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公开(公告)号：US20120210450A1
公开(公告)日：2012-08-16
申请号：US13082706
申请日：2011-04-08
申请人： Fred de Sauvage , Dorothy French , Lino Gonzalez , Asja Praetor , Weilan Ye , Katherin E. Combs , Zhiyong Ding , Allison Anne Byers Horner , Erin Marie Massey , Charles Montgomery , Laurie Jeanette Minze , Carolina Rangel , Tracy Ellen Willis Sevaux , Zheng-Zheng Shi , Mary Jean Sparks , Joy Anne Stala , Peter Vogel
发明人： Fred de Sauvage , Dorothy French , Lino Gonzalez , Asja Praetor , Weilan Ye , Katherin E. Combs , Zhiyong Ding , Allison Anne Byers Horner , Erin Marie Massey , Charles Montgomery , Laurie Jeanette Minze , Carolina Rangel , Tracy Ellen Willis Sevaux , Zheng-Zheng Shi , Mary Jean Sparks , Joy Anne Stala , Peter Vogel
IPC分类号： G01N33/48
CPC分类号： A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/035
摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO194, PRO220, PRO241, PRO284, PRO331, PRO354, PRO355, PRO533, PRO541, PRO725, PRO937, PRO1014, PRO1120, PRO1182, PRO1325, PRO1382, PRO1410, PRO1555, PRO1556, PRO1760, PRO1787, PRO1868, PRO4326, PRO4332, PRO4346, PRO4400, PRO6003, PRO6094, PRO6244, PRO9820, PRO9828, PRO10274, PRO16090, PRO19644, PRO21340, PRO92165, PRO85143, PRO1124, PRO1026 or PRO23370 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.
摘要翻译： 本发明涉及转基因动物，以及与基因功能表征相关的组合物和方法。 具体地，本发明提供转基因小鼠，其包括PRO194，PRO220，PRO241，PRO284，PRO331，PRO354，PRO355，PRO533，PRO541，PRO725，PRO937，PRO1014，PRO1120，PRO1182，PRO1325，PRO1382，PRO1410，PRO1555，PRO1556，PRO1760中的中断 ，PRO1787，PRO1868，PRO4326，PRO4332，PRO4346，PRO4400，PRO6003，PRO6094，PRO6244，PRO9820，PRO9828，PRO10274，PRO16090，PRO19644，PRO21340，PRO92165，PRO85143，PRO1124，PRO1026或PRO23370基因。 这样的体内研究和表征可以提供有用的识别和发现治疗和/或治疗用于预防，改善或矫正与基因中断相关的疾病或功能障碍如神经障碍; 心血管，内皮或血管生成障碍; 眼睛异常; 免疫学障碍; 肿瘤疾病; 骨代谢异常或障碍; 脂代谢紊乱 或发育异常。
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公开(公告)号：US20110045474A1
公开(公告)日：2011-02-24
申请号：US12826537
申请日：2010-06-29
申请人： David Dornan , Dorothy French , Vishva Dixit
发明人： David Dornan , Dorothy French , Vishva Dixit
CPC分类号： G01N33/57496 , G01N33/574 , G01N2333/9015 , G01N2500/02 , G01N2800/52
摘要： The invention provides diagnostic, prognostic, and therapeutic uses for detecting COP1 overexpression in a variety of cancers. The methods and uses can further include detecting p53 expression. The invention also provides reagents and kits for use in screening for test compounds that interfere with COP1 and p53 binding.
摘要翻译： 本发明提供用于检测各种癌症中COP1过表达的诊断，预后和治疗用途。 所述方法和用途还可以包括检测p53表达。 本发明还提供用于筛选干扰COP1和p53结合的测试化合物的试剂和试剂盒。
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公开(公告)号：US07846691B2
公开(公告)日：2010-12-07
申请号：US12692468
申请日：2010-01-22
申请人： Luc Desnoyers , Dorothy French
发明人： Luc Desnoyers , Dorothy French
CPC分类号： C07K16/22 , A61K2039/505 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , Y10S435/81
摘要： The invention provides anti-FGF19 antibodies, and compositions comprising and methods of using these antibodies, methods using anti-FGF19 antibodies, and methods comprising detection of FGF19 and/or FGFR4.
摘要翻译： 本发明提供了抗FGF19抗体，组合物和使用这些抗体的方法，使用抗FGF19抗体的方法，以及包括检测FGF19和/或FGFR4的方法。
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公开(公告)号：US20100028343A1
公开(公告)日：2010-02-04
申请号：US12549497
申请日：2009-08-28
申请人： Jian Chen , Ellen Filvaroff , Sherman Fong , Dorothy French , Audrey Goddard , Paul J. Godowski , J. Christopher Grimaldi , Austin L. Gurney , Kenneth J. Hillan , Sarah G. Hymowitz , Hanzhong Li , James Pan , Melissa A. Starovasnik , Daniel Tumas , Menno Van Lookeren , Richard Vandlen , Colin K. Watanabe , P. Mickey Williams , William I. Wood , Daniel G. Yansura
发明人： Jian Chen , Ellen Filvaroff , Sherman Fong , Dorothy French , Audrey Goddard , Paul J. Godowski , J. Christopher Grimaldi , Austin L. Gurney , Kenneth J. Hillan , Sarah G. Hymowitz , Hanzhong Li , James Pan , Melissa A. Starovasnik , Daniel Tumas , Menno Van Lookeren , Richard Vandlen , Colin K. Watanabe , P. Mickey Williams , William I. Wood , Daniel G. Yansura
IPC分类号： A61K39/395 , A61P19/02
CPC分类号： C07K16/244 , A61K38/00 , C07H21/04 , C07K14/54 , C07K14/7155 , C07K2317/21 , C07K2317/24 , C07K2317/35 , C07K2317/54 , C07K2317/55 , C07K2317/62 , G01N33/505 , G01N33/564 , G01N33/574 , G01N33/57407 , G01N33/57423 , G01N33/57438 , G01N33/57492 , G01N2333/54 , G01N2333/7155
摘要： The present invention is directed to novel polypeptides having sequence identity with IL-17, IL-17 receptors and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.
摘要翻译： 本发明涉及与IL-17，IL-17受体和编码那些多肽的核酸分子具有序列同一性的新型多肽。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。 本文还提供了治疗退行性软骨疾病和其它炎性疾病的方法。
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公开(公告)号：US20070248604A1
公开(公告)日：2007-10-25
申请号：US11673411
申请日：2007-02-09
申请人： Luc Desnoyers , Dorothy French
发明人： Luc Desnoyers , Dorothy French
CPC分类号： C07K16/22 , A61K2039/505 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , Y10S435/81
摘要： The invention provides anti-FGF19 antibodies, and compositions comprising and methods of using these antibodies, methods using anti-FGF19 antibodies, and methods comprising detection of FGF19 and/or FGFR4.
摘要翻译： 本发明提供了抗FGF19抗体，组合物和使用这些抗体的方法，使用抗FGF19抗体的方法，以及包括检测FGF19和/或FGFR4的方法。
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公开(公告)号：US20070025962A1
公开(公告)日：2007-02-01
申请号：US11528596
申请日：2006-09-28
申请人： Dan Eaton , Dorothy French , J. Grimaldi , Kenneth Hillan , Maria Pisabarro , Kerstin Schmidt , Victoria Smith , Daniel Tumas , Richard Vandlen , Colin Watanabe , P. Williams , William Wood
发明人： Dan Eaton , Dorothy French , J. Grimaldi , Kenneth Hillan , Maria Pisabarro , Kerstin Schmidt , Victoria Smith , Daniel Tumas , Richard Vandlen , Colin Watanabe , P. Williams , William Wood
IPC分类号： A61K38/20 , C12Q1/68 , G01N33/567 , C07H21/04 , C12P21/04 , C12N5/06 , C07K14/54 , C07K16/24
CPC分类号： C07K14/52 , C07K14/47 , C07K14/5421 , C07K14/705 , C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , G01N33/564 , G01N33/6863 , G01N33/6869 , G01N33/6893
摘要： The present invention is directed to novel polypeptides having structural homology to IL-8 and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treatment and diagnosis of inflammatory diseases.
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公开(公告)号：US20130089562A1
公开(公告)日：2013-04-11
申请号：US13441753
申请日：2012-04-06
IPC分类号： A61K39/395 , C12N5/071 , A61P1/16
CPC分类号： C07K16/28 , A61K38/177 , A61K38/179 , A61K38/18 , A61K39/395 , A61K39/3955 , A61K2039/505 , C07K14/475 , C07K14/52 , C07K14/705 , C07K14/71 , C07K14/715 , C07K16/2863 , C07K16/2866 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/76 , C07K2319/30 , C07K2319/32 , Y02A50/463
摘要： Methods and compositions for the treatment of liver conditions are provided, such methods and compositions comprising Notch2 antagonists, e.g., anti-Notch2 antibodies. Liver conditions include, but are not limited to, chronic liver disease.
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公开(公告)号：US08241633B2
公开(公告)日：2012-08-14
申请号：US12913660
申请日：2010-10-27
申请人： Luc Desnoyers , Dorothy French
发明人： Luc Desnoyers , Dorothy French
IPC分类号： A61K39/395
CPC分类号： C07K16/22 , A61K2039/505 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , Y10S435/81
摘要： The invention provides anti-FGF19 antibodies, and compositions comprising and methods of using these antibodies, methods using anti-FGF19 antibodies, and methods comprising detection of FGF19 and/or FGFR4.
摘要翻译： 本发明提供了抗FGF19抗体，组合物和使用这些抗体的方法，使用抗FGF19抗体的方法，以及包括检测FGF19和/或FGFR4的方法。
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公开(公告)号：US20120064073A1
公开(公告)日：2012-03-15
申请号：US13270006
申请日：2011-10-10
申请人： Jian Chen , Ellen Fllvaroff , Sherman Fong , Dorothy French , Audrey Goddard , Paul J. Godowski , J. Christopher Grimaldi , Austin L. Gurney , Kenneth J. Hillan , Sarah G. Hymowitz , Hanzhong Li , James Pan , Melissa A. Starovasnik , Daniel Tumas , Menno Van Lookeren , Richard Vandlen , Colin K. Watanabe , P. Mickey Williams , William I. Wood , Daniel G. Yansura
发明人： Jian Chen , Ellen Fllvaroff , Sherman Fong , Dorothy French , Audrey Goddard , Paul J. Godowski , J. Christopher Grimaldi , Austin L. Gurney , Kenneth J. Hillan , Sarah G. Hymowitz , Hanzhong Li , James Pan , Melissa A. Starovasnik , Daniel Tumas , Menno Van Lookeren , Richard Vandlen , Colin K. Watanabe , P. Mickey Williams , William I. Wood , Daniel G. Yansura
IPC分类号： A61K39/395 , A61P19/02 , A61P11/06 , A61P17/00 , A61P17/06 , A61P37/08 , A61P29/00 , A61P1/00
CPC分类号： C07K16/244 , A61K38/00 , C07H21/04 , C07K14/54 , C07K14/7155 , C07K2317/21 , C07K2317/24 , C07K2317/35 , C07K2317/54 , C07K2317/55 , C07K2317/62 , G01N33/505 , G01N33/564 , G01N33/574 , G01N33/57407 , G01N33/57423 , G01N33/57438 , G01N33/57492 , G01N2333/54 , G01N2333/7155
摘要： The present invention is directed to novel polypeptides having sequence identity with IL-17, IL-17 receptors and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.
摘要翻译： 本发明涉及与IL-17，IL-17受体和编码那些多肽的核酸分子具有序列同一性的新型多肽。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。 本文还提供了治疗退行性软骨疾病和其它炎性疾病的方法。
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公开(公告)号：US20090196876A1
公开(公告)日：2009-08-06
申请号：US11577547
申请日：2005-10-18
申请人： Fred de Sauvage , Dorothy French , Lino Gonzalez , Asja Praetor , Weilan Ye , Katherin E. Combs , Zhiyong Ding , Allison Anne Byers Horner , Erin Marie Massey , Charles Montgomery , Laurie Jeanette Minze , Carolina Rangel , Tracy Ellen Willis Sevaux , Zheng-Zheng Shi , Mary Jean Sparks , Joy Anne Stala , Peter Vogel
发明人： Fred de Sauvage , Dorothy French , Lino Gonzalez , Asja Praetor , Weilan Ye , Katherin E. Combs , Zhiyong Ding , Allison Anne Byers Horner , Erin Marie Massey , Charles Montgomery , Laurie Jeanette Minze , Carolina Rangel , Tracy Ellen Willis Sevaux , Zheng-Zheng Shi , Mary Jean Sparks , Joy Anne Stala , Peter Vogel
IPC分类号： A61K39/395 , G01N33/00 , C12N5/10 , C07K16/18 , A61P27/00 , A61P25/00 , A61P25/18 , A61P25/22 , A61P37/00 , A61P13/12 , A61P3/00 , A61P19/00 , A61P9/00 , A61P35/00 , A61P41/00 , A61P3/10
CPC分类号： A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/035
摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO194, PRO220, PRO241, PRO284, PRO331, PRO354, PRO355, PRO533, PRO541, PRO725, PRO937, PRO1014, PRO1120, PRO1182, PRO1325, PRO1382, PRO1410, PRO1555, PRO1556, PRO1760, PRO1787, PRO1868, PRO4326, PRO4332, PRO4346, PRO4400, PRO6003, PRO6094, PRO6244, PRO9820, PRO9828, PRO10274, PRO16090, PRO19644, PRO21340, PRO92165, PRO85143, PRO1124, PRO1026 or PRO23370 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.
摘要翻译： 本发明涉及转基因动物，以及与基因功能表征相关的组合物和方法。 具体地，本发明提供转基因小鼠，其包括PRO194，PRO220，PRO241，PRO284，PRO331，PRO354，PRO355，PRO533，PRO541，PRO725，PRO937，PRO1014，PRO1120，PRO1182，PRO1325，PRO1382，PRO1410，PRO1555，PRO1556，PRO1760中的中断 ，PRO1787，PRO1868，PRO4326，PRO4332，PRO4346，PRO4400，PRO6003，PRO6094，PRO6244，PRO9820，PRO9828，PRO10274，PRO16090，PRO19644，PRO21340，PRO92165，PRO85143，PRO1124，PRO1026或PRO23370基因。 这样的体内研究和表征可以提供有用的识别和发现治疗和/或治疗用于预防，改善或矫正与基因中断相关的疾病或功能障碍如神经障碍; 心血管，内皮或血管生成障碍; 眼睛异常; 免疫学障碍; 肿瘤疾病; 骨代谢异常或障碍; 脂代谢紊乱 或发育异常。
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