公开(公告)号：US5819860A

公开(公告)日：1998-10-13

申请号：US834440

申请日：1997-04-16

申请人： Alex Newton ,  Steven Taylor ,  Andrew Murdock ,  John M. Clegg

发明人： Alex Newton ,  Steven Taylor ,  Andrew Murdock ,  John M. Clegg

IPC分类号： E21B10/00 ,  E21B10/54 ,  E21B10/55 ,  E21B10/56 ,  E21B10/567 ,  E21B10/60 ,  E21B17/10

CPC分类号： E21B10/567 ,  E21B10/00 ,  E21B10/55 ,  E21B10/60 ,  E21B10/602 ,  E21B17/1064 ,  E21B17/1092

摘要： A rotary drill bit for use in drilling holes in subsurface formations comprises a bit body having a leading face and a gauge region, a number of blades formed on the leading face of the bit and extending outwardly away from the axis of the bit so as to define between the blades a number of fluid channels leading towards the gauge region, a number of cutting elements mounted side-by-side along each blade, and a number of nozzles in the bit body for supplying drilling fluid to the fluid channels for cleaning and cooling the cutting elements. In at least one of the fluid channels, adjacent the gauge region, is an opening into an enclosed passage which passes internally through the bit body to an outlet which, in use, communicates with the annulus between the drill string and the wall of the borehole being drilled. The portion of the gauge region outwardly of the opening comprises a bearing surface which, in use bears against the wall of the bore hole and extends across the width of the channel.

摘要翻译： 用于在地下地层中钻孔的旋转钻头包括具有前表面和表面区域的钻头体，形成在钻头的前表面上并且向外远离钻头的轴线延伸的多个刀片，以便 在叶片之间限定通向仪表区域的许多流体通道，沿着每个叶片并排安装的多个切割元件，以及钻头体中的多个喷嘴，用于将钻井流体供应到用于清洁的流体通道和 冷却切割元件。 在靠近仪表区域的至少一个流体通道中，是通向内部通过钻头体的封闭通道的开口，该出口在使用中与钻柱和钻孔壁之间的环形空间连通 正在钻 测量区域在开口外部的部分包括支承表面，其在使用中抵靠钻孔的壁并且延伸穿过通道的宽度。

公开(公告)号：US20190355069A1

公开(公告)日：2019-11-21

申请号：US15983089

申请日：2018-05-17

申请人： Philip Baker ,  Steven Taylor

发明人： Philip Baker ,  Steven Taylor

IPC分类号： G06Q50/00 ,  G06Q10/06 ,  G06Q40/04 ,  G06Q30/02

摘要： This invention includes original systems and methodologies required to conduct perpetual online competitions within social networked marketplaces and economies. Among these systems and methodologies are: perpetual competition-based earnings model, Judges' ranking expiration and devaluation, Judges' ranking upvaluation, and perpetual competition-based business entities and exchanges. The first three inventions are intended to motivate and incentivize four groups of competition participants: Organizers, Contestants, Judges and Followers. The fourth invention provides entrepreneurs the systems and methods for creating a multifaceted business entity within the framework of an online social platform. All inventions function in tandem to form a dynamic and endlessly evolving competitive environment to maximize entertainment value and business development opportunities.

公开(公告)号：US10112096B1

公开(公告)日：2018-10-30

申请号：US15717466

申请日：2017-09-27

申请人： Steven Taylor

发明人： Steven Taylor ,  Robert G. Dickie

IPC分类号： A63B69/00 ,  A63B59/14 ,  A63B59/70 ,  A63B102/24 ,  A63B102/22

摘要： A hockey training device and method of using the same to teach a hockey player how to play a shot, particularly a wrist shot. The device includes a connector assembly that is selectively engaged with a hockey stick blade during training; a puck holding assembly for holding the puck in an optimum position; and a hinge connecting the connector assembly and puck holding assembly together. The hinge allows the connector assembly and puck holding assembly to pivot relative to each other as the stick is maneuvered to make a shot. The puck holding assembly includes a flexible region that is moved out of the way of the puck as a shot is played and the puck is accelerated by the stick toward a net or another player. The hinge ensures that the puck holding assembly maintains its position relative to the ice as the shot is played.

公开(公告)号：US20160153989A1

公开(公告)日：2016-06-02

申请号：US14931941

申请日：2015-11-04

申请人： Milan N. Stojanovic ,  Sergei Rudchenko ,  Maria Rudchenko ,  Steven Taylor

发明人： Milan N. Stojanovic ,  Sergei Rudchenko ,  Maria Rudchenko ,  Steven Taylor

IPC分类号： G01N33/569

CPC分类号： G01N33/56966 ,  G01N2333/705

摘要： Provided herein are molecular automaton systems for identification, isolation, or elimination of a target biological object. Some embodiments include modules specific for a target biological object having a first biological object surface marker and a second biological object surface marker. Some embodiments include modules specific for a target biological object having a first biological object surface marker but not a second biological object surface marker.

摘要翻译： 本文提供了用于鉴定，分离或消除靶生物的物质的分子自动机系统。 一些实施方案包括特定于具有第一生物物体表面标记和第二生物物体表面标记的靶生物的物质的模块。 一些实施方案包括对具有第一生物物体表面标记而不是第二生物物体表面标记的目标生物体特异性的模块。

公开(公告)号：US20150044672A1

公开(公告)日：2015-02-12

申请号：US14343741

申请日：2012-09-07

申请人： Milan Stojanovic ,  Steven Taylor

发明人： Milan Stojanovic ,  Steven Taylor

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6876 ,  C12Q1/6816 ,  C12Q2525/207 ,  C12Q2537/161 ,  C12Q2563/131

摘要： Provided are compositions including a streptavidin composition in which a plurality of biotin binding sites are blocked by tethered biotins. Also provided are methods of using such compositions, including cell imaging, nucleic acid analysis or detection, or biotinylation quantification.

摘要翻译： 提供了包含链霉亲和素组合物的组合物，其中多个生物素结合位点被系链生物素阻断。 还提供了使用这种组合物的方法，包括细胞成像，核酸分析或检测或生物素化定量。

公开(公告)号：US20100333008A1

公开(公告)日：2010-12-30

申请号：US12495505

申请日：2009-06-30

申请人： Steven Taylor

发明人： Steven Taylor

IPC分类号： G06F3/048

CPC分类号： G06F9/543 ,  G06F3/0486

摘要： The present disclosure involves systems, software, and computer implemented methods for dragging and dropping a component of an application onto a virtual desktop. One process includes operations for receiving a request to copy a selected component of an application from a plurality of components of the application onto the virtual desktop. A display window for displaying the selected component of the application is executed and the unselected components of the application are filtered by visually concealing the unselected components. The process can further include presenting the selected component of the application in the display window.

摘要翻译： 本公开涉及用于将应用程序的组件拖放到虚拟桌面上的系统，软件和计算机实现的方法。 一个过程包括用于接收将应用程序的选定组件从应用程序的多个组件复制到虚拟桌面上的请求的操作。 执行用于显示所选择的应用程序组件的显示窗口，并通过视觉上隐藏未选择的组件来过滤应用程序的未选择的组件。 该过程还可以包括在显示窗口中呈现应用的所选择的组件。

公开(公告)号：US20100143341A1

公开(公告)日：2010-06-10

申请号：US11993433

申请日：2006-06-21

申请人： Steven Taylor ,  Stephen Murfin ,  Thomas Stephen Coulter ,  Stefan Jakel ,  Babette Aicher ,  Arndt-Rene Kelter ,  Joachim Kraemer ,  Christian Kirchhoff ,  Andreas Scheel ,  Julian Woelcke

发明人： Steven Taylor ,  Stephen Murfin ,  Thomas Stephen Coulter ,  Stefan Jakel ,  Babette Aicher ,  Arndt-Rene Kelter ,  Joachim Kraemer ,  Christian Kirchhoff ,  Andreas Scheel ,  Julian Woelcke

IPC分类号： A61K31/519 ,  C07D495/04 ,  A61K31/5377 ,  A61K38/28 ,  A61K31/60 ,  A61K39/395 ,  A61K31/704 ,  A61P3/00

CPC分类号： C07D495/04

摘要： The present invention relates to novel pharmaceutical compositions of general formula (I) comprising thienopyrimidine compounds. Moreover, the present invention relates to the use of the thienopyrimidine compounds of the invention for the production of pharmaceutical compositions for the prophylaxis and/or treatment of diseases which can be influenced by the inhibition of the kinase activity of Mnk1 and/or Mnk2 (Mnk2a or Mnk2b) and/or variants thereof.

摘要翻译： 本发明涉及包含噻吩并嘧啶化合物的通式（I）的新型药物组合物。 此外，本发明涉及本发明的噻吩并嘧啶化合物用于生产药物组合物用于预防和/或治疗可受到抑制Mnk1和/或Mnk2（Mnk2a）激酶活性的疾病的用途 或Mnk2b）和/或其变体。

公开(公告)号：US20060172990A1

公开(公告)日：2006-08-03

申请号：US10538928

申请日：2003-12-11

申请人： Stephen East ,  Ryan Bragg ,  Steven Taylor

发明人： Stephen East ,  Ryan Bragg ,  Steven Taylor

IPC分类号： A61K31/553 ,  A61K31/502

CPC分类号： C07D295/108 ,  A61K31/16 ,  C07C243/34 ,  C07C2601/08 ,  C07D207/06 ,  C07D211/14 ,  C07D217/06 ,  C07D237/04 ,  C07D241/02 ,  C07D277/46 ,  C07D317/58

摘要： Compounds of formula (I) have antibacterial activity, wherein Q represents —N(OH)CH(═O) or —C(═)NH(OH); Y represents —C(═O)—, —C(═S)—, —S(═O)—, or —SO2—; R1 represents hydrogen, C1-C6 alkyl or C1-C6 alkyl substituted by one or more halogen atoms, or, except when Q is a radical of formula —N(OH)CH(═O), a hydroxy, C1-C6 alkoxy, C1-C6 alkenyloxy, halogen, amino, C1-C6 alkylamino, or di-(C1-C6 alkyl)amino group; R2 represents a substituted or unsubstituted C1-C6 alkyl, C1-C3 alkyl-O—C1-C3 alkyl, C1-C3 alkyl-C1-C3 alkyl, cycloalkyl(C1-C3 alkyl)-, aryl(C1-C3 alkyl)-, heterocyclyl(C1-C3 alkyl)-, or R1R2N—C1-C3 alkyl group wherein R1 represents hydrogen or C1-C3 alkyl and R2 represents C1-C3 alkyl, or R1R2N— represents a cyclic amino group; R3 and R5 independently represent hydrogen or a substituted or unsubstituted C1-C6 alkyl group or R3 and R5 taken together with the carbon and nitrogen atoms to which they are respectively attached form a saturated heterocyclic ring of from 5 to 7 ring atoms, which may be fused to a second carbocyclic or heterocyclic ring, either of which rings may optionally be substituted; R4 represents hydrogen or a substituted or unsubstituted C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, cycloalkyl, aryl, heterocyclyl, C1-C3 alkyl-O—C1-C3 alkyl, C1-C3 alkyl-S—C1-C3 alkyl, C1-C3 alkyl-NH—(C1-C3 alkyl)-, cycloalkyl(C1-C3 alkyl)-, heterocyclic(C1-C3 alkyl)-group; and A represents a primary, secondary or tertiary amino group or a group —R6, —OR6, wherein R6 is a substituted or unsubstituted C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, cycloalkyl, aryl, heterocyclyl, C1-C3 alkyl-O—(C1-C3 alky)-1, C1-C3 alkyl-S—(C1-C3 alkyl)-, C1-C3 alkyl-NH—(C1-C3 alkyl)-, cycloalkyl(C1-C3 alkyl)-, heterocyclic(C1-C3 alky)-1 or aryl(C1-C3 alkyl)-group.

公开(公告)号：US20060135411A1

公开(公告)日：2006-06-22

申请号：US10531564

申请日：2003-10-15

申请人： Trent Woodruff ,  Steven Taylor ,  David Fairlie

发明人： Trent Woodruff ,  Steven Taylor ,  David Fairlie

IPC分类号： A61K38/12

CPC分类号： C07K16/241 ,  A61K38/12 ,  A61K2039/505

摘要： This invention relates to methods of treatment of inflammatory bowel disease, and especially to treatment of this condition with cyclic peptidic and peptidomimetic compounds which have the ability to modulate the activity of G protein-coupled receptors. The compounds preferably act as antagonists of the C5a receptor, and are active against C5a receptors on polymorphonuclear leukocytes and macrophages. Particularly preferred compounds for use in the methods of the invention are disclosed.

摘要翻译： 本发明涉及治疗炎症性肠病的方法，尤其涉及具有调节G蛋白偶联受体活性的能力的环状肽和拟肽化合物治疗这种病症的方法。 化合物优选作为C5a受体的拮抗剂，并且对多形核白细胞和巨噬细胞上的C5a受体具有活性。 公开了用于本发明方法的特别优选的化合物。

公开(公告)号：US20050155841A1

公开(公告)日：2005-07-21

申请号：US11012080

申请日：2004-12-14

申请人： Tom Gattrell ,  Steven Taylor

发明人： Tom Gattrell ,  Steven Taylor

IPC分类号： B65G7/08 ,  B23K37/00 ,  B23K37/04 ,  B23Q1/48 ,  B23Q1/54 ,  B65G47/24

CPC分类号： B23K37/0443 ,  B23Q1/4852 ,  B23Q1/5468

摘要： A transfer device has an undercarriage with two or more carriage portions which are movable along a travel path between a first location and a second location. The carriage portions carrying at least one work piece support. A linkage extending between the carriage portions, where the linkage is operable to change the position of the work piece support when one carriage portion moves relative to another along the travel path.

摘要翻译： 传送装置具有底架，其具有两个或多个托架部分，其可沿第一位置和第二位置之间的行进路径移动。 托架部分承载至少一个工件支撑件。 一个在滑架部分之间延伸的连杆，其中当一个托架部分沿着行进路径相对于另一个移动时，连杆可操作以改变工件支撑件的位置。