为4-羟基丁酸酯聚合物或共聚物。 聚-4-羟基丁酸酯的无纺布是最优选的。 无纺布具有平均直径范围为0.01μm至50μm的细纤维，并通过干纺处理得到，其中将聚合物溶液注入到高速空气流中，压力为1至 500 psi用于溶剂剥离和聚合物链衰减。 无纺布可以用于各种目的，包括制造医疗装置。

公开(公告)号：US20110135707A1

公开(公告)日：2011-06-09

申请号：US13021419

申请日：2011-02-04

申请人： Simon F. Williams ,  David P. Martin ,  Tillman Gerngross ,  Daniel M. Horowitz

发明人： Simon F. Williams ,  David P. Martin ,  Tillman Gerngross ,  Daniel M. Horowitz

IPC分类号： A61F2/28 ,  C12N5/07 ,  A61F2/00 ,  A61K9/00 ,  A61K49/00 ,  A61K38/02 ,  A61K31/7088 ,  A61K31/715 ,  A61K31/70 ,  A61K31/20 ,  A61K9/70 ,  A61P17/02 ,  A61P19/08 ,  A61P9/00 ,  C08G63/91 ,  B32B1/08

CPC分类号： C12P7/625 ,  A61B17/06166 ,  A61B42/00 ,  A61K47/593 ,  A61K47/6957 ,  A61L15/26 ,  A61L17/10 ,  A61L27/18 ,  A61L27/34 ,  A61L29/06 ,  A61L31/06 ,  C08G63/06 ,  C08G63/6852 ,  C08G63/6882 ,  C08G63/912 ,  C12N5/0068 ,  C12N2533/30 ,  Y10S977/775 ,  Y10T428/139 ,  C08L67/04

摘要： Polyhydroxyalkanoates (PHAs) from which pyrogen has been removed are provided for use in numerous biomedical applications. PHAs which have been chemically modified to enhance physical and/or chemical properties, for targeting or to modify biodegradability or clearance by the reticuloendothelial system (RES), are described. Methods for depyrogenating PHA polymers prepared by bacterial fermentation processes are also provided, wherein pyrogens are removed from the polymers without adversely impacting the polymers' inherent chemical structures and physical properties. PHAs with advantageous processing characteristics, including low melting points and/or solubility in non-toxic solvents, are also described. PHAs are provided which are suitable for use in in vivo applications such as in tissue coatings, stents, sutures, tubing, bone and other prostheses, bone or tissue cements, tissue regeneration devices, wound dressings, drug delivery, and for diagnostic and prophylactic uses. Properties which are selected for include degradability, elasticity, inclusion of functional groups or derivatized groups, which can in turn be used to attach targeting agents, and bioadhesion.

摘要翻译： 已经除去热原的聚羟基链烷酸酯（PHA）被提供用于许多生物医学应用。 已经化学改性以增强物理和/或化学性质的PHA用于通过网状内皮系统（RES）靶向或修饰生物降解性或清除的PHA。 还提供了通过细菌发酵方法制备的PHA聚合物去热原化方法，其中热原从聚合物中除去而不会不利地影响聚合物固有的化学结构和物理性质。 还描述了具有有利处理特性的PHA，包括低熔点和/或在无毒溶剂中的溶解度。 提供适用于体内应用的PHA，例如在组织涂层，支架，缝线，管，骨和其他假体，骨或组织水泥，组织再生装置，伤口敷料，药物递送以及用于诊断和预防用途 。 选择的性质包括降解性，弹性，包含官能团或衍生基团，其又可用于附着靶向剂，以及生物粘附。

公开(公告)号：US20090162276A1

公开(公告)日：2009-06-25

申请号：US12336755

申请日：2008-12-17

申请人： David P. Martin ,  Said Rizk ,  Kicherl Ho ,  Simon F. Williams

发明人： David P. Martin ,  Said Rizk ,  Kicherl Ho ,  Simon F. Williams

IPC分类号： A61K51/00 ,  D04H13/00 ,  B32B27/02 ,  A61F2/02 ,  A61K49/00 ,  D04H3/16

CPC分类号： A61L29/06 ,  A61L15/26 ,  A61L15/44 ,  A61L27/18 ,  A61L27/54 ,  A61L29/16 ,  A61L31/06 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/00 ,  D04H1/4382 ,  D04H1/56 ,  Y10T442/608 ,  C08L67/04

摘要： Continuous processing methods for making absorbable polymeric non-wovens with one or more of the following properties: high burst strength, fine fibers of average diameter from 1 μm to 50 μm, and thickness from 10 μm to 50 mm, have been developed. Improved fiber cohesion is made possible by allowing the fibers of the non-woven to initially remain molten during web collection. In the preferred embodiment, the polymer is a polyhydroxyalkanoate, and in the most preferred embodiment, the polymer comprises 4-hydroxybutyrate. A particularly preferred embodiment is a non-woven of poly-4-hydroxybutyrate or copolymer thereof, wherein the non-woven has a burst strength greater than 0.1 Kgf, wherein the non-woven is derived by a continuous melt-blown process. The non-wovens can be used for a variety of purposes including fabrication of medical devices.

摘要翻译： 已经开发了用于制造具有以下特性中的一种或多种的可吸收聚合非织造物的连续加工方法：高破裂强度，平均直径为1μm至50μm的细纤维和厚度为10um至50mm。 通过允许无纺布的纤维在网收集期间最初保持熔融，可以实现改进的纤维内聚力。 在优选的实施方案中，聚合物是聚羟基链烷酸酯，并且在最优选的实施方案中，聚合物包含4-羟基丁酸酯。 特别优选的实施方案是聚-4-羟基丁酸酯或其共聚物的无纺布，其中无纺布具有大于0.1Kgff的破裂强度，其中无纺织物通过连续熔喷法得到。 无纺布可以用于各种目的，包括制造医疗装置。

公开(公告)号：US20080198422A1

公开(公告)日：2008-08-21

申请号：US11676400

申请日：2007-02-19

申请人： Tamara Lynne Casey ,  David P. Martin

发明人： Tamara Lynne Casey ,  David P. Martin

IPC分类号： H04J15/00

CPC分类号： H04L41/0686

摘要： A communication device invokes its various device capabilities according to context information about the device. Events, which may be initiated by a user or may occur without direct user involvement, are mapped to the various functions that implement the capabilities of the device. The mapping may be updated dynamically and automatically as the context information changes and new context information received. User data and system data are also stored as the data are accumulated. When an event occurs, one or more functions that are associated with the event according to the current mapping are invoked. The user and system data may also be passed on for use with the invoked functions.

摘要翻译： 通信设备根据关于设备的上下文信息调用其各种设备能力。 可以由用户发起或者可以在没有直接用户参与的情况下发生的事件被映射到实现设备的能力的各种功能。 当上下文信息改变并且接收到新的上下文信息时，可以动态地和自动地更新映射。 当数据被累积时，用户数据和系统数据也被存储。 当事件发生时，调用根据当前映射与事件相关联的一个或多个函数。 用户和系统数据也可以被传递以与被调用的功能一起使用。

公开(公告)号：US20070182041A1

公开(公告)日：2007-08-09

申请号：US11671544

申请日：2007-02-06

申请人： Said Rizk ,  David P. Martin ,  Kicherl Ho ,  Amit Ganatra ,  Simon F. Williams

发明人： Said Rizk ,  David P. Martin ,  Kicherl Ho ,  Amit Ganatra ,  Simon F. Williams

IPC分类号： B29B9/08 ,  C08G63/08

CPC分类号： C08L67/04 ,  A61K47/34 ,  A61L15/26 ,  A61L17/105 ,  A61L17/12 ,  A61L27/18 ,  A61L27/26 ,  A61L29/049 ,  A61L29/06 ,  A61L31/041 ,  A61L31/06 ,  A61L31/10 ,  A61L31/148 ,  A61L31/18 ,  C08G63/06 ,  C08K3/014 ,  C08K5/0016 ,  C08K5/005 ,  C08K5/0083 ,  C08L2666/18

摘要： Toughened compositions of PLA and PLA copolymers are disclosed, which also have low tensile modulus values and greater elongation to break. These toughened compositions are prepared by blending PLA and PLA copolymers with poly-4-hydroxybutyrate, and copolymers thereof. Blending of poly-4-hydroxybutyrate with PLA and its copolymers has been found to impart advantageous properties to the resulting blend. These compositions, and objects formed from these compositions, have improved toughness and lower stiffness than polylactic acid polymers or copolymers alone.

摘要翻译： 公开了PLA和PLA共聚物的增韧组合物，其也具有低拉伸模量值和较大的断裂伸长率。 这些增韧的组合物通过将PLA和PLA共聚物与聚-4-羟基丁酸酯及其共聚物共混来制备。 已经发现聚-4-羟基丁酸酯与PLA及其共聚物的混合赋予所得共混物有利的性质。 这些组合物和由这些组合物形成的物体比单独的聚乳酸聚合物或共聚物具有改善的韧性和较低的刚度。