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    CARTRIDGE ASSEMBLY
    21.
    发明申请
    CARTRIDGE ASSEMBLY 有权

    公开(公告)号：US20220387998A1

    公开(公告)日：2022-12-08

    申请号：US17888318

    申请日：2022-08-15

    Applicant: ILLUMINA, INC. ,  ILLUMINA SINGAPORE PTE. LTD.

    Inventor： Richard L. Lemoine ,  James Osmus ,  Sz-Chin Steven Lin ,  Beng Keong Ang

    IPC: B01L3/00 ,  G01N21/75 ,  G01N21/01 ,  F04B19/00 ,  F16K99/00 ,  G01N21/00

    Abstract: A cartridge assembly comprises a housing having an illumination chamber and a well plate. The well plate is maintained within the housing and has liquid wells to receive desired amounts of liquids. The well plate includes a fluidics analysis station aligned with the illumination chamber, and an interface window and interface ports located at the fluidics analysis station. The well plate includes a valve station and pump station. A piercer unit is provided in the housing and positioned proximate to the wells. The piercer unit includes a piercer element and is to be moved to a piercing position where the piercer element pierces a cover for the corresponding well. A pump assembly on the well plate at the pump station manages fluid flow through the channels between the pump station and the fluidics analysis station. The housing includes a flow cell chamber to receive a removable flow cell cartridge.

    Assay instrument for detecting optical signals from samples having a controlled optics adjustment system based on the priority statuses of the samples
    25.
    发明授权
    Assay instrument for detecting optical signals from samples having a controlled optics adjustment system based on the priority statuses of the samples 有权
    用于根据样品的优先级状态从具有受控光学调节系统的样品检测光信号的测定仪器

    公开(公告)号：US09139875B2

    公开(公告)日：2015-09-22

    申请号：US14263746

    申请日：2014-04-28

    Applicant: ILLUMINA, INC.

    Inventor： Alexander Triener ,  Erik Allegoren ,  Wenyi Feng ,  Dale Buermann ,  Erik Olson ,  James Osmus

    IPC: C12Q1/68 ,  G01N21/64

    CPC classification number: C12Q1/6874 ,  C12Q1/6837 ,  G01N21/6428 ,  G01N21/645 ,  G01N21/6456

    Abstract: An optical system configured to detect optical signals during imaging sessions. The optical system includes an objective lens that has a collecting end that is positioned proximate to a sample and configured to receive optical signals therefrom. The optical system also includes a removable path compensator that is configured to be located at an imaging position between the collecting end of the objective lens and the sample. The path compensator adjusts an optical path of the light emissions when in the imaging position. Also, the optical system includes a transfer device that is configured to move the path compensator. The transfer device locates the path compensator at the imaging position for a first imaging session and removes the path compensator from the imaging position for a second imaging session.

    Abstract translation: 一种配置成在成像会话期间检测光信号的光学系统。 光学系统包括物镜，该物镜具有位于样品附近并被配置为从其接收光信号的收集端。 光学系统还包括被配置为位于物镜的收集端和样品之间的成像位置处的可移除路径补偿器。 路径补偿器在成像位置调整光发射的光路。 此外，光学系统包括被配置为移动路径补偿器的传送装置。 传送装置将路径补偿器定位在用于第一成像会话的成像位置处，并从第二成像会话的成像位置移除路径补偿器。

    Assay instrument for detecting optical signals from samples
    26.
    发明授权
    Assay instrument for detecting optical signals from samples 有权
    用于检测样品光学信号的测定仪器

    公开(公告)号：US08748789B2

    公开(公告)日：2014-06-10

    申请号：US13905633

    申请日：2013-05-30

    Applicant: Illumina, Inc.

    Inventor： Alexander Triener ,  Erik Allegoren ,  Wenyi Feng ,  Dale Buermann ,  Erik Olson ,  James Osmus

    IPC: G02B7/04

    CPC classification number: C12Q1/6874 ,  C12Q1/6837 ,  G01N21/6428 ,  G01N21/645 ,  G01N21/6456

    Abstract: An optical system configured to detect optical signals during imaging sessions. The optical system includes an objective lens that has a collecting end that is positioned proximate to a sample and configured to receive optical signals therefrom. The optical system also includes a removable path compensator that is configured to be located at an imaging position between the collecting end of the objective lens and the sample. The path compensator adjusts an optical path of the light emissions when in the imaging position. Also, the optical system includes a transfer device that is configured to move the path compensator. The transfer device locates the path compensator at the imaging position for a first imaging session and removes the path compensator from the imaging position for a second imaging session.

    Abstract translation: 一种配置成在成像会话期间检测光信号的光学系统。 光学系统包括物镜，该物镜具有位于样品附近并被配置为从其接收光信号的收集端。 光学系统还包括被配置为位于物镜的收集端和样品之间的成像位置处的可移除路径补偿器。 路径补偿器在成像位置调整光发射的光路。 此外，光学系统包括被配置为移动路径补偿器的传送装置。 传送装置将路径补偿器定位在用于第一成像会话的成像位置处，并从第二成像会话的成像位置移除路径补偿器。

    Reagent Cartridges and Related Systems and Methods
    27.
    发明公开
    Reagent Cartridges and Related Systems and Methods 审中-公开

    公开(公告)号：US20240288462A1

    公开(公告)日：2024-08-29

    申请号：US18572188

    申请日：2023-03-17

    Applicant: ILLUMINA, INC.

    Inventor： James Osmus ,  Hao Yu ,  Shih-Chung Wei ,  Jian En Koh

    IPC: G01N35/10 ,  G01N35/00

    CPC classification number: G01N35/1002 ,  G01N35/00871 ,  G01N2035/00544 ,  G01N2035/0091

    Abstract: Reagent cartridges and related systems and methods are disclosed. In accordance with an implementation, an apparatus includes a first flexible container, a second flexible container, and a coupling. The first flexible container has an end and defines a first interior containing reagent. The second flexible container has an end and defines a second interior. The first flexible container is positioned within the second interior. The coupling has a first portion coupled to the end of the first flexible container and a second portion coupled to the end of the second flexible container. The coupling has a reagent port fluidly coupled to the first interior of the first flexible container and a pressure port fluidly coupled to the second interior of the second flexible container.

    FLOW CELL ASSEMBLIES AND RELATED SYSTEMS
    28.
    发明公开
    FLOW CELL ASSEMBLIES AND RELATED SYSTEMS 审中-公开

    公开(公告)号：US20240125387A1

    公开(公告)日：2024-04-18

    申请号：US18398826

    申请日：2023-12-28

    Applicant: ILLUMINA, INC.

    Inventor： Ashish Kumar ,  James Osmus ,  David Kaplan ,  Richard Lemoine

    IPC: F16J15/10 ,  H01M50/183

    CPC classification number: F16J15/104 ,  H01M50/183 ,  F28F3/10

    Abstract: Gasket assemblies and related system and methods. An apparatus includes a system, a flow cell, and a plurality of gasket assemblies. The system includes a flow cell interface and the flow cell has one or more channels. Each channel has a first channel opening and a second channel opening. The first channel openings are positioned at a first end of the flow cell and the second channel openings are positioned at a second end of the flow cell. A gasket assembly coupled at each second channel opening. Each gasket assembly includes an adhesive stack and a gasket. The adhesive stack includes a first side bonded to the gasket and a second side bonded to the flow cell. The flow cell interface is engagable with the corresponding gaskets to establish a fluidic coupling between system and the flow cell.

    Cartridge assembly
    29.
    发明授权
    Cartridge assembly 有权

    公开(公告)号：US11458469B2

    公开(公告)日：2022-10-04

    申请号：US16443727

    申请日：2019-06-17

    Applicant: ILLUMINA, INC. ,  ILLUMINA SINGAPORE PTE. LTD.

    Inventor： Richard L. Lemoine ,  James Osmus ,  Sz-Chin Steven Lin ,  Beng Keong Ang

    IPC: B01L3/00 ,  G01N21/75 ,  G01N21/01 ,  F04B19/00 ,  F16K99/00 ,  G01N21/00

    Abstract: A cartridge assembly comprises a housing having an illumination chamber and a well plate. The well plate is maintained within the housing and has liquid wells to receive desired amounts of liquids. The well plate includes a fluidics analysis station aligned with the illumination chamber, and an interface window and interface ports located at the fluidics analysis station. The well plate includes a valve station and pump station. A piercer unit is provided in the housing and positioned proximate to the wells. The piercer unit includes a piercer element and is to be moved to a piercing position where the piercer element pierces a cover for the corresponding well. A pump assembly on the well plate at the pump station manages fluid flow through the channels between the pump station and the fluidics analysis station. The housing includes a flow cell chamber to receive a removable flow cell cartridge.

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