公开(公告)号：US07589184B2

公开(公告)日：2009-09-15

申请号：US11137806

申请日：2005-05-24

Applicant: Michael Hogan ,  James C. Davis

Inventor： Michael Hogan ,  James C. Davis

IPC: C07K14/00 ,  G01N1/00

CPC classification number: A01N1/0263 ,  A61K38/02 ,  C07K1/042 ,  C07K1/047 ,  C07K17/00 ,  C07K17/08 ,  C12N15/1006 ,  G01N33/543 ,  G01N33/68 ,  G01N33/6842 ,  Y10T436/2525

Abstract: The invention provides compositions and methods for storage of biomolecules. The biomolecules are stored via absorption to a substrate. Absorbed biomolecules can be eluted or recovered from the substrate at a future time, and optionally be subjected to a subsequent analysis or application. Biomolecules absorbed to a substrate for storage may also optionally be preserved, i.e., the absorbed biomolecule is resistant to or resists degradation.

Abstract translation: 本发明提供用于储存生物分子的组合物和方法。 通过吸收将生物分子储存到底物中。 吸收的生物分子可以在将来的时间从底物洗脱或回收，并且任选地进行随后的分析或应用。 吸收到用于储存的底物的生物分子也可以任选地被保留，即，所吸收的生物分子对抗或抵抗降解。

公开(公告)号：US5853884A

公开(公告)日：1998-12-29

申请号：US825165

申请日：1997-03-26

Applicant: Randall W. Nichols ,  James C. Davis

Inventor： Randall W. Nichols ,  James C. Davis

IPC: A61M16/10 ,  A61M16/14 ,  B01D63/02 ,  D01D5/24 ,  D06M11/155 ,  D06M13/148 ,  D06M15/333 ,  D06M15/356 ,  D02G3/00 ,  A62B18/08 ,  B29C65/00

CPC classification number: D06M11/155 ,  A61M16/145 ,  B01D63/021 ,  D01D5/24 ,  D06M13/148 ,  D06M15/333 ,  D06M15/3562 ,  A61M16/1045 ,  Y10T428/2913 ,  Y10T428/2933 ,  Y10T428/2935 ,  Y10T428/2975

Abstract: A method for forming a hollow fiber bundle unit for insertion into an assisted breathing device comprising spinning a hollow fiber or hollow fibers, collecting multiple fibers into a bundle, filling the walls of the hollow fibers within the hollow fiber bundle with an humectant, coating the hollow fibers containing the humectant with a solution of an adhesive material, forming and drying the hollow fiber bundle coated with the solution, and preparing the hollow fiber bundle coated with the solution for insertion into the assisted breathing device.

Abstract translation: 一种用于形成用于插入辅助呼吸装置的中空纤维束单元的方法，包括纺丝中空纤维或中空纤维，将多根纤维收集成束，用保湿剂填充中空纤维束内的中空纤维的壁， 用粘合剂材料的溶液含有保湿剂的中空纤维，形成和干燥涂布有溶液的中空纤维束，以及制备涂有溶液以插入辅助呼吸装置的中空纤维束。

公开(公告)号：US5006287A

公开(公告)日：1991-04-09

申请号：US478392

申请日：1990-02-12

Applicant: James C. Davis

Inventor： James C. Davis

IPC: B01D67/00 ,  B01D69/14 ,  B01D71/82 ,  B01J20/28 ,  C07K14/765 ,  C12N9/16 ,  G01N33/545

CPC classification number: B01D67/0093 ,  B01D67/0011 ,  B01D69/141 ,  B01D71/76 ,  B01D71/82 ,  B01J20/28033 ,  C07K14/765 ,  C12N9/16 ,  G01N33/545 ,  B01D2323/08 ,  B01D2323/12 ,  B01D71/52 ,  Y10S264/48 ,  Y10S264/62

Abstract: Polymeric affinity membranes comprise a precursor filtration membrane and a plurality of reaction sites provided on the surface of the membrane selective to binding a specific biological material. A process for the preparation of such affinity membranes includes the steps of providing a copolymer compatible with a water insoluble polymer matrix and having a plurality of hydroxyl groups, activating the hydroxyl groups with a compound selected from the group consisting of organic compounds reactive with a hydroxyl group in the presence of a water miscible solvent to provide a derivatized copolymer containing active adducts, forming a solution of the derivatized copolymer and the polymer matrix to form a polymer blend solution, casting the polymer blend solution and, quenching the cast polymer blend solution in water. A process for selectively removing biological materials from fluids includes the step of passing the fluids over an affinity membrane which comprises a precursor filtration membrane and a plurality of reaction sites provided on the surface of the membrane selective to binding a specific biological material.

Abstract translation: 聚合亲和膜包括前体过滤膜和在膜的表面上提供选择性地结合特定生物材料的多个反应位点。 制备这种亲和膜的方法包括以下步骤：提供与水不溶性聚合物基质相容并且具有多个羟基的共聚物，用选自与羟基反应的有机化合物的化合物活化羟基 在存在水混溶性溶剂的情况下提供含有活性加合物的衍生化共聚物，形成衍生化共聚物和聚合物基质的溶液以形成聚合物共混物溶液，浇铸聚合物共混物溶液，并将铸塑聚合物共混物溶液淬火 水。 用于从流体中选择性地除去生物材料的方法包括使流体通过亲和膜的步骤，所述亲和膜包含前体过滤膜和在膜的表面上提供选择性地结合特定生物材料的多个反应位点。

公开(公告)号：US5006256A

公开(公告)日：1991-04-09

申请号：US565085

申请日：1990-08-10

Applicant: James C. Davis

Inventor： James C. Davis

IPC: B01D67/00 ,  B01D69/14 ,  B01D71/82 ,  B01J20/28 ,  C07K14/765 ,  C12N9/16 ,  G01N33/545

CPC classification number: B01D67/0093 ,  B01D67/0011 ,  B01D69/141 ,  B01D71/82 ,  B01J20/28033 ,  C07K14/765 ,  C12N9/16 ,  G01N33/545 ,  B01D2323/12 ,  B01D2323/36

Abstract: A process for selectively removing biological materials from fluids includes the step of passing the fluids over an affinity membrane which comprises a precursor filtration membrane and a plurality of reaction sites provided on the surface of the membrane selective to binding a specific biological material.

Abstract translation: 用于从流体中选择性地除去生物材料的方法包括使流体通过亲和膜的步骤，所述亲和膜包含前体过滤膜和在膜的表面上提供选择性地结合特定生物材料的多个反应位点。

公开(公告)号：US4857159A

公开(公告)日：1989-08-15

申请号：US30209

申请日：1987-03-25

Applicant: James C. Davis ,  Michael F. McGuiggan ,  Edward A. Cuellar ,  Frederick W. Haas

Inventor： James C. Davis ,  Michael F. McGuiggan ,  Edward A. Cuellar ,  Frederick W. Haas

IPC: C25C1/00 ,  C25C1/12 ,  C25C1/14

CPC classification number: C25C1/00 ,  C25C1/12 ,  C25C1/14 ,  Y02P10/212

Abstract: The process of the present invention for the recovery of metal ions from a polymeric chelating agent stream or solution comprises the circulation of a loaded polymeric chelating agent stream or solution through an electrolytic recovery cell. The chelating agent is loaded with metal ions or complexes of the species to be recovered which have been extracted from a feed stream or solution. These metal ions or complexes will be reduced and recovered from the chelating polymer by an electrodeposition method. If the chelating agent is used in a continuous flow-type system, the lean polymeric chelating agent can optionally be recycled for further use in extraction of the desired metal species. The addition of scrub and regeneration stages to such a system is optional, depending on feed stream composition.

Abstract translation: 从聚合物螯合剂流或溶液中回收金属离子的本发明的方法包括负载的聚合物螯合剂流或溶液通过电解回收池的循环。 螯合剂装载有从进料流或溶液中提取的待回收物质的金属离子或络合物。 这些金属离子或络合物将通过电沉积方法从螯合聚合物中还原并回收。 如果螯合剂用于连续流动型系统中，则可以将稀的聚合物螯合剂任选地再循环用于进一步用于提取所需的金属物质。 洗涤和再生阶段添加到这种系统是任选的，这取决于进料流组成。

公开(公告)号：US4661629A

公开(公告)日：1987-04-28

申请号：US803754

申请日：1985-12-02

Applicant: Ronald J. Valus ,  James C. Davis

Inventor： Ronald J. Valus ,  James C. Davis

IPC: C07C99/12

CPC classification number: C07C227/40

Abstract: Separating phenylalanine from its admixture with phenylalanine ethyl ester by preferential permeation through a sulfonated polystyrene cation exchange resin membrane.

Abstract translation: 通过优先渗透通过磺化聚苯乙烯阳离子交换树脂膜将苯丙氨酸与苯丙氨酸乙酯的混合物分离。

公开(公告)号：USD665143S1

公开(公告)日：2012-08-07

申请号：US29382011

申请日：2010-12-28

Applicant: James C. Davis

Designer： James C. Davis

公开(公告)号：US07915916B2

公开(公告)日：2011-03-29

申请号：US11421614

申请日：2006-06-01

Applicant: William J. Wilcox ,  James C. Davis ,  Dwayne K. Kreipl ,  Michael B. Pearson

Inventor： William J. Wilcox ,  James C. Davis ,  Dwayne K. Kreipl ,  Michael B. Pearson

IPC: G06F7/38 ,  H03K19/173 ,  H03K19/094 ,  G11C17/00 ,  G11C17/18

CPC classification number: H03K19/17748 ,  H03K19/1776 ,  H03K19/1778

Abstract: An antifuse circuit includes a terminal, an antifuse, and a select transistor. The antifuse is coupled to the terminal and has an associated program voltage. The select transistor is coupled to the antifuse and has a gate terminal coupled to receive a first select signal. The select transistor operates in a snapback mode of operation in response to an assertion of the first select signal and the program voltage at the terminal.

Abstract translation: 反熔丝电路包括端子，反熔丝和选择晶体管。 反熔丝耦合到终端并具有相关的编程电压。 选择晶体管耦合到反熔丝，并且具有耦合以接收第一选择信号的栅极端子。 响应于终端处的第一选择信号和程序电压的断言，选择晶体管工作在快速恢复操作模式。

公开(公告)号：US20090043087A1

公开(公告)日：2009-02-12

申请号：US12075700

申请日：2008-03-12

Applicant: James C. Davis ,  Martin A. Smith ,  Frank D. Igoe ,  Marcela A. Vera-Garcia

Inventor： James C. Davis ,  Martin A. Smith ,  Frank D. Igoe ,  Marcela A. Vera-Garcia

IPC: C07H21/00 ,  C12M1/12

CPC classification number: C12N15/1017

Abstract: This invention relates to methods for rapid nucleic acid purification from sources heavily contaminated with high particulate material, such as cellular debris, and solids, including suspended solids. In particular, this invention provides methods for rapid, quantifiable recovery and purification of nucleic acids from a variety of sources heavily contaminated with solids, such as small organisms, tissue samples, samples of blood found on soil, or samples of washing from foods, which are frequently difficult sources for nucleic acid isolation due to their propensity to clog filters and columns. A device and kit are also provided.

Abstract translation: 本发明涉及从高度颗粒物质如细胞碎片和固体（包括悬浮固体）严重污染​​的来源快速核酸纯化的方法。 特别地，本发明提供了用于快速，可量化回收和纯化来自严重被固体污染的各种来源的核酸的方法，例如小生物，组织样品，在土壤上发现的血液样品或从食物中洗涤的样品， 由于其阻塞过滤器和色谱柱的倾向，核酸分离常常是困难的来源。 还提供了一个设备和套件。

公开(公告)号：US06881543B2

公开(公告)日：2005-04-19

申请号：US09993736

申请日：2001-11-14

Applicant: Richard Philpott ,  Martin A. Smith ,  Frank D. Igoe ,  James C. Davis

Inventor： Richard Philpott ,  Martin A. Smith ,  Frank D. Igoe ,  James C. Davis

IPC: C12N15/10 ,  C12Q1/68 ,  C07H21/04

CPC classification number: C12N15/1017 ,  C12Q1/6806 ,  Y10S977/924

Abstract: The invention relates to methods, a kit, and an apparatus for detecting and analyzing genetic material from a biological sample. The method can be used to analyze samples from a wide variety of sources, including tissues, blood, plasma, sera, mucus, urine, saliva, sweat, semen, and cultures, as well as analyzing samples of contaminated water, food, beverages, and other items.

Abstract translation: 本发明涉及用于从生物样品中检测和分析遗传物质的方法，试剂盒和装置。 该方法可用于分析各种来源的样品，包括组织，血液，血浆，血清，粘液，尿液，唾液，汗液，精液和培养物，以及分析污染水，食品，饮料， 和其他项目。