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公开(公告)号：US20250091042A1
公开(公告)日：2025-03-20
申请号：US18965657
申请日：2024-12-02
Applicant: ILLUMINA, INC.
Inventor： Lewis J. Kraft , Tarun Kumar Khurana , Yir-Shyuan Wu , Xi-Jun Chen , Arnaud Rival , Justin Fullerton , M. Shane Bowen , Hui Han , Jeffrey S. Fisher , Yasaman Farshchi , Mathieu Lessard-Viger
Abstract: An example of a flow cell includes a substrate, a plurality of chambers defined on or in the substrate, and a plurality of depressions defined in the substrate and within a perimeter of each of the plurality of chambers. The depressions are separated by interstitial regions. Primers are attached within each of the plurality of depressions, and a capture site is located within each of the plurality of chambers.
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公开(公告)号：US11384392B2
公开(公告)日：2022-07-12
申请号：US17139834
申请日：2020-12-31
Applicant: ILLUMINA, INC. , ILLUMINA CAMBRIDGE LIMITED
Inventor： Jeffrey S. Fisher , Brian D. Mather , Maria Candelaria Rogert Bacigalupo , Justin Fullerton , Ludovic Vincent , Lewis J. Kraft , Sahngki Hong , Boyan Boyanov , M. Shane Bowen , Sang Park , Wayne N. George , Andrew A. Brown
IPC: C12Q1/6869 , C08F220/56 , C08G77/04 , G03F7/075 , G03F7/16 , G03F7/00 , G03F7/004
Abstract: An example of a flow cell includes a substrate; a first primer set attached to a first region on the substrate, the first primer set including an un-cleavable first primer and a cleavable second primer; and a second primer set attached to a second region on the substrate, the second primer set including a cleavable first primer and an un-cleavable second primer.
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公开(公告)号：US10913975B2
公开(公告)日：2021-02-09
申请号：US15747670
申请日：2016-07-21
Applicant: ILLUMINA, INC.
Inventor： Alex So , Li Liu , Min-Jui Richard Shen , Neeraj Salathia , Kathryn M. Stephens , Anne Jager , Timothy Wilson , Justin Fullerton , Sean M. Ramirez , Shannon Kaplan , Rigo Pantoja , Bala Murali Venkatesan , Steven Modiano
IPC: C12Q1/68 , C12Q1/6837 , C12Q1/6874 , C12Q1/6816 , C12Q1/6855
Abstract: Presented are methods and compositions for spatial detection and analysis of nucleic acids in a tissue sample. The methods can enable the characterization of transcriptomes and/or genomic variations in tissues while preserving spatial information about the tissue.
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公开(公告)号：US20210024991A1
公开(公告)日：2021-01-28
申请号：US16626452
申请日：2019-06-07
Applicant: ILLUMINA, INC. , ILLUMINA CAMBRIDGE LIMITED
Inventor： Jeffrey S. Fisher , Brian D. Mather , Maria Candelaria Rogert Bacigalupo , Justin Fullerton , Ludovic Vincent , Lewis J. Kraft , Sahngki Hong , Boyan Boyanov , M. Shane Bowen , Sang Park , Wayne N. George , Andrew A. Brown , Dajun Yuan
IPC: C12Q1/6869 , G03F7/075 , C08G77/04 , C08F220/56
Abstract: An example of a flow cell includes a substrate; a first primer set attached to a first region on the substrate, the first primer set including an un-cleavable first primer and a cleavable second primer; and a second primer set attached to a second region on the substrate, the second primer set including a cleavable first primer and an un-cleavable second primer.
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公开(公告)号：US20240426739A1
公开(公告)日：2024-12-26
申请号：US18739578
申请日：2024-06-11
Applicant: ILLUMINA, INC.
Inventor： Jeffrey S. Fisher , Justin Fullerton , Brian D. Mather , Maxwell Zimmerley
IPC: G01N15/1434
Abstract: An example flow cell includes a first substrate; a second substrate attached to the first substrate; a flow channel defined between the first substrate and the second substrate; a first primer set attached to the first substrate, the first primer set including an un-cleavable first primer and a cleavable second primer; a second primer set attached to the second substrate, the second primer set including a cleavable first primer and an un-cleavable second primer; and a removable blocking mechanism passivating i) the first primer set or the second primer set or ii) the cleavable first primer and the cleavable second primer.
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Patent Agency Ranking
公开(公告)号：US20230332224A1
公开(公告)日：2023-10-19
申请号：US18317865
申请日：2023-05-15
Applicant: ILLUMINA, INC. , ILLUMINA CAMBRIDGE LIMITED
Inventor： Jeffrey S. Fisher , Brian D. Mather , Maria Candelaria Rogert Bacigalupo , Justin Fullerton , Ludovic Vincent , Lewis J. Kraft , Sahngki Hong , Boyan Boyanov , M. Shane Bowen , Sang Park , Wayne N. George , Andrew A. Brown
IPC: C12Q1/6869 , C08F220/56 , C08G77/04 , G03F7/075 , G03F7/16
CPC classification number: C12Q1/6869 , C08F220/56 , C08G77/04 , G03F7/0757 , G03F7/165 , G03F7/0002
Abstract: An example of a flow cell includes a substrate; a first primer set attached to a first region on the substrate, the first primer set including an un-cleavable first primer and a cleavable second primer; and a second primer set attached to a second region on the substrate, the second primer set including a cleavable first primer and an un-cleavable second primer.
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公开(公告)号：US20180214869A1
公开(公告)日：2018-08-02
申请号：US15839509
申请日：2017-12-12
Applicant: Illumina, Inc.
Inventor： John Gerhardt Earney , Justin Fullerton , Kaleb Smith , Bala Murali K. Venkatesan
Abstract: An example method includes providing a working stack having a first substrate layer, a second substrate layer, and a radiation-absorbing material disposed between the first and second substrate layers. The working stack includes a cavity therein having a designated liquid. A bonding interface is defined between the radiation-absorbing material and at least one of the first substrate layer or the second substrate layer. The bonding interface has a film of the designated liquid. The method also includes directing radiation onto the bonding interface to form a perimeter seal. The perimeter seal separates the cavity from an outer area of the bonding interface. The method also includes directing the radiation onto the outer area of the bonding interface to secure the first and second substrate layers together. The perimeter seal impedes an ingress of bubbles from the outer area into the cavity as the radiation is directed onto the outer area.
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公开(公告)号：US20240207846A1
公开(公告)日：2024-06-27
申请号：US18542447
申请日：2023-12-15
Applicant: ILLUMINA, INC.
Inventor： Johan Sebastian Basuki , Tyler J. Dill , Justin Fullerton , Tanmay Ghonge , Brian D. Mather , Wei Wei
IPC: B01L3/00
CPC classification number: B01L3/502715 , B01L3/502753 , B01L2300/0645 , B01L2300/0887
Abstract: An example of a flow cell includes a substrate; a plurality of reactive regions spatially separated from one another across the substrate; and a plurality of independently removable coatings respectively positioned over each of the plurality of reactive regions. Each of the plurality of reactive regions includes a polymeric hydrogel layer; and a reactive entity attached to the polymeric hydrogel layer.
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公开(公告)号：US11680292B2
公开(公告)日：2023-06-20
申请号：US17840569
申请日：2022-06-14
Applicant: ILLUMINA, INC. , ILLUMINA CAMBRIDGE LIMITED
Inventor： Jeffrey S. Fisher , Brian D. Mather , Maria Candelaria Rogert Bacigalupo , Justin Fullerton , Ludovic Vincent , Lewis J. Kraft , Sahngki Hong , Boyan Boyanov , M. Shane Bowen , Sang Park , Wayne N. George , Andrew A. Brown
IPC: C12Q1/6869 , C08F220/56 , C08G77/04 , G03F7/075 , G03F7/16 , G03F7/00 , G03F7/004
CPC classification number: C12Q1/6869 , C08F220/56 , C08G77/04 , G03F7/0757 , G03F7/165 , G03F7/0002 , G03F7/0046
Abstract: An example of a flow cell includes a substrate; a first primer set attached to a first region on the substrate, the first primer set including an un-cleavable first primer and a cleavable second primer; and a second primer set attached to a second region on the substrate, the second primer set including a cleavable first primer and an un-cleavable second primer.
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公开(公告)号：US20230002822A1
公开(公告)日：2023-01-05
申请号：US17840569
申请日：2022-06-14
Applicant: ILLUMINA, INC. , ILLUMINA CAMBRIDGE LIMITED
Inventor： Jeffrey S. Fisher , Brian D. Mather , Maria Candelaria Rogert Bacigalupo , Justin Fullerton , Ludovic Vincent , Lewis J. Kraft , Sahngki Hong , Boyan Boyanov , M. Shane Bowen , Sang Park , Wayne N. George , Andrew A. Brown
IPC: C12Q1/6869 , C08F220/56 , C08G77/04 , G03F7/075 , G03F7/16
Abstract: An example of a flow cell includes a substrate; a first primer set attached to a first region on the substrate, the first primer set including an un-cleavable first primer and a cleavable second primer; and a second primer set attached to a second region on the substrate, the second primer set including a cleavable first primer and an un-cleavable second primer.
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