公开(公告)号：US20180262557A1

公开(公告)日：2018-09-13

申请号：US15910743

申请日：2018-03-02

Applicant: IntegenX Inc.

Inventor： Robert A. Schueren ,  David King ,  Chungsoo Charles Park ,  Arnaldo Barican ,  Charles David Troup

IPC: H04L29/08 ,  G01N27/447 ,  G06F19/24

CPC classification number: H04L67/10 ,  G01N27/447 ,  G01N27/44704 ,  G06F3/04817 ,  G16B40/00 ,  G16B50/40 ,  H04L67/18 ,  H04L67/22 ,  H04L67/306

Abstract: A command center includes at least one network communications interface configured for two-way communications with a plurality of sites remote from the command center and at least one display screen and user interface. Each of the plurality of sites includes at least one forensic field test device configured to identify individuals using DNA samples from the individuals. The display screen and user interface are configured to depict aspects of forensic field test devices of the plurality of sites, wherein the aspects include a site identifier for each of the forensic field test devices and one or more additional aspects.

公开(公告)号：US20170002399A1

公开(公告)日：2017-01-05

申请号：US15117053

申请日：2015-04-30

Applicant: INTEGENX INC.

Inventor： David Eberhart ,  William D. Nielsen ,  Helen Franklin ,  Stevan B. Jovanovich ,  Dennis Lehto ,  Kaiwan Chear ,  David King ,  James Klevenberg ,  Chungsoo Charles Park ,  Corey Smith ,  Philip Justus Wunderle

IPC: C12Q1/68 ,  G01N27/447 ,  B01L3/00

CPC classification number: C12Q1/6806 ,  B01L3/502707 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502738 ,  B01L2200/027 ,  B01L2200/0689 ,  B01L2200/12 ,  B01L2300/041 ,  B01L2300/0654 ,  B01L2300/0681 ,  B01L2300/0848 ,  B01L2300/087 ,  B01L2300/123 ,  B01L2400/0406 ,  B01L2400/0478 ,  C12Q1/686 ,  G01N27/44743 ,  G01N27/44791 ,  C12Q1/6846 ,  C12Q2565/629

Abstract: Provided herein is a fluidic cartridge having a body comprising a malleable material and a layer comprising a deformable material bonded to a surface of the body that seals one or more fluidic channels that communicate with one or more valve bodies formed in a surface of the body. The valve can be closed by applying pressure to the deformable material sufficient to crush and close off a fluidic channel in the body. Also provided are a cartridge interface configured to engage the cartridge. Also provided is a system including a cartridge interface and methods of using the cartridge and system.

Abstract translation: 本文提供了一种流体盒，其具有包括可延展材料的主体和包含结合到主体表面的可变形材料的层，所述可变形材料密封与形成在主体表面中的一个或多个阀体连通的一个或多个流体通道。 可以通过向可变形材料施加足够的压力来关闭阀门，以压缩和关闭体内的流体通道。 还提供了构造成接合盒的盒接口。 还提供了包括盒式接口和使用盒和系统的方法的系统。

公开(公告)号：US20160367981A1

公开(公告)日：2016-12-22

申请号：US15173894

申请日：2016-06-06

Applicant: IntegenX Inc.

Inventor： Philip Justus Wunderle ,  Chungsoo Charles Park ,  David King ,  Dennis Lehto

IPC: B01L3/00 ,  C12Q1/68

CPC classification number: C12Q1/6874 ,  B01F13/0059 ,  B01F13/02 ,  B01L3/502738 ,  B01L3/502753 ,  B01L7/52 ,  B01L2200/04 ,  B01L2200/0668 ,  B01L2200/16 ,  B01L2300/0816 ,  B01L2300/0887 ,  B01L2300/123 ,  B01L2400/043 ,  B01L2400/0478 ,  B01L2400/0655 ,  C12Q1/686 ,  F16K99/0015 ,  F16K99/0034 ,  F16K2099/0078 ,  F16K2099/0084

Abstract: This disclosure provides, among other things, a cartridge comprising: (a) a cartridge body comprising a malleable material and having, disposed on a surface of the body, at least one valve body comprising a valve inlet and a valve outlet, each fluidically connected to a fluidic channel; and (b) a layer comprising a deformable material bonded to a surface of the cartridge body and sealing the at least one valve body at points of attachment, thereby forming at least one valve; wherein the at least one valve body is depressed in the cartridge body relative to the points of attachment and wherein the deformable material covering the at least one valve body retains sufficient elasticity after deformation such that in a ground state the valve is open. Also disclosed is an instrument comprising a cartridge interface and a cartridge as described herein engaged with the cartridge interface, wherein (II) the cartridge interface comprises: (A) at least one mechanical actuator, each mechanical actuator positioned to actuate a valve; and (B) at least one motor operatively coupled to actuate a mechanical actuator toward or away from a valve.

Abstract translation: 本公开尤其提供了一种盒，其包括：（a）包括可延展材料的盒体，并且具有设置在主体表面上的至少一个阀体，其包括阀入口和阀出口，每个阀体流体连接 到流体通道; 和（b）包含结合到所述盒体表面的可变形材料并且在附接点处密封所述至少一个阀体从而形成至少一个阀的层; 其中所述至少一个阀体相对于所述连接点在所述盒体中被压下，并且其中覆盖所述至少一个阀体的所述可变形材料在变形之后保持足够的弹性，使得在基础状态下所述阀是打开的。 还公开了一种包括如本文所述的盒接口和与盒接口接合的盒的仪器，其中（II）盒接口包括：（A）至少一个机械致动器，每个机械致动器被定位成致动阀; 和（B）至少一个电动机，其可操作地联接以朝向或远离阀致动机械致动器。

公开(公告)号：US12099032B2

公开(公告)日：2024-09-24

申请号：US16871797

申请日：2020-05-11

Applicant: IntegenX Inc.

Inventor： Alexander Kindwall ,  Chungsoo Charles Park ,  Fedor IIkov ,  Stevan Jovanovich ,  David King ,  Tristan Robert Littlehale ,  David Grant Nilson ,  Rick Pittaro ,  Robert A. Schueren ,  Mattias Vangbo ,  Philip Justus Wunderle

IPC: G01N27/447 ,  B01L3/00 ,  B01L7/00 ,  G01N27/453

CPC classification number: G01N27/44791 ,  B01L3/502715 ,  G01N27/44704 ,  G01N27/44786 ,  G01N27/453 ,  B01L7/52 ,  B01L2200/04 ,  B01L2200/10 ,  B01L2200/16 ,  B01L2300/0681 ,  B01L2300/0867 ,  B01L2300/1822 ,  B01L2300/1827 ,  B01L2400/0421 ,  G01N27/44743

Abstract: An electrophoresis cartridge can include an integrated electrophoresis assembly including an anode sub-assembly comprising an anode, a cathode sub-assembly comprising a cathode; and at least one electrophoresis capillary having a first end in fluid communication with the cathode sub-assembly and a second end in fluid communication with the anode sub-assembly. The cartridge can further include a reagent container comprising electrophoresis buffer; a fluid conduit in fluidic communication with the reagent container; a pump in fluidic communication with the fluid conduit, the pump configured to transfer the electrophoresis buffer through the fluid conduit from the reagent container to the passage of the cathode sub-assembly; and a sample inlet port and at least one sample line, wherein the sample line places the sample inlet port in fluidic communication with the first end of the electrophoresis capillary through a passage in the cathode sub-assembly.

公开(公告)号：US20230392203A1

公开(公告)日：2023-12-07

申请号：US18312197

申请日：2023-05-04

Applicant: IntegenX, Inc.

Inventor： Philip Justus Wunderle ,  Chungsoo Charles Park ,  David King ,  Dennis Lehto

IPC: C12Q1/6874 ,  C12Q1/686 ,  B01L3/00 ,  F16K99/00

CPC classification number: C12Q1/6874 ,  C12Q1/686 ,  B01L3/502738 ,  F16K99/0015 ,  F16K99/0034 ,  B01L2300/0887 ,  B01L2300/123 ,  B01L2400/0655 ,  B01L3/502753 ,  B01L7/52

Abstract: A method of controlling fluid flow in a fluid channel of fluidic cartridge can include closing a valve by actuating a mechanical actuator against the valve to force a deformable layer against walls of a valve body, wherein the valve body comprises a valve inlet and a valve outlet and each of the valve inlet and valve outlet are fluidically coupled to a fluidic channel; releasing the valve by retracting the mechanical actuator away from the valve body; and moving liquid through the valve by applying positive or negative pressure to the fluidic channel.

公开(公告)号：US11649496B2

公开(公告)日：2023-05-16

申请号：US16983796

申请日：2020-08-03

Applicant: IntegenX, Inc.

Inventor： Philip Justus Wunderle ,  Chungsoo Charles Park ,  David King ,  Dennis Lehto

IPC: B01L3/00 ,  F16K99/00 ,  B01L7/00 ,  B01F33/30 ,  B01F33/40 ,  C12Q1/6874 ,  C12Q1/686

CPC classification number: C12Q1/6874 ,  B01L3/502738 ,  C12Q1/686 ,  F16K99/0015 ,  F16K99/0034 ,  B01F33/30 ,  B01F33/40 ,  B01L3/502753 ,  B01L7/52 ,  B01L2200/04 ,  B01L2200/0668 ,  B01L2200/16 ,  B01L2300/0816 ,  B01L2300/0887 ,  B01L2300/123 ,  B01L2400/043 ,  B01L2400/0478 ,  B01L2400/0655 ,  F16K2099/0078 ,  F16K2099/0084

Abstract: A method of making an article bonding a layer of deformable material to a surface of a cartridge body having at least one valve body thereon to seal the at least one valve body, the valve body comprising a valve floor and valve walls comprising upper parts, wherein the valve floor is recessed from the surface and the valve walls extend from the surface to the valve floor, and wherein the valve body comprises walls that are curved or sloped in a direction that is non-normal to the plane defined by the surface; and deforming the layer such that upon release of a force causing the deformation, the layer is in contact with the upper parts of the valve walls and is in spaced from the valve floor so as to bias the valve to an open state.

公开(公告)号：US11482052B2

公开(公告)日：2022-10-25

申请号：US16234385

申请日：2018-12-27

Applicant: IntegenX Inc.

Inventor： Robert A. Schueren ,  David King ,  Chungsoo Charles Park ,  Stevan B. Jovanovich

IPC: G06V40/70 ,  G10L17/00 ,  G16H40/63 ,  G16H10/40 ,  G16B50/00 ,  G16B50/30 ,  G06V40/10 ,  G06V40/60 ,  G16B99/00 ,  G06K9/00

Abstract: A biometric biochemical analysis system includes a user interface module to provide instructions for collecting and handling biochemical sampling and processing related to biometric data gathering as well as capturing biometric data using digital data capturing devices. The user interface module and display are integrated with analysis and communications portions of the biometric biochemical analysis system to provide a portable system for multi-portion data collecting, storage, verification, and analysis.

公开(公告)号：US11231945B2

公开(公告)日：2022-01-25

申请号：US16941169

申请日：2020-07-28

Applicant: INTEGENX INC.

Inventor： David King ,  Chungsoo Charles Park

IPC: G06F3/0481 ,  G06F9/451 ,  G06F3/0487 ,  G06Q30/00

Abstract: A live help system provides an intuitive display of help information on a user's graphical user interface. A request is received from a client device for help, and a live help provider interface is initiated at a live help location. Data is acquired regarding a user's location, including data on external devices in the user's location. Indicators are provided to allow the live help provider to point to or otherwise indicate items on the user interface or outside of the user interface. Live help input is captured at the live help provider interface. Instructions are then transmitted to the display of the client device to display live help input, as though the agent were present and interacting with or indicating items on the screen or off the screen.

公开(公告)号：US10855748B2

公开(公告)日：2020-12-01

申请号：US15910743

申请日：2018-03-02

Applicant: IntegenX Inc.

Inventor： Robert A. Schueren ,  David King ,  Chungsoo Charles Park ,  Arnaldo Barican ,  Charles David Troup

IPC: H04L29/08 ,  G01N27/447 ,  G16B40/00 ,  G16B50/40 ,  G06F3/01 ,  G06F3/0481

Abstract: A command center includes at least one network communications interface configured for two-way communications with a plurality of sites remote from the command center and at least one display screen and user interface. Each of the plurality of sites includes at least one forensic field test device configured to identify individuals using DNA samples from the individuals. The display screen and user interface are configured to depict aspects of forensic field test devices of the plurality of sites, wherein the aspects include a site identifier for each of the forensic field test devices and one or more additional aspects.

公开(公告)号：US20190233888A1

公开(公告)日：2019-08-01

申请号：US16264389

申请日：2019-01-31

Applicant: IntegenX, Inc.

Inventor： Philip Justus Wunderle ,  Chungsoo Charles Park ,  David King ,  Dennis Lehto

IPC: C12Q1/6874 ,  C12Q1/686 ,  F16K99/00 ,  B01L3/00

CPC classification number: C12Q1/6874 ,  B01F13/0059 ,  B01F13/02 ,  B01L3/502738 ,  B01L3/502753 ,  B01L7/52 ,  B01L2200/04 ,  B01L2200/0668 ,  B01L2200/16 ,  B01L2300/0816 ,  B01L2300/0887 ,  B01L2300/123 ,  B01L2400/043 ,  B01L2400/0478 ,  B01L2400/0655 ,  C12Q1/686 ,  F16K99/0015 ,  F16K99/0034 ,  F16K2099/0078 ,  F16K2099/0084

Abstract: This disclosure provides, among other things, a cartridge comprising: (a) a cartridge body comprising a malleable material and having, disposed on a surface of the body, at least one valve body comprising a valve inlet and a valve outlet, each fluidically connected to a fluidic channel; and (b) a layer comprising a deformable material bonded to a surface of the cartridge body and sealing the at least one valve body at points of attachment, thereby forming at least one valve; wherein the at least one valve body is depressed in the cartridge body relative to the points of attachment and wherein the deformable material covering the at least one valve body retains sufficient elasticity after deformation such that in a ground state the valve is open. Also disclosed is an instrument comprising a cartridge interface and a cartridge as described herein engaged with the cartridge interface, wherein (II) the cartridge interface comprises: (A) at least one mechanical actuator, each mechanical actuator positioned to actuate a valve; and (B) at least one motor operatively coupled to actuate a mechanical actuator toward or away from a valve.