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公开(公告)号：US08053456B2
公开(公告)日：2011-11-08
申请号：US11807327
申请日：2007-05-25
申请人： Lijun Sun , Weiwen Ying , Junghyun Chae , Teresa Przewloka , Shijie Zhang , Dinesh U. Chimmanamada , Kevin Foley , Zhenjian Du , Hao Li , David James , Howard P. Ng , Zachary Demko , Dan Zhou , Shuzhen Qin
发明人： Lijun Sun , Weiwen Ying , Junghyun Chae , Teresa Przewloka , Shijie Zhang , Dinesh U. Chimmanamada , Kevin Foley , Zhenjian Du , Hao Li , David James , Howard P. Ng , Zachary Demko , Dan Zhou , Shuzhen Qin
IPC分类号： A61K31/4196 , C07D249/12
CPC分类号： C07D403/04 , A61K31/4196 , A61K31/422 , A61K31/4439 , A61K31/475 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D249/12 , C07D401/04 , C07D401/14 , C07D403/12 , C07D405/04 , C07D405/14 , C07D413/14 , C07D487/04
摘要： The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.
摘要翻译： 本发明涉及取代的三唑化合物和包含取代的三唑化合物的组合物。 本发明还涉及在有需要的受试者中抑制Hsp90的活性的方法和在有需要的受试者中预防或治疗过度增殖性疾病如癌症的方法，其包括向受试者施用本发明的取代的三唑化合物， 或包含这种化合物的组合物。
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公开(公告)号：US20110009397A1
公开(公告)日：2011-01-13
申请号：US12604970
申请日：2009-10-23
申请人： Weiwen Ying , David James , Shijie Zhang , Teresa Przewloka , Junghyun Chae , Dinesh U. Chimmanamada , Chi-Wan Lee , Elena Kostik , Howard P. Ng , Kevin Foley , Zhenjian Du , James Barsoum
发明人： Weiwen Ying , David James , Shijie Zhang , Teresa Przewloka , Junghyun Chae , Dinesh U. Chimmanamada , Chi-Wan Lee , Elena Kostik , Howard P. Ng , Kevin Foley , Zhenjian Du , James Barsoum
IPC分类号： A61K31/4196 , A61K31/4709 , A61K31/4439 , A61K31/4725 , A61K31/5377 , A61K31/538 , C12N5/00
CPC分类号： C07D249/08 , A61K31/4196 , C07D249/12 , C07D401/04 , C07D403/04 , C07D403/10 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04 , C07D473/00 , C07D473/34
摘要： The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.
摘要翻译： 本发明涉及取代的三唑化合物和包含取代的三唑化合物的组合物。 本发明还涉及在有需要的受试者中抑制Hsp90的活性的方法和在有需要的受试者中预防或治疗过度增殖性疾病如癌症的方法，其包括向受试者施用本发明的取代的三唑化合物， 或包含这种化合物的组合物。
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公开(公告)号：US20080176840A1
公开(公告)日：2008-07-24
申请号：US11807327
申请日：2007-05-25
申请人： Lijun Sun , Weiwen Ying , Junghyun Chae , Teresa Przewloka , Shijie Zhang , Dinesh U. Chimmanamada , Kevin Foley , Zhenjian Du , Hao Li , David James , Howard P. Ng , Zachary Demko , Dan Zhou , Shuzhen Qin
发明人： Lijun Sun , Weiwen Ying , Junghyun Chae , Teresa Przewloka , Shijie Zhang , Dinesh U. Chimmanamada , Kevin Foley , Zhenjian Du , Hao Li , David James , Howard P. Ng , Zachary Demko , Dan Zhou , Shuzhen Qin
IPC分类号： A61K31/4196 , C07D401/14 , A61K31/4439 , C07D471/04 , A61K31/538 , A61K31/496 , A61P37/00 , A61P29/00 , A61P31/00 , A61P35/00 , A61K31/5377 , C07D413/14 , A61K31/52 , A61K31/4709 , C07D403/02
CPC分类号： C07D403/04 , A61K31/4196 , A61K31/422 , A61K31/4439 , A61K31/475 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D249/12 , C07D401/04 , C07D401/14 , C07D403/12 , C07D405/04 , C07D405/14 , C07D413/14 , C07D487/04
摘要： The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.
摘要翻译： 本发明涉及取代的三唑化合物和包含取代的三唑化合物的组合物。 本发明还涉及在有需要的受试者中抑制Hsp90的活性的方法和在有需要的受试者中预防或治疗过度增殖性疾病如癌症的方法，其包括向受试者施用本发明的取代的三唑化合物， 或包含这种化合物的组合物。
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公开(公告)号：US20130303493A1
公开(公告)日：2013-11-14
申请号：US13941081
申请日：2013-07-12
申请人： Joseph Burlison , Shijie Zhang , Weiwen Ying , Dinesh U. Chimmanamada , Minghu Song , Junghyun Chae , Stefan M. Schweizer
发明人： Joseph Burlison , Shijie Zhang , Weiwen Ying , Dinesh U. Chimmanamada , Minghu Song , Junghyun Chae , Stefan M. Schweizer
IPC分类号： C07D249/10 , A61K31/5377 , C07D401/04 , A61K31/541 , A61K31/635 , A61K31/454 , A61K31/4196 , C07D403/04 , C07D401/10 , C07D409/12 , A61K31/4439 , C07D401/12 , A61K45/06 , C07D405/04 , C07D405/06 , C07D403/12 , C07D409/04 , C07D405/10 , C07D403/10 , A61K31/496
CPC分类号： A61K31/4196 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K31/635 , A61K45/06 , C07D249/08 , C07D249/10 , C07D249/12 , C07D249/14 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/08 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/06 , C07D405/10 , C07D409/04 , C07D409/12
摘要： The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a pharmaceutical composition comprising such a compound.
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公开(公告)号：US08183384B2
公开(公告)日：2012-05-22
申请号：US11807331
申请日：2007-05-25
申请人： Dinesh U. Chimmanamada , Weiwen Ying , Teresa Przewloka , Shijie Zhang , Kevin Foley , Zhenjian Du , Dan Zhou , Shuzhen Qin
发明人： Dinesh U. Chimmanamada , Weiwen Ying , Teresa Przewloka , Shijie Zhang , Kevin Foley , Zhenjian Du , Dan Zhou , Shuzhen Qin
IPC分类号： C07D249/12 , A61K31/4196
CPC分类号： C07D249/12 , C07D401/06 , C07D403/06 , C07D403/10 , C07D403/12 , C07D405/06 , C07D405/12 , C07D407/10 , C07D413/10 , C07F9/6518
摘要： The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.
摘要翻译： 本发明涉及取代的三唑化合物和包含取代的三唑化合物的组合物。 本发明还涉及在有需要的受试者中抑制Hsp90的活性的方法和在有需要的受试者中预防或治疗过度增殖性疾病如癌症的方法，其包括向受试者施用本发明的取代的三唑化合物， 或包含这种化合物的组合物。
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公开(公告)号：US09126953B2
公开(公告)日：2015-09-08
申请号：US13057962
申请日：2009-08-07
申请人： Weiwen Ying , Dinesh U. Chimmanamada , Joseph Burlison , Shijie Zhang , Minghu Song , Junghyun Chae
发明人： Weiwen Ying , Dinesh U. Chimmanamada , Joseph Burlison , Shijie Zhang , Minghu Song , Junghyun Chae
IPC分类号： A01N43/64 , A61K31/41 , C07D249/10 , C07D401/04 , C07D403/04 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/14
CPC分类号： C07D249/10 , C07D401/04 , C07D403/04 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/14
摘要： The present invention relates to substituted pyrrole compounds of formula I and compositions comprising substituted tri-substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a tri-substituted’ triazole compound of the invention, or a pharmaceutical composition comprising such a compound.
摘要翻译： 本发明涉及式I的取代吡咯化合物和包含取代的三取代三唑化合物的组合物。 本发明还涉及在有需要的受试者中抑制Hsp90的活性的方法和在有需要的受试者中治疗过度增殖性疾病如癌症的方法，其包括向受试者施用本发明的三取代的“三唑化合物 ，或包含这种化合物的药物组合物。
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公开(公告)号：US20120202813A1
公开(公告)日：2012-08-09
申请号：US13452200
申请日：2012-04-20
申请人： Dinesh U. Chimmanamada , Weiwen Ying , Teresa Kowalczyk Przewloka , Shijie Zhang , Kevin Foley , Zhenjian Du , Dan Zhou , Shuzhen Qin
发明人： Dinesh U. Chimmanamada , Weiwen Ying , Teresa Kowalczyk Przewloka , Shijie Zhang , Kevin Foley , Zhenjian Du , Dan Zhou , Shuzhen Qin
IPC分类号： A61K31/4196 , A61P35/00 , A61P35/02 , A61K31/4439 , A61K31/5377
CPC分类号： C07D249/12 , C07D401/06 , C07D403/06 , C07D403/10 , C07D403/12 , C07D405/06 , C07D405/12 , C07D407/10 , C07D413/10 , C07F9/6518
摘要： The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.
摘要翻译： 本发明涉及取代的三唑化合物和包含取代的三唑化合物的组合物。 本发明还涉及在有需要的受试者中抑制Hsp90的活性的方法和在有需要的受试者中预防或治疗过度增殖性疾病如癌症的方法，其包括向受试者施用本发明的取代的三唑化合物， 或包含这种化合物的组合物。
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公开(公告)号：US08742133B2
公开(公告)日：2014-06-03
申请号：US12673254
申请日：2008-08-13
申请人： Weiwen Ying , Lijun Sun , Keizo Koya , Dinesh U. Chimmanamada , Shijie Zhang , Teresa Kowalcyzk-Przewloka , Hao Li
发明人： Weiwen Ying , Lijun Sun , Keizo Koya , Dinesh U. Chimmanamada , Shijie Zhang , Teresa Kowalcyzk-Przewloka , Hao Li
IPC分类号： C07D403/04 , C07D209/04 , C07D249/08
CPC分类号： A61K31/675 , C07D209/04 , C07D249/08 , C07D403/04 , C07F9/6518 , C07F9/65583 , C07F9/65586
摘要： The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.
摘要翻译： 本发明涉及取代的三唑化合物和包含取代的三唑化合物的组合物。 本发明还涉及在有需要的受试者中抑制Hsp90的活性的方法和在有需要的受试者中预防或治疗过度增殖性疾病如癌症的方法，其包括向受试者施用本发明的取代的三唑化合物， 或包含这种化合物的组合物。
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公开(公告)号：US08329736B2
公开(公告)日：2012-12-11
申请号：US13452200
申请日：2012-04-20
申请人： Dinesh U. Chimmanamada , Weiwen Ying , Teresa Kowalczyk Przewloka , Shijie Zhang , Kevin Foley , Zhenjian Du , Dan Zhou , Shuzhen Qin
发明人： Dinesh U. Chimmanamada , Weiwen Ying , Teresa Kowalczyk Przewloka , Shijie Zhang , Kevin Foley , Zhenjian Du , Dan Zhou , Shuzhen Qin
IPC分类号： A61K31/4196 , C07D249/12
CPC分类号： C07D249/12 , C07D401/06 , C07D403/06 , C07D403/10 , C07D403/12 , C07D405/06 , C07D405/12 , C07D407/10 , C07D413/10 , C07F9/6518
摘要： The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.
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公开(公告)号：US20110195094A1
公开(公告)日：2011-08-11
申请号：US12673254
申请日：2008-08-13
申请人： Weiwen Ying , Lijun Sun , Keizo Koya , Dinesh U. Chimmanamada , Shijie Zhang , Teresa Kowalcyzk Przewloka , Hao Li
发明人： Weiwen Ying , Lijun Sun , Keizo Koya , Dinesh U. Chimmanamada , Shijie Zhang , Teresa Kowalcyzk Przewloka , Hao Li
IPC分类号： A61K31/675 , C07F9/12 , C07D413/14 , A61P35/00 , A61P29/00 , C12N5/071 , A61P31/10 , A61P33/00 , A61P31/12 , A61P31/04 , A61P37/06 , A61P37/02
CPC分类号： A61K31/675 , C07D209/04 , C07D249/08 , C07D403/04 , C07F9/6518 , C07F9/65583 , C07F9/65586
摘要： The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.
摘要翻译： 本发明涉及取代的三唑化合物和包含取代的三唑化合物的组合物。 本发明还涉及在有需要的受试者中抑制Hsp90的活性的方法和在有需要的受试者中预防或治疗过度增殖性疾病如癌症的方法，其包括向受试者施用本发明的取代的三唑化合物， 或包含这种化合物的组合物。
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