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公开(公告)号：US20220184614A1
公开(公告)日：2022-06-16
申请号：US17683293
申请日：2022-02-28
Applicant: Illumina, Inc.
Inventor： Shang-Ying TSAI , Li-Min Hung , Jung-Huei Peng , Shane Bowen , Hui Han , Danny Chan , Sang Park
Abstract: A flow cell includes: a first substrate; a second substrate; a first resin layer disposed over an inner surface of the first substrate; a second resin layer disposed over an inner surface of the second substrate; a first plurality of biological capture sites located at the first resin layer; a second plurality of biological capture sites located at the second resin layer; and a polymer layer interposed between the first resin layer and the second resin layer, such that the first substrate is attached to the second substrate via at least the first resin layer, the polymer layer, and the second resin layer, wherein the polymer layer defines a plurality of microfluidic channels that extend through polymer layer.
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公开(公告)号：US11298697B2
公开(公告)日：2022-04-12
申请号：US16677501
申请日：2019-11-07
Applicant: Illumina, Inc.
Inventor： Shang-Ying Tsai , Li-Min Hung , Jung-Huei Peng , Shane Bowen , Hui Han , Danny Chan , Sang Park
Abstract: A flow cell includes: a first substrate; a second substrate; a first resin layer disposed over an inner surface of the first substrate; a second resin layer disposed over an inner surface of the second substrate; a first plurality of biological capture sites located at the first resin layer; a second plurality of biological capture sites located at the second resin layer; and a polymer layer interposed between the first resin layer and the second resin layer, such that the first substrate is attached to the second substrate via at least the first resin layer, the polymer layer, and the second resin layer, wherein the polymer layer defines a plurality of microfluidic channels that extend through polymer layer.
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Patent Agency Ranking
公开(公告)号：US11192083B2
公开(公告)日：2021-12-07
申请号：US16750831
申请日：2020-01-23
Applicant: ILLUMINA, INC.
Inventor： Lewis J. Kraft , Tarun Kumar Khurana , Yir-Shyuan Wu , Xi-Jun Chen , Arnaud Rival , Justin Fullerton , M. Shane Bowen , Hui Han , Jeffrey S. Fisher , Yasaman Farshchi , Mathieu Lessard-Viger
Abstract: An example of a flow cell includes a substrate, a plurality of chambers defined on or in the substrate, and a plurality of depressions defined in the substrate and within a perimeter of each of the plurality of chambers. The depressions are separated by interstitial regions. Primers are attached within each of the plurality of depressions, and a capture site is located within each of the plurality of chambers.
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公开(公告)号：US11020739B2
公开(公告)日：2021-06-01
申请号：US15700731
申请日：2017-09-11
Applicant: Illumina, Inc.
Inventor： Hui Han , Dajun A. Yuan , M. Shane Bowen
IPC: B01L3/00 , B29C65/16 , B29C65/14 , H01J37/32 , B32B17/06 , G03F7/038 , G03F7/00 , B81C1/00 , G03F7/30 , G03F7/16 , G03F7/20
Abstract: Imprinted substrates are often used to produce miniaturized devices for use in electrical, optic and biochemical applications. Imprinting techniques, such as nanoimprinting lithography, may leave residues in the surface of substrates that affect bonding and decrease the quality of the produced devices. An imprinted substrate with residue-free region, or regions with a reduced amount of residue for improved bonding quality is introduced. Methods to produce imprinted substrates without residues from the imprinting process are also introduced. Methods include physical exclusion methods, selective etching methods and energy application methods. These methods may produce residue-free regions in the surface of the substrate that can be used to produce higher strength bonding.
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公开(公告)号：US20200238247A1
公开(公告)日：2020-07-30
申请号：US16750831
申请日：2020-01-23
Applicant: ILLUMINA, INC.
Inventor： Lewis J. Kraft , Tarun Kumar Khurana , Yir-Shyuan Wu , Xi-Jun Chen , Arnaud Rival , Justin Fullerton , M. Shane Bowen , Hui Han , Jeffrey S. Fisher , Yasaman Farshchi , Mathieu Lessard-Viger
Abstract: An example of a flow cell includes a substrate, a plurality of chambers defined on or in the substrate, and a plurality of depressions defined in the substrate and within a perimeter of each of the plurality of chambers. The depressions are separated by interstitial regions. Primers are attached within each of the plurality of depressions, and a capture site is located within each of the plurality of chambers.
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公开(公告)号：US20200011800A1
公开(公告)日：2020-01-09
申请号：US16482638
申请日：2018-01-31
Applicant: Illumina, Inc.
Inventor： John S. Vieceli , Alex Nemiroski , Paul Belitz , Robert Langlois , M. Shane Bowen , Danny Yuan Chan , Bala Murali K. Venkatesan , Hui Han , Kevan Samiee , Stephen Tanner
Abstract: Fiducial markers are provided on patterned arrays of the type that may be used for molecular analysis, such as sequencing. The fiducials may have configurations and layouts that enhance their detection in image or detection data, that facilitate or improve processing, that provide encoding of useful information, and so forth. Examples of the fiducials may include offset layouts that may be useful in detecting the fiducials in different types and approaches in imaging, and that may help to distinguish regions of the array from one another in image data.
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公开(公告)号：US20200003692A1
公开(公告)日：2020-01-02
申请号：US16482630
申请日：2018-01-31
Applicant: Illumina, Inc.
Inventor： John S. Vieceli , Alex Nemiroski , Paul Belitz , Robert Langlois , M. Shane Bowen , Danny Yuan Chan , Bala Murali K. Venkatesan , Hui Han , Kevan Samiee , Stephen Tanner
IPC: G01N21/64
Abstract: Fiducial markers are provided on patterned arrays of the type that may be used for molecular analysis, such as sequencing. The fiducials may have configurations and layouts that that enhance their detection in image or detection data, that facilitate or improve processing, that provide encoding of useful information, and so forth. Examples of the fiducials may include non-rectilinear layouts that may provide for more robust location of both the fiducials and sites of the array.
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