-
21.发明授权公开(公告)号：US07291594B2
公开(公告)日：2007-11-06
申请号：US10530125
申请日：2003-10-10
IPC分类号： A61K38/26 , C07K14/605
CPC分类号： C07K14/605 , A61K38/26 , Y10S514/866
摘要： A GLP-1 derivative is provided including an amino acid sequence of GLP-1 (7-35) having deletion, substitution and/or addition of one or more amino acids and having Waa-(Xaa)n-Yaa (in which Waa is Arg or Lys, Xaa is Arg or Lys, n is an integer of 0 to 14, and Yaa is Arg, Arg-NH2, Lys, Lys-NH2 or Hse) added to the C-terminus of the peptide having a GLP-1 activity. These derivatives are highly absorbable via a mucous membrane. The GLP-1 derivative can be conferred with resistance to dipeptidyl peptidase IV by substituting amino acid 8 in its GLP-1 amino acid sequence with Ser, or with resistance to trypsin by substituting amino acids 26 and 34 with Gln and Asn, respectively.The absorption efficiency of the GLP-1 derivatives via mucous membranes can be further improved by preparing a composition using a charge-regulated fat emulsion regulated to be negatively charged thereon.
摘要翻译： 提供GLP-1衍生物，其包含具有缺失，取代和/或添加一个或多个氨基酸并具有Waa-（Xaa）n-Yaa的GLP-1（7-35）的氨基酸序列（其中Waa为 Arg或Lys，Xaa是Arg或Lys，n是0-14的整数，Yaa是Arg，Arg-NH 2，Lys，Lys-NH 2或 Hse）加入具有GLP-1活性的肽的C末端。 这些衍生物通过粘膜是高度可吸收的。 通过用Ser取代其GLP-1氨基酸序列中的氨基酸8，或分别用Gln和Asn取代氨基酸26和34，对胰蛋白酶具有抗性，GLP-1衍生物可赋予对二肽基肽酶IV的抗性。 通过使用调节为带负电荷的电荷调节脂肪乳液制备组合物，可以进一步提高通过粘膜的GLP-1衍生物的吸收效率。
-
公开(公告)号：US20070195556A1
公开(公告)日：2007-08-23
申请号：US11708672
申请日：2007-02-21
IPC分类号： H02M3/335
CPC分类号： H02M1/38 , H03K17/04123 , H03K17/162 , H03K17/6871 , H03K17/691 , H03K2017/066
摘要： A driving circuit has a p-channel transistor and an n-channel transistor. A power switching element is set at an on state each time the p-channel transistor sets a charging line at a conductive state in response to a leading edge of an output pulse to supply a positive charge to a gate of the element through the charging line. The element is set at an off state each time the n-channel transistor sets a discharging line at a conductive state in response to a trailing edge of the output pulse to discharge the supplied charge through the discharging line. A through current occasionally flows through the transistors set at the on state together. The driving circuit has resistors between the transistors to suppress the through current.
摘要翻译： 驱动电路具有p沟道晶体管和n沟道晶体管。 每当p沟道晶体管响应于输出脉冲的前沿将充电线设置在导通状态，电源开关元件被设置为导通状态，以通过充电线向元件的栅极提供正电荷 。 每当n沟道晶体管响应于输出脉冲的后沿而将导线状态设置为放电线以将所提供的电荷放电通过放电线时，该元件被设置为截止状态。 通过电流偶尔会流过设置在导通状态的晶体管。 驱动电路在晶体管之间具有抑制直通电流的电阻。
-
公开(公告)号：US20070177409A1
公开(公告)日：2007-08-02
申请号：US11699075
申请日：2007-01-29
IPC分类号： H02M3/335
CPC分类号： H02M3/33592 , Y02B70/1475
摘要： The control apparatus for controlling a voltage transforming apparatus having a transformer, power switching elements disposed in a primary side, and synchronous-rectifying switching elements disposed in a secondary side includes a judging circuit making a judgment as to whether or not an output current of the voltage transforming apparatus is smaller than a specified current on the basis of a primary-side current of the transformer and an inhibition circuit inhibiting the synchronous-rectifying switching elements from performing their synchronous-rectifying control operation when the judging circuit judges that the output current is smaller than the specified current. The judging circuit makes the judgment on the basis of the primary-side current flowing through the primary coil of the transformer immediately before the power switching elements are turned off.
摘要翻译： 用于控制具有变压器的电压变换装置的控制装置，设置在初级侧的功率开关元件和设置在次级侧的同步整流开关元件包括判断电路，判断是否输出电流 电压变换装置基于变压器的初级侧电流小于规定电流，抑制电路在判定电路判断为输出电流为止时，禁止同步整流用开关元件进行同步整流控制动作 小于指定电流。 判断电路基于在功率开关元件断开之前流过变压器的初级线圈的初级侧电流进行判断。
-
24.发明申请公开(公告)号：US20070033676A1
公开(公告)日：2007-02-08
申请号：US10550624
申请日：2004-03-26
申请人： Koichi Sugita , Saori Kasahara , Hiroyasu Ebinuma , Humio Takaiwa , Takahito Jomori , Yuji Hayashi , Akira Tashita , Yukari Kobara
发明人： Koichi Sugita , Saori Kasahara , Hiroyasu Ebinuma , Humio Takaiwa , Takahito Jomori , Yuji Hayashi , Akira Tashita , Yukari Kobara
IPC分类号： A01H5/00 , C12N15/82 , A01H1/00 , C07K14/605
CPC分类号： C12N15/8257 , C07K14/605 , C12N15/8216
摘要： The present invention provides a method for highly producing a recombinant protein in a plant storage organ and a GLP-1 derivative. The plant storage organ in which the recombinant protein is highly produced is obtained by transformation with the use of a vector which comprises a recombinant protein gene, a cytokinin-related gene, a drug-resistant gene and a removable DNA element, in which the cytokinin-related gene and the drug-resistant gene exist in the positions so that they can behave together with the DNA element, while the recombinant protein to be expressed in the plant storage organ exists in the position so that it would not behave together with the DNA element. The GLP-1 is produced by using the method, and a derivative having been stabilized against enzymatic digestion is further provided.
摘要翻译： 本发明提供了在植物贮藏器官和GLP-1衍生物中高度产生重组蛋白的方法。 通过使用包含重组蛋白基因，细胞分裂素相关基因，耐药性基因和可移除DNA元件的载体转化获得重组蛋白质高度产生的植物贮藏器官，其中细胞分裂素 相关基因和耐药基因存在于与DNA元件一起表现的位置，而在植物储存器官中表达的重组蛋白存在于与DNA不一致的位置 元件。 通过使用该方法制备GLP-1，进一步提供了稳定的酶促消化的衍生物。
-
公开(公告)号：US20060229286A1
公开(公告)日：2006-10-12
申请号：US10541108
申请日：2004-01-30
申请人： Takuji Kakigami , Mitsuru Oka , Noriyasu Katoh , Masahiro Yoshida , Masahiro Shirai , Toru Murase , Masao Sakairi , Takayo Murase , Mitsuaki Takeuchi , Yuji Hayashi , Motohiro Takeda , Mitsuhiro Makino
发明人： Takuji Kakigami , Mitsuru Oka , Noriyasu Katoh , Masahiro Yoshida , Masahiro Shirai , Toru Murase , Masao Sakairi , Takayo Murase , Mitsuaki Takeuchi , Yuji Hayashi , Motohiro Takeda , Mitsuhiro Makino
IPC分类号： A61K31/537 , A61K31/445 , A61K31/426 , A61K31/401
CPC分类号： C07D487/04 , C07D207/16 , C07D209/42 , C07D209/44 , C07D215/54 , C07D217/26 , C07D277/62 , C07D311/16 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12 , C07D417/12 , C07D473/34 , C07D513/04
摘要： A dipeptidyl peptidase IV inhibitor which is satisfactory in respect of activity, stability and safety and has an excellent action as a pharmaceutical agent. A compound represented by the following general formula or a pharmaceutically acceptable salt thereof: wherein R1 and R2 each represents hydrogen, an optionally substituted C1-6 alkyl group, or —COOR5 whereupon R5 represents hydrogen or an optionally substituted C1-6 alkyl group, or R1, R2, and a carbon atom together represent a 3- to 6-membered cycloalkyl group, R3 represents hydrogen or an optionally substituted C6-10 aryl group, R4 represents a hydrogen or a cyano group, D represents —CONR6—, —CO— or —NR6CO—, R6 represents hydrogen or an optionally substituted C1-6 alkyl group, E represents —(CH2)m— whereupon m is 1 to 3, —CH2OCH2—, or —SCH2—, n is 0 to 3, and A represents an optionally substituted bicyclic heterocyclic group or bicyclic hydrocarbon group.
摘要翻译： 二肽基肽酶IV抑制剂在活性，稳定性和安全性方面令人满意，并且作为药剂具有优异的作用。 由以下通式表示的化合物或其药学上可接受的盐：其中R 1和R 2各自表示氢，任选取代的C 1-6烷基或 - COOR 5其中R 5表示氢或任选取代的C 1-6烷基，或R 1，R 2，O， >，并且碳原子一起表示3至6元环烷基，R 3表示氢或任选取代的C 6-10芳基，R 4表示 氢或氰基，D表示-CONR 6 - ， - CO-或-NR 6 CO-，R 6表示氢或 任选取代的C 1-6烷基，E表示 - （CH 2 CH 2）m - ，其中m为1至3，-CH 2 OCH 2， 或-SCH 2 - ，n为0至3，A表示任选取代的双环杂环基或双环烃基。
-
公开(公告)号：US06719035B1
公开(公告)日：2004-04-13
申请号：US09672388
申请日：2000-09-28
IPC分类号： B22D1700
CPC分类号： B22D17/2061
摘要： An injection molding apparatus of a metal material places a heating cylinder in an inclined position. The heating cylinder includes a nozzle at a tip thereof and a screw disposed inside. In this way, the metal material in a liquid phase state can be transferred and metered accurately in a reliable manner at all times by flowing due to the inclination and a transfer force produced by rotation of the screw. A clamping apparatus is provided to oppose the injection apparatus and includes a mold having a sprue bush inside. The injection apparatus and the clamping apparatus are placed on an apparatus platform in an inclined position at the same angle with the mold in a lower end, so that the metal material in the liquid phase state in the heating cylinder flows down toward the head due to self-weight. The nozzle and sprue bush are positioned on the same straight line, thereby maintaining nozzle touch without bending the nozzle.
摘要翻译： 金属材料的注射成型装置将加热缸放置在倾斜位置。 加热缸包括在其尖端处的喷嘴和设置在内部的螺钉。 以这种方式，可以通过由于倾斜和由螺杆的旋转产生的转印力而流动而以可靠的方式精确地转移和计量处于液相状态的金属材料。 设置有与注射装置相对的夹紧装置，并且包括在其内部具有浇口衬套的模具。 注射装置和夹紧装置在下端以与模具成相同角度的倾斜位置放置在装置平台上，使得加热缸内处于液相状态的金属材料向下流向头部，由于 自重。 喷嘴和浇道衬套位于相同的直线上，从而保持喷嘴接触而不使喷嘴弯曲。
-
27.发明授权公开(公告)号：US06562100B2
公开(公告)日：2003-05-13
申请号：US09924864
申请日：2001-08-08
申请人： Kiyoto Takizawa , Toshiyasu Koda , Yuji Hayashi , Mamoru Miyagawa
发明人： Kiyoto Takizawa , Toshiyasu Koda , Yuji Hayashi , Mamoru Miyagawa
IPC分类号： B22D1300
CPC分类号： B22D17/30
摘要： The invention has an object to permit to make the accumulation amount and the temperature of molten metal in the metal material molding machine constant, by performing material supply and melting taking the accumulation amount as reference during the molding operation. The supply apparatus 11 and the agitation means 29 of metal material at the moment of operation starting are controlled to be inactive until the temperature of the melting vessel attains a predetermined value and to start operating when the predetermined temperature is attained, allowing to supply and agitate the metal material. The supply and the agitation of metal material after the predetermined temperature is attained, are performed while gradually supplying and agitating the metal material until metal material of at least 6 times or more of the maximum injection volume is accumulated in melt state.
摘要翻译： 本发明的目的是通过在成型操作期间以累积量作为参考，进行材料供给和熔化，使金属材料成型机中的熔融金属的积存量和温度恒定。 供给装置11和操作启动时的金属材料搅拌装置29被控制为无效，直到熔化容器的温度达到预定值，并在达到预定温度时开始运行，允许供应和搅动 金属材料。 在达到预定温度之后进行金属材料的供给和搅拌，同时逐渐地供给和搅拌金属材料，直到最大注入体积的至少6倍以上的金属材料在熔融状态下积聚。
-
公开(公告)号：US5818413A
公开(公告)日：1998-10-06
申请号：US607135
申请日：1996-02-26
CPC分类号： G09G3/3677 , G09G3/3648 , G09G2310/0205 , G09G2310/0224 , G09G2310/0281 , G09G2340/0414 , G09G2340/0442 , G09G2340/045 , G09G2340/0471 , G09G2340/0485
摘要： A display apparatus comprises arrayed pixels, a vertical-scanning circuit, and a horizontal-scanning circuit. The vertical-scanning circuit outputs selection pulses one after another to sequentially scan pixels in one vertical-scanning period in units of lines. The horizontal-scanning circuit sends and writes a video signal into the pixel line selected by the sequential scanning in one horizontal-scanning period. The vertical-scanning circuit is provided with a switching section to control the consecutive outputs of the selection pulses and to adjust the number of pixel lines to be selected in one horizontal period according to the specification of the video signal used. This configuration enables both noninterlaced drive and interlaced drive.
摘要翻译： 显示装置包括阵列像素，垂直扫描电路和水平扫描电路。 垂直扫描电路依次输出选择脉冲，以一行垂直扫描期间顺序扫描像素。 水平扫描电路在一个水平扫描周期中将视频信号发送并写入由顺序扫描选择的像素线。 垂直扫描电路设置有切换部分，用于控制选择脉冲的连续输出，并且根据所使用的视频信号的指定，在一个水平周期中调整要选择的像素线的数量。 这种配置可以实现非隔行驱动和隔行驱动。
-
公开(公告)号：US5748026A
公开(公告)日：1998-05-05
申请号：US796039
申请日：1997-02-05
申请人： Toshikazu Maekawa , Yuji Hayashi
发明人： Toshikazu Maekawa , Yuji Hayashi
IPC分类号： G09G3/36 , H03K3/356 , H03K5/02 , H03K19/0185
CPC分类号： H03K3/356113 , H03K19/018521 , H03K3/356017 , G09G2310/0289 , G09G3/3648
摘要： A level converting circuit for an input clock signal having a relatively low amplitude comprising a level converting circuit for converting the input clock signal to an output clock signal having a relatively high amplitude, the level converting circuit having an input transistor which has a predetermined threshold voltage, and detecting/offsetting circuit for detecting the threshold voltage of the input transistor and adding an offset voltage in response to the detected threshold voltage to the input clock signal and then for providing the offset input clock signal to the level converting circuit. The novel setup performs clock interfacing of a thin-film transistor integrated circuit device represented by an active-matrix liquid crystal display device at a relatively high speed at a low voltage below 3 V for example. This allows to fully cope with a recent trend of ever reducing operating voltage of a CMOS gate array constituting an external timing generator, eliminating necessity for building a pulse amplifier based especially on high dielectric-strength MOS process into the gate array to eventually reduce size of the chip.
摘要翻译： 一种用于具有相对较低幅度的输入时钟信号的电平转换电路，包括用于将输入时钟信号转换为具有相对高幅度的输出时钟信号的电平转换电路，该电平转换电路具有输入晶体管，其具有预定阈值电压 以及用于检测输入晶体管的阈值电压的检测/补偿电路，并且响应于检测到的阈值电压而将偏移电压加到输入时钟信号上，然后将偏移输入时钟信号提供给电平转换电路。 新颖的设置例如在低于3V的低电压下以相对较高的速度执行由有源矩阵液晶显示装置表示的薄膜晶体管集成电路器件的时钟接口。 这允许充分应对构成外部定时发生器的CMOS门阵列的工作电压不断降低的趋势，消除了将特别是基于高介电强度MOS工艺的脉冲放大器构建到门阵列中的必要性，以最终减小 芯片。
-
公开(公告)号：US4959692A
公开(公告)日：1990-09-25
申请号：US282449
申请日：1988-12-09
申请人： Yuji Hayashi , Susumu Sakakibara , Katsumi Maeda
发明人： Yuji Hayashi , Susumu Sakakibara , Katsumi Maeda
IPC分类号： G03G15/09
CPC分类号： G03G15/09 , G03G15/0921
摘要： A developing device including a rotatable developing sleeve confronting an electrostatic latent image support member, a supply device for supplying developer to a peripheral surface of the developing sleeve, a bristle height regulating member, a device for removing from the peripheral surface of the developing sleeve, the developer having passed through a developing region, a cutoff device for cutting off supply of the developer from the supply device to the developing sleeve, which is retractably projected into a developer supply region defined between the developing sleeve and the supply device and a magnet member provided fixedly in the developing sleeve and having a developing magnetic pole confronting the support member, a first magnetic pole confronting the bristle height regulating member and a second magnetic pole of a polarity identical with that of the first magnetic pole such that the developer is continuously held in an erect state on the developing sleeve by the first and second magnetic poles.
摘要翻译： 一种显影装置，包括面向静电潜像支撑构件的可旋转显影套筒，用于向显影套筒的外周表面供应显影剂的供应装置，刷毛高度调节构件，用于从显影套筒的外周表面移除的装置， 已经通过显影区域的显影剂，用于切断从供给装置向显影套筒供应显影剂的切断装置，其可伸缩地突出到限定在显影套筒和供给装置之间的显影剂供应区域中，磁体构件 固定地安装在显影套筒中并且具有与支撑构件相对的显影磁极，面对刷毛高度调节构件的第一磁极和与第一磁极的极性相同的极性的第二磁极，使得显影剂被连续地保持 在开发套筒上的直立状态由第一和第二 第二磁极。
-
-
-
-
-
-
-
-
-
搜索结果
88 条记录 (耗时 0.023 秒)
