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    CURVED SURFACE INPUT DEVICE WITH NORMALIZED CAPACITIVE SENSING
    21.
    发明申请
    CURVED SURFACE INPUT DEVICE WITH NORMALIZED CAPACITIVE SENSING 审中-公开
    具有正常电容感应的弯曲表面输入装置

    公开(公告)号：US20100060568A1

    公开(公告)日：2010-03-11

    申请号：US12205770

    申请日：2008-09-05

    申请人： Joseph Fisher ,  Erturk Kocalar

    发明人： Joseph Fisher ,  Erturk Kocalar

    IPC分类号： G09G5/08 ,  G09G5/00

    CPC分类号： G06F3/03547 ,  H03K17/9622 ,  H03K2217/96031 ,  H03K2217/96066 ,  H03K2217/960725 ,  H03K2217/960755

    摘要： A curved surface input device with normalized capacitive sensing is disclosed. The input device can normalize capacitive sensing through an overlay having a varying thickness, such as an overlay with a curved surface. The capacitive sensing normalization can be implemented in software, hardware or a combination of software and hardware. A software implementation for normalizing capacitive sensing can comprise adjusting the sensitivity of a sensing operation associated with different sensor elements of the input device. A hardware implementation for normalizing capacitive sensing can comprise adjusting a hardware configuration of the input device associated with one or more physical parameters that can influence the capacitive sensitivity of the sensor elements, such as an area of the sensor elements, a distance between the sensor elements and other conductive input device elements (such as a ground plane), and a dielectric constant associated with the overlay.

    摘要翻译： 公开了一种具有归一化电容感测的曲面输入装置。 输入设备可以通过具有变化厚度的覆盖层（例如具有弯曲表面的覆盖层）来对电容感测进行归一化。 电容感测归一化可以在软件，硬件或软件和硬件的组合中实现。 用于规范化电容感测的软件实现可以包括调整与输入设备的不同传感器元件相关联的感测操作的灵敏度。 用于规范化电容感测的硬件实现可以包括调整与一个或多个物理参数相关联的输入设备的硬件配置，该物理参数可以影响传感器元件的电容灵敏度，例如传感器元件的区域，传感器元件之间的距离 和其它导电输入设备元件（例如接地平面）以及与覆盖层相关联的介电常数。

    NON-INVASIVE CARDIAC OUTPUT DETERMINATION
    23.
    发明申请
    NON-INVASIVE CARDIAC OUTPUT DETERMINATION 审中-公开

    公开(公告)号：US20170224230A1

    公开(公告)日：2017-08-10

    申请号：US15438503

    申请日：2017-02-21

    申请人： Joseph Fisher ,  Michael Klein ,  James Duffin

    发明人： Joseph Fisher ,  Michael Klein ,  James Duffin

    IPC分类号： A61B5/0205 ,  A61B5/00

    CPC分类号： A61B5/0205 ,  A61B5/026 ,  A61B5/029 ,  A61B5/0813 ,  A61B5/082 ,  A61B5/0836 ,  A61B5/7225 ,  A61B5/7278 ,  A61M16/0057 ,  A61M16/12

    摘要： A method of controlling a gas delivery apparatus including an apparatus controllable variable using an iterative algorithm to deliver a test gas (TG) for non-invasively determining a subject's pulmonary blood flow comprising iteratively generating and evaluating test values of a iterated variable based on an iterative algorithm in order output a test value of the iterated variable that meets a test criterion wherein iterative algorithm is characterized in that it defines a test mathematical relationship between the at least one apparatus controllable variable, the iterated variable and an end tidal concentration of test gas attained by setting the apparatus controllable variable, such that the iterative algorithm is determinative of whether iteration on the test value satisfies a test criterion or iteratively generates a progressively refined test value.

    Multiparameter FACS assays to detect alterations in exocytosis
    29.
    发明授权
    Multiparameter FACS assays to detect alterations in exocytosis 失效
    多参数FACS测定以检测胞吐的变化

    公开(公告)号：US06897031B1

    公开(公告)日：2005-05-24

    申请号：US09062330

    申请日：1998-04-17

    申请人： Joseph Fisher ,  James Lorens ,  Donald Payan ,  Alexander Rossi

    发明人： Joseph Fisher ,  James Lorens ,  Donald Payan ,  Alexander Rossi

    IPC分类号： G01N33/50 ,  G01N33/569 ,  G01N33/567

    CPC分类号： G01N33/5011 ,  G01N33/5008 ,  G01N33/5014 ,  G01N33/502 ,  G01N33/5047 ,  G01N33/56966 ,  G01N2333/43595 ,  G01N2333/4718

    摘要： Described is a method for screening for alterations in exocytosis of a population of cells. The cells are sorted by a FACS machine by assaying for alterations in at least three of the properties selected from the group consisting of light scattering, fluorescent dye uptake, fluorescent dye release, annexin granule binding, surface granule enzyme activity, and the quantity of granule specific proteins. Methods for screening for bioactive agents capable of modulating exocytosis in a cell are also described. The methods provide for reduced background and increased specificity without increasing the time or steps involved in assaying for exocytosis.

    摘要翻译： 描述了筛选细胞群的胞吐作用的方法。 细胞由FACS机通过测定至少三种选自光散射，荧光染料摄取，荧光染料释放，膜联蛋白颗粒结合，表面颗粒酶活性和颗粒数量的性质的变化进行分选 特异性蛋白质。 还描述了筛选能够调节细胞中胞吐作用的生物活性剂的方法。 所述方法提供降低的背景和增加的特异性，而不增加测定胞吐的时间或步骤。

    Exo1 and Exo2, exocytotic proteins
    30.
    发明授权
    Exo1 and Exo2, exocytotic proteins 有权
    Exo1和Exo2，胞吐蛋白

    公开(公告)号：US06623980B1

    公开(公告)日：2003-09-23

    申请号：US09255920

    申请日：1999-02-23

    申请人： Joseph Fisher ,  James Lorens ,  David Anderson ,  Ying Luo ,  Chao Bai (Betty) Huang ,  Mary Shen

    发明人： Joseph Fisher ,  James Lorens ,  David Anderson ,  Ying Luo ,  Chao Bai (Betty) Huang ,  Mary Shen

    IPC分类号： G01N33566

    CPC分类号： C07K14/4703

    摘要： The present invention is directed to novel exocytotic polypeptides, such as Exo1 and Exo2 polypeptides and related molecules, which have an inhibitory effect on exocytosis and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided by the present invention are method for identifying novel compositions which mediate exocytotic polypeptide bioactivity, and the use of such compositions in diagnosis and treatment of disease.

    摘要翻译： 本发明涉及新颖的胞吐多肽，例如Exo1和Exo2多肽及相关分子，其对胞吐作用具有抑制作用，以及编码这些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。 本发明还提供了鉴定介导胞吐多肽生物活性的新组合物的方法，以及这些组合物在疾病诊断和治疗中的应用。