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42 条记录 (耗时 0.038 秒)

    TIME-OF-FLIGHT MASS SPECTROMETRY OF SURFACE
    23.
    发明申请
    TIME-OF-FLIGHT MASS SPECTROMETRY OF SURFACE 有权
    表面飞行时间质谱

    公开(公告)号：US20120085898A1

    公开(公告)日：2012-04-12

    申请号：US13328091

    申请日：2011-12-16

    申请人： Thomas F. Egan ,  J. Albert Schultz ,  Steven R. Ulrich ,  Kelley L. Waters

    发明人： Thomas F. Egan ,  J. Albert Schultz ,  Steven R. Ulrich ,  Kelley L. Waters

    IPC分类号： H01J49/40 ,  H05H3/02 ,  H01J47/00 ,  H01J37/26

    CPC分类号： H01J49/40 ,  G01N23/203 ,  G01N23/2206 ,  G01N23/2255

    摘要： The present invent provides a particle detector for counting and measuring the flight time of secondary electrons and scattered ions and neutrals and to correlate coincidences between these and backscattered ions/and neutrals while maintaining a continuous unpulsed microfocused primary ion beam for impinging a surface. Intensities of the primary particle scattering and secondary particle emissions are correlated with the position of impact of the focused beam onto a materials surface so that a spatially resolved surface elemental and electronic structural mapping is obtained by scanning the focused beam across the surface.

    摘要翻译： 本发明提供了一种用于计数和测量二次电子和散射离子和中性粒子的飞行时间的粒子检测器，并且使这些和背散射离子和中性粒子之间的一致性相关联，同时保持用于冲击表面的连续的未脉冲的聚焦的初始离子束。 初级粒子散射和二次粒子发射的强度与聚焦光束在材料表面上的冲击位置相关，从而通过扫描聚焦束穿过表面获得空间分辨的表面元素和电子结构映射。

    Time-of-flight mass spectrometry of surfaces
    25.
    发明授权
    Time-of-flight mass spectrometry of surfaces 有权
    飞行时间质谱的表面

    公开(公告)号：US08519329B2

    公开(公告)日：2013-08-27

    申请号：US13328091

    申请日：2011-12-16

    申请人： J. Albert Schultz ,  Thomas F. Egan ,  Steven R. Ulrich ,  Kelley L. Waters

    发明人： J. Albert Schultz ,  Thomas F. Egan ,  Steven R. Ulrich ,  Kelley L. Waters

    IPC分类号： H01J49/40

    CPC分类号： H01J49/40 ,  G01N23/203 ,  G01N23/2206 ,  G01N23/2255

    摘要： The present invent provides a particle detector for counting and measuring the flight time of secondary electrons and scattered ions and neutrals and to correlate coincidences between these and backscattered ions/and neutrals while maintaining a continuous unpulsed microfocused primary ion beam for impinging a surface. Intensities of the primary particle scattering and secondary particle emissions are correlated with the position of impact of the focused beam onto a materials surface so that a spatially resolved surface elemental and electronic structural mapping is obtained by scanning the focused beam across the surface.

    摘要翻译： 本发明提供了一种用于计数和测量二次电子和散射离子和中性粒子的飞行时间的粒子检测器，并且使这些和背散射离子和中性粒子之间的一致性相关联，同时保持用于冲击表面的连续的未脉冲的聚焦的初始离子束。 初级粒子散射和二次粒子发射的强度与聚焦光束在材料表面上的冲击位置相关，从而通过扫描聚焦束穿过表面获得空间分辨的表面元素和电子结构映射。

    Post-ionization of neutrals for ion mobility oTOFMS identification of molecules and elements desorbed from surfaces
    26.
    发明授权
    Post-ionization of neutrals for ion mobility oTOFMS identification of molecules and elements desorbed from surfaces 有权
    用于离子迁移的中性粒子的离子化oTOFMS鉴定从表面解吸的分子和元素

    公开(公告)号：US08384023B2

    公开(公告)日：2013-02-26

    申请号：US12692604

    申请日：2010-01-23

    申请人： J. Albert Schultz ,  Thomas F. Egan ,  Kelley L. Waters ,  Ernest K. Lewis

    发明人： J. Albert Schultz ,  Thomas F. Egan ,  Kelley L. Waters ,  Ernest K. Lewis

    IPC分类号： H01J49/00

    CPC分类号： H01J49/40 ,  G01N27/622 ,  H01J49/0027 ,  H01J49/0045 ,  H01J49/107

    摘要： The present invention relates to a method and apparatus for ionizing a neutral MALDI desorption plume, and in particular, for efficiently measuring the ionized MALDI desorption plume when post-ionization techniques are combined with a medium pressure MALDI-IM-oTOFMS instrument. Additionally, the present disclosure provides a method and apparatus that simultaneously separates tissue-sample MALDI ions by IM-oTOFMS according to their chemical family. After separation, the MALDI ions are directly compared to the ions created by post-ionizing the co-desorbed neutral molecules with a second laser wherein the second laser is delayed by a few hundred microseconds. The present disclosure further provides novel approaches that enhance the analysis of ions, including the use of giant fullerene internal standards to enhance mass accuracy, and ultraviolet (UV) declustering lasers to generate intact peptides and proteins, either of which may be followed by VUV post-ionization which generates identifiable structural fragments.

    摘要翻译： 本发明涉及一种用于离子化中性MALDI解吸羽流的方法和装置，特别是当电离后技术与中压MALDI-IM-OTOFMS仪器结合时，用于有效测量电离的MALDI解吸羽流。 此外，本公开提供了一种方法和装置，其通过IM-oTOFMS根据其化学族同时分离组织样品MALDI离子。 分离后，将MALDI离子直接与通过用第二激光离子化共解吸的中性分子产生的离子进行比较，其中第二激光器延迟几百微秒。 本公开进一步提供了增强离子分析的新方法，包括使用巨富勒烯内标来提高质量精度，以及紫外（UV）去聚簇激光以产生完整的肽和蛋白质，其中之一可以是VUV柱 产生可识别的结构碎片。

    POST-IONIZATION OF NEUTRALS FOR ION MOBILITY OTOFMS IDENTIFICATION OF MOLECULES AND ELEMENTS DESORBED FROM SURFACES
    28.
    发明申请
    POST-IONIZATION OF NEUTRALS FOR ION MOBILITY OTOFMS IDENTIFICATION OF MOLECULES AND ELEMENTS DESORBED FROM SURFACES 有权
    离子移动物质中和离子的离子化鉴定从表面脱落的分子和元素

    公开(公告)号：US20100200742A1

    公开(公告)日：2010-08-12

    申请号：US12692604

    申请日：2010-01-23

    申请人： J. Albert Schultz ,  Thomas F. Egan ,  Kelley L. Waters ,  Ernest K. Lewis

    发明人： J. Albert Schultz ,  Thomas F. Egan ,  Kelley L. Waters ,  Ernest K. Lewis

    IPC分类号： H01J49/40 ,  H01J49/04 ,  G12B13/00

    CPC分类号： H01J49/40 ,  G01N27/622 ,  H01J49/0027 ,  H01J49/0045 ,  H01J49/107

    摘要： The present invention relates to a method and apparatus for ionizing a neutral MALDI desorption plume, and in particular, for efficiently measuring the ionized MALDI desorption plume when post-ionization techniques are combined with a medium pressure MALDI-IM-oTOFMS instrument. Additionally, the present disclosure provides a method and apparatus that simultaneously separates tissue-sample MALDI ions by IM-oTOFMS according to their chemical family. After separation, the MALDI ions are directly compared to the ions created by post-ionizing the co-desorbed neutral molecules with a second laser wherein the second laser is delayed by a few hundred microseconds. The present disclosure further provides novel approaches that enhance the analysis of ions, including the use of giant fullerene internal standards to enhance mass accuracy, and ultraviolet (UV) declustering lasers to generate intact peptides and proteins, either of which may be followed by VUV post-ionization which generates identifiable structural fragments.

    摘要翻译： 本发明涉及一种用于离子化中性MALDI解吸羽流的方法和装置，特别是当电离后技术与中压MALDI-IM-OTOFMS仪器结合时，用于有效测量电离的MALDI解吸羽流。 此外，本公开提供了一种方法和装置，其通过IM-oTOFMS根据其化学族同时分离组织样品MALDI离子。 分离后，将MALDI离子直接与通过用第二激光离子化共解吸的中性分子产生的离子进行比较，其中第二激光器延迟几百微秒。 本公开进一步提供了增强离子分析的新方法，包括使用巨富勒烯内标来提高质量精度，以及紫外（UV）去聚簇激光以产生完整的肽和蛋白质，其中之一可以是VUV柱 产生可识别的结构碎片。