公开(公告)号：US20110067015A1

公开(公告)日：2011-03-17

申请号：US12866219

申请日：2009-02-12

申请人： Masamichi Takagi ,  Junji Sakai

发明人： Masamichi Takagi ,  Junji Sakai

IPC分类号： G06F9/45

CPC分类号： G06F8/456

摘要： A program parallelization apparatus which generates a parallelized program of shorter parallel execution time is provided. The program parallelization apparatus inputs a sequential processing intermediate program and outputs a parallelized intermediate program. In the apparatus, a thread start time limitation analysis part analyzes an instruction-allocatable time based on a limitation on an instruction execution start time of each thread. A thread end time limitation analysis part analyzes an instruction-allocatable time based on a limitation on an instruction execution end time of each thread. An occupancy status analysis part analyzes a time not occupied by already-scheduled instructions. A dependence delay analysis part analyzes an instruction-allocatable time based on a delay resulting from dependence between instructions. A schedule candidate instruction select part selects a next instruction to schedule. An instruction arrangement part allocates a processor and time to execute to an instruction.

摘要翻译： 提供了一种生成并行执行时间较短并行程序的程序并行化装置。 程序并行化装置输入顺序处理中间程序并输出并行化的中间程序。 在该装置中，线程开始时间限制分析部分基于对每个线程的指令执行开始时间的限制来分析指令可分配时间。 线程结束时间限制分析部分基于对每个线程的指令执行结束时间的限制来分析指令可分配时间。 占用状态分析部分分析未被计划的指令占用的时间。 依赖延迟分析部分基于由指令之间的依赖导致的延迟来分析指令可分配时间。 时间表候选指令选择部分选择要调度的下一个指令。 指令排列部分分配处理器和执行指令的时间。

公开(公告)号：US20100070958A1

公开(公告)日：2010-03-18

申请号：US12449160

申请日：2007-11-15

申请人： Masamichi Takagi

发明人： Masamichi Takagi

IPC分类号： G06F9/45

CPC分类号： G06F8/456

摘要： Provided is a program parallelizing method and a program parallelizing apparatus that enable to efficiently generate a parallelized program with shorter parallel execution time.An instruction is scheduled by referring to inter-instruction dependency. A dependency between an instruction in a function fp/f0 and an instruction of a function fq of its descendant is analyzed, and parallelization is performed with the analysis result. First, an instruction of a deeper function fq is relatively scheduled to analyze whether each instruction has dependency with an instruction of another function fp. When there is inter-instruction dependency, scheduling of the instruction of the function fq is performed so as to maintain the dependency and realize the shortest execution time.

摘要翻译： 提供了一种能够以较短的并行执行时间有效地生成并行化程序的程序并行化方法和程序并行化装置。 通过参考指令间相关性来安排指令。 分析函数fp / f0中的指令与其后代的函数fq的指令之间的依赖关系，并进行分析结果的并行处理。 首先，相对地调度更深层函数fq的指令来分析每个指令是否与另一函数fp的指令相关。 当存在指令间相关性时，执行函数fq的指令的调度以保持依赖性并实现最短的执行时间。

公开(公告)号：US08214521B2

公开(公告)日：2012-07-03

申请号：US12629048

申请日：2009-12-02

申请人： Masamichi Takagi ,  Yoshiki Seo ,  Akio Yamada ,  Takeo Hosomi

发明人： Masamichi Takagi ,  Yoshiki Seo ,  Akio Yamada ,  Takeo Hosomi

IPC分类号： G06F15/16 ,  G06F9/46

CPC分类号： G06F9/5038

摘要： Systems and methods are disclosed to process streaming data units (tuples) for an application using a plurality of processing units, the application have a predetermined processing time requirement, by changing an operator-set applied to the tuple by a processing unit, on a tuple-by-tuple basis; estimating code requirement for potential operators based on processing unit capability; and assigning the potential operators to the processing units.

摘要翻译： 公开了系统和方法来处理使用多个处理单元的应用的流数据单元（元组），该应用具有预定的处理时间要求，通过在元组上改变由处理单元应用于元组的操作符集 元组 基于处理单元能力估算潜在运营商的代码要求; 并将潜在的操作者分配给处理单元。

公开(公告)号：US07521563B2

公开(公告)日：2009-04-21

申请号：US11659810

申请日：2004-08-10

申请人： Kiyoshi Nakatogawa ,  Masamichi Takagi ,  Makoto Akashima

发明人： Kiyoshi Nakatogawa ,  Masamichi Takagi ,  Makoto Akashima

IPC分类号： C07D263/30 ,  C07D413/00 ,  C07D277/20 ,  A61K31/42 ,  A61K31/425

CPC分类号： C07D277/30 ,  C07D263/32 ,  C07D277/22

摘要： A compound which inhibits the production of IL-6 and/or TNFα by inflammatory cytokines and is useful in the prevention of or treatments for diseases such as various inflammatory diseases in which these cytokines participate and autoimmune diseases. It is a hydroxamic acid derivative represented by the following formula (1): (1) (wherein A and B each represents phenyl, etc.; n is an integer of 1 to 8; and Y represents oxygen or sulfur). This compound has excellent interleukin-6 and/or TNFα production inhibitory activity and is useful as a therapeutic agent for various inflammatory diseases, autoimmune diseases, etc.

摘要翻译： 抑制炎性细胞因子产生IL-6和/或TNFα的化合物，可用于预防或治疗诸如这些细胞因子参与的各种炎性疾病和自身免疫性疾病等疾病。 由下式（1）表示的异羟肟酸衍生物：（1）（其中A和B各自表示苯基等; n为1〜8的整数，Y为氧或硫）。 该化合物具有优异的白细胞介素-6和/或TNFα产生抑制活性，可用作各种炎性疾病，自身免疫性疾病等的治疗剂。

公开(公告)号：US07429469B2

公开(公告)日：2008-09-30

申请号：US10491498

申请日：2002-10-09

申请人： Satoru Yokomizo ,  Takeshi Fukuchi ,  Fumio Osakada ,  Keiji Matsumoto ,  Masamichi Takagi ,  Akinori Ohta

发明人： Satoru Yokomizo ,  Takeshi Fukuchi ,  Fumio Osakada ,  Keiji Matsumoto ,  Masamichi Takagi ,  Akinori Ohta

IPC分类号： C07H21/04 ,  C12P7/62 ,  C12N15/74 ,  C12N1/21

CPC分类号： C07K14/40 ,  C07K2319/01 ,  C12N9/88 ,  C12N15/52 ,  C12P7/625

摘要： This invention relates to a method of producing polyesters resulting from homopolymerization or copolymerization of a 3-hydroxyalkanoic acid(s) and having biodegradability and good physical properties using yeasts as hosts. By constructing at least one enzyme gene involved in polyester synthesis by adding a DNA coding a peroxisome-targeting signal, introducing an enzyme gene expression cassette containing that gene into yeast, and cultivating the thus-obtained transformant, it becomes possible to cause accumulation of a polyester resulting from homopolymerization or copolymerization of a 3-hydroxyalkanoic acid(s) in yeast cells and recover the polyester from the culture.

摘要翻译： 本发明涉及由使用酵母作为宿主的3-羟基烷酸的均聚或共聚而具有生物降解性和良好物理性能的聚酯的制造方法。 通过添加编码过氧化物酶体靶向信号的DNA构建至少一个参与聚酯合成的酶基因，将含有该基因的酶基因表达盒导入酵母中，培养由此得到的转化体，可以使 由酵母细胞中的3-羟基链烷酸的均聚或共聚得到的聚酯，并从培养物中回收聚酯。

公开(公告)号：US20080044878A1

公开(公告)日：2008-02-21

申请号：US10505229

申请日：2003-04-08

申请人： Tetsuya Nagaoka ,  Satoru Yokomizo ,  Kenji Miyamoto ,  Fumio Osakada ,  Keiji Matsumoto ,  Masamichi Takagi ,  Akinori Ota

发明人： Tetsuya Nagaoka ,  Satoru Yokomizo ,  Kenji Miyamoto ,  Fumio Osakada ,  Keiji Matsumoto ,  Masamichi Takagi ,  Akinori Ota

IPC分类号： C07H21/04 ,  C12N1/00 ,  C12P1/02

CPC分类号： C07K14/4716 ,  C12N9/1025 ,  C12N15/815

摘要： The present invention provides a production method of a copolymeric polyester which comprises culturing an ACT1 gene promoter shown under SEQ ID NO: 9, a GAP3 gene promoter shown under SEQ ID NO: 10; a PMA1 gene promoter shown under SEQ ID NO: 11, and, a TEF1 gene promoter shown under SEQ ID NO: 12; a plasmid which contains the gene expression unit comprising said promoter; a transformed cell as resulting from transformation of the said plasmid; and said transformed cell.

摘要翻译： 本发明提供共聚聚酯的制造方法，其包括培养SEQ ID NO：9所示的ACT1基因启动子，SEQ ID NO：10所示的GAP3基因启动子; SEQ ID NO：11所示的PMA1基因启动子和SEQ ID NO：12所示的TEF1基因启动子; 含有包含所述启动子的基因表达单元的质粒; 由所述质粒转化产生的转化细胞; 和转化细胞。

公开(公告)号：US4879230A

公开(公告)日：1989-11-07

申请号：US813193

申请日：1985-12-24

申请人： Masamichi Takagi ,  Keiji Yano ,  Ichiro Shibuya ,  Minoru Morikawa

发明人： Masamichi Takagi ,  Keiji Yano ,  Ichiro Shibuya ,  Minoru Morikawa

IPC分类号： C12N15/81

CPC分类号： C12N15/81

摘要： The present invention relates to plasmids whose hosts can be Escherichia coli and some kinds of yeasts, namely, shuttle vectors, as well as to processes for producing said plasmids. There are provided in the present invention (1) plasmids containing an autonomously replicating sequence of Candida maltosa, Leu 2 gene derived from Saccharomyces cerevisiae and an ampicillin resistance gene and (2) plasmids further containing a tetracycline resistance gene as well as the genes described in (1).The plasmids (shuttle vectors) of the present invention can be utilized as follows. A useful foreign gene is inserted into plasmids of the present invention; using the resulting new plasid, Escherichia coli is transformed and cultured in order to obtain the plasmid in a large amount; and using this plasmid, Saccharomyces cerevisiae or Candida maltosa as a host is allowed to produce useful substances such as hormones and enzymes on a large scale.

摘要翻译： 本发明涉及其宿主可以是大肠杆菌和一些种类的酵母的质粒，即穿梭载体，以及生产所述质粒的方法。 在本发明中提供了（1）含有自愿复制的假丝酵母（Candida maltosa）的质粒，来源于酿酒酵母的Leu 2基因和氨苄青霉素抗性基因的质粒和（2）进一步含有四环素抗性基因的质粒以及描述于 （1）。 本发明的质粒（穿梭载体）可以如下使用。 将有用的外源基因插入本发明的质粒中; 使用所得的新的质粒，转化和培养大肠杆菌以获得大量的质粒; 使用该质粒，可以将酿酒酵母或麦芽假丝酵母作为宿主大量产生有用的物质如激素和酶。

公开(公告)号：US20130006452A1

公开(公告)日：2013-01-03

申请号：US13634307

申请日：2010-04-28

申请人： Masamichi Takagi

发明人： Masamichi Takagi

IPC分类号： B60L15/40

CPC分类号： B60L15/40 ,  B60L9/00 ,  B60L15/20 ,  B60L2200/26 ,  Y02T10/72 ,  Y02T10/7275

摘要： To stop a train at a desired target stop position without outputting excessive brake by outputting an appropriate braking instruction in accordance with a running condition of the train. An on-train computing device causes an acceleration estimating unit to determine the presence/absence of a current acceleration of a train and to estimate the current acceleration based on train-car information obtained from a train-car performance manager unit, and causes a profile calculating unit to generate a braking instruction profile based on a presumption that the train is running at the current acceleration when the train is in an accelerating condition, and to generate the braking instruction profile based on a presumption that there is no acceleration applied to a train car of the train by a propulsion control of the train car itself when the train is in a coasting condition.

摘要翻译： 通过根据列车的行驶状态输出适当的制动指令，将列车停在期望的目标停止位置而不输出过大的制动。 列车计算装置使加速度估计单元确定列车的当前加速度的存在/不存在，并且基于从列车车辆性能管理器单元获得的列车信息来估计当前加速度，并且使轮廓 计算单元，基于当列车处于加速状态时以当前加速度行驶的推测，生成制动指令轮廓，并且基于对列车没有加速度的推定生成制动指令轮廓 火车的汽车在火车处于滑行状态时，通过火车车辆的推进控制。

公开(公告)号：US20100015672A1

公开(公告)日：2010-01-21

申请号：US11887445

申请日：2006-03-23

申请人： Masamichi Takagi ,  Takahisa Kogure ,  Naoki Wakisaka ,  Hiroaki Takaku ,  Katsumi Ajisaka ,  Tatsuo Miyazaki ,  Masao Hirayama

发明人： Masamichi Takagi ,  Takahisa Kogure ,  Naoki Wakisaka ,  Hiroaki Takaku ,  Katsumi Ajisaka ,  Tatsuo Miyazaki ,  Masao Hirayama

IPC分类号： C12P19/02 ,  C12N15/00 ,  C12N1/21 ,  C07H3/02

CPC分类号： C12P17/06 ,  C07D309/30 ,  C12N9/88 ,  C12N9/90 ,  C12N9/92 ,  C12P7/26 ,  C12Y503/01009

摘要： A transformant is prepared to insert at least a gene expression cassette comprising a gene involved in the synthesis of 2-deoxy-scyllo-inosose into E. coli as host cells. A 2-deoxy-scyllo-inosose is synthesized from D-glucose, oligosaccharide, polysaccharide, starch and rice bran, using the transformant. A culture solution containing the 2-deoxy-scyllo-inosose is treated with a mixed bed or double bed type column comprising a hydrogen form of strong acidic cation exchange resin and an organic ion form of basic anion exchange resin. The 2-deoxy-scyllo-inosose as purified is reacted with trimethoxymethane to convert into 2-deoxy-scyllo-inosose dimethylketal, and the dimethylketal is crystallized and purified. Then, DOI is highly purified through hydrolyzing the dimethylketal in the presence of acid.

摘要翻译： 制备转化体至少将含有参与合成2-脱氧 - 青蟹肌糖的基因的基因表达盒插入大肠杆菌作为宿主细胞。 使用转化体从D-葡萄糖，寡糖，多糖，淀粉和米糠合成2-脱氧 - 青蟹肌糖。 含有2-脱氧 - 青蟹肌糖的培养液用含氢形式的强酸性阳离子交换树脂和有机离子形式的碱性阴离子交换树脂的混合床或双床型柱处理。 将纯化的2-脱氧 - 青蟹肌糖与三甲氧基甲烷反应以转化成2-脱氧 - 鲨糖醛糖二甲基缩酮，并将二甲基缩酮结晶并纯化。 然后，DOI通过在酸存在下水解二甲基缩酮而高度纯化。

公开(公告)号：US20070208065A1

公开(公告)日：2007-09-06

申请号：US11659810

申请日：2004-08-10

申请人： Kiyoshi Nakatogawa ,  Masamichi Takagi ,  Makoto Akashima

发明人： Kiyoshi Nakatogawa ,  Masamichi Takagi ,  Makoto Akashima

IPC分类号： A61K31/426 ,  A61K31/421 ,  C07D277/30 ,  C07D263/34

CPC分类号： C07D277/30 ,  C07D263/32 ,  C07D277/22

摘要： A compound which inhibits the production of IL-6 and/or TNFα by inflammatory cytokines and is useful in the prevention of or treatments for diseases such as various inflammatory diseases in which these cytokines participate and autoimmune diseases. It is a hydroxamic acid derivative represented by the following formula (1): (1) (wherein A and B each represents phenyl, etc.; n is an integer of 1 to 8; and Y represents oxygen or sulfur). This compound has excellent interleukin-6 and/or TNFα production inhibitory activity and is useful as a therapeutic agent for various inflammatory diseases, autoimmune diseases, etc.

摘要翻译： 抑制炎性细胞因子产生IL-6和/或TNFα的化合物，可用于预防或治疗诸如这些细胞因子参与的各种炎性疾病和自身免疫性疾病等疾病。 由下式（1）表示的异羟肟酸衍生物：（1）（其中A和B各自表示苯基等; n为1〜8的整数，Y为氧或硫）。 该化合物具有优异的白细胞介素-6和/或TNFα产生抑制活性，可用作各种炎性疾病，自身免疫性疾病等的治疗剂。