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    IMPLANTABLE ELASTOMERIC CAPROLACTONE DEPOT COMPOSITIONS AND USES THEREOF
    23.
    发明申请
    IMPLANTABLE ELASTOMERIC CAPROLACTONE DEPOT COMPOSITIONS AND USES THEREOF 审中-公开
    可植入式弹性体夹心剂组合物及其用途

    公开(公告)号：US20070184084A1

    公开(公告)日：2007-08-09

    申请号：US11554540

    申请日：2006-10-30

    Applicant: Guohua Chen ,  Lothar Kleiner ,  Paul Houston ,  Aruna Nathan ,  Joel Rosenblatt

    Inventor： Guohua Chen ,  Lothar Kleiner ,  Paul Houston ,  Aruna Nathan ,  Joel Rosenblatt

    IPC: A61K48/00 ,  A61K38/16 ,  A61K38/17 ,  A61K31/715 ,  A61K38/43 ,  A61K31/56

    CPC classification number: A61K9/0024

    Abstract: Methods and compositions for systemically or locally administering a beneficial agent to a subject are described, and include, for example, implantable elastomeric depot compositions that can be injected into a desired location and which can provide controlled release of a beneficial agent over a prolonged duration of time. The compositions include a biocompatible, elastomeric caprolactone copolymer, a biocompatible solvent having low water miscibility that forms an elastomeric viscous gel with the polymer and limits water uptake by the implant, and a beneficial agent.

    Abstract translation: 描述了用于向受试者全身或局部施用有益剂的方法和组合物，并且包括例如可植入的弹性体贮库组合物，其可以注射到期望的位置并且可以在延长的持续时间内提供有益剂的受控释放 时间。 组合物包括生物相容的弹性体己内酯共聚物，具有低水混溶性的生物相容性溶剂，其与聚合物形成弹性粘性凝胶并限制植入物吸收水分，以及有益剂。

    End-capped poly(ester amide) copolymers
    25.
    发明申请
    End-capped poly(ester amide) copolymers 审中-公开
    封端的聚（酯酰胺）共聚物

    公开(公告)号：US20060089485A1

    公开(公告)日：2006-04-27

    申请号：US10975247

    申请日：2004-10-27

    Applicant: Jessica DesNoyer ,  Stephen Pacetti ,  Vidya Nayak ,  Lothar Kleiner

    Inventor： Jessica DesNoyer ,  Stephen Pacetti ,  Vidya Nayak ,  Lothar Kleiner

    IPC: C08G63/02 ,  C08G69/08

    CPC classification number: A61L27/34 ,  A61L31/10 ,  C08L77/12

    Abstract: Provided herein is an end-capped poly(ester amide) PEA) polymer and the method of making the polymer. The PEA polymer is substantially free of active amino end groups and/or activated carboxyl groups. The PEA polymer can form a coating on an implantable device, one example of which is a stent. The coating can optionally include a biobeneficial material and/or optionally with a bioactive agent. The implantable device can be used to treat or prevent a disorder such as one of atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, and combinations thereof.

    Abstract translation: 本文提供封端的聚（酯酰胺）PEA）聚合物和制备聚合物的方法。 PEA聚合物基本上不含活性氨基端基和/或活化的羧基。 PEA聚合物可以在可植入装置上形成涂层，其一个例子是支架。 涂层可任选地包括生物有益材料和/或任选地含有生物活性剂。 可植入装置可用于治疗或预防动脉粥样硬化，血栓形成，再狭窄，出血，血管解剖或穿孔之一，血管动脉瘤，易损斑块，慢性完全闭塞，跛行，静脉和人造移植物的吻合增殖等障碍 导管阻塞，输尿管阻塞，肿瘤阻塞及其组合。

    STENT COATING APPARATUS USING FOCUSED ACOUSTIC ENERGY
    26.
    发明申请
    STENT COATING APPARATUS USING FOCUSED ACOUSTIC ENERGY 审中-公开
    使用聚焦能量的STENT涂料设备

    公开(公告)号：US20110239939A1

    公开(公告)日：2011-10-06

    申请号：US13161343

    申请日：2011-06-15

    Applicant: Jason Van Sciver ,  Yung-Ming Chen ,  Lothar Kleiner

    Inventor： Jason Van Sciver ,  Yung-Ming Chen ,  Lothar Kleiner

    IPC: B05C11/00

    CPC classification number: B05D1/002

    Abstract: An apparatus for coating a stent includes an optical feedback system used to align a transducer with a stent strut. Once alignment is achieved, the transducer causes a coating to be ejected onto the stent strut and the transducer is moved along the stent strut to coat the stent strut.

    Abstract translation: 用于涂覆支架的装置包括用于将换能器与支架支柱对准的光学反馈系统。 一旦达到定位，换能器将涂层喷射到支架支柱上，并且换能器沿着支架支柱移动以涂覆支架支柱。

    Poly(ester amide) filler blends for modulation of coating properties
    29.
    发明授权
    Poly(ester amide) filler blends for modulation of coating properties 有权
    用于调节涂层性能的聚（酯酰胺）填料混合物

    公开(公告)号：US07390497B2

    公开(公告)日：2008-06-24

    申请号：US10976551

    申请日：2004-10-29

    Applicant: Jessica Renee DesNoyer ,  Stephen Dirk Pacetti ,  Syed Faiyaz Shmed Hossainy ,  Lothar Kleiner ,  Yiwen Tang ,  Gina Zhang

    Inventor： Jessica Renee DesNoyer ,  Stephen Dirk Pacetti ,  Syed Faiyaz Shmed Hossainy ,  Lothar Kleiner ,  Yiwen Tang ,  Gina Zhang

    IPC: A61K31/00 ,  A61L31/10 ,  A61L27/34 ,  A61L29/08 ,  C08G63/02

    CPC classification number: C09D177/12 ,  A61L31/06 ,  A61L31/10 ,  Y10S623/90 ,  Y10T428/31725 ,  Y10T428/31786 ,  C08L77/12

    Abstract: Provided herein is a PEA polymer blend and coatings or implantable devices formed therefrom. The PEA polymer blend is formed of a PEA polymer and a material capable of hydrogen bonding with the PEA. The PEA polymer blend can form a coating on an implantable device, one example of which is a stent. The coating can optionally include a biobeneficial material and/or optionally with a bioactive agent. The implantable device can be used to treat or prevent a disorder such as one of atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, and combinations thereof.

    Abstract translation: 本文提供了由其形成的PEA聚合物共混物和涂层或可植入装置。 PEA聚合物共混物由PEA聚合物和能够与PEA氢键合的材料形成。 PEA聚合物共混物可以在可植入装置上形成涂层，其一个实例是支架。 涂层可任选地包括生物有益材料和/或任选地含有生物活性剂。 可植入装置可用于治疗或预防动脉粥样硬化，血栓形成，再狭窄，出血，血管解剖或穿孔之一，血管动脉瘤，易损斑块，慢性完全闭塞，跛行，静脉和人造移植物的吻合增殖等障碍 导管阻塞，输尿管阻塞，肿瘤阻塞及其组合。

    DEPOT COMPOSITIONS WITH MULTIPLE DRUG RELEASE RATE CONTROLS AND USES THEREOF
    30.
    发明申请
    DEPOT COMPOSITIONS WITH MULTIPLE DRUG RELEASE RATE CONTROLS AND USES THEREOF 审中-公开
    具有多种药物释放速率控制的DEPOT组合物及其用途

    公开(公告)号：US20070196415A1

    公开(公告)日：2007-08-23

    申请号：US11553925

    申请日：2006-10-27

    Applicant: Guohua Chen ,  Lothar Kleiner ,  Paul Houston ,  Jeremy Wright

    Inventor： Guohua Chen ,  Lothar Kleiner ,  Paul Houston ,  Jeremy Wright

    IPC: A61F2/02

    CPC classification number: A61K47/34 ,  A61K9/0024 ,  A61K9/143 ,  A61K9/145 ,  A61K9/146 ,  A61K9/19 ,  A61K47/10 ,  A61K47/14

    Abstract: Injectable depot compositions with dual mechanisms of release rate control are provided for sustained beneficial agent delivery in a patient. The composition includes bioerodible particles and an injectable depot vehicle containing a bioerodible polymer in an organic solvent, for forming a bioerodible depot implant after administration to the patient. The bioerodible particles are dispersed in the depot vehicle and contain a beneficial agent and a release rate controlling agent retarding the release of the beneficial agent from the bioerodible particles and from the depot implant.

    Abstract translation: 提供具有释放速率控制的双重机制的可注射储库组合物，用于在患者中持续的有益药物递送。 该组合物包括生物可腐蚀颗粒和在有机溶剂中含有生物可腐蚀聚合物的可注射贮存载体，用于在给予患者之后形成生物可浸润的储库植入物。 生物可腐蚀颗粒分散在贮存载体中并含有有益剂和释放速率控制剂，其阻止有益剂从生物可侵蚀颗粒和贮存植入物的释放。

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