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公开(公告)号：US09365419B2
公开(公告)日：2016-06-14
申请号：US13424763
申请日：2012-03-20
Applicant: Hossam Haick , Urike Tisch
Inventor： Hossam Haick , Urike Tisch
CPC classification number: B82Y5/00 , A61B5/082 , A61B5/4082 , A61B5/4842 , B82Y15/00 , G06F19/707
Abstract: The present invention provides a system and method for diagnosing, monitoring or prognosing Alzheimer's disease using at least one sensor comprising carbon nanotubes coated with cyclodextrin or derivatives thereof and/or at least one sensor comprising metal nanoparticles coated with various organic coatings in conjunction with a learning and pattern recognition algorithm.
Abstract translation: 本发明提供了一种用于使用至少一个传感器来诊断，监测或预测阿尔茨海默病的系统和方法，所述传感器包括涂覆有环糊精或其衍生物的碳纳米管和/或至少一个传感器，其包括涂覆有各种有机涂层的金属纳米粒子与学习 和模式识别算法。
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22.发明申请METHOD FOR MANUFACTURING A NANO-WIRE ARRAY AND A DEVICE THAT COMPRISES A NANO-WIRE ARRAY 审中-公开制造纳米线阵列的方法和包含纳米线阵列的装置公开(公告)号：US20140044865A1
公开(公告)日：2014-02-13
申请号：US13747558
申请日：2013-01-23
Applicant: Hossam Haick , Ossama Assad
Inventor： Hossam Haick , Ossama Assad
IPC: H01B13/30
CPC classification number: H01B13/30 , B81C1/00031 , B82Y40/00 , H01B1/04
Abstract: A device having a nano-wire array and a method for manufacturing an array of nano-wires. The method includes spraying on a substrate droplets of a suspension that comprises nano-wires and at least a partially volatile solvent; and evaporating the at least partially volatile solvent of the droplets to form the array of nano-wires. At least one of the spraying and the evaporating comprises executing at least one aggregation reduction measure for limiting a formation of three dimensional aggregations of nano-wires on the substrate.
Abstract translation: 具有纳米线阵列的装置和用于制造纳米线阵列的方法。 该方法包括在衬底上喷涂包含纳米线和至少部分挥发性溶剂的悬浮液的液滴; 并蒸发液滴的至少部分挥发性溶剂以形成纳米线阵列。 喷射和蒸发中的至少一个包括执行至少一个聚集还原措施，以限制在基底上形成纳米线的三维聚集体。
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23.发明申请VOLATILE ORGANIC COMPOUNDS FOR DETECTING CELL DYSPLASIA AND GENETIC ALTERATIONS ASSOCIATED WITH LUNG CANCER 有权用于检测细胞色素的挥发性有机化合物和与肺癌相关的遗传变异公开(公告)号：US20130143247A1
公开(公告)日：2013-06-06
申请号：US13817285
申请日：2011-08-17
Applicant: Hossam Haick , Nir Peled
Inventor： Hossam Haick , Nir Peled
CPC classification number: C12Q1/025 , C12Q1/485 , C12Q1/6886 , C12Q2600/156 , G01N30/00 , G01N33/57423 , G01N2030/8854 , G01N2333/71 , G01N2333/82 , H01J49/0027 , Y10T436/212 , Y10T436/214 , Y10T436/216 , Y10T436/24
Abstract: The present invention provides methods of identifying a genetic abnormality such as mutation in EGFR or KRAS or ALK which is associated with the management of lung cancer or diagnosing, prognosing or monitoring the treatment of pre-cancerous conditions of the lung, such as bronchial dysplasia or atypical alveolar hyperplasia (AAH), through the detection of at least one volatile organic compound indicative of these states.
Abstract translation: 本发明提供鉴定EGFR或KRAS或ALK的突变的遗传异常的方法，其与肺癌的管理相关联或诊断，预后或监测肺的癌前病症的治疗，例如支气管发育不良或 通过检测指示这些状态的至少一种挥发性有机化合物，非典型性肺泡增生（AAH）。
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公开(公告)号：US20130034910A1
公开(公告)日：2013-02-07
申请号：US13563812
申请日：2012-08-01
Applicant: Hossam Haick , Ariel Miller
Inventor： Hossam Haick , Ariel Miller
CPC classification number: G01N33/564 , B82Y15/00 , G01N27/127 , G01N27/4145 , G01N27/4146 , G01N33/497 , G01N2800/285 , Y10T436/20 , Y10T436/200833 , Y10T436/214
Abstract: The present invention provides a system and method for diagnosing, monitoring or prognosing Multiple Sclerosis at different stages as well as affording the prediction of disease activity and response to a treatment regimen, using at least one sensor comprising carbon nanotubes or metal nanoparticles, each coated with various organic coatings in conjunction with a pattern recognition algorithm.
Abstract translation: 本发明提供了一种用于在不同阶段诊断，监测或预测多发性硬化的系统和方法，并且使用至少一个包含碳纳米管或金属纳米颗粒的传感器提供对治疗方案的疾病活性和反应的预测， 各种有机涂层结合模式识别算法。
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Patent Agency Ranking
25.发明授权Carbon nanotube structures in sensor apparatuses for analyzing biomarkers in breath samples 有权用于分析呼吸样本中生物标志物的传感器装置中的碳纳米管结构公开(公告)号：US08366630B2
公开(公告)日：2013-02-05
申请号：US12994177
申请日：2009-05-27
Applicant: Hossam Haick , Peng Gang
Inventor： Hossam Haick , Peng Gang
IPC: A61B5/08
CPC classification number: G01N33/497 , B82Y15/00 , G01N27/02 , G01N27/04 , G01N27/22 , G01N27/414 , G01N33/0034 , G01N33/0047 , G01N2033/4975
Abstract: The present invention provides a system for measuring biomarker analytes indicative of various diseases comprising an array of sensors sensitive to volatile organic compounds. Particularly, the system is composed of a random network of single-walled carbon nanotubes (SWCNTs) coated with non-polar small organic molecules in conjunction with learning and pattern recognition algorithms. Methods of discriminating between breath samples of healthy individuals and of lung cancer patients are disclosed.
Abstract translation: 本发明提供了一种用于测量指示各种疾病的生物标志物分析物的系统，其包括对挥发性有机化合物敏感的传感器阵列。 特别地，该系统由结合学习和模式识别算法的非极性小有机分子涂覆的单壁碳纳米管（SWCNT）的随机网络组成。 公开了健康个体和肺癌患者呼吸样本之间的区别方法。
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公开(公告)号：US20120245434A1
公开(公告)日：2012-09-27
申请号：US13424685
申请日：2012-03-20
Applicant: Hossam Haick , Abraham Marmur , Urike Tisch
Inventor： Hossam Haick , Abraham Marmur , Urike Tisch
CPC classification number: B82Y5/00 , A61B5/082 , A61B5/4082 , A61B5/4842 , B82Y15/00 , G06F19/707
Abstract: The present invention provides a system and method for diagnosing, monitoring, prognosing or staging Parkinson's disease using at least one sensor comprising carbon nanotubes coated with cyclodextrin or derivatives thereof or metal nanoparticles coated with various organic coatings in conjunction with a learning and pattern recognition algorithm.
Abstract translation: 本发明提供了一种用于使用至少一个传感器诊断，监测，预后或分期帕金森病的系统和方法，所述传感器包括涂覆有环糊精或其衍生物的碳纳米管，或结合学习和模式识别算法涂覆有各种有机涂层的金属纳米颗粒。
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27.发明申请CHEMICAL SENSORS BASED ON CUBIC NANOPARTICLES CAPPED WITH AN ORGANIC COATING FOR DETECTING EXPLOSIVES 有权基于用于检测爆炸物的有机涂层的CUBIC纳米颗粒的化学传感器公开(公告)号：US20110015872A1
公开(公告)日：2011-01-20
申请号：US12933439
申请日：2009-03-26
Applicant: Hossam Haick , Ekaterina Dovgolevsky
Inventor： Hossam Haick , Ekaterina Dovgolevsky
CPC classification number: G01N33/0057 , B82Y15/00 , B82Y30/00 , Y10T436/17
Abstract: The present application describes a sensor apparatus, especially an electronic nose, based on 2D films or 3D assemblies of cubic nanoparticles capped with an organic coating. The organic coating is modified with unique compositions of functional moieties, e.g. cyclodextrins, to provide the detection of volatile and non-volatile compounds derived from explosive materials, e.g. PETN, RDX, TNT etc. with very high sensitivity. The nose employs pattern recognition algorithms and methods, e.g. PCA, for detecting and quantifying specific explosive compounds.
Abstract translation: 本申请描述了基于用有机涂层覆盖的立方体纳米颗粒的2D膜或3D组件的传感器装置，特别是电子鼻。 有机涂层用功能部分的独特组合，例如， 环糊精，以提供从爆炸性材料衍生的挥发性和非挥发性化合物的检测。 PETN，RDX，TNT等，灵敏度非常高。 鼻子采用模式识别算法和方法，例如 PCA，用于检测和定量特定的爆炸性化合物。
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28.发明申请NITROGEN OXIDE SENSITIVE FIELD EFFECT TRANSISTORS FOR EXPLOSIVE DETECTION COMPRISING FUNCTIONALIZED NON-OXIDIZED SILICON NANOWIRES 审中-公开用于包含功能性非氧化硅纳米管的爆炸性检测的氮氧化物敏感场效应晶体管公开(公告)号：US20100325073A1
公开(公告)日：2010-12-23
申请号：US12867258
申请日：2009-02-18
Applicant: Hossam Haick
Inventor： Hossam Haick
IPC: G06F15/18 , H01L29/772
CPC classification number: G01N27/4146 , B82Y15/00 , G01N27/4141 , G01N33/0037 , G01N33/0057 , Y02A50/245
Abstract: An apparatus for detecting volatile compounds derived from explosive materials with very high sensitivity. The apparatus is composed of field effect transistors of non-oxidized silicon nanowires modified with specific functional groups including, in particular, amine, imine and/or carboxyl moieties. Further a system is provided comprising the apparatus in conjunction with learning and pattern recognition algorithms and methods of use thereof for detecting and quantifying specific explosive compounds.
Abstract translation: 用于以非常高的灵敏度检测源自爆炸性材料的挥发性化合物的装置。 该装置由用特定官能团改性的非氧化硅纳米线的场效应晶体管组成，特别是胺，亚胺和/或羧基部分。 此外，提供一种系统，其包括结合学习和模式识别算法的装置及其用于检测和量化特定爆炸性化合物的方法。
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29.发明申请CHEMICALLY SENSITIVE FIELD EFFECT TRANSISTORS AND USES THEREOF IN ELECTRONIC NOSE DEVICES 有权化学敏感场效应晶体管及其在电子设备中的应用公开(公告)号：US20100198521A1
公开(公告)日：2010-08-05
申请号：US12669965
申请日：2008-07-24
Applicant: Hossam Haick
Inventor： Hossam Haick
CPC classification number: B82Y15/00 , B82Y30/00 , G01N27/4146 , G01N33/0034 , G01N33/54373 , G01N2033/4975 , H01L29/0843
Abstract: The present invention provides an electronic nose device based on chemically sensitive field effect transistors. In particular, the sensors of the electronic nose device are composed of non-oxidized, functionalized silicon nanowires which can detect volatile organic compounds with very high sensitivity. Methods of use in diagnosing diseases including various types of cancer are disclosed.
Abstract translation: 本发明提供一种基于化学敏感场效应晶体管的电子鼻装置。 特别地，电子鼻装置的传感器由非氧化的官能化硅纳米线组成，其可以以非常高的灵敏度检测挥发性有机化合物。 公开了用于诊断包括各种类型的癌症的疾病的方法。
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