摘要:
There is provided a calcium receptor modulator comprising a compound of the formula (I): wherein ring A is an optionally substituted 5- to 7-membered ring; ring B is an optionally substituted 5- to 7-membered heterocyclic ring; X1 is CR1, CR1R2, N or NR13; X2 is N or NR3; Y is C, CR4 or N, Z is CR5, CR5R6, N or NR7; Ar is an optionally substituted cyclic group; R is H, an optionally substituted hydrocarbon group, etc.; and is a single bond or a double bond; R1, R2, R3, R4, R5, R6, R7 and R13 are independently H, an optionally substituted hydrocarbon group; or a salt thereof or a prodrug thereof. Compounds of the formula (II) and (III): wherein ring A is an optionally substituted 5- to 7-membered ring; Q is C, CR5 or N; R8, R9, R10, R11 and R12 are independently, H, an optionally substituted hydrocarbon group, etc., or a salt thereof are also provided. Also specify X1, R3, R1, Y and X3 in formula (II) and (III) as before.
摘要翻译:提供了包含式(I)化合物的钙受体调节剂:其中环A是任选取代的5-至7-元环; 环B是任选取代的5-至7-元杂环; X 1是CR 1,CR 1,R 2,N或NR 13, ; X 2是N或NR 3; Y是C,CR 4或N,Z是CR 5,CR 5,R 6,N或NR 7 SUP>; Ar是任选取代的环状基团; R为H,任选取代的烃基等; “img id =”custom-character-00001“he =”1.78mm“wi =”2.12mm“file =”US20060079536A1-20060413-P00001.TIF“alt =”custom character“img-content =”character“img- format =“tif”/>是单键或双键; R 1,R 2,R 3,R 4,R 5, R 6,R 7和R 13独立地是H,任选取代的烃基; 或其盐或其前药。 式(II)和(III)的化合物:其中环A是任选取代的5-至7-元环; Q是C,CR 5或N; R 9,R 9,R 10,R 11和R 12都是 还可以提供H,任选取代的烃基等,或其盐。 还可以在式(II)中指定X 1,R 3,R 3,R 3,Y和X 3,和( III)。
摘要:
A technology that increases bill discrimination precision, wherein a bill discriminating apparatus detects the thickness distribution of a bill P that is subject to discrimination, and by comparing this thickness distribution data and the reference thickness distribution data that shows the thickness distribution of an authentic note held in advance, performs discrimination processing that includes double feed detection, tape detection, and authenticity discrimination. Then, authenticity discrimination is performed on areas for which the difference between the thickness distribution data and the reference thickness data is within a specified range.
摘要:
A dot mark having at its center a peaked portion rising from a face to be marked is provided on a cut face or ground face of a semiconductor wafer with the face to be marked having surface roughness of 0.3 &mgr;m or less. The rising dot mark is 1 to 15 &mgr;m in maximum length along the face to be marked and 0.01 to 5 &mgr;m in height. With even such a fine size, the dot mark is superior in visibility. This makes it possible to provide a semiconductor base material in which all processing histories in a process for manufacturing a semiconductor wafer and a semiconductor, wafer ID, chip ID, and manufacturing number or the like can be recognized.
摘要:
The invention provides compounds of the formula: wherein the ring A is an optionally substituted benzene ring; R1 is an optionally substituted non-aromatic heterocyclic group; R2 and R3 are independently hydrogen atom or an optionally substituted hydrocarbon group; n is an integer of 0-3; or salts thereof, which are useful as medicines having an osteogenesis promoting effect and chondrogensis promoting effect. The present invention relates to an amine compound having an excellent effect of inhibiting production and/or secretion of amyloid-b protein, a production and use thereof. Especially, it is effective for preventing and/or treating, for example, neurodegenerative diseases, amyloid angiopathy, neurological disorders caused by cerebrovascular disorders, and so forth.
摘要:
A camera having an autofocus function, independent of a photographing optical system, includes a photographing optical system including synthetic resin lenses and an autofocus optical system, provided independent of the photographing optical system, having at least one synthetic resin lens and a stop decentered in a direction perpendicular to the optical axis of the synthetic resin lens. Thus, in the camera, the shift of the imaging position of the photographing optical system which is caused by an ambient temperature or humidity change is favorably corrected, and good photography can be performed.
摘要:
A laser marking system and method with a laser oscillator generating a laser beam that is scanned in a single direction onto a mask (such as a liquid crystal) that displays sequentially a plurality of divided pattern blocks, and a second deflector that deflects the scanned laser beams onto corresponding portions of the surface of a workpiece so as to mark on the surface of the workpiece a combination of the divided pattern blocks . In another embodiment a plurality of masks and a second optical system for combining the beams from the masks can be used to create the mark. The system can be used with a conveyor and a loading and unloading unit using a controller.
摘要:
The present invention provides a method and a device for color laser marking for attaining visible coloring without drastic modification of conventional devices and without using dyestuffs. To this end, in a color laser marking method, a workpiece (10) is a synthetic material made from organic and inorganic materials and, when irradiating laser light, patterns in different colors can be obtained by varying the received light intensity on the workpiece (10). In addition, in a color laser marking device, when the workpiece (10) is a synthetic material made from organic and inorganic materials, a controller (11) outputs laser irradiation intensity varying signals to at least one of laser irradiation intensity varying means, such as a laser oscillator (1).
摘要:
A metal particle detecting sensor (10), having a simple structure, can perform in-line analysis for metal particles in fluid and also can precisely estimate or detect the number of metal particles for each particle size. Metal films (1) and insulating films (2) are alternately laminated one upon another, and every other metal film (1) in the laminate is connected in parallel with one another to one of two lead wires (3a, 3b) so as to form comb electrodes in the laminate of the sensor, and one end face of the laminate is immersed in a fluid (4) containing metal particles so as to detect the metal particles.
摘要:
The present disclosure concerns a thermally controlled valve, such as may be installed in the cooling water system of internal combustion engines. The thermally controlled valve eliminates thermal hunting as the temperature of the cooling water increases by restricting the initial flow of cooling water. Subsequently, additional cooling water flow is permitted as the temperature of the cooling water further increases.
摘要:
A position detecting apparatus for magnetically detecting the position of, for example, a cylinder rod of a construction or industrial machine, a piston of an automotive engine or a scaler of a magnetic scale, improved to reduce a delay of response of processing through a low-pass active filter. To this end, the apparatus has a mean value calculating circuit (22) which calculates the mean value of an output voltage from a detecting circuit (10) and delivers the mean value to a comparator circuit (32) as a reference voltage. In addition, diodes (D.sub.1, D.sub.2) for charging the capacitors (C.sub.1, C.sub.2) of the low-pass active filters constituting the mean value calculating circuit can be connected in parallel with resistors (R.sub.1, R.sub.2) of the filters.