公开(公告)号：US20070088205A1

公开(公告)日：2007-04-19

申请号：US11561380

申请日：2006-11-17

申请人： Edward Hull ,  Marwood Ediger ,  Christopher Brown ,  John Maynard ,  Robert Johnson

发明人： Edward Hull ,  Marwood Ediger ,  Christopher Brown ,  John Maynard ,  Robert Johnson

IPC分类号： A61B5/00

CPC分类号： A61B5/1455 ,  A61B5/0059 ,  A61B5/0064 ,  A61B5/0066 ,  A61B5/0068 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/14532 ,  A61B5/412 ,  A61B5/441

摘要： A method of detefnnining a measure of a tissue state (e.g., glycation end-product or disease state) in an individual. A portion of the tissue of the individual is illuminated with excitation light, then light emitted by the tissue due to fluorescence of a chemical with the tissue responsive to the excitation light is detected. The detected light can be combined with a model relating fluorescence with a measure of tissue state to determine a tissue state. The invention can comprise single wavelength excitation light, scanning of excitation light (illuminating the tissue at a plurality of waveliengths), detection at a single wavelength, scanning of detection wavelengths (detecting emitted light at a plurality of wavelengths), and combinations thereof. The invention also can comprise correction techniques that reduce determination errors due to detection of light other than that from fluorescence of a chemical in the tissue. For example, the reflectance of the tissue can lead to errors if appropriate correction is not employed. The invention can also comprise a variety of models relating fluorescence to a measure of tissue state, including a variety of methods for generating such models. Other biologic information can be used in combination with the fluorescence properties to aid in the determination of a measure of tissue state. The invention also comprises apparatuses suitable for carrying out the method, including appropriate light sources, detectors, and models (for example, implemented on computers) used to relate detected fluorescence and a measure of tissue state.

摘要翻译： 确定个体中组织状态（例如，糖基化终产物或疾病状态）的量度的方法。 用激发光照射个体组织的一部分，然后检测由组织响应于激发光的化学物质的荧光而由组织发出的光。 检测到的光可以与将荧光与组织状态的测量相关联的模型组合以确定组织状态。 本发明可以包括单波长激发光，激发光的扫描（以多个波长照射组织），单个波长的检测，检测波长的扫描（检测多个波长的发射光）及其组合。 本发明还可以包括校正技术，其减少由于检测到除了组织中的化学物质的荧光以外的光的测定误差。 例如，如果不采用适当的校正，组织的反射率可能导致错误。 本发明还可以包括将荧光与组织状态的测量相关联的各种模型，包括用于产生这种模型的各种方法。 其他生物信息可与荧光性质结合使用，有助于测定组织状态。 本发明还包括适于执行该方法的装置，包括用于检测荧光和组织状态测量的适当的光源，检测器和模型（例如，在计算机上实现）。

公开(公告)号：US20070026380A1

公开(公告)日：2007-02-01

申请号：US11190513

申请日：2005-07-27

申请人： Robert Johnson ,  Stephen MacDonald

发明人： Robert Johnson ,  Stephen MacDonald

IPC分类号： C12Q1/00 ,  C12M3/00 ,  H05B3/00

CPC分类号： B01D71/32 ,  B01D61/18 ,  B01D69/02 ,  G01N1/4022 ,  G01N2001/4088 ,  Y10T436/25

摘要： An apparatus and method for separating residual water from a solvent and removing a solvent. The apparatus may be sealed and automated. The method comprises providing a solution comprising solvent and residual water and an analyte. The solution may be passed through a membrane to reduce water content wherein an analyte is present at a first concentration. This then may be followed by removing solvent from the solution.

摘要翻译： 一种从溶剂中分离残留水并除去溶剂的装置和方法。 该装置可以被密封和自动化。 该方法包括提供包含溶剂和残留水和分析物的溶液。 溶液可以通过膜以减少水分含量，其中分析物以第一浓度存在。 然后可以从溶液中除去溶剂。

公开(公告)号：US20060196556A1

公开(公告)日：2006-09-07

申请号：US11276591

申请日：2006-03-07

申请人： Robert Johnson

发明人： Robert Johnson

IPC分类号： F16K15/06

CPC分类号： F16K15/063 ,  F16K27/0209 ,  Y10T137/1632 ,  Y10T137/6116 ,  Y10T137/7043 ,  Y10T137/7932 ,  Y10T137/8811

摘要： A poppet valve member includes a main body, and a cover portion disposed at the first end of the valve member. The cover portion is removable from the main body, the cover portion including a first seal disposed about an outer perimeter of the cover portion. The valve member includes a head portion disposed proximate the first end and behind the cover portion, the head portion including a second seal disposed about an outer perimeter defined by the head portion. A webbing portion is disposed between the cover portion and the head portion, the webbing portion including a fault structure to enable the cover portion to be removed from the main body and broken off from the head portion. The main body is formed of a molded material, and the first and second seals are formed of an overmold material molded onto the main body.

摘要翻译： 提升阀构件包括主体和设置在阀构件的第一端处的盖部。 盖部分可从主体移除，盖部分包括围绕盖部分的外周布置的第一密封件。 阀构件包括靠近第一端设置在盖部分后面的头部，头部包括围绕由头部限定的外周设置的第二密封件。 一个织带部分设置在盖部分和头部之间，织带部分包括故障结构，以使得盖部分能够从主体移除并从头部断开。 主体由模制材料形成，并且第一和第二密封件由模制在主体上的包覆模制材料形成。

公开(公告)号：US20060189968A1

公开(公告)日：2006-08-24

申请号：US11222353

申请日：2005-09-08

申请人： Harold Howlett ,  Robert Johnson ,  Charles Lundy ,  Eric Su

发明人： Harold Howlett ,  Robert Johnson ,  Charles Lundy ,  Eric Su

IPC分类号： A61B18/02

CPC分类号： A61B18/0218

摘要： A cryosurgery device includes an aerosol container holding a liquid refrigerant and having a valve and a stem extending out therefrom; an actuator seated on the stem and including an outlet tube for receiving released refrigerant from the container; a hub mounted on the container and including slots therein; and a base having a central opening for receiving the hub, the base including aligning projections that enter the slots in the hub to engage and apply pressure to the actuator to cause the actuator to depress the stem and release refrigerant into the base. The container may further contain an applicator tube mounted to the hub in fluid communication with the outlet tube with a porous tip mounted to a distal end of the applicator tube for receiving the refrigerant and, being chilled thereby, applied to a skin lesion to be treated.

公开(公告)号：US20060181749A1

公开(公告)日：2006-08-17

申请号：US10549781

申请日：2004-04-07

申请人： Richard Browne ,  Robert Canning Jr. ,  Michael Evans ,  Robert Johnson ,  Barry Rubin ,  Douglas Stilwell

发明人： Richard Browne ,  Robert Canning Jr. ,  Michael Evans ,  Robert Johnson ,  Barry Rubin ,  Douglas Stilwell

IPC分类号： H04N1/46

CPC分类号： H04N1/4095 ,  G01N21/59 ,  G01N2021/8663 ,  H04N1/00005 ,  H04N1/00034 ,  H04N1/00045 ,  H04N1/00047 ,  H04N1/0005 ,  H04N1/00068

摘要： An image analysis method to quantify visual showthrough of printed images on the reverse face of planar objects, such as paper. An illumination level is set using a white reference object. A white reference image is stored in a computer memory. An image of a planar object having a printed image on the reverse face is stored in a computer memory. A pixel by pixel ratio of the two images is calculated and a mean value of the ratios is calculated to characterize the visual showthrough. The measurements are substantially independent of both the illumination level and image shading.

公开(公告)号：US20060178570A1

公开(公告)日：2006-08-10

申请号：US11350916

申请日：2006-02-09

申请人： M. Robinson ,  Russell Abbink ,  Robert Johnson

发明人： M. Robinson ,  Russell Abbink ,  Robert Johnson

IPC分类号： A61B5/00 ,  G01J4/00

CPC分类号： G01N21/21 ,  A61B5/14558 ,  G01N21/49 ,  G01N2021/4792

摘要： The present invention provides methods and apparatuses for accurate noninvasive determination of tissue properties. Some embodiments of the present invention comprise an optical sampler having an illumination subsystem, adapted to communicate light having a first polarization to a tissue surface; a collection subsystem, adapted to collect light having a second polarization communicated from the tissue after interaction with the tissue; wherein the first polarization is different from the second polarization. The difference in the polarizations can discourage collection of light specularly reflected from the tissue surface, and can encourage preferential collection of light that has interacted with a desired depth of penetration or path length distribution in the tissue. The different polarizations can, as examples, be linear polarizations with an angle between, or elliptical polarizations of different handedness.

摘要翻译： 本发明提供用于精确无创确定组织性质的方法和装置。 本发明的一些实施例包括具有照明子系统的光学采样器，适于将具有第一偏振光的光传送到组织表面; 收集子系统，适于在与所述组织相互作用之后收集从所述组织传递的具有第二极化的光; 其中所述第一极化不同于所述第二极化。 极化的差异可以阻止从组织表面反射的光的收集，并且可以鼓励优先收集与组织中所需的穿透深度或路径长度分布相互作用的光。 作为示例，不同的极化可以是具有不同手性的角度或椭圆偏振之间的线性偏振。

公开(公告)号：US20060080838A1

公开(公告)日：2006-04-20

申请号：US10969392

申请日：2004-10-20

申请人： Robert Johnson ,  Robert Trotta ,  Kelly Bridges

发明人： Robert Johnson ,  Robert Trotta ,  Kelly Bridges

IPC分类号： B26B21/00

CPC分类号： B26B21/225 ,  B26B21/222

摘要： Connecting structures are provided, for connecting a cartridge to a handle in a shaving razor, e.g., a razor for wet shaving.

摘要翻译： 提供连接结构，用于将药筒连接到剃须刀中的手柄上，例如用于湿剃的剃须刀。

公开(公告)号：US20060076534A1

公开(公告)日：2006-04-13

申请号：US11284306

申请日：2005-11-21

申请人： David Szum ,  Robert Johnson

发明人： David Szum ,  Robert Johnson

IPC分类号： C09K3/00

CPC分类号： C08F290/141 ,  C03C25/1065 ,  C08F222/1006 ,  C08F290/06 ,  C08F290/061 ,  C08F290/14 ,  C08F2222/1086 ,  C09D4/00 ,  C08F220/00 ,  C08F2220/302 ,  C08F2220/1891 ,  C08F2222/102 ,  C08F226/06 ,  C08F2222/1013 ,  C08F2222/1026

摘要： Inner and outer primary and matrix material compositions which, after curing, exhibit a high degree of uniformity after curing even when the coating is applied onto optical fibers at relatively high shear rates, e.g., such as those experienced at high optical fiber coating line speeds. These compositions are provided in significant part by the selective incorporation of at least one radiation-curable oligomer into the compositions. In particular, and with respect to inner primary coatings, the oligomer should be selected so that the value m of an uncured radiation-curable inner primary coating composition in the equation τ = K ⁢   ⁢ λ ⁢   ⁢ γ 1 + ( λ ⁢   ⁢ γ ) m ( I ) is advantageously equal to or greater than about 0.90.

摘要翻译： 固化后的固化后的内外原料和基体材料组合物即使在以较高的剪切速率将涂料施加到光纤上（例如在高光纤涂布线速度下经历的那些）下也能在固化后表现出高度的均匀性。 这些组合物在很大程度上通过将至少一种可辐射固化的低聚物选择性掺入组合物来提供。 特别地，对于内部主要涂层，应该选择低聚物，使得在等式