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    Process for producing sterile suspensions of slightly soluble basic peptide complexes, sterile suspensions of slightly soluble basic peptide complexes, pharmaceutical formulations containing them, and the use thereof as medicaments
    21.
    发明申请
    Process for producing sterile suspensions of slightly soluble basic peptide complexes, sterile suspensions of slightly soluble basic peptide complexes, pharmaceutical formulations containing them, and the use thereof as medicaments 失效
    用于生产微溶碱性肽复合物的无菌悬浮液，微溶性碱性肽复合物的无菌悬浮液，含有它们的药物制剂及其作为药物的用途的方法

    公开(公告)号：US20060135405A1

    公开(公告)日：2006-06-22

    申请号：US11304548

    申请日：2005-12-16

    申请人： Matthias Rischer ,  Horst Mueller ,  Karl Werner ,  Juergen Engel

    发明人： Matthias Rischer ,  Horst Mueller ,  Karl Werner ,  Juergen Engel

    IPC分类号： A61K38/16

    CPC分类号： A61K9/19 ,  A61K9/0019 ,  A61K9/10 ,  A61K31/19 ,  A61K38/09 ,  A61K47/26 ,  G06F19/00 ,  A61K2300/00

    摘要： The present invention provides a novel process for producing sterile suspensions of slightly soluble basic peptide complexes. The present invention further provides a novel process for producing sterile lyophilizates of slightly soluble basic peptide complexes. In addition, a novel process for producing sterile suspensions suitable for the parenteral administration of slightly soluble basic peptide complexes is provided. The invention moreover provides sterile suspensions and sterile lyophilizates of slightly soluble basic peptide complexes, and pharmaceutical formulations comprising them. The provided sterile suspensions, sterile lyophilizates and pharmaceutical formulations comprising them are particularly suitable for use in a parenteral dosage form as medicaments for the treatment and prophylaxis of diseases and pathological states in mammals, especially in humans.

    摘要翻译： 本发明提供了一种生产微溶性碱性肽复合物的无菌悬浮液的新方法。 本发明还提供了用于生产微溶性碱性肽复合物的无菌冻干物的新方法。 此外，提供了一种用于生产适于胃肠外施用微溶性碱性肽复合物的无菌悬浮液的新方法。 此外，本发明提供了无菌悬浮液和微溶性碱性肽复合物的无菌冻干物，以及包含它们的药物制剂。 提供的无菌悬浮液，无菌冻干物和包含它们的药物制剂特别适用于肠胃外剂型，作为用于治疗和预防哺乳动物，特别是人的疾病和病理状态的药物。

    Light source pulsed with irregular pulse sequence in analog photometric signal evaluation for a test carrier analysis system
    22.
    发明授权
    Light source pulsed with irregular pulse sequence in analog photometric signal evaluation for a test carrier analysis system 失效
    用于测试载体分析系统的模拟光度信号评估中用不规则脉冲序列脉冲的光源

    公开(公告)号：US5463467A

    公开(公告)日：1995-10-31

    申请号：US266378

    申请日：1994-06-27

    申请人： Edgar Baumann ,  Wolfgang Obermeier ,  Karl Werner

    发明人： Edgar Baumann ,  Wolfgang Obermeier ,  Karl Werner

    IPC分类号： G01N33/52 ,  G01J1/42 ,  G01N21/25 ,  G01N21/27 ,  G01N21/77 ,  G01N21/86 ,  G01N21/47 ,  G01J1/44

    CPC分类号： G01N21/8483 ,  G01N21/255 ,  G01N21/27 ,  G01J2001/4238 ,  G01N2201/0699

    摘要： Method of detecting and evaluating analog photometric signals in a test carrier analysis system, and apparatus for carrying out the method. The test field of a test carrier is irradiated by a light source clocked in light-dark phases. The reflected light is detected by a measurement receiver over a measurement period having several light-dark phases, and integrated. An effective suppression of stray and secondary light, which permits measurement even without the hitherto conventional shielding from ambient light, is achieved by a method in which the sequence of the light and dark phases integrated over the measurement period is irregular in such a way that the Fourier-transformed frequency spectrum includes a large number of different frequencies. Each individual frequency therefore makes only a small contribution to the measurement result.

    摘要翻译： 在测试载体分析系统中检测和评估模拟光度信号的方法，以及用于执行该方法的装置。 测试载体的测试场由光暗时钟的光源照射。 反射光在测量周期内由测量接收器检测，具有几个亮暗阶段，并被整合。 通过这样一种方法可以实现对杂散和二次光的有效抑制，即使在迄今常规的环境光屏蔽下也能进行测量，其中在测量周期内整合的光和暗相的序列是不规则的， 傅里叶变换频谱包括大量不同的频率。 因此，每个单独的频率对测量结果只有很小的贡献。

    Device and method for determining blood glucose characteristics
    23.
    发明授权
    Device and method for determining blood glucose characteristics 有权
    用于测定血糖特征的装置和方法

    公开(公告)号：US09033877B2

    公开(公告)日：2015-05-19

    申请号：US13032672

    申请日：2011-02-23

    申请人： Karl Werner ,  Peter Blasberg

    发明人： Karl Werner ,  Peter Blasberg

    IPC分类号： A61B5/00 ,  A61B5/145 ,  G06F19/00

    CPC分类号： A61B5/14532 ,  A61B5/7275 ,  A61B5/743 ,  G06F19/00 ,  G16H40/63

    摘要： A device is provided for determining blood glucose characteristics including a display configured for presenting a graphical representation of a plurality of measurements of blood glucose values, wherein the graphical representation comprises a trend indicator indicating an approximate value trend in the sensed blood glucose value over a recent series of measurements, based on graphical segments having different graphical styles assigned to different ranges of sensed blood glucose values to indicate a transition from a first range to a second range of sensed blood glucose values. An associated method for operating a device for determining blood glucose characteristics is also provided.

    摘要翻译： 提供了一种用于确定血糖特征的装置，包括被配置为呈现血糖值的多个测量值的图形表示的显示器，其中所述图形表示包括指示所感测的血糖值近似值趋势的趋势指标， 基于具有分配给感测血糖值的不同范围的不同图形的图形片段来指示从第一范围到感测的血糖值的第二范围的转变。 还提供了用于操作用于确定血糖特性的装置的相关方法。

    DEVICE AND METHOD FOR DETERMINING BLOOD GLUCOSE CHARACTERISTICS
    24.
    发明申请
    DEVICE AND METHOD FOR DETERMINING BLOOD GLUCOSE CHARACTERISTICS 有权
    用于确定血液葡萄糖特征的装置和方法

    公开(公告)号：US20120215085A1

    公开(公告)日：2012-08-23

    申请号：US13032672

    申请日：2011-02-23

    申请人： Karl Werner ,  Peter Blasberg

    发明人： Karl Werner ,  Peter Blasberg

    IPC分类号： A61B5/145

    CPC分类号： A61B5/14532 ,  A61B5/7275 ,  A61B5/743 ,  G06F19/00 ,  G16H40/63

    摘要： A device is provided for determining blood glucose characteristics including a display configured for presenting a graphical representation of a plurality of measurements of blood glucose values, wherein the graphical representation comprises a trend indicator indicating an approximate value trend in the sensed blood glucose value over a recent series of measurements, based on graphical segments having different graphical styles assigned to different ranges of sensed blood glucose values in order to indicating a transition from a first range to a second range of sensed blood glucose values. An associated method for operating a device for determining blood glucose characteristics is also provided.

    摘要翻译： 提供了一种用于确定血糖特征的装置，包括被配置为呈现血糖值的多个测量值的图形表示的显示器，其中所述图形表示包括指示所感测的血糖值近似值趋势的趋势指标， 基于具有分配给感测血糖值的不同范围的不同图形的图形段，以便指示从第一范围到感测血糖值的第二范围的转变。 还提供了用于操作用于确定血糖特性的装置的相关方法。

    SYSTEMS AND METHODS FOR OPTIMIZING INSULIN DOSAGE
    26.
    发明申请
    SYSTEMS AND METHODS FOR OPTIMIZING INSULIN DOSAGE 有权
    用于优化胰岛素剂量的系统和方法

    公开(公告)号：US20110015511A1

    公开(公告)日：2011-01-20

    申请号：US12818310

    申请日：2010-06-18

    申请人： Steven Bousamra ,  Stefan Weinert ,  Juergen Rasch-Menges ,  P. Douglas Walling ,  John F. Price ,  Heino Eikmeier ,  Birgit Kraeling ,  Karl Werner ,  Ulrich Porsch

    发明人： Steven Bousamra ,  Stefan Weinert ,  Juergen Rasch-Menges ,  P. Douglas Walling ,  John F. Price ,  Heino Eikmeier ,  Birgit Kraeling ,  Karl Werner ,  Ulrich Porsch

    IPC分类号： A61B5/145 ,  G06F19/00 ,  G01N33/48 ,  G09B23/28

    CPC分类号： A61B5/0002 ,  A61B5/05 ,  A61B5/14532 ,  A61B5/14546 ,  A61M31/00 ,  A61M2230/201 ,  C12Q1/006 ,  G06F19/00 ,  G06F19/3418 ,  G06F19/3456 ,  G16H10/20 ,  G16H10/40 ,  G16H20/17 ,  G16H80/00

    摘要： Embodiments of a testing method suitable for diabetic persons to optimize their administered insulin dosage comprise collecting one or more sampling sets of biomarker data, wherein each sampling set comprises a sufficient plurality of non-adverse sampling instances and wherein each sampling instance comprises an acceptable biomarker reading at a single point in time recorded upon compliance with adherence criteria, determining a biomarker sampling parameter from each sampling set, comparing the biomarker sampling parameter to a target biomarker range, calculating an insulin adjustment parameter associated with the biomarker sampling parameter if the biomarker sampling parameter falls outside the target biomarker range, adjusting the insulin dosage by the insulin adjustment parameter if the biomarker sampling parameter falls outside the target biomarker range and if the insulin dosage does not exceed maximum dosage, and exiting the testing method if the adjusted insulin dosage is optimized. The insulin dosage is optimized when one or more biomarker sampling parameters fall within a target biomarker range.

    摘要翻译： 适于糖尿病患者优化其施用的胰岛素剂量的测试方法的实施方案包括收集一个或多个生物标志物数据的采样组，其中每个采样组包括足够多个非不良采样实例，并且其中每个采样实例包括可接受的生物标志物读数 在符合遵守标准的单个时间点上，从每个采样组确定生物标志物采样参数，将生物标志物采样参数与目标生物标志物范围进行比较，计算与生物标志物采样参数相关联的胰岛素调节参数，如果生物标志物采样参数 如果生物标志物采样参数落在目标生物标志物范围之外，并且如果胰岛素剂量不超过最大剂量，并且如果调整的胰岛素剂量是最佳的则退出测试方法，则超出目标生物标志物范围，通过胰岛素调节参数调整胰岛素剂量 zed。 当一个或多个生物标志物采样参数落入目标生物标志物范围内时，胰岛素剂量被优化。

    Electronic device for analysis of a body fluid
    29.
    发明申请
    Electronic device for analysis of a body fluid 审中-公开
    用于体液分析的电子装置

    公开(公告)号：US20070152683A1

    公开(公告)日：2007-07-05

    申请号：US11322542

    申请日：2005-12-30

    申请人： Karl Werner ,  Nader Afshar ,  Morris Young ,  Paul Galley ,  Alan Greenburg

    发明人： Karl Werner ,  Nader Afshar ,  Morris Young ,  Paul Galley ,  Alan Greenburg

    IPC分类号： G01R27/08

    CPC分类号： A61B5/14532 ,  A61B5/0002 ,  A61B5/1455 ,  A61B5/1468 ,  A61B2562/0295 ,  G01N33/48785

    摘要： An electronic device for analysis of a body fluid comprises a housing defining an opening therein, a measuring facility and at least one electrical circuit arranged inside the housing, and a multi-wire connector carried by the housing. The measuring facility is configured to receive a test element therein via the opening and to produce measuring values relating to a sample of the body fluid received on the test element. The at least one electrical circuit is configured to process the measuring values to yield analytical data corresponding to a component of the sample of the body fluid. The multi-wire connector has at least one wire defining a voltage supply input to the electronic device, and is configured to be connected to a mating connector of an external electronic device with the at least one wire configured to receive a supply voltage from the external electronic device.

    摘要翻译： 用于分析体液的电子装置包括限定其中的开口的壳体，测量装置和布置在壳体内的至少一个电路以及由壳体承载的多线连接器。 测量设备被配置成经由开口接收测试元件，并且产生与在测试元件上接收的体液样本有关的测量值。 至少一个电路被配置为处理测量值以产生对应于体液样品的分量的分析数据。 所述多线连接器具有至少一根线，其限定向所述电子设备输入的电压源，并且被配置为连接到外部电子设备的匹配连接器，所述至少一个配线被配置为从外部接收电源电压 电子设备。

    METHOD FOR THE AUDIBLE OUTPUT OF A PIECE OF INFORMATION IN AN ANALYSIS SYSTEM
    30.
    发明申请
    METHOD FOR THE AUDIBLE OUTPUT OF A PIECE OF INFORMATION IN AN ANALYSIS SYSTEM 有权
    用于分析系统中信息的可视输出的方法

    公开(公告)号：US20070144235A1

    公开(公告)日：2007-06-28

    申请号：US11565149

    申请日：2006-11-30

    申请人： Karl Werner ,  Gertrud Albrecht

    发明人： Karl Werner ,  Gertrud Albrecht

    IPC分类号： G01N29/30 ,  G01N29/02 ,  G01N33/49

    CPC分类号： A61B5/14532 ,  A61B5/7415 ,  G01N33/48785 ,  G01N2035/009

    摘要： The invention relates to a method for the audible output of a piece of information by an audible signal generator, where the signal generator is arranged in an analysis system and the analysis system analyses a fluid sample using a test element, where analysis results are generated and are processed by a data processing unit, and where a control unit in the analysis system actuates the signal generator, so that the signal generator audibly outputs a piece of information, the signal generator sending an audible test signal in order to test the operability of the signal generator.

    摘要翻译： 本发明涉及一种用于通过可听信号发生器对一条信息的可听输出的方法，其中信号发生器布置在分析系统中，分析系统使用测试元件分析流体样本，其中产生分析结果， 由数据处理单元处理，并且分析系统中的控制单元致动信号发生器，使得信号发生器可听见地输出一条信息，信号发生器发送可听见的测试信号，以便测试该信号的可操作性 信号发生器。