公开(公告)号：US06479657B1

公开(公告)日：2002-11-12

申请号：US09091182

申请日：1998-09-29

申请人： Koji Nishizawa ,  Hitoshi Matsumoto ,  Hirofumi Nakamura ,  Takashi Kawakami ,  Yuko Nakada ,  Masao Hirayama ,  Takashi Adachi

发明人： Koji Nishizawa ,  Hitoshi Matsumoto ,  Hirofumi Nakamura ,  Takashi Kawakami ,  Yuko Nakada ,  Masao Hirayama ,  Takashi Adachi

IPC分类号： C07H106

CPC分类号： C07H3/06 ,  C12P19/18 ,  C30B7/00

摘要： A process for producing crystal 1-kestose wherein granular crystal 1-kestose in the form of large crystals can be produced at a high yield is disclosed. A highly pure solution of 1-kestose is concentrated to a Brix of 75 or higher; either seed crystals are added, or the solution is vacuum-concentrated to generate microcrystals for use as nuclei; then, a crystal growing step by vacuum-concentration and a microcrystal dissolving step for redissolving microcrystals which have formed in the concentrate are repeated at least twice each. Alternatively, a highly pure solution of 1-kestose is concentrated to a Brix of 80 or higher; either seed crystals are added, or the solution is allowed to initiate crystallization; after crystals are allowed to grow, a cooling step where the temperature is lowered by 5° C. to 20° C. from the previous step and a crystal growing step where the concentrate is maintained at the temperature to allow the crystals to grow are repeated at least twice each. Also, an enzyme for producing 1-kestose efficiently from sucrose is disclosed.

摘要翻译： 公开了一种生产晶体1-晶体的方法，其中可以以高产率制备大晶体形式的颗粒状晶体1-晶体。 1-kestose的高纯度溶液浓缩至75或更高的白利糖度; 加入晶种，或者将溶液真空浓缩以产生用作核的微晶; 然后，通过真空浓缩的晶体生长步骤和在浓缩物中形成的再溶解微晶的微晶溶解步骤重复至少两次。 或者，将高效纯化的1-kestose溶液浓缩至白利糖度为80或更高; 加入晶种，或使溶液开始结晶; 在使晶体生长之后，重复上述步骤的温度降低5℃至20℃的冷却步骤和将浓缩物保持在允许晶体生长的温度的晶体生长步骤 至少两次。 另外，公开了一种从蔗糖中有效产生1-kestose的酶。

公开(公告)号：US08722126B2

公开(公告)日：2014-05-13

申请号：US12585783

申请日：2009-09-24

申请人： Hitoshi Matsumoto ,  Shigeru Tominaga ,  Mitsuo Kishi ,  Takashi Kawakami ,  Takahisa Tokunaga ,  Masao Hirayama

发明人： Hitoshi Matsumoto ,  Shigeru Tominaga ,  Mitsuo Kishi ,  Takashi Kawakami ,  Takahisa Tokunaga ,  Masao Hirayama

IPC分类号： A23L2/06 ,  A23L1/29 ,  B01D61/02 ,  A61K36/45 ,  A61K36/00 ,  A23G3/36 ,  A23G1/42 ,  A23G4/12

CPC分类号： A23G3/368 ,  A23G1/30 ,  A23G1/426 ,  A23G1/48 ,  A23G3/36 ,  A23G3/48 ,  A23G4/06 ,  A23G4/068 ,  A23G4/126 ,  A23L2/085 ,  A23L2/52 ,  A23L33/105 ,  A23V2002/00 ,  A23V2250/21 ,  A23V2250/2104

摘要： Black currant anthocyanin-containing compositions for foods comprising 1 to 25% by weight of black currant anthocyanin on the basis of solid matters; a process for producing a black currant anthocyanin-containing composition for foods characterized by purifying and concentrating black currant juice employed as a starting material by using a charged reverse osmosis membrane; functional foods and drinks characterized by containing the above compositions for foods; and the above-described compositions for foods and the above-described functional foods and drinks having an effect of improving visual function, a function of improving blood fluidity, and/or a function of lowering blood pressure. The conventional black currant anthocyanin compositions have a low black currant anthocyanin content, strong acidity and poor stability, which makes them unsuitable as additives for foods and drinks. However, the production process according to the present invention makes it possible to provide black currant anthocyanin-containing compositions for foods which have a high black currant anthocyanin content, an adequate acidity, and a high stability and can be added to foods and drinks. Moreover, functional foods and drinks containing these compositions, which have an effect of improving visual function, a function of improving blood fluidity, or a function of lowering blood pressure, can be provided.

摘要翻译： 含有黑醋栗花青素的食品组合物，其包含基于固体物质的1至25重量％的黑醋栗花青素; 一种用于生产含黑醋栗花青素的食品组合物的方法，其特征在于通过使用带电的反渗透膜来纯化和浓缩用作原料的黑醋栗汁; 特征在于含有上述食品组合物的功能性食品和饮料; 和上述食品用组合物和上述具有改善视觉功能的作用的功能食品和饮料，改善血液流动性的功能和/或降低血压的功能。 常规的黑醋栗花青素组合物具有低黑醋栗花青素含量，酸度强，稳定性差，使得它们不适合作为食品和饮料的添加剂。 然而，根据本发明的制备方法使得可以提供含黑醋栗花青素的组合物，其具有高黑醋栗花青素含量，足够的酸度和高稳定性的食品，并且可以添加到食品和饮料中。 此外，可以提供含有这些组合物的功能性食品和饮料，其具有改善视觉功能的效果，改善血液流动性的功能或降低血压的功能。

公开(公告)号：US07658963B1

公开(公告)日：2010-02-09

申请号：US10019402

申请日：2000-06-30

申请人： Hitoshi Matsumoto ,  Shigeru Tominaga ,  Mitsuo Kishi ,  Takashi Kawakami ,  Takahisa Tokunaga ,  Masao Hirayama

发明人： Hitoshi Matsumoto ,  Shigeru Tominaga ,  Mitsuo Kishi ,  Takashi Kawakami ,  Takahisa Tokunaga ,  Masao Hirayama

IPC分类号： A23L2/06 ,  A23L1/29 ,  B01D61/02 ,  A61K36/45 ,  A61K36/00

CPC分类号： A23G3/368 ,  A23G1/30 ,  A23G1/426 ,  A23G1/48 ,  A23G3/36 ,  A23G3/48 ,  A23G4/06 ,  A23G4/068 ,  A23G4/126 ,  A23L2/085 ,  A23L2/52 ,  A23L33/105 ,  A23V2002/00 ,  A23V2250/21 ,  A23V2250/2104

摘要： Black currant anthocyanin-containing compositions for foods comprising 1 to 25% by weight of black currant anthocyanin on the basis of solid matters; a process for producing a black currant anthocyanin-containing composition for foods characterized by purifying and concentrating black currant juice employed as a starting material by using a charged reverse osmosis membrane; functional foods and drinks characterized by containing the above compositions for foods; and the above-described compositions for foods and the above-described functional foods and drinks having an effect of improving visual function, a function of improving blood fluidity, and/or a function of lowering blood pressure. The conventional black currant anthocyanin compositions have a low black currant anthocyanin content, strong acidity and poor stability, which makes them unsuitable as additives for foods and drinks. However, the production process according to the present invention makes it possible to provide black currant anthocyanin-containing compositions for foods which have a high black currant anthocyanin content, an adequate acidity, and a high stability and can be added to foods and drinks. Moreover, functional foods and drinks containing these compositions, which have an effect of improving visual function, a function of improving blood fluidity, or a function of lowering blood pressure, can be provided.

摘要翻译： 含有黑醋栗花青素的食品组合物，其包含基于固体物质的1至25重量％的黑醋栗花青素; 一种用于生产含黑醋栗花青素的食品组合物的方法，其特征在于通过使用带电的反渗透膜来纯化和浓缩用作原料的黑醋栗汁; 特征在于含有上述食品组合物的功能性食品和饮料; 和上述食品用组合物和上述具有改善视觉功能的作用的功能食品和饮料，改善血液流动性的功能和/或降低血压的功能。 常规的黑醋栗花青素组合物具有低黑醋栗花青素含量，酸度强，稳定性差，使得它们不适合作为食品和饮料的添加剂。 然而，根据本发明的制备方法使得可以提供含黑醋栗花青素的组合物，其具有高黑醋栗花青素含量，足够的酸度和高稳定性的食品，并且可以添加到食品和饮料中。 此外，可以提供含有这些组合物的功能性食品和饮料，其具有改善视觉功能的效果，改善血液流动性的功能或降低血压的功能。

公开(公告)号：US5591478A

公开(公告)日：1997-01-07

申请号：US487585

申请日：1995-06-07

申请人： Takahisa Tokunaga ,  Junko Kajihara ,  Masao Hirayama ,  Hidemasa Hidaka ,  Hayami Itoh ,  Masao Hayashitani ,  Yoshihiro Kajibata ,  Tatsuya Imura

发明人： Takahisa Tokunaga ,  Junko Kajihara ,  Masao Hirayama ,  Hidemasa Hidaka ,  Hayami Itoh ,  Masao Hayashitani ,  Yoshihiro Kajibata ,  Tatsuya Imura

IPC分类号： A23L3/42 ,  A23G1/00 ,  A23G1/56 ,  A23G3/34 ,  B01J20/22 ,  A23G3/00

CPC分类号： A23G1/56 ,  A23G3/346 ,  A23L3/42 ,  A23G2200/06 ,  Y10S426/804

摘要： A desiccant comprising crystalline, anhydrated nystose, which contains 70% or more of nystose and 2% or less of moisture and is in the form of a crystalline powder, is capable of maintaining water activity of a food at an extremely low level without heat drying the food or drying the food with silica gel or the like and can safely prevent deteriorations of foods and maintain the qualities at a low cost. The desiccant can be produced by anhydrating crystalline nystose hydrate under reduced pressure or in the presence of a dehydrating agent. The desiccant is used for lowering water activity of a food and maintaining the same, by directly contacting the desiccant with the food or mixing the same with the food.

摘要翻译： 含有70％以上的含水分和2％以下的水分并且呈结晶性粉末状的结晶性，水合性的干燥剂能够将食品的水分活度维持在极低的水平而不加热干燥 食品或用硅胶等干燥食物，能够安全地防止食品的劣化，并以低成本维持品质。 干燥剂可以通过在减压下或在脱水剂的存在下通过水合水合半胱氨酸水合物来制备。 干燥剂用于降低食物的水分活性并保持其状态，通过将干燥剂与食物直接接触或将其与食物混合。

公开(公告)号：US4350548A

公开(公告)日：1982-09-21

申请号：US234861

申请日：1981-02-13

申请人： Katsuaki Zenbayashi ,  Akio Morinaga ,  Masao Hirayama ,  Akira Morita

发明人： Katsuaki Zenbayashi ,  Akio Morinaga ,  Masao Hirayama ,  Akira Morita

IPC分类号： F16L9/00 ,  B29B13/02 ,  B29C51/00 ,  B29C63/00 ,  B29C63/36 ,  B32B31/20

CPC分类号： B29B13/024 ,  B29C63/0069 ,  B29L2023/22

摘要： A method and apparatus for causing a flexible tubular lining material to be fixed to the inner surface of a pipe line wherein the tubular lining material is initially attached to the inner surface of the pipe line by a binder provided on the surface of the tubular lining material which comprises providing a flexible hose material having a porous structure inside the pipe line which has been lined with the tubular lining material and introducing a heated gaseous fluid stream into the interior of the flexible hose whereby the heated gaseous fluid stream is introduced through the pores of the flexible hose along the inner surface of the lined pipe line, the flexible tubular lining material being warmed to accelerate the curing of the binder interposed between the inner surface of the pipe line and the flexible lining material.

摘要翻译： 一种用于使柔性管状衬里材料固定到管线的内表面的方法和装置，其中管状衬里材料最初通过设置在管状衬里材料的表面上的粘合剂附接到管线的内表面 其包括提供在管线内具有多孔结构的柔性软管材料，其已经衬有管状衬里材料并将加热的气态流体流引入柔性软管的内部，由此将加热的气态流体流通过 柔性软管沿着衬里管线的内表面，柔性管状衬里材料被加热以加速夹在管线内表面和柔性衬里材料之间的粘合剂的固化。

公开(公告)号：US20130040005A1

公开(公告)日：2013-02-14

申请号：US13278793

申请日：2011-10-21

申请人： Masao HIRAYAMA ,  Ryo FURUUCHI ,  Tadayuki YOKOYAMA

发明人： Masao HIRAYAMA ,  Ryo FURUUCHI ,  Tadayuki YOKOYAMA

IPC分类号： A61K36/73 ,  A61K31/353 ,  A61P9/12

CPC分类号： A61K31/353 ,  A23G1/48 ,  A23G3/48 ,  A23L2/52 ,  A23L33/105 ,  A23V2002/00 ,  A23V2200/326 ,  A23V2250/21 ,  A23V2250/2106

摘要： The present invention relates to an antihypertensive agent including a boysenberry seed extract as an active ingredient. According to the invention, there can be provided an effective and highly safe antihypertensive agent having antihypertensive effect so that the agent can contribute to the prevention and amelioration of hypertension and having very little risk of side effects even in continuous intake, and a method for producing the antihypertensive agent at low cost and efficiently.

摘要翻译： 本发明涉及一种抗高血压药，其含有作为活性成分的松嫩莓种子提取物。 根据本发明，可以提供一种具有抗高血压作用的有效且高度安全的抗高血压药，使得该试剂可有助于预防和改善高血压，并且即使在连续摄入中也具有很小的副作用风险， 抗高血压药物，成本低廉。

公开(公告)号：US20100015672A1

公开(公告)日：2010-01-21

申请号：US11887445

申请日：2006-03-23

申请人： Masamichi Takagi ,  Takahisa Kogure ,  Naoki Wakisaka ,  Hiroaki Takaku ,  Katsumi Ajisaka ,  Tatsuo Miyazaki ,  Masao Hirayama

发明人： Masamichi Takagi ,  Takahisa Kogure ,  Naoki Wakisaka ,  Hiroaki Takaku ,  Katsumi Ajisaka ,  Tatsuo Miyazaki ,  Masao Hirayama

IPC分类号： C12P19/02 ,  C12N15/00 ,  C12N1/21 ,  C07H3/02

CPC分类号： C12P17/06 ,  C07D309/30 ,  C12N9/88 ,  C12N9/90 ,  C12N9/92 ,  C12P7/26 ,  C12Y503/01009

摘要： A transformant is prepared to insert at least a gene expression cassette comprising a gene involved in the synthesis of 2-deoxy-scyllo-inosose into E. coli as host cells. A 2-deoxy-scyllo-inosose is synthesized from D-glucose, oligosaccharide, polysaccharide, starch and rice bran, using the transformant. A culture solution containing the 2-deoxy-scyllo-inosose is treated with a mixed bed or double bed type column comprising a hydrogen form of strong acidic cation exchange resin and an organic ion form of basic anion exchange resin. The 2-deoxy-scyllo-inosose as purified is reacted with trimethoxymethane to convert into 2-deoxy-scyllo-inosose dimethylketal, and the dimethylketal is crystallized and purified. Then, DOI is highly purified through hydrolyzing the dimethylketal in the presence of acid.

摘要翻译： 制备转化体至少将含有参与合成2-脱氧 - 青蟹肌糖的基因的基因表达盒插入大肠杆菌作为宿主细胞。 使用转化体从D-葡萄糖，寡糖，多糖，淀粉和米糠合成2-脱氧 - 青蟹肌糖。 含有2-脱氧 - 青蟹肌糖的培养液用含氢形式的强酸性阳离子交换树脂和有机离子形式的碱性阴离子交换树脂的混合床或双床型柱处理。 将纯化的2-脱氧 - 青蟹肌糖与三甲氧基甲烷反应以转化成2-脱氧 - 鲨糖醛糖二甲基缩酮，并将二甲基缩酮结晶并纯化。 然后，DOI通过在酸存在下水解二甲基缩酮而高度纯化。

公开(公告)号：US20100015065A1

公开(公告)日：2010-01-21

申请号：US12585783

申请日：2009-09-24

申请人： Hitoshi Matsumoto ,  Shigeru Tominaga ,  Mitsuo Kishi ,  Takashi Kawakami ,  Takahisa Tokunaga ,  Masao Hirayama

发明人： Hitoshi Matsumoto ,  Shigeru Tominaga ,  Mitsuo Kishi ,  Takashi Kawakami ,  Takahisa Tokunaga ,  Masao Hirayama

IPC分类号： A61K9/68 ,  A61K31/35 ,  A61P27/02 ,  A61P7/00

CPC分类号： A23G3/368 ,  A23G1/30 ,  A23G1/426 ,  A23G1/48 ,  A23G3/36 ,  A23G3/48 ,  A23G4/06 ,  A23G4/068 ,  A23G4/126 ,  A23L2/085 ,  A23L2/52 ,  A23L33/105 ,  A23V2002/00 ,  A23V2250/21 ,  A23V2250/2104

摘要： Black currant anthocyanin-containing compositions for foods comprising 1 to 25% by weight of black currant anthocyanin on the basis of solid matters; a process for producing a black currant anthocyanin-containing composition for foods characterized by purifying and concentrating black currant juice employed as a starting material by using a charged reverse osmosis membrane; functional foods and drinks characterized by containing the above compositions for foods; and the above-described compositions for foods and the above-described functional foods and drinks having an effect of improving visual function, a function of improving blood fluidity, and/or a function of lowering blood pressure. The conventional black currant anthocyanin compositions have a low black currant anthocyanin content, strong acidity and poor stability, which makes them unsuitable as additives for foods and drinks. However, the production process according to the present invention makes it possible to provide black currant anthocyanin-containing compositions for foods which have a high black currant anthocyanin content, an adequate acidity, and a high stability and can be added to foods and drinks. Moreover, functional foods and drinks containing these compositions, which have an effect of improving visual function, a function of improving blood fluidity, or a function of lowering blood pressure, can be provided.

摘要翻译： 含有黑醋栗花青素的食品组合物，其包含基于固体物质的1至25重量％的黑醋栗花青素; 一种用于生产含黑醋栗花青素的食品组合物的方法，其特征在于通过使用带电的反渗透膜来纯化和浓缩用作原料的黑醋栗汁; 特征在于含有上述食品组合物的功能性食品和饮料; 和上述食品用组合物和上述具有改善视觉功能的作用的功能食品和饮料，改善血液流动性的功能和/或降低血压的功能。 常规的黑醋栗花青素组合物具有低黑醋栗花青素含量，酸度强，稳定性差，使得它们不适合作为食品和饮料的添加剂。 然而，根据本发明的制备方法使得可以提供含黑醋栗花青素的组合物，其具有高黑醋栗花青素含量，足够的酸度和高稳定性的食品，并且可以添加到食品和饮料中。 此外，可以提供含有这些组合物的功能性食品和饮料，其具有改善视觉功能的效果，改善血液流动性的功能或降低血压的功能。

公开(公告)号：US20060166330A1

公开(公告)日：2006-07-27

申请号：US11392599

申请日：2006-03-30

申请人： Hitoshi Matsumoto ,  Satoshi Hanamura ,  Masao Hirayama

发明人： Hitoshi Matsumoto ,  Satoshi Hanamura ,  Masao Hirayama

IPC分类号： C12P19/58

CPC分类号： C07H17/00 ,  C07H17/065 ,  C09B61/00 ,  C12P19/14 ,  C12P19/44

摘要： Provided are a process for producing purified anthocyanidin glucoside in which a rhamnose end of anthocyanidin rutinoside is cleaved using rhamnosidase to convert the anthocyanidin rutinoside component into anthocyanidin glucoside, the anthocyanidin glucoside component being then purified and isolated; or a crystalline anthocyanidin glucoside salt obtained by further crystallizing the purified anthocyanidin glucoside and a process for producing the same. Also provided are a process for producing purified anthocyanidin rutinoside in which a glucose end of anthocyanidin glucoside is cleaved using β-glucosidase to degrade and remove the end, the anthocyanidin rutinoside component being then purified and isolated; or a crystalline anthocyanidin rutinoside salt obtained by further crystallizing the purified anthocyanidin rutinoside and a process for producing the same.

摘要翻译： 提供了使用鼠李糖苷酶将花色素芸香糖苷成分转化为花色素苷葡糖苷的花青素芸香糖苷的鼠李糖末端切割纯化花青素葡糖苷的方法，然后纯化和分离花色素苷苷组分; 或通过进一步结晶纯化的花青素葡糖苷获得的结晶花色素苷糖苷及其制备方法。 还提供了生产纯化的花青素芸香糖苷的方法，其中使用β-葡糖苷酶切割花青素葡糖苷的葡萄糖末端以降解和除去末端，然后纯化和分离花色素芸香糖苷组分; 或通过进一步结晶纯化的花青素芸香苷获得的结晶花色素芸香糖苷盐及其制备方法。

公开(公告)号：US06337201B1

公开(公告)日：2002-01-08

申请号：US09142623

申请日：1998-09-10

申请人： Koji Yanai ,  Akitaka Nakane ,  Hirofumi Nakamura ,  Yuko Baba ,  Akemi Watabe ,  Masao Hirayama

发明人： Koji Yanai ,  Akitaka Nakane ,  Hirofumi Nakamura ,  Yuko Baba ,  Akemi Watabe ,  Masao Hirayama

IPC分类号： C12N924

CPC分类号： C12Y302/01026 ,  C12N9/2431

摘要： A novel &bgr;-fructofuranosidase gene and a &bgr;-fructofuranosidase encoded by the gene, a process for isolating a &bgr;-fructofuranosidase gene using the novel &bgr;-fructofuranosidase gene, and a novel &bgr;-fructofuranosidase obtained by this isolation process are disclosed. A novel mold fungus having no &bgr;-fructofuranosidase activity suitable for the production of &bgr;-fructofuranosidase, and a system for producing a recombinant &bgr;-fructofuranosidase using the novel mold fungus as a host is disclosed. Further, a &bgr;-fructofuranosidase variant which selectively and efficiently produces a specific fructooligosaccharide such as 1-kestose from sucrose is disclosed.

摘要翻译： 公开了一种新颖的β-呋喃果糖苷酶基因和由该基因编码的β-呋喃果糖苷酶，使用新的β-呋喃果糖苷酶基因分离β-呋喃果糖苷酶基因的方法和通过该分离方法获得的新型β-呋喃果糖苷酶。 公开了一种不具有适用于β-呋喃果糖苷酶生产的β-呋喃果糖苷酶活性的新型霉菌，以及使用该新型霉菌作为宿主生产重组β-呋喃果糖苷酶的体系。 此外，公开了一种β-蔗糖呋喃糖苷酶变体，其选择性和有效地产生特定的低聚果糖，例如来自蔗糖的1-kestose。