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76 条记录 (耗时 0.036 秒)

    Bicycle wheel securing structure
    21.
    发明授权
    Bicycle wheel securing structure 有权

    公开(公告)号：US08424975B2

    公开(公告)日：2013-04-23

    申请号：US13290178

    申请日：2011-11-07

    申请人： Jun Inoue ,  Takanori Kanehisa

    发明人： Jun Inoue ,  Takanori Kanehisa

    IPC分类号： B60B27/00

    CPC分类号： B62K25/02 ,  B62K23/06 ,  B62K2206/00 ,  B62M25/04

    摘要： A bicycle wheel securing structure includes a bicycle fork, an adapter and a holding member. The bicycle fork has two axle support portions that are spaced apart for receiving a bicycle hub therebetween. The adapter is disposed in an adapter receiving bore in one of the axle support portions. The adapter includes a threaded axle mounting opening. The holding member is operatively coupled between the adapter and the one of the axle support portions with the adapter. The holding member prevents both rotational movement of the adapter with respect to the bicycle fork and axial movement of the adapter with respect to the bicycle fork along an axis of the axle mounting opening when the holding member is in a retaining position. The adapter is rotatable within the adapter receiving bore without moving axially with respect to the bicycle fork when the holding member is in a releasing position.

    OPHTHALMIC COMPOSITION
    22.
    发明申请
    OPHTHALMIC COMPOSITION 审中-公开
    眼科组合物

    公开(公告)号：US20130053374A1

    公开(公告)日：2013-02-28

    申请号：US13695930

    申请日：2011-05-04

    申请人： Jun Inoue ,  Tapan Shah

    发明人： Jun Inoue ,  Tapan Shah

    IPC分类号： A61K47/34 ,  A61K31/382 ,  A61P27/02 ,  A61K47/38 ,  A61K47/22 ,  A61K31/5377 ,  C07C211/02 ,  A61K31/542

    CPC分类号： A61K31/382 ,  A61K9/0048 ,  A61K31/138 ,  A61K31/433 ,  A61K31/4704 ,  A61K31/5377 ,  A61K31/542 ,  A61K47/34 ,  A61K2300/00

    摘要： The present invention provides an ophthalmic composition comprising a hyperbranched polyester. The ophthalmic compositions may also comprise carbonic anhydrase inhibitors, wherein the hyperbranched polyester increases the aqueous solubility of the carbonic anhydrase inhibitor, and increases corneal permeation of the active agent. The ophthalmic compositions may also comprise non-ionic surfactants, such as PEG, Polysorbate, HPMC or HEC, and beta-blockers, such as Carteolol, Levobunolol, Betaxolol, Metipranolol, Timolol or Propranolol. The concentration of the hyperbranched polyester in the ophthalmic formulation should be less than or equal to 4% (w/v) in order to avoid any cytotoxic effects on human corneal cells and thus the eye irritation.

    摘要翻译： 本发明提供了一种包含超支化聚酯的眼用组合物。 眼用组合物还可以包含碳酸酐酶抑制剂，其中超支化聚酯增加碳酸酐酶抑制剂的水溶性，并增加活性剂的角膜渗透。 眼用组合物还可以包含非离子表面活性剂，例如PEG，聚山梨醇酯，HPMC或HEC，以及β-阻滞剂，例如卡替洛尔，左布洛尔，倍他洛尔，美替洛尔，噻吗洛尔或普萘洛尔。 眼用配方中超支化聚酯的浓度应小于或等于4％（w / v），以避免对人角膜细胞产生任何细胞毒作用，从而引起眼睛刺激。

    Method of preparing honeycomb segment joined body
    23.
    发明授权
    Method of preparing honeycomb segment joined body 有权
    蜂窝段接合体的制备方法

    公开(公告)号：US08343302B2

    公开(公告)日：2013-01-01

    申请号：US12275010

    申请日：2008-11-20

    申请人： Akifumi Nishio ,  Takao Tani ,  Jun Inoue

    发明人： Akifumi Nishio ,  Takao Tani ,  Jun Inoue

    IPC分类号： C04B33/34 ,  B29C65/00 ,  C09J5/00 ,  B32B37/00 ,  B32B3/12 ,  B01D39/14

    CPC分类号： B01D46/2418 ,  B28B1/002 ,  C04B37/005 ,  C04B2237/09 ,  C04B2237/341 ,  C04B2237/343 ,  C04B2237/346 ,  C04B2237/365 ,  C04B2237/368 ,  Y10T29/49826 ,  Y10T428/24157

    摘要： There is disclosed a method for preparing a honeycomb segment joined body in which a plurality of honeycomb segments are arranged in directions parallel to a first flat surface and a second flat surface of an installation reference jig to install the honeycomb segments in predetermined positions via a paste-like joining material on the installation reference jig by use of the installation reference jig having the first flat surface and the second flat surface forming a right angle therebetween, and then the joining material is dried and cured to join the plurality of honeycomb segments together. In the preparation method, in at least a part of a process of successively installing the plurality of honeycomb segments in the predetermined positions, when a new honeycomb segment is installed, at least a part of the installed honeycomb segments is pressurized and held in the predetermined positions so that the already installed honeycomb segments are not displaced.

    摘要翻译： 公开了一种制备蜂窝段接合体的方法，其中多个蜂窝段沿平行于第一平坦表面的方向和安装基准夹具的第二平坦表面布置，以通过糊状物将蜂窝段安装在预定位置 通过使用具有第一平面和第二平面的安装参考夹具在安装参考夹具上形成直角的接合材料，然后将接合材料干燥并固化以将多个蜂窝段连接在一起。 在制备方法中，在将多个蜂窝片段连续地安装在预定位置的过程的至少一部分中，当安装新的蜂窝片段时，至少一部分安装的蜂窝片段被加压并保持在预定的 位置使得已经安装的蜂窝段不被移动。

    Pharmaceutical comprising PPAR agonist
    24.
    发明授权
    Pharmaceutical comprising PPAR agonist 有权
    包含PPAR激动剂的药物

    公开(公告)号：US08148389B2

    公开(公告)日：2012-04-03

    申请号：US12085548

    申请日：2006-11-27

    申请人： Yoshikuni Nakamura ,  Ikuko Hanano ,  Jun Inoue

    发明人： Yoshikuni Nakamura ,  Ikuko Hanano ,  Jun Inoue

    IPC分类号： A01N43/54 ,  A01N43/78 ,  A01N37/10

    CPC分类号： C07D239/47 ,  A61K31/216 ,  A61K31/426 ,  A61K31/505 ,  C07D277/26

    摘要： An object of the present invention is to provide an agent for promoting proliferation of a meibomian gland epithelial cell and a corneal epithelial cell, as well as provide an agent for treating an ocular disease such as meibomian gland dysfunction or evaporative dry eye.There are provided an agent for promoting proliferation of a meibomian gland epithelial cell or a corneal epithelial cell, containing a PPARα or δ agonist as an active ingredient, as well as an agent for treating an ocular disease such as meibomian gland dysfunction or evaporative dry eye, containing a PPARα or δ agonist as an active ingredient.

    摘要翻译： 本发明的目的是提供一种用于促进睑板腺上皮细胞和角膜上皮细胞增殖的药剂，以及提供用于治疗诸如睑板腺功能障碍或蒸发干眼症的眼部疾病的药剂。 提供了用于促进睑板腺上皮细胞或角膜上皮细胞的增殖的试剂，其含有PPARα或δ激动剂作为活性成分，以及用于治疗眼部疾病如睑板腺功能障碍或蒸发性干眼症的药剂 ，含有PPARα或δ激动剂作为活性成分。

    Method for detecting multiple myeloma and method for inhibiting the same
    27.
    发明申请
    Method for detecting multiple myeloma and method for inhibiting the same 审中-公开
    多发性骨髓瘤检测方法及其抑制方法

    公开(公告)号：US20080182250A1

    公开(公告)日：2008-07-31

    申请号：US11902504

    申请日：2007-09-21

    申请人： Chen Zhao ,  Jun Inoue ,  Issei Imoto ,  Johji Inazawa

    发明人： Chen Zhao ,  Jun Inoue ,  Issei Imoto ,  Johji Inazawa

    IPC分类号： C12Q1/68 ,  C12N5/06 ,  C07H1/00

    CPC分类号： C12Q1/6886 ,  C12Q2600/158

    摘要： It is an object of the present invention to identify a gene that relates to exhibition of behavior peculiar to cancer such as multiple myeloma to provide a method for detecting cancer and a cell-growth inhibitor. The present invention provides a method for detecting cancer which comprises detecting and/or typing tumorigenesis of a specimen by employing gene amplification in the chromosome 11 q23 region of the specimen as an indicator.

    摘要翻译： 本发明的目的是鉴定与多发性骨髓瘤等癌症特有的显示有关的基因，提供检测癌症的方法和细胞生长抑制剂。 本发明提供了一种检测癌症的方法，其包括通过在样本的染色体11q23区域中进行基因扩增作为指标检测和/或分类标本的肿瘤发生。