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公开(公告)号：US20100111891A1
公开(公告)日：2010-05-06
申请号：US12545810
申请日：2009-08-22
申请人： Detlef Albrecht , Michael Burdick , Han-Ting Chang , Dominique Charmot , Ramakrishnan Chidambaram , Eric Connor , Sherin Halfon , I-Zu Huang , Mingjun Liu , Jonathan Mills , Werner Strüver
发明人： Detlef Albrecht , Michael Burdick , Han-Ting Chang , Dominique Charmot , Ramakrishnan Chidambaram , Eric Connor , Sherin Halfon , I-Zu Huang , Mingjun Liu , Jonathan Mills , Werner Strüver
CPC分类号： A61K31/78 , A61K31/7004 , C08K5/053 , A61K2300/00
摘要： The present invention is directed to compositions of a linear polyol and a salt of a crosslinked cation exchange polymer comprising a fluoro group and an acid group. These compositions are useful to bind potassium in the gastrointestinal tract.
摘要翻译： 本发明涉及线性多元醇和包含氟基团和酸基团的交联阳离子交换聚合物的盐的组合物。 这些组合物可用于结合胃肠道中的钾。
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公开(公告)号：US20090148533A1
公开(公告)日：2009-06-11
申请号：US12238844
申请日：2008-09-26
申请人： Dominique Charmot , Han-Ting Chang , Eric Connor , Mingjun Liu , Gerrit Klaerner
发明人： Dominique Charmot , Han-Ting Chang , Eric Connor , Mingjun Liu , Gerrit Klaerner
IPC分类号： A61K9/16 , A61K31/795 , A61K31/80 , A61K31/74 , A61P7/00
CPC分类号： A61K31/78 , A61K9/14 , A61K9/1635 , A61K9/5026 , A61K9/5031 , A61K31/74 , A61K31/785 , A61K31/795 , A61K31/80 , A61K45/06 , C08F120/06 , C08F128/02 , Y10S514/838 , Y10S514/869 , Y10S514/87 , Y10S514/893
摘要： The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides core-shell compositions and pharmaceutical compositions thereof. Methods of use of the core-shell compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of phosphate imbalance disorders, hypertension, chronic heart failure, end stage renal disease, liver cirrhosis, chronic renal insufficiency, fluid overload, or sodium overload.
摘要翻译： 本发明提供了用于治疗离子失衡的方法和组合物。 特别地，本发明提供了核 - 壳组合物及其药物组合物。 本文公开了用于治疗和/或预防益处的核 - 壳组合物的使用方法。 这些方法的实例包括治疗磷酸盐不平衡障碍，高血压，慢性心力衰竭，终末期肾病，肝硬化，慢性肾功能不全，流体过载或钠过载。
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公开(公告)号：US07399806B2
公开(公告)日：2008-07-15
申请号：US11734474
申请日：2007-04-12
申请人： Didier Benoit , Adam Safir , Han-Ting Chang , Dominique Charmot , Kenji Okamoto , Isao Nishimura , Yong Wang
发明人： Didier Benoit , Adam Safir , Han-Ting Chang , Dominique Charmot , Kenji Okamoto , Isao Nishimura , Yong Wang
CPC分类号： C08F220/30 , C08F2/38 , C08F20/30 , C08F220/18 , C08F293/005 , G03F7/0046 , G03F7/0397
摘要： The present invention is directed to the preparation of photoresist polymers via living free radical polymerization techniques. Sterically bulky ester monomers are utilized as the polymerization components. Use of chain transfer agents is included in polymerization processing conditions. Cleavage of polymer terminal end groups that include a heteroatom are described.
摘要翻译： 本发明涉及通过活性自由基聚合技术制备光致抗蚀剂聚合物。 用作单体体积大的酯单体作为聚合组分。 链转移剂的使用包括在聚合工艺条件中。 描述了包含杂原子的聚合物末端基团的切割。
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公开(公告)号：US07510817B2
公开(公告)日：2009-03-31
申请号：US11300657
申请日：2005-12-12
申请人： Didier Benoit , Adam Safir , Han-Ting Chang , Dominique Charmot , Isao Nishimura , Akimasa Soyano , Kenji Okamoto , Yong Wang
发明人： Didier Benoit , Adam Safir , Han-Ting Chang , Dominique Charmot , Isao Nishimura , Akimasa Soyano , Kenji Okamoto , Yong Wang
CPC分类号： C08F220/18 , C08F20/18 , C08F220/28 , G03F7/0397
摘要： The present invention is directed to the preparation of photoresist polymers via living free radical polymerization techniques. Sterically bulky ester monomers are utilized as the polymerization components. Use of chain transfer agents is included in polymerization processing conditions. Cleavage of polymer terminal end groups that include a heteroatom are described.
摘要翻译： 本发明涉及通过活性自由基聚合技术制备光致抗蚀剂聚合物。 用作单体体积大的酯单体作为聚合组分。 链转移剂的使用包括在聚合工艺条件中。 描述了包含杂原子的聚合物末端基团的切割。
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公开(公告)号：US20070292385A1
公开(公告)日：2007-12-20
申请号：US11579251
申请日：2005-05-03
申请人： Dominique Charmot , Jerry Buysse , Han-Ting Chang , Michael Cope , David Hui
发明人： Dominique Charmot , Jerry Buysse , Han-Ting Chang , Michael Cope , David Hui
IPC分类号： A61K31/785 , A61P3/00
CPC分类号： A61K31/785 , A23L33/10 , A61K31/195 , A61K31/381 , A61K31/40 , A61K31/404 , A61K31/405 , A61K31/519 , A61K31/66 , A61K31/74
摘要： The present invention provides methods and compositions for the treatment of phospholipase-related conditions. In particular, the invention provides a method of treating insulin-related, weight-related conditions and/or cholesterol-related conditions in an animal subject. The method generally involves the administration of a non-absorbed and/or effluxed phospholipase A2 inhibitor that is localized in a gastrointestinal lumen.
摘要翻译： 本发明提供了治疗磷脂酶相关病症的方法和组合物。 特别地，本发明提供了一种在动物受试者中治疗胰岛素相关，体重相关病症和/或胆固醇相关病症的方法。 该方法通常涉及施用定位在胃肠腔中的未吸收和/或流出的磷脂酶A2抑制剂。
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公开(公告)号：US20070185276A1
公开(公告)日：2007-08-09
申请号：US11734474
申请日：2007-04-12
申请人： Didier Benoit , Adam Safir , Han-Ting Chang , Dominique Charmot , Kenji Okamoto , Isao Nishimura , Yong Wang
发明人： Didier Benoit , Adam Safir , Han-Ting Chang , Dominique Charmot , Kenji Okamoto , Isao Nishimura , Yong Wang
IPC分类号： C08F287/00
CPC分类号： C08F220/30 , C08F2/38 , C08F20/30 , C08F220/18 , C08F293/005 , G03F7/0046 , G03F7/0397
摘要： The present invention is directed to the preparation of photoresist polymers via living free radical polymerization techniques. Sterically bulky ester monomers are utilized as the polymerization components. Use of chain transfer agents is included in polymerization processing conditions. Cleavage of polymer terminal end groups that include a heteroatom are described.
摘要翻译： 本发明涉及通过活性自由基聚合技术制备光致抗蚀剂聚合物。 用作单体体积大的酯单体作为聚合组分。 链转移剂的使用包括在聚合工艺条件中。 描述了包含杂原子的聚合物末端基团的切割。
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27.发明授权公开(公告)号：US06667376B2
公开(公告)日：2003-12-23
申请号：US10104740
申请日：2002-03-22
IPC分类号： C08F200
CPC分类号： C07D295/24 , C07C329/16 , C07C2601/14 , C07D207/46 , C07D209/30 , C07D291/06 , C08F2/38 , C08F293/005
摘要： Control agents that have an oxygen-nitrogen bond covalently bonded to a thiocarbonyl moiety are provided for living-type free radical polymerization of a wide variety of monomers, particularly vinyl monomers.
摘要翻译： 具有共价键合到硫代羰基部分上的氧 - 氮键的对照试剂被提供用于多种单体，特别是乙烯基单体的活性型自由基聚合。
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公开(公告)号：US08282913B2
公开(公告)日：2012-10-09
申请号：US12055746
申请日：2008-03-26
IPC分类号： A61K31/74
CPC分类号： A61K31/78 , A61K9/14 , A61K9/1635 , A61K9/5026 , A61K9/5031 , A61K31/74 , A61K31/785 , A61K31/795 , A61K31/80 , A61K45/06 , C08F120/06 , C08F128/02 , Y10S514/838 , Y10S514/869 , Y10S514/87 , Y10S514/893
摘要： The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides compositions comprising potassium binding polymers and pharmaceutical compositions thereof. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of hyperkalemia, such as hyperkalemia caused by renal failure and/or the use of hyperkalemia causing drugs.
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29.发明申请CROSSLINKED CATION EXCHANGE POLYMERS, COMPOSITIONS AND USE IN TREATING HYPERKALEMIA 审中-公开交联剂交联聚合物，组合物和用于治疗高血压公开(公告)号：US20110236340A1
公开(公告)日：2011-09-29
申请号：US13060207
申请日：2009-08-22
申请人： Paul Mansky , Detlef Albrecht , Michael Burdick , Han-Ting Chang , Dominique Charmot , Eric Connor , Sherin Halfon , I-Zu Huang , Mingjun Liu , Ramakrishnan Chidambaram , Jonathan Mills , Werner Strüver
发明人： Paul Mansky , Detlef Albrecht , Michael Burdick , Han-Ting Chang , Dominique Charmot , Eric Connor , Sherin Halfon , I-Zu Huang , Mingjun Liu , Ramakrishnan Chidambaram , Jonathan Mills , Werner Strüver
CPC分类号： A61K31/78 , A61K9/14 , A61K31/7004 , A61K47/26 , B01J39/20 , C08F212/36 , C08F220/22
摘要： The present invention is directed to crosslinked cation exchange polymers comprising a fluoro group and an acid group, pharmaceutical compositions of these polymers, compositions of a linear polyol and a salt of such polymer. Crosslinked cation exchange polymers having beneficial physical properties, including combinations of particle size, particle shape, particle size distribution, viscosity, yield stress, compressibility, surface morphology, and/or swelling ratio are also described. These polymers and compositions are useful to bind potassium in the gastrointestinal tract.
摘要翻译： 本发明涉及包含氟基团和酸基团的交联阳离子交换聚合物，这些聚合物的药物组合物，线性多元醇的组合物和这种聚合物的盐。 还描述了具有有益物理性质的交联阳离子交换聚合物，包括粒度，颗粒形状，粒度分布，粘度，屈服应力，压缩性，表面形态和/或溶胀比的组合。 这些聚合物和组合物可用于结合胃肠道中的钾。
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30.发明申请公开(公告)号：US20100111892A1
公开(公告)日：2010-05-06
申请号：US12545812
申请日：2009-08-22
申请人： Han-Ting Chang , Dominique Charmot , Mingjun Liu , Werner Strüver
发明人： Han-Ting Chang , Dominique Charmot , Mingjun Liu , Werner Strüver
CPC分类号： C08F220/22
摘要： The present invention is directed to crosslinked cation exchange polymers comprising a fluoro group and an acid group and being a polymerization product of at least three monomers. Pharmaceutical compositions of these polymers are useful to bind potassium in the gastrointestinal tract.
摘要翻译： 本发明涉及包含氟基和酸基的交联阳离子交换聚合物，并且是至少三种单体的聚合产物。 这些聚合物的药物组合物可用于结合胃肠道中的钾。
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