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公开(公告)号:US07803945B2
公开(公告)日:2010-09-28
申请号:US12411740
申请日:2009-03-26
申请人: Klaus Pekari , Thomas Baer , Bjoern Bartels , Mathias Schmidt , Thomas Beckers
发明人: Klaus Pekari , Thomas Baer , Bjoern Bartels , Mathias Schmidt , Thomas Beckers
IPC分类号: C07D513/02
CPC分类号: C07D495/04
摘要: Compounds of a certain formula (I), in which Ra and Rb have the meanings indicated in the description, are novel effective compounds with anti-proliferative and/or apoptosis inducing activity.
摘要翻译: 其中Ra和Rb具有说明书中所示含义的某种式(I)的化合物是具有抗增殖和/或凋亡诱导活性的新型有效化合物。
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公开(公告)号:US20090270271A1
公开(公告)日:2009-10-29
申请号:US12210807
申请日:2008-09-15
申请人: Mark G. Erlander , Xiao-Jun Ma , Thomas Baer
发明人: Mark G. Erlander , Xiao-Jun Ma , Thomas Baer
IPC分类号: C40B30/04
CPC分类号: C12Q1/6876 , C12Q1/6809 , C12Q1/6851 , C12Q1/686 , C12Q2565/501
摘要: The invention provides materials and methods for the detection of nucleic acid expression via the 3′ portion of expressed sequences. Embodiments of the invention include the use of microarrays comprising nucleic acid probes that are complementary to the 3′ end of expressed sequences and by the use of quantitative PCR (Q-PCR) based amplification of sequences found at or near the 3′ end of expressed sequences. The invention may be used to detect the presence of expressed nucleic acids encoding particular gene products (sequences present in a “transcriptome”).
摘要翻译: 本发明提供了通过表达序列的3'部分检测核酸表达的材料和方法。 本发明的实施方案包括使用包含与表达的序列的3'末端互补的核酸探针的微阵列,以及通过使用基于定量PCR(Q-PCR)的扩增在3'末端发现的序列的表达 序列。 本发明可用于检测编码特定基因产物(“转录组”中存在的序列)的表达的核酸的存在。
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公开(公告)号:US20070244112A1
公开(公告)日:2007-10-18
申请号:US11597142
申请日:2005-05-25
申请人: Klaus Pekari , Thomas Baer , Bjorn Bartels , Mathias Schmidt , Thomas Beckers
发明人: Klaus Pekari , Thomas Baer , Bjorn Bartels , Mathias Schmidt , Thomas Beckers
IPC分类号: A61K31/44 , A61K31/497 , A61K31/535 , A61P35/00 , C07D401/14 , C07D413/14 , C07D471/04
CPC分类号: C07D495/04
摘要: Compounds of a certain formula (I) in which Ra and Rb have the meanings indicated in the description, are novel, effective compounds with anti-proliferative and/or apoptosis inducing activity.
摘要翻译: 其中Ra和Rb具有说明书中所示含义的某种式(I)的化合物是具有抗增殖和/或凋亡诱导活性的新型有效化合物。
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公开(公告)号:US07723523B2
公开(公告)日:2010-05-25
申请号:US11597142
申请日:2005-05-25
申请人: Klaus Pekari , Thomas Baer , Björn Bartels , Mathias Schmidt , Thomas Beckers
发明人: Klaus Pekari , Thomas Baer , Björn Bartels , Mathias Schmidt , Thomas Beckers
IPC分类号: C07D471/02
CPC分类号: C07D495/04
摘要: Compounds of a certain formula (I) in which Ra and Rb have the meanings indicated in the description, are novel, effective compounds with anti-proliferative and/or apoptosis inducing activity.
摘要翻译: 其中Ra和Rb具有说明书中所示含义的某种式(I)的化合物是具有抗增殖和/或凋亡诱导活性的新型有效化合物。
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公开(公告)号:US07714134B2
公开(公告)日:2010-05-11
申请号:US11628369
申请日:2005-06-10
申请人: Klaus Pekari , Thomas Baer , Mathias Schmidt , Thomas Beckers
发明人: Klaus Pekari , Thomas Baer , Mathias Schmidt , Thomas Beckers
IPC分类号: C07D471/02
CPC分类号: C07D495/04 , A61K31/4365
摘要: The compounds of a certain formula (1) in which Ra and Rb have the meanings indicated in the description are novel for treating hyperproliferative diseases and/or disorders responsive to the induction of apoptosis. The invention further relates to certain compounds of formula (I), in which Ra and Rb have the meanings indicated in the description.
摘要翻译: 其中Ra和Rb具有本说明书中指出的含义的某种式(1)的化合物是新型的用于治疗对诱导凋亡有反应的过度增殖性疾病和/或病症。 本发明还涉及某些式(I)化合物,其中Ra和Rb具有说明书中所示的含义。
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公开(公告)号:US20070213360A1
公开(公告)日:2007-09-13
申请号:US11597556
申请日:2005-06-03
申请人: Klaus Pekari , Thomas Baer , Mathias Schmidt , Thomas Beckers
发明人: Klaus Pekari , Thomas Baer , Mathias Schmidt , Thomas Beckers
IPC分类号: A61K31/4743 , C07D498/02
CPC分类号: C07D495/04
摘要: Compounds of the formula (I) in which Ra and Rb have the meanings indicated in the description, are novel effective compounds with anti-proliferative and/or apoptosis inducing activity.
摘要翻译: 其中Ra和Rb具有说明书中所示含义的式(I)化合物是具有抗增殖和/或凋亡诱导活性的新型有效化合物。
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公开(公告)号:US20050089949A1
公开(公告)日:2005-04-28
申请号:US10989206
申请日:2004-11-15
申请人: Thomas Baer , Norbert Hagen , Bruce Richardson , David Brewer , Lisa Reese
发明人: Thomas Baer , Norbert Hagen , Bruce Richardson , David Brewer , Lisa Reese
CPC分类号: G02B21/0076 , G01N1/2813 , G01N2001/284 , G01N2015/1472 , G02B21/32 , G02B21/36 , Y10T83/141
摘要: Systems and methods for automated laser capture microdissection are disclosed. High throughput microdissection is provided by using cell procurement and multi-imaging tools for pre-selecting cells of interest. Novel methods of computer-controlled cap transfer along with automated multi-slide and multi-cap placements, and automated slide and cap detection are provided. The systems and methods provide the advantages of increased speed and much lower rates of contamination.
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公开(公告)号:US20050014168A1
公开(公告)日:2005-01-20
申请号:US10769476
申请日:2004-01-30
申请人: Mark Erlander , Xiao-Jun Ma , Thomas Baer
发明人: Mark Erlander , Xiao-Jun Ma , Thomas Baer
CPC分类号: C12Q1/6876 , C12Q1/6809 , C12Q1/6851 , C12Q1/686 , C12Q2565/501
摘要: The invention provides materials and methods for the detection of nucleic acid expression via the 3′ portion of expressed sequences. Embodiments of the invention include the use of microarrays comprising nucleic acid probes that are complementary to the 3′ end of expressed sequences and by the use of quantitative PCR (Q-PCR) based amplification of sequences found at or near the 3′ end of expressed sequences. The invention may be used to detect the presence of expressed nucleic acids encoding particular gene products (sequences present in a “transcriptome”).
摘要翻译: 本发明提供了通过表达序列的3'部分检测核酸表达的材料和方法。 本发明的实施方案包括使用包含与表达的序列的3'末端互补的核酸探针的微阵列,以及通过使用基于定量PCR(Q-PCR)的扩增在3'末端发现的序列的表达 序列。 本发明可用于检测编码特定基因产物(“转录组”中存在的序列)的表达的核酸的存在。
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公开(公告)号:US07745446B2
公开(公告)日:2010-06-29
申请号:US11661111
申请日:2005-09-05
申请人: Thomas Maier , Armin Zuelch , Thomas Ciossek , Thomas Baer , Thomas Beckers
发明人: Thomas Maier , Armin Zuelch , Thomas Ciossek , Thomas Baer , Thomas Beckers
IPC分类号: C07D487/04 , A61K31/519 , A61P35/04 , A61P35/02
CPC分类号: C07D487/04
摘要: Compounds of a certain formula I in which R1, R2, R3 and R4 have the meanings indicated in the description are novel compounds expected to be useful in the therapy of (hyper)proliferative diseases and/or disorders responsive to induction of apoptosis.
摘要翻译: 其中R 1,R 2,R 3和R 4具有本说明书所述含义的某种式I的化合物是预期可用于治疗对于诱导凋亡有反应的(超)增殖性疾病和/或病症的新化合物。
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公开(公告)号:US20090209534A1
公开(公告)日:2009-08-20
申请号:US12412532
申请日:2009-03-27
申请人: Klaus PEKARI , Thomas Baer , Mathias Schmidt , Thomas Beckers
发明人: Klaus PEKARI , Thomas Baer , Mathias Schmidt , Thomas Beckers
IPC分类号: A61K31/4365 , A61P35/00 , A61K31/5377
CPC分类号: C07D495/04 , A61K31/4365
摘要: The use of tetrahydropyridothiophenes of a certain formula (I), in which Ra and Rb have the meanings indicated in the description, is novel for treating hyperproliferative diseases and/or disorders responsive to the induction of apoptosis.
摘要翻译: 使用具有式(I)的式(I)的四氢吡啶并噻吩,其中Ra和Rb具有说明书中所示的含义,其用于治疗对诱导凋亡有反应的过度增殖性疾病和/或病症。
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