3' Biased Detection of Nucleic Acids
    22.
    发明申请
    3' Biased Detection of Nucleic Acids 审中-公开
    3'核酸的偏置检测

    公开(公告)号:US20090270271A1

    公开(公告)日:2009-10-29

    申请号:US12210807

    申请日:2008-09-15

    IPC分类号: C40B30/04

    摘要: The invention provides materials and methods for the detection of nucleic acid expression via the 3′ portion of expressed sequences. Embodiments of the invention include the use of microarrays comprising nucleic acid probes that are complementary to the 3′ end of expressed sequences and by the use of quantitative PCR (Q-PCR) based amplification of sequences found at or near the 3′ end of expressed sequences. The invention may be used to detect the presence of expressed nucleic acids encoding particular gene products (sequences present in a “transcriptome”).

    摘要翻译: 本发明提供了通过表达序列的3'部分检测核酸表达的材料和方法。 本发明的实施方案包括使用包含与表达的序列的3'末端互补的核酸探针的微阵列,以及通过使用基于定量PCR(Q-PCR)的扩增在3'末端发现的序列的表达 序列。 本发明可用于检测编码特定基因产物(“转录组”中存在的序列)的表达的核酸的存在。

    Compounds and use of tetrahydropyridothiophenes
    25.
    发明授权
    Compounds and use of tetrahydropyridothiophenes 失效
    四氢吡啶并噻吩的化合物和用途

    公开(公告)号:US07714134B2

    公开(公告)日:2010-05-11

    申请号:US11628369

    申请日:2005-06-10

    IPC分类号: C07D471/02

    CPC分类号: C07D495/04 A61K31/4365

    摘要: The compounds of a certain formula (1) in which Ra and Rb have the meanings indicated in the description are novel for treating hyperproliferative diseases and/or disorders responsive to the induction of apoptosis. The invention further relates to certain compounds of formula (I), in which Ra and Rb have the meanings indicated in the description.

    摘要翻译: 其中Ra和Rb具有本说明书中指出的含义的某种式(1)的化合物是新型的用于治疗对诱导凋亡有反应的过度增殖性疾病和/或病症。 本发明还涉及某些式(I)化合物,其中Ra和Rb具有说明书中所示的含义。

    3' biased microarrays
    28.
    发明申请
    3' biased microarrays 审中-公开
    3'偏置微阵列

    公开(公告)号:US20050014168A1

    公开(公告)日:2005-01-20

    申请号:US10769476

    申请日:2004-01-30

    IPC分类号: C12Q1/68 C12M1/34

    摘要: The invention provides materials and methods for the detection of nucleic acid expression via the 3′ portion of expressed sequences. Embodiments of the invention include the use of microarrays comprising nucleic acid probes that are complementary to the 3′ end of expressed sequences and by the use of quantitative PCR (Q-PCR) based amplification of sequences found at or near the 3′ end of expressed sequences. The invention may be used to detect the presence of expressed nucleic acids encoding particular gene products (sequences present in a “transcriptome”).

    摘要翻译: 本发明提供了通过表达序列的3'部分检测核酸表达的材料和方法。 本发明的实施方案包括使用包含与表达的序列的3'末端互补的核酸探针的微阵列,以及通过使用基于定量PCR(Q-PCR)的扩增在3'末端发现的序列的表达 序列。 本发明可用于检测编码特定基因产物(“转录组”中存在的序列)的表达的核酸的存在。