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公开(公告)号：US07378489B1
公开(公告)日：2008-05-27
申请号：US09470997
申请日：1999-12-23
IPC分类号： C07K7/14
CPC分类号： C07K7/14
摘要： An angiotensin derivative comprising at least one angiotensin peptide moiety coupled to a peptide carrier-binding moiety which can be used for therapy and prophylaxis of conditions associated with the renin activated angiotensin system.
摘要翻译： 包含与肽载体结合部分偶联的至少一种血管紧张素肽部分的血管紧张素衍生物，其可用于治疗和预防与肾素活化的血管紧张素系统相关的病症。
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公开(公告)号：US07351822B2
公开(公告)日：2008-04-01
申请号：US10803157
申请日：2004-03-18
申请人： John Walter Liebeschuetz , Christopher William Murray , Stephen Clinton Young , Nicholas Paul Camp , Stuart Donald Jones , William Alexander Wylie , John Joseph Masters , Michael Robert Wiley , Scott Martin Sheehan , David Birenbaum Engel , Brian Morgan Watson , Peter Robert Guzzo , Michael John Mayer
发明人： John Walter Liebeschuetz , Christopher William Murray , Stephen Clinton Young , Nicholas Paul Camp , Stuart Donald Jones , William Alexander Wylie , John Joseph Masters , Michael Robert Wiley , Scott Martin Sheehan , David Birenbaum Engel , Brian Morgan Watson , Peter Robert Guzzo , Michael John Mayer
IPC分类号： C07D401/12 , C07D401/14 , A61K31/496
CPC分类号： C07D295/185 , C07D207/12 , C07D207/14 , C07D211/26 , C07D211/46 , C07D213/36 , C07D213/56 , C07D231/12 , C07D233/56 , C07D249/08 , C07D309/34 , C07D335/02 , C07D401/12 , C07D401/14 , C07D403/12 , C07D409/12 , C07D417/12 , C07D417/14
摘要： Compounds of formula (I) in which R2, X, Y, Cy, L and Lp(D)n have the meanings given in the specification, are inhibitors of the serine protease, Factor Xa and are useful in the treatment of cardiovascular disorders.
摘要翻译： 其中R 2，X，Y，Cy，L和Lp（D）n N具有本说明书中给出的含义的式（I）化合物是 丝氨酸蛋白酶，因子Xa，可用于治疗心血管疾病。
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公开(公告)号：US07294627B2
公开(公告)日：2007-11-13
申请号：US10496018
申请日：2002-12-09
申请人： Steven Douglas Hiscock , Stuart Donald Jones , Daniel Jon Sall , Stephen Clinton Young , Michael Robert Wiley
发明人： Steven Douglas Hiscock , Stuart Donald Jones , Daniel Jon Sall , Stephen Clinton Young , Michael Robert Wiley
IPC分类号： A61K31/501 , A61K31/506 , A61K31/4545 , C07D401/14 , C07D401/12
CPC分类号： C07D401/12 , C07D401/14
摘要： Compounds of formula (I) in which R1, R2, R3 and R4, have the meanings given in the specification are Factor Xa inhibitors useful in the treatment of thrombotic disorders.
摘要翻译： 其中R 1，R 2，R 3和R 4的式（I）化合物具有 说明书中给出的含义是可用于治疗血栓形成障碍的因子Xa抑制剂。
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公开(公告)号：US07053078B2
公开(公告)日：2006-05-30
申请号：US10030188
申请日：2001-06-12
申请人： John Walter Liebeschuetz , Christopher William Murray , Stephen Clinton Young , Nicholas Paul Camp , Stuart Donald Jones , William Alexander Wylie , John Joseph Masters , Michael Robert Wiley , Scott Martin Sheehan , David Birenbaum Engel , Brian Morgan Watson
发明人： John Walter Liebeschuetz , Christopher William Murray , Stephen Clinton Young , Nicholas Paul Camp , Stuart Donald Jones , William Alexander Wylie , John Joseph Masters , Michael Robert Wiley , Scott Martin Sheehan , David Birenbaum Engel , Brian Morgan Watson
IPC分类号： A61K31/33 , A61K31/445 , C07D211/00 , C07D401/00 , C07D209/04
CPC分类号： C07D401/04 , C07D207/12 , C07D211/26 , C07D211/46 , C07D211/58 , C07D211/62 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/12 , C07D409/14 , C07D417/14
摘要： Compounds of formula (I) in which R2, X, Y, Cy, L and Lp(D)n have the meanings given in the specification, are inhibitors of the serine protease, Factor Xa and are useful in the treatment of cardiovascular disorders.
摘要翻译： 其中R 2，X，Y，Cy，L和Lp（D）n N具有本说明书中给出的含义的式（I）化合物是 丝氨酸蛋白酶，因子Xa，可用于治疗心血管疾病。
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公开(公告)号：US07220781B2
公开(公告)日：2007-05-22
申请号：US10752568
申请日：2004-01-08
申请人： John Walter Liebeschuetz , William Alexander Wylie , Bohdan Waszkowycz , Christopher William Murray , Andrew David Rimmer , Pauline Mary Welsh , Stuart Donald Jones , Jonathan Michael Ernest Roscoe , Stephen Clinton Young , Phillip John Morgan
发明人： John Walter Liebeschuetz , William Alexander Wylie , Bohdan Waszkowycz , Christopher William Murray , Andrew David Rimmer , Pauline Mary Welsh , Stuart Donald Jones , Jonathan Michael Ernest Roscoe , Stephen Clinton Young , Phillip John Morgan
IPC分类号： A01N37/52
CPC分类号： C07K5/0207 , A61K38/00 , C07C237/36 , C07C255/60 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07C2602/42 , C07D209/08 , C07D209/30 , C07D209/34 , C07D209/42 , C07D211/26 , C07D211/34 , C07D211/46 , C07D211/60 , C07D213/53 , C07D213/74 , C07D213/82 , C07D215/38 , C07D217/04 , C07D217/06 , C07D217/22 , C07D217/24 , C07D231/56 , C07D235/06 , C07D241/24 , C07D277/28 , C07D277/46 , C07D277/64 , C07D277/82 , C07D295/135 , C07D295/185 , C07D317/68 , C07D333/38 , C07D333/68 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/06 , C07D487/04
摘要： Compounds of formula I in which R1, R2, R3, each X, L, Y, Cy, Lp, D and n have the meanings as set out in the specification, and corresponding compounds in which the unsubstituted or substituted amidine group is replaced with an unsubstituted or substituted aminomethyl group, are useful as serine protease inhibitors.
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公开(公告)号：US06936611B2
公开(公告)日：2005-08-30
申请号：US10754923
申请日：2004-01-12
申请人： John Walter Liebeschuetz , Christopher William Murray , Stephen Clinton Young , Nicholas Paul Camp , Stuart Donald Jones , William Alexander Wylie , John Joseph Masters , Michael Robert Wiley , Scott Martin Sheehan , David Birenbaum Engel , Brian Morgan Watson , Peter Robert Guzzo , Michael John Mayer
发明人： John Walter Liebeschuetz , Christopher William Murray , Stephen Clinton Young , Nicholas Paul Camp , Stuart Donald Jones , William Alexander Wylie , John Joseph Masters , Michael Robert Wiley , Scott Martin Sheehan , David Birenbaum Engel , Brian Morgan Watson , Peter Robert Guzzo , Michael John Mayer
IPC分类号： C07D295/16 , A61K31/395 , A61K31/445 , A61K31/495 , A61K31/496 , A61K31/497 , A61K31/501 , A61P1/16 , A61P7/02 , A61P9/00 , A61P9/10 , A61P11/00 , A61P11/06 , A61P17/02 , A61P19/02 , A61P29/00 , A61P35/00 , A61P43/00 , C07D207/12 , C07D207/14 , C07D211/26 , C07D211/46 , C07D211/58 , C07D213/36 , C07D213/38 , C07D213/56 , C07D213/74 , C07D231/56 , C07D277/64 , C07D295/18 , C07D295/185 , C07D309/14 , C07D309/32 , C07D309/34 , C07D335/02 , C07D401/12 , C07D401/14 , C07D403/12 , C07D409/12 , C07D417/12 , C07D417/14 , C07D521/00
CPC分类号： C07D295/185 , C07D207/12 , C07D207/14 , C07D211/26 , C07D211/46 , C07D213/36 , C07D213/56 , C07D231/12 , C07D233/56 , C07D249/08 , C07D309/34 , C07D335/02 , C07D401/12 , C07D401/14 , C07D403/12 , C07D409/12 , C07D417/12 , C07D417/14
摘要： Compounds of formula (I) in which R2, X, Y, Cy, L and Lp(D)n have the meanings given in the specification, are inhibitors of the serine protease, Factor Xa and are useful in the treatment of cardiovascular disorders.
摘要翻译： 其中R 2，X，Y，Cy，L和Lp（D）n N具有本说明书中给出的含义的式（I）化合物是 丝氨酸蛋白酶，因子Xa，可用于治疗心血管疾病。
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公开(公告)号：US06900196B2
公开(公告)日：2005-05-31
申请号：US10883715
申请日：2004-07-06
申请人： John Walter Liebeschuetz , Christopher William Murray , Stephen Clinton Young , Nicholas Paul Camp , Stuart Donald Jones , William Alexander Wylie , John Joseph Masters , Michael Robert Wiley , Scott Martin Sheehan , David Birenbaum Engel , Brian Morgan Watson
发明人： John Walter Liebeschuetz , Christopher William Murray , Stephen Clinton Young , Nicholas Paul Camp , Stuart Donald Jones , William Alexander Wylie , John Joseph Masters , Michael Robert Wiley , Scott Martin Sheehan , David Birenbaum Engel , Brian Morgan Watson
IPC分类号： C07D207/12 , C07D211/26 , C07D211/46 , C07D211/58 , C07D211/62 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/12 , C07D409/14 , C07D417/14 , A61K31/33 , A61K31/445 , C07D209/04 , C07D211/00 , C07D401/00
CPC分类号： C07D401/04 , C07D207/12 , C07D211/26 , C07D211/46 , C07D211/58 , C07D211/62 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/12 , C07D409/14 , C07D417/14
摘要： Compounds of formula (I) in which R2, X, Y, Cy, L and Lp(D)n have the meanings given in the specification, are inhibitors of the serine protease, Factor Xa and are useful in the treatment of cardiovascular disorders.
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公开(公告)号：US07928137B2
公开(公告)日：2011-04-19
申请号：US11712906
申请日：2007-03-02
申请人： John Walter Liebeschuetz , William Alexander Wylie , Bohdan Waszkowycz , Christopher William Murray , Andrew David Rimmer , Pauline Mary Welsh , Stuart Donald Jones , Jonathan Michael Ernest Roscoe , Stephen Clinton Young , Phillip John Morgan
发明人： John Walter Liebeschuetz , William Alexander Wylie , Bohdan Waszkowycz , Christopher William Murray , Andrew David Rimmer , Pauline Mary Welsh , Stuart Donald Jones , Jonathan Michael Ernest Roscoe , Stephen Clinton Young , Phillip John Morgan
IPC分类号： A61K31/404 , C07D333/10
CPC分类号： C07K5/0207 , A61K38/00 , C07C237/36 , C07C255/60 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07C2602/42 , C07D209/08 , C07D209/30 , C07D209/34 , C07D209/42 , C07D211/26 , C07D211/34 , C07D211/46 , C07D211/60 , C07D213/53 , C07D213/74 , C07D213/82 , C07D215/38 , C07D217/04 , C07D217/06 , C07D217/22 , C07D217/24 , C07D231/56 , C07D235/06 , C07D241/24 , C07D277/28 , C07D277/46 , C07D277/64 , C07D277/82 , C07D295/135 , C07D295/185 , C07D317/68 , C07D333/38 , C07D333/68 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/06 , C07D487/04
摘要： Compounds of formula I in which R1, R2, R3, each X, L, Y, Cy, Lp, D and n have the meanings as set out in the specification, and corresponding compounds in which the unsubstituted or substituted amidine group is replaced with an unsubstituted or substituted aminomethyl group, are useful as serine protease inhibitors.
摘要翻译： 其中R 1，R 2，R 3，各X，L，Y，Cy，Lp，D和n具有本说明书中所述的含义的式Ⅰ化合物，其中未取代或取代的脒基被替换为 未取代或取代的氨基甲基可用作丝氨酸蛋白酶抑制剂。
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公开(公告)号：US20090105150A1
公开(公告)日：2009-04-23
申请号：US12150101
申请日：2008-04-24
IPC分类号： A61K38/10 , A61K38/08 , C07K7/14 , C07H21/00 , C12N15/63 , C12N5/00 , A61K31/7052 , A61P37/00
CPC分类号： C07K7/14 , A61K38/00 , A61K39/00 , A61K47/62 , C07K2319/00
摘要： An angiotensin derivative comprising at least one angiotensin peptide moiety coupled to a peptide carrier-binding moiety which can be used for therapy and prophylaxis of conditions associated with the renin activated angiotensin system.
摘要翻译： 包含与肽载体结合部分偶联的至少一种血管紧张素肽部分的血管紧张素衍生物，其可用于治疗和预防与肾素活化的血管紧张素系统相关的病症。
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公开(公告)号：US06878725B2
公开(公告)日：2005-04-12
申请号：US10030189
申请日：2001-06-12
申请人： John Walter Liebeschuetz , Christopher William Murray , Stephen Clinton Young , Nicholas Paul Camp , Stuart Donald Jones , William Alexander Wylie , John Joseph Masters , Michael Robert Wiley , Scott Martin Sheehan , David Birenbaum Engel , Brian Morgan Watson
发明人： John Walter Liebeschuetz , Christopher William Murray , Stephen Clinton Young , Nicholas Paul Camp , Stuart Donald Jones , William Alexander Wylie , John Joseph Masters , Michael Robert Wiley , Scott Martin Sheehan , David Birenbaum Engel , Brian Morgan Watson
IPC分类号： A61K31/40 , A61K31/4439 , A61K31/445 , A61K31/4545 , A61K31/4709 , A61P1/16 , A61P7/02 , A61P9/02 , A61P9/10 , A61P11/00 , A61P11/06 , A61P17/00 , A61P17/02 , A61P19/02 , A61P29/00 , A61P35/00 , A61P43/00 , C07D207/12 , C07D211/46 , C07D401/12 , C07D401/14 , C07D417/14
CPC分类号： C07D401/14 , C07D207/12 , C07D211/46 , C07D401/12 , C07D417/14
摘要： Compounds of formula (I) in which R2, X, Y, Cy, L and Lp(D)n have the meanings given in the specification, are inhibitors of the serine protease, Factor Xa and are useful in the treatment of cardiovascular disorders.
摘要翻译： 其中R2，X，Y，Cy，L和Lp（D）n具有本说明书中给出的含义的式（I）化合物是丝氨酸蛋白酶因子Xa的抑制剂，可用于治疗心血管疾病。
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