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    Method and system for improving fuel economy and environmental impact operating a 2-stroke engine
    21.
    发明申请
    Method and system for improving fuel economy and environmental impact operating a 2-stroke engine 失效
    提高二冲程发动机的燃油经济性和环境影响的方法和系统

    公开(公告)号：US20060148661A1

    公开(公告)日：2006-07-06

    申请号：US11027573

    申请日：2004-12-30

    申请人： Giuseppe Natoli ,  Giulio Pometto ,  Alfio Bonciolini ,  Hans Petersen ,  Jorn Dragsted ,  Claus Olesen ,  Klaus-Werner Damm

    发明人： Giuseppe Natoli ,  Giulio Pometto ,  Alfio Bonciolini ,  Hans Petersen ,  Jorn Dragsted ,  Claus Olesen ,  Klaus-Werner Damm

    IPC分类号： C10M139/00

    CPC分类号： C10M175/0091 ,  C10M2207/026 ,  C10M2207/042 ,  C10M2207/283 ,  C10M2207/40 ,  C10M2215/04 ,  C10M2215/042 ,  C10M2215/08 ,  C10M2215/224 ,  C10M2219/022 ,  C10M2223/04 ,  C10M2227/061 ,  C10N2230/06 ,  C10N2230/52 ,  C10N2240/102 ,  C10N2260/14

    摘要： The present invention relates to a method of and a corresponding system for reducing fuel consumption and environmental impact in a two-stroke engine, comprising the steps of obtaining system oil/consumable system oil (301′) from at least one engine (300), adding (102) at least one friction modifier (101) to at least a part of the obtained system oil/consumable system oil (301′), where the addition of the at least one friction modifier (101) reduces the friction coefficient of the obtained system oil/consumable system oil (301′), resulting in a system oil/consumable system oil with reduced friction (301″), and supplying said system oil/consumable system oil with reduced friction (301″) to said at least one engine (300). In this way, frictional losses caused by contamination of the system oil/consumable system oil are avoided or minimised, which normally take place as the oil is used and which would otherwise cause a continuous decrease in engine efficiency resulting in increased fuel consumption and emissions. In addition, the present invention related to a method and a corresponding system to convert system oil/consumable system oil into cylinder oil. Finally, the present invention relates to a method to use a consumable system oil as it is being converted into cylinder oil. This furthermore allows for the consumable system oil to contain a lower performance additive package and/or additive treat rate. Thus great economical savings and environmental improvements are achieved.

    摘要翻译： 本发明涉及一种用于降低二冲程发动机的燃料消耗和环境影响的方法和相应的系统，包括以下步骤：从至少一个发动机（300）获得系统油/消耗系统油（301'）， 向所获得的系统油/可消耗系统油（301'）的至少一部分添加（102）至少一种摩擦改进剂（101），其中所述至少一种摩擦改进剂（101）的添加降低了 获得系统油/消耗系统油（301'），导致系统油/消耗系统具有减小摩擦力（301“）的油，并且将所述系统油/消耗系统油减少摩擦（301”）供应到所述 至少一个发动机（300）。 以这种方式，避免或最小化系统油/消耗系统油污染引起的摩擦损失，这通常在油被使用时发生，否则将导致发动机效率的持续降低，从而导致燃料消耗和排放增加。 此外，本发明涉及将系统油/消耗系统油转化为汽缸油的方法和相应的系统。 最后，本发明涉及一种使用消耗性系统油的方法，因为其被转化成汽缸油。 这进一步允许消耗系统油含有较低性能的添加剂包和/或添加剂处理速率。 因此实现了巨大的经济节约和环境改善。

    Method for the preparation of citalopram
    22.
    发明授权
    Method for the preparation of citalopram 失效

    公开(公告)号：US07030252B2

    公开(公告)日：2006-04-18

    申请号：US10958067

    申请日：2004-10-04

    申请人： Hans Petersen

    发明人： Hans Petersen

    IPC分类号： C07D307/87

    CPC分类号： C07D307/87

    摘要： A method for the preparation of citalopram comprising reductive hydrolysis of a compound of Formula (IV) wherein R is a N,N-disubstituted amid group or an optionally substituted 4,5-dihydro-1,3-oxazol-2-yl group, and conversion of the resulting 5-formyl compound to citalopram.

    Method for the preparation of citalopram
    24.
    发明授权
    Method for the preparation of citalopram 失效
    西酞普兰制备方法

    公开(公告)号：US06762307B2

    公开(公告)日：2004-07-13

    申请号：US10183958

    申请日：2002-06-25

    申请人： Hans Petersen ,  Jakob Felding

    发明人： Hans Petersen ,  Jakob Felding

    IPC分类号： C07D30778

    CPC分类号： C07D307/87 ,  C07C215/34 ,  C07D307/28 ,  Y02P20/55

    摘要： The present invention relates to a method for the preparation of citalopram or any of its enantiomers and acid addition salts thereof comprising reaction of a compound of formula II with a diene having the formula wherein X is O, S, SO2, —N═N—, —CO—O—, —O—CO—, or or with a diene having the formula wherein R is alkyl or optionally substituted aryl or arylalkyl. The invention also relates to intermediates used in the new process for the preparation of citalopram, as well as citalopram prepared according to the new process.

    摘要翻译： 本发明涉及一种制备西酞普兰或其任何对映异构体及其酸加成盐的方法，其包括式Ⅱ化合物与具有式（Ⅳ）的二烯的反应为O，S，SO 2，-N = N-， CO-O-，-O-CO-，oror与具有式R取代的二烯的烷基或任选取代的芳基或芳基烷基。本发明还涉及用于制备西酞普兰的新方法中的中间体，以及西酞普兰 根据新进程。

    Method for the preparation of citalopram
    26.
    发明授权
    Method for the preparation of citalopram 失效
    西酞普兰制备方法

    公开(公告)号：US06291689B1

    公开(公告)日：2001-09-18

    申请号：US09565061

    申请日：2000-05-03

    申请人： Hans Petersen ,  Klaus Peter Bøgesø ,  Michael Bech Sommer

    发明人： Hans Petersen ,  Klaus Peter Bøgesø ,  Michael Bech Sommer

    IPC分类号： C07D30787

    CPC分类号： C07C69/76 ,  C07C235/42 ,  C07C255/53 ,  C07D307/87

    摘要： A method for the preparation of citalopram is described comprising reduction of the oxo group of a compound of formula (IV), wherein R1 is CN, C1-6 alkyloxycarbonyl or C1-6 alkylaminocarbonyl, ring closure of the resulting hydroxy compound thereby obtaining the corresponding 1-(4-fluorophenyl)-1,3-dihydroisobenzofuran, then if R1 is cyano using it directly in the next step and if R1 is C1-6 alkyloxycarbonyl or C1-6 alkylaminocarbonyl, conversion of the compound to the corresponding compound wherein R1 is a cyano; and alkylation of the resulting 5-cyano compound with 3-dimethyl-aminopropylhalogenide in basic conditions thereby obtaining citalopram.

    摘要翻译： 描述了制备西酞普兰的方法，其包括将式（Ⅳ）化合物的氧代基还原，其中R 1是CN，C 1-6烷氧基羰基或C 1-6烷基氨基羰基，所得羟基化合物闭环，从而得到相应的 1-（4-氟苯基）-1,3-二氢异苯并呋喃，然后如果R 1是氰基，则直接用于下一步骤，如果R 1是C 1-6烷氧基羰基或C 1-6烷基氨基羰基，则化合物转化成相应的化合物，其中R 1 是氰基; 并在碱性条件下用3-二甲基 - 氨基丙基卤化物烷基化所得的5-氰基化合物，从而得到西酞普兰。

    METHOD FOR THE PREPARATION OF CITALOPRAM
    29.
    发明申请
    METHOD FOR THE PREPARATION OF CITALOPRAM 审中-公开
    方法制备CITALOPRAM

    公开(公告)号：US20090088469A1

    公开(公告)日：2009-04-02

    申请号：US12329750

    申请日：2008-12-08

    申请人： Hans Petersen ,  Michael Harold Rock ,  Henrik Svane

    发明人： Hans Petersen ,  Michael Harold Rock ,  Henrik Svane

    IPC分类号： A61K31/343 ,  C07D307/81 ,  C07D307/80 ,  A61P25/24

    CPC分类号： C07D307/87 ,  C07D307/81

    摘要： Method for the preparation of citalopram comprising reaction of a compound of Formula (IV) wherein R is halogen, or CF3—(CF2)n—SO2—, n being 0 to 8, with a cyanide source in the presence of a palladium catalyst and a catalytic amount of Cu+ or Zn2+, or with Zn(CN)2 in the presence of a palladium catalyst.

    摘要翻译： 制备西酞普兰的方法，其包括其中R为卤素的式（IV）化合物或CF 3 - （CF 2）n -SO 2 - ，n为0至8的化合物与氰化物源在钯催化剂存在下反应， 催化量的Cu +或Zn2 +，或与Zn（CN）2在钯催化剂存在下反应。

    Method for manufacture of THIP
    30.
    发明授权
    Method for manufacture of THIP 失效
    制造THIP的方法

    公开(公告)号：US07371863B2

    公开(公告)日：2008-05-13

    申请号：US10570551

    申请日：2004-09-01

    申请人： Hans Petersen ,  Michael Bech Sommer ,  Robert Dancer

    发明人： Hans Petersen ,  Michael Bech Sommer ,  Robert Dancer

    IPC分类号： C07D471/02 ,  C07D491/02 ,  C07D498/02

    CPC分类号： C07D498/04

    摘要： The present invention relates to a new method of preparing gaboxadol (THIP), which is useful for treating sleep disorders. In particular a method of preparing THIP comprising reacting a compound of formula (8b) or a salt thereof with an acid, typically a mineral acid, to obtain THIP as an acid addition salt. The present invention also relates to several intermediates

    摘要翻译： 本发明涉及一种制备加波沙朵（THIP）的新方法，其可用于治疗睡眠障碍。 特别是制备THIP的方法，包括使式（8b）的化合物或其盐与酸（通常为无机酸）反应，得到THIP作为酸加成盐。 本发明还涉及几种中间体