Calcium receptor modulating compound and use thereof
    21.
    发明申请
    Calcium receptor modulating compound and use thereof 有权
    钙受体调节化合物及其用途

    公开(公告)号:US20060079536A1

    公开(公告)日:2006-04-13

    申请号:US10525158

    申请日:2003-08-21

    IPC分类号: A61K31/519 C07D487/04

    CPC分类号: C07D487/04

    摘要: There is provided a calcium receptor modulator comprising a compound of the formula (I): wherein ring A is an optionally substituted 5- to 7-membered ring; ring B is an optionally substituted 5- to 7-membered heterocyclic ring; X1 is CR1, CR1R2, N or NR13; X2 is N or NR3; Y is C, CR4 or N, Z is CR5, CR5R6, N or NR7; Ar is an optionally substituted cyclic group; R is H, an optionally substituted hydrocarbon group, etc.; and is a single bond or a double bond; R1, R2, R3, R4, R5, R6, R7 and R13 are independently H, an optionally substituted hydrocarbon group; or a salt thereof or a prodrug thereof. Compounds of the formula (II) and (III): wherein ring A is an optionally substituted 5- to 7-membered ring; Q is C, CR5 or N; R8, R9, R10, R11 and R12 are independently, H, an optionally substituted hydrocarbon group, etc., or a salt thereof are also provided. Also specify X1, R3, R1, Y and X3 in formula (II) and (III) as before.

    摘要翻译: 提供了包含式(I)化合物的钙受体调节剂:其中环A是任选取代的5-至7-元环; 环B是任选取代的5-至7-元杂环; X 1是CR 1,CR 1,R 2,N或NR 13, ; X 2是N或NR 3; Y是C,CR 4或N,Z是CR 5,CR 5,R 6,N或NR 7 ; Ar是任选取代的环状基团; R为H,任选取代的烃基等; “img id =”custom-character-00001“he =”1.78mm“wi =”2.12mm“file =”US20060079536A1-20060413-P00001.TIF“alt =”custom character“img-content =”character“img- format =“tif”/>是单键或双键; R 1,R 2,R 3,R 4,R 5, R 6,R 7和R 13独立地是H,任选取代的烃基; 或其盐或其前药。 式(II)和(III)的化合物:其中环A是任选取代的5-至7-元环; Q是C,CR 5或N; R 9,R 9,R 10,R 11和R 12都是 还可以提供H,任选取代的烃基等,或其盐。 还可以在式(II)中指定X 1,R 3,R 3,R 3,Y和X 3,和( III)。

    Bill discriminating apparatus
    22.
    发明申请
    Bill discriminating apparatus 失效
    票据识别装置

    公开(公告)号:US20050141759A1

    公开(公告)日:2005-06-30

    申请号:US10999157

    申请日:2004-11-30

    CPC分类号: G07D7/187 G07D7/164 G07D7/183

    摘要: A technology that increases bill discrimination precision, wherein a bill discriminating apparatus detects the thickness distribution of a bill P that is subject to discrimination, and by comparing this thickness distribution data and the reference thickness distribution data that shows the thickness distribution of an authentic note held in advance, performs discrimination processing that includes double feed detection, tape detection, and authenticity discrimination. Then, authenticity discrimination is performed on areas for which the difference between the thickness distribution data and the reference thickness data is within a specified range.

    摘要翻译: 一种提高纸币辨别精度的技术,其中纸币识别装置检测被鉴别的纸币P的厚度分布,并且通过比较该厚度分布数据和示出保持的真实纸币的厚度分布的参考厚度分布数据 提前执行包括双进纸检测,带检测和真实性鉴别的鉴别处理。 然后,对厚度分布数据和基准厚度数据之间的差在规定范围内的区域进行真伪判别。

    Semiconductor base material having fine dot mark
    23.
    发明授权
    Semiconductor base material having fine dot mark 失效
    具有细点标记的半导体基材

    公开(公告)号:US06437454B1

    公开(公告)日:2002-08-20

    申请号:US09687995

    申请日:2000-10-13

    IPC分类号: H01L2358

    摘要: A dot mark having at its center a peaked portion rising from a face to be marked is provided on a cut face or ground face of a semiconductor wafer with the face to be marked having surface roughness of 0.3 &mgr;m or less. The rising dot mark is 1 to 15 &mgr;m in maximum length along the face to be marked and 0.01 to 5 &mgr;m in height. With even such a fine size, the dot mark is superior in visibility. This makes it possible to provide a semiconductor base material in which all processing histories in a process for manufacturing a semiconductor wafer and a semiconductor, wafer ID, chip ID, and manufacturing number or the like can be recognized.

    摘要翻译: 在其表面粗糙度为0.3μm以下的情况下,在半导体晶片的切割面或接地面上设置有从其被标记的面上升起的峰部的点标记。 上标点在标记面上的最大长度为1〜15um,高度为0.01〜5mum。 即使是这么精细的尺寸,点标记的能见度也是优越的。 这使得可以提供其中可以识别半导体晶片和半导体的制造工艺中的所有处理历史,晶片ID,芯片ID和制造数量等的半导体基底材料。

    Benzothiepin derivatives, process for the preparation of the same and uses thereof
    24.
    发明授权
    Benzothiepin derivatives, process for the preparation of the same and uses thereof 失效
    苯并噻吩衍生物,其制备方法及其用途

    公开(公告)号:US06355672B1

    公开(公告)日:2002-03-12

    申请号:US09744857

    申请日:2001-01-30

    IPC分类号: C07D33708

    摘要: The invention provides compounds of the formula: wherein the ring A is an optionally substituted benzene ring; R1 is an optionally substituted non-aromatic heterocyclic group; R2 and R3 are independently hydrogen atom or an optionally substituted hydrocarbon group; n is an integer of 0-3; or salts thereof, which are useful as medicines having an osteogenesis promoting effect and chondrogensis promoting effect. The present invention relates to an amine compound having an excellent effect of inhibiting production and/or secretion of amyloid-b protein, a production and use thereof. Especially, it is effective for preventing and/or treating, for example, neurodegenerative diseases, amyloid angiopathy, neurological disorders caused by cerebrovascular disorders, and so forth.

    摘要翻译: 本发明提供下式的化合物:其中环A是任选取代的苯环; R1是任选取代的非芳族杂环基; R2和R3独立地为氢原子或任选取代的烃基; n为0-3的整数; 或其盐,其可用作具有成骨促进作用的药物和软骨素促进作用。本发明涉及具有抑制淀粉样蛋白b蛋白的产生和/或分泌的优异效果的胺化合物及其制备和用途。 特别地,对于预防和/或治疗例如神经变性疾病,淀粉样血管病,由脑血管障碍引起的神经障碍等是有效的。

    Camera having autofocus function independent of photographing optical system
    25.
    发明授权
    Camera having autofocus function independent of photographing optical system 失效
    相机具有独立于拍摄光学系统的自动对焦功能

    公开(公告)号:US06215959B1

    公开(公告)日:2001-04-10

    申请号:US09136291

    申请日:1998-08-19

    IPC分类号: G03B1322

    CPC分类号: G02B7/28

    摘要: A camera having an autofocus function, independent of a photographing optical system, includes a photographing optical system including synthetic resin lenses and an autofocus optical system, provided independent of the photographing optical system, having at least one synthetic resin lens and a stop decentered in a direction perpendicular to the optical axis of the synthetic resin lens. Thus, in the camera, the shift of the imaging position of the photographing optical system which is caused by an ambient temperature or humidity change is favorably corrected, and good photography can be performed.

    摘要翻译: 具有独立于拍摄光学系统的自动对焦功能的相机包括拍摄光学系统,其包括合成树脂透镜和独立于摄影光学系统的自动聚焦光学系统,其具有至少一个合成树脂透镜和偏心于 方向垂直于合成树脂透镜的光轴。 因此,在相机中,有利地校正了由环境温度或湿度变化引起的拍摄光学系统的成像位置的偏移,并且可以执行良好的拍摄。

    Laser marking system and laser marking method
    26.
    发明授权
    Laser marking system and laser marking method 失效
    激光打标系统和激光打标法

    公开(公告)号:US5821497A

    公开(公告)日:1998-10-13

    申请号:US495451

    申请日:1995-08-28

    IPC分类号: B23K26/00

    CPC分类号: B23K26/0838 B23K26/066

    摘要: A laser marking system and method with a laser oscillator generating a laser beam that is scanned in a single direction onto a mask (such as a liquid crystal) that displays sequentially a plurality of divided pattern blocks, and a second deflector that deflects the scanned laser beams onto corresponding portions of the surface of a workpiece so as to mark on the surface of the workpiece a combination of the divided pattern blocks . In another embodiment a plurality of masks and a second optical system for combining the beams from the masks can be used to create the mark. The system can be used with a conveyor and a loading and unloading unit using a controller.

    摘要翻译: PCT No.PCT / JP94 / 00069 Sec。 371日期:1995年8月28日 102(e)日期1995年8月28日PCT 1994年1月20日PCT PCT。 公开号WO94 / 16858 日期1994年8月4日激光打标系统和激光振荡器的方法,该激光振荡器产生沿单一方向扫描的激光束到顺序地显示多个划分的图案块的掩模(例如液晶),以及第二偏转器 其将扫描的激光束偏转到工件表面的相应部分上,以便在工件的表面上标记分割图案块的组合。 在另一个实施例中,可以使用多个掩模和用于组合来自掩模的光束的第二光学系统来产生标记。 该系统可以与输送机和使用控制器的装卸单元一起使用。

    Method and device for color laser marking
    27.
    发明授权
    Method and device for color laser marking 失效
    彩色激光打标的方法和装置

    公开(公告)号:US5703709A

    公开(公告)日:1997-12-30

    申请号:US652518

    申请日:1996-06-10

    摘要: The present invention provides a method and a device for color laser marking for attaining visible coloring without drastic modification of conventional devices and without using dyestuffs. To this end, in a color laser marking method, a workpiece (10) is a synthetic material made from organic and inorganic materials and, when irradiating laser light, patterns in different colors can be obtained by varying the received light intensity on the workpiece (10). In addition, in a color laser marking device, when the workpiece (10) is a synthetic material made from organic and inorganic materials, a controller (11) outputs laser irradiation intensity varying signals to at least one of laser irradiation intensity varying means, such as a laser oscillator (1).

    摘要翻译: PCT No.PCT / JP94 / 02054 Sec。 371日期1996年6月10日 102(e)1996年6月10日PCT 1994年12月7日PCT PCT。 公开号WO95 / 15833 日期:1995年6月15日本发明提供了一种用于获得可见着色的彩色激光标记的方法和装置,而没有对常规装置进行大幅度修改,而不使用染料。 为此,在彩色激光打标方法中,工件(10)是由有机和无机材料制成的合成材料,并且当照射激光时,可以通过改变工件上的接收光强度来获得不同颜色的图案( 10)。 此外,在彩色激光打标装置中,当工件(10)是由有机和无机材料制成的合成材料时,控制器(11)将激光照射强度变化信号输出到激光照射强度变化装置中的至少一个, 作为激光振荡器(1)。

    Metal particle detecting sensor, metal particle detecting method and
metal particle detecting apparatus
    28.
    发明授权
    Metal particle detecting sensor, metal particle detecting method and metal particle detecting apparatus 失效
    金属颗粒检测传感器,金属颗粒检测方法和金属颗粒检测装置

    公开(公告)号:US5596266A

    公开(公告)日:1997-01-21

    申请号:US232235

    申请日:1994-06-23

    CPC分类号: G01N15/1031 G01N33/2858

    摘要: A metal particle detecting sensor (10), having a simple structure, can perform in-line analysis for metal particles in fluid and also can precisely estimate or detect the number of metal particles for each particle size. Metal films (1) and insulating films (2) are alternately laminated one upon another, and every other metal film (1) in the laminate is connected in parallel with one another to one of two lead wires (3a, 3b) so as to form comb electrodes in the laminate of the sensor, and one end face of the laminate is immersed in a fluid (4) containing metal particles so as to detect the metal particles.

    摘要翻译: PCT No.PCT / JP92 / 01436 Sec。 371日期1994年6月23日 102(e)日期1994年6月23日PCT提交于1992年11月6日PCT公布。 第WO93 / 09425号公报 日期:1993年5月13日具有简单结构的金属颗粒检测传感器(10)可以对流体中的金属颗粒进行在线分析,并且可以精确地估计或检测每个粒度的金属颗粒的数量。 金属膜(1)和绝缘膜(2)彼此交替层叠,并且层叠体中的每隔一层的金属膜(1)彼此并联连接到两条引线(3a,3b)中的一条,以便 在传感器的叠层中形成梳电极,并且将层压体的一个端面浸入含有金属颗粒的流体(4)中以检测金属颗粒。

    Position detecting apparstus having a mean value calculating circuit
including a low pass filter
    30.
    发明授权
    Position detecting apparstus having a mean value calculating circuit including a low pass filter 失效
    具有包括低通滤波器的平均值计算电路的位置检测装置

    公开(公告)号:US5327078A

    公开(公告)日:1994-07-05

    申请号:US915850

    申请日:1992-07-29

    申请人: Akira Mori

    发明人: Akira Mori

    CPC分类号: G01D1/02 G01D5/243

    摘要: A position detecting apparatus for magnetically detecting the position of, for example, a cylinder rod of a construction or industrial machine, a piston of an automotive engine or a scaler of a magnetic scale, improved to reduce a delay of response of processing through a low-pass active filter. To this end, the apparatus has a mean value calculating circuit (22) which calculates the mean value of an output voltage from a detecting circuit (10) and delivers the mean value to a comparator circuit (32) as a reference voltage. In addition, diodes (D.sub.1, D.sub.2) for charging the capacitors (C.sub.1, C.sub.2) of the low-pass active filters constituting the mean value calculating circuit can be connected in parallel with resistors (R.sub.1, R.sub.2) of the filters.

    摘要翻译: PCT No.PCT / JP91 / 00096 Sec。 371日期:1992年7月29日 102(e)日期1992年7月29日PCT 1991年1月29日PCT PCT。 公开号WO91 / 11685 日期:1991年8月8日。一种位置检测装置,用于磁性检测例如建筑或工业机械的气缸杆,汽车发动机的活塞或磁性秤的定标器的位置,以减少延迟 通过低通有源滤波器处理的响应。 为此,该装置具有计算来自检测电路(10)的输出电压的平均值的平均值计算电路(22),并将平均值作为基准电压输出到比较电路(32)。 另外,用于对构成平均值计算电路的低通有源滤波器的电容器(C1,C2)进行充电的二极管(D1,D2)可以与滤波器的电阻器(R1,R2)并联连接。