公开(公告)号：US20080249409A1

公开(公告)日：2008-10-09

申请号：US12065343

申请日：2006-08-25

申请人： John Fraser ,  Jeffry E. Powers ,  Michalakis Averkiou

发明人： John Fraser ,  Jeffry E. Powers ,  Michalakis Averkiou

IPC分类号： A61N7/00 ,  A61B8/00

CPC分类号： A61N7/02 ,  A61B8/0833 ,  A61B8/14 ,  A61B8/4405 ,  A61B8/481 ,  A61B2017/22008 ,  A61B2090/378 ,  A61N2007/0078

摘要： A combined ultrasound imaging and therapy transducer includes a linear array of imaging transducer elements. First and second linear arrays of therapy transducer elements extend longitudinally along respective first and second sides of the imaging transducer elements and are canted inwardly toward each other. The imaging and therapy transducer is used with an ultrasound imaging system to locate clots in a region of interest. After the region of interest has been perfused with a microbubble contrast agent, the therapy transducer elements are driven by an amplifier located in the transducer to dissolve the clot. The use of the imaging transducer elements and the therapy transducer elements can be interleaved so that the therapy can be conditioned on an ultrasound image showing substantial destruction of the contrast agent microbubbles, re-perfusion of microbubbles in the region of interest, or the continued presence of the clot.

摘要翻译： 组合的超声成像和治疗换能器包括成像换能器元件的线性阵列。 治疗换能器元件的第一和第二线性阵列沿着成像换能器元件的相应第一和第二侧纵向延伸并且向内朝向彼此倾斜。 成像和治疗传感器与超声成像系统一起使用以定位感兴趣区域中的凝块。 在用微泡造影剂灌注感兴趣区域之后，治疗换能器元件由位于换能器中的放大器驱动以溶解凝块。 可以使用成像换能器元件和治疗换能器元件进行交织，使得治疗可以对超声图像进行调节，该超声图像显示造影剂微泡的显着破坏，感兴趣区域中的微泡再灌注，或继续存在 的凝块。

公开(公告)号：US5879303A

公开(公告)日：1999-03-09

申请号：US943546

申请日：1997-10-03

申请人： Michalakis Averkiou ,  Jeffry E. Powers ,  Peter N. Burns ,  David N. Roundhill ,  Juin-Jet Hwang

发明人： Michalakis Averkiou ,  Jeffry E. Powers ,  Peter N. Burns ,  David N. Roundhill ,  Juin-Jet Hwang

IPC分类号： A61B8/08 ,  A61B8/14 ,  G01S7/52 ,  G01S15/89 ,  A61B8/00

CPC分类号： G01S7/52038 ,  A61B8/08 ,  A61B8/14 ,  A61B8/463 ,  A61B8/488 ,  G01S15/895 ,  G01S7/52026 ,  G01S7/52036 ,  G01S7/52046 ,  G01S7/52077 ,  G01S15/8979 ,  G01S15/8993 ,  G01S7/52033 ,  G01S7/5206 ,  G01S7/52074

摘要： An ultrasonic diagnostic imaging system and methods are described which produces ultrasonic images from harmonic echo components of a transmitted fundamental frequency. Preferably, a programmable digital filter is used to pass harmonic echo components for image processing to the exclusion of fundamental frequency signals. In a preferred embodiment, artifacts are removed by producing decorrelated replicas of the harmonic signals, which are then combined and used for imaging. To produce an image in the presence of depth dependent attenuation of high frequency echo signals, both fundamental and harmonic echo signals are processed and used to produce an image blended from components of both fundamental and harmonic echo signals.

摘要翻译： 描述了从发射的基频的谐波回波分量产生超声波图像的超声诊断成像系统和方法。 优选地，可编程数字滤波器用于将用于图像处理的谐波回波分量传送到排除基频信号。 在优选实施例中，通过产生谐波信号的去相关副本来去除伪影，然后将它们组合并用于成像。 为了在高频回波信号存在深度相关衰减的情况下产生图像，基波和谐波回波信号被处理并用于产生从基波和谐波回波信号的分量混合的图像。

公开(公告)号：US20110263985A1

公开(公告)日：2011-10-27

申请号：US12674500

申请日：2008-08-14

申请人： Thomas Gauthier ,  Aline Criton ,  Matthew Bruce ,  Robert Entrekin ,  Jeffry E. Powers

发明人： Thomas Gauthier ,  Aline Criton ,  Matthew Bruce ,  Robert Entrekin ,  Jeffry E. Powers

IPC分类号： A61B8/06

CPC分类号： G01S15/8979 ,  A61B8/06 ,  A61B8/0833 ,  A61B8/0841 ,  A61B8/13 ,  A61B8/488 ,  A61B2017/3413 ,  G01S7/52026 ,  G01S7/52084

摘要： An ultrasound imaging system (10) is disclosed for creating simultaneous needle and vascular blood flow color Doppler imaging. A B mode image of an anatomical area of interest is created. A first set of Doppler image data optimized for the visualization of vascular blood flow is created along one Doppler image processing path. A second set of Doppler image data optimized for the visualization of a needle or other invasive device is created along another, parallel Doppler image processing path. A color Doppler image is created, and then displayed, by combining some or all of the B mode image, the first Doppler image data and the second Doppler image data based on a plurality of user selectable modes.

摘要翻译： 公开了一种用于创建同时针和血管血流彩色多普勒成像的超声成像系统（10）。 创建感兴趣的解剖区域的B模式图像。 沿着一个多普勒图像处理路径创建针对血管血流可视化优化的第一组多普勒图像数据。 沿着另一个并行的多普勒图像处理路径创建针对针或其他侵入性设备的可视化优化的第二组多普勒图像数据。 通过基于多个用户可选择模式组合B模式图像，第一多普勒图像数据和第二多普勒图像数据中的一些或全部来创建彩色多普勒图像，然后显示。

公开(公告)号：US5456257A

公开(公告)日：1995-10-10

申请号：US344266

申请日：1994-11-23

申请人： Keith W. Johnson ,  Jeffry E. Powers

发明人： Keith W. Johnson ,  Jeffry E. Powers

IPC分类号： A61B8/00 ,  G01S7/52

CPC分类号： A61B8/481 ,  G01S7/52041 ,  G01S7/52049

摘要： An ultrasonic diagnostic system is provided which detects the presence of coated microbubble contrast agents in the body of a patient by transmitting ultrasonic energy which causes the destruction of the coated microbubbles and detects the microbubble destruction through phase insensitive detection and differentiation of echoes received from two consecutive ultrasonic transmissions. The destruction of a microbubble can also be used as a point source of acoustic energy for aberration correction, whereby the timing of the beamformer is adjusted from an analysis of beamformer signals resulting from a detected microbubble destruction event.

摘要翻译： 提供了一种超声波诊断系统，其通过发射引起包被的微泡破坏的超声能量来检测涂覆的微泡造影剂的存在，并且通过相位不敏感检测和微分从两个连续的接收到的回波检测微泡破坏 超声波传输。 微泡的破坏也可以用作用于像差校正的声能的点源，由此根据检测到的微泡破坏事件导致的波束形成信号的分析来调整波束形成器的定时。

公开(公告)号：US06692438B2

公开(公告)日：2004-02-17

申请号：US10025200

申请日：2001-12-18

申请人： Danny M. Skyba ,  Damien Dolimier ,  Jeffry E. Powers

发明人： Danny M. Skyba ,  Damien Dolimier ,  Jeffry E. Powers

IPC分类号： A61B800

CPC分类号： A61B8/463 ,  A61B8/065 ,  A61B8/08 ,  A61B8/0883 ,  A61B8/481 ,  A61B8/543 ,  G01S7/52038 ,  G01S15/8993

摘要： A method and system for displaying a parametric image showing tissue perfusion includes an ultrasonic imaging system coupled to an ECG device. The ECG device triggers the imaging system to obtain contrast image data showing tissue perfusion at a respective predetermined time during each of a plurality of heartbeats. Parametric image data for discrete locations in the area of interest such as the myocardium is determined from the temporal contrast data acquired during reperfusion of the tissue in the area of interest. The parameters are mapped to a display value such as color to produce a parametric perfusion ultrasound image. Sequences of images may be produced which depict both perfusion characteristics and dynamic wall motion of the myocardium in a common image sequence.

摘要翻译： 用于显示显示组织灌注的参数图像的方法和系统包括耦合到ECG装置的超声成像系统。 ECG装置触发成像系统以获得在多个心跳期间的每个期间在相应的预定时间显示组织灌注的对比度图像数据。 在感兴趣区域（例如心肌）中的离散位置的参数图像数据是从感兴趣区域中的组织再灌注期间获取的时间对比数据确定的。 将参数映射到诸如颜色的显示值以产生参数灌注超声图像。 可以产生描绘在共同图像序列中的心肌的灌注特性和动态壁运动的图像序列。

公开(公告)号：US20120143058A1

公开(公告)日：2012-06-07

申请号：US13379747

申请日：2010-06-30

申请人： Jeffry E. Powers ,  William Tao Shi ,  Francois Guy Gerald Marie Vignon ,  Emil George Radulescu

发明人： Jeffry E. Powers ,  William Tao Shi ,  Francois Guy Gerald Marie Vignon ,  Emil George Radulescu

IPC分类号： A61B8/14 ,  A61B8/00

CPC分类号： G01S7/52077 ,  A61B8/0816 ,  G01S15/8945

摘要： Acquired echo data is corrected to reduce content from ultrasound that has undergone at least one reflection off the probe surface, for example, to reduce corresponding reverberation artefacts from imaging. In some embodiments, the propagation medium, i.e., layer or adjoining layers, through which the reverberation occurs, is, after a set of echo radiofrequency data (404, 408) has been acquired, modified in preparation for a next application of ultrasound. During that next application, it is the reverberating ultrasound signals (424), according to embodiments of the invention, that are more affected by the modification than are the non-reverberating, i.e., direct signals (420). This difference in effect is due, for example, to greater overall time of flight through the modified medium on account of reverberation in the propagation path.

摘要翻译： 对获得的回波数据进行校正，以减少从经过探头表面的至少一个反射的超声波的内容，例如，以减少成像中相应的混响伪影。 在一些实施例中，在获得了一组回波射频数据（404,408）之后，经过修改的传播介质，即发生混响的层或相邻层，在为下一次超声波应用做准备时进行了修改。 在下一个应用中，根据本发明的实施例，与非混响即直接信号（420）相比，更多地受到修改的影响的是混响超声信号（424）。 这种差异是由于例如由于传播路径中的混响而导致通过修改的介质的更大的总飞行时间。

公开(公告)号：US5386830A

公开(公告)日：1995-02-07

申请号：US142784

申请日：1993-10-25

申请人： Jeffry E. Powers ,  Thanasis Loupas

发明人： Jeffry E. Powers ,  Thanasis Loupas

IPC分类号： A61B8/06 ,  G01S7/52 ,  G01S15/52 ,  G01S15/58 ,  G01S15/89 ,  A61B8/00

CPC分类号： G01S15/8979 ,  G01S15/52 ,  G01S15/582 ,  G01S7/52034 ,  G01S7/52071

摘要： A velocity estimation technique is provided for a pulse-echo ultrasonic diagnostic system in which a two dimensional array of samples is acquired from a sample volume. The two dimensions of the array are depth, in which echo signal samples are acquired in response to transmission of a pulse to the sample volume, and pulse time, in which samples are acquired in response to transmission of the pulses in the pulse ensemble to the sample volume. Two autocorrelation calculations are performed on the array, one in the depth dimension and another in the pulse time dimension to yield two correlation functions, the first related to echo frequency and the second related to the Doppler frequency. The two correlation functions are then employed in a Doppler velocity estimation to determine the velocity of motion at the sample volume. The technique utilizes the full information content present in the bandwidth of the received echo signals, thereby overcoming inaccuracies due to depth dependent frequency decline or coherent signal cancellation. Since accuracy is premised upon the number of samples in the array and not its size in a particular dimension, performance can be tailored to favor frame rate or axial resolution while maintaining the accuracy of velocity estimation.

摘要翻译： 提供了一种脉冲回波超声波诊断系统的速度估计技术，其中从样本体积获取二维样本阵列。 阵列的两个维度是深度，其中响应于向采样体积的脉冲的传输获取回波信号样本，以及脉冲时间，其中响应于脉冲集合中的脉冲的传输获取采样 样品量。 在阵列上执行两个自相关计算，一个在深度维度上，另一个在脉冲时间维度上，以产生两个相关函数，第一个与回波频率相关，第二个与多普勒频率相关。 然后在多普勒速度估计中采用两个相关函数来确定样本体积下的运动速度。 该技术利用存在于所接收的回波信号的带宽中的全部信息内容，从而克服由于深度依赖的频率衰减或相干信号消除引起的不准确性。 由于精度是基于阵列中的样本数量而不是其特定尺寸的尺寸，因此可以调整性能以有利于帧速率或轴向分辨率，同时保持速度估计的准确性。

公开(公告)号：US4887246A

公开(公告)日：1989-12-12

申请号：US532576

申请日：1983-09-15

申请人： James M. Hossack ,  Jeffry E. Powers ,  John K. Billings

发明人： James M. Hossack ,  Jeffry E. Powers ,  John K. Billings

IPC分类号： G01S15/89 ,  G01B17/00 ,  G01B17/06 ,  G01B17/08 ,  G01H11/06 ,  G01S7/521 ,  G01S15/04 ,  G01S15/42 ,  G01S15/87 ,  G01S15/88 ,  G10K11/34

CPC分类号： G01S7/521 ,  G01B17/00 ,  G01H11/06 ,  G01S15/87 ,  G10K11/346 ,  G01S15/42 ,  G01S15/88

摘要： Ultrasonic apparatus for use in detecting an object having a transducer. The transducer has an array of at least one element coupled directly into air. The apparatus also includes a transmitter which may be multi-channel, a receiver which may be multi-channel, a transmit receive switch, and a computer for causing operation of said transmit receive switch to cause sequential supplying of pulses of energy from the transmitter to the element or elements of the transducer and for receiving energy received by the transducer. The element or elements of the transducer are provided with a roughened surface to produce high frequency ultrasonic energy.

摘要翻译： 用于检测具有换能器的物体的超声波装置。 换能器具有直接耦合到空气中的至少一个元件阵列。 该装置还包括可以是多信道的发射机，可以是多信道的接收机，发射接收开关和计算机，用于使所述发射接收开关的操作导致从发射机向 换能器的元件或元件，用于接收由换能器接收的能量。 换能器的元件设置有粗糙表面以产生高频超声波能量。

公开(公告)号：US20100056924A1

公开(公告)日：2010-03-04

申请号：US12515222

申请日：2007-11-13

申请人： Jeffry E. Powers

发明人： Jeffry E. Powers

IPC分类号： A61B8/14

CPC分类号： G01S7/52041 ,  A61B8/0816 ,  A61B8/481 ,  A61B2017/00106 ,  A61N7/00 ,  A61N2007/0039 ,  A61N2007/0052 ,  A61N2007/0095 ,  G01S7/52019 ,  G01S7/52038 ,  G01S7/52046 ,  G01S7/5205 ,  G01S7/52071 ,  G01S7/52073

摘要： An ultrasonic diagnostic imaging system is used to insonify a subject infused with a microbubble contrast agent. At low energy levels stable cavitation occurs as the bubbles oscillate radially without breaking up. At higher energy levels the bubbles dissolve or break up, termed inertial cavitation. Echo signals from microbubbles are bandpass filtered to produce signal components in a subharmonic band, indicative of stable cavitation, and signal component in a higher harmonic band indicative of inertial cavitation. Detection of the mode of cavitation is used to automatically or manually control the mode of cavitation by controlling the transmitted acoustic energy of the system.

摘要翻译： 超声波诊断成像系统用于使注入微泡造影剂的受试者进行增殖。 在低能量水平下，随着气泡在径向上振荡而不会分解，发生稳定的气蚀。 在更高的能量水平下，气泡溶解或分解，称为惯性空化。 来自微泡的回波信号被带通滤波以产生表示稳定气蚀的次谐波带中的信号分量，以及指示惯性空化的高次谐波带中的信号分量。 气蚀模式的检测用于通过控制系统的传输声能来自动或手动地控制气蚀模式。

公开(公告)号：US5215094A

公开(公告)日：1993-06-01

申请号：US799667

申请日：1991-11-21

申请人： Donn D. Franklin ,  Jeffry E. Powers

发明人： Donn D. Franklin ,  Jeffry E. Powers

IPC分类号： G01S15/89

CPC分类号： G01S15/8909 ,  A61B8/585

摘要： An ultrasonic diagnostic imaging system is described which enhances the presentation of flow velocity images through asymmetric persistence of visually displayed changes in fluid velocity. Preferably the asymmetric persistence employs a shorter (i.e., faster) time constant for increases in fluid velocity and a longer (i.e., slower) time constant for decreases in fluid velocity. In a preferred embodiment of the present invention, increases in fluid velocity are displayed at their rate of occurrence, and decreases in fluid velocity are displayed with a longer, user-selectable time constant. In the preferred embodiment the persistence enhancement is determined as a function of displayed image frame rate so that the persistence time constant remains fixed as a function of time despite user changes affecting the frame rate.

摘要翻译： 描述了一种超声诊断成像系统，其通过视觉显示的流体速度变化的不对称持久性来增强流速图像的呈现。 优选地，不对称持久性对于流体速度的增加使用更短的（即更快的）时间常数，并且对于流体速度的降低使用较长的（即较慢的）时间常数。 在本发明的优选实施例中，以其出现的速率显示流体速度的增加，并以较长的用户可选择的时间常数来显示流体速度的降低。 在优选实施例中，持久性增强被确定为显示的图像帧速率的函数，使得持续时间常数作为时间的函数保持固定，尽管用户改变影响帧速率。