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    METHOD TO ASSESS HEMODYNAMIC PERFORMANCE DURING CARDIAC RESYNCHRONIZATION THERAPY OPTIMIZATION USING ADMITTANCE WAVEFORMS AND DERIVATIVES
    21.
    发明申请
    METHOD TO ASSESS HEMODYNAMIC PERFORMANCE DURING CARDIAC RESYNCHRONIZATION THERAPY OPTIMIZATION USING ADMITTANCE WAVEFORMS AND DERIVATIVES 有权
    在使用化疗波形和衍生物的心脏再生治疗治疗优化中评估血液动力学性能的方法

    公开(公告)号：US20130110188A1

    公开(公告)日：2013-05-02

    申请号：US13663920

    申请日：2012-10-30

    Applicant: Medtronic , Inc.

    Inventor： Yong K. Cho ,  Douglas A. Hettrick ,  Todd M. Zielinski

    IPC: A61N1/365

    CPC classification number: A61N1/36521 ,  A61N1/3682 ,  A61N1/3684 ,  A61N1/3686

    Abstract: An implantable medical device and associated method to determine an optimal control parameter setting for controlling a cardiac therapy that includes a therapy delivery module to deliver cardiac pacing signals at a plurality of pacing rates, and an admittance measurement module to determine admittance signals associated with each of the plurality of pacing rates. A control unit determines metrics of hemodynamic performance corresponding to each of the plurality of pacing rates in response to the determined admittance signals, identifies pacing rates of the plurality of pacing rates as rejected rates in response to the determined metrics of hemodynamic performance, and determines a pacing rate of the plurality of pacing rates as an optimal rate for delivering the cardiac therapy in response to the identified pacing rates.

    Abstract translation: 一种可植入医疗装置和相关联的方法，用于确定用于控制心脏治疗的最佳控制参数设置，所述心脏治疗包括治疗递送模块，其以多个起搏速率递送心脏起搏信号;以及导纳测量模块，用于确定与每个起搏信号相关联的导纳信号 多个起搏率。 响应于所确定的导纳信号，控制单元确定对应于多个起搏速率中的每一个的血流动力学性能的指标，根据所确定的血流动力学性能的度量，将多个起搏速率的起搏速率识别为拒绝率，并且确定 多个起搏速率的起搏速率作为响应于所识别的起搏速率递送心脏治疗的最佳速率。

    SENSING FOR HEART FAILURE MANAGEMENT
    22.
    发明申请
    SENSING FOR HEART FAILURE MANAGEMENT 有权

    公开(公告)号：US20220323007A1

    公开(公告)日：2022-10-13

    申请号：US17808924

    申请日：2022-06-24

    Applicant: Medtronic, Inc.

    Inventor： Jonathan L. Kuhn ,  James K. Carney ,  Vinod Sharma ,  Shantanu Sarkar ,  Todd M. Zielinski ,  Tommy D. Bennett

    IPC: A61B5/00 ,  A61B5/0205 ,  A61B5/07 ,  A61B5/1455 ,  A61B5/1459 ,  A61B5/287

    Abstract: In some examples, determining a heart failure status includes using an implantable medical device configured for subcutaneous implantation and comprising a plurality of electrodes and an optical sensor. Processing circuitry of a system comprising the device may determine, for a patient, a current tissue oxygen saturation value based on a signal received from the at least one optical sensor, a current tissue impedance value based on a subcutaneous tissue impedance signal received from the electrodes, and a current pulse transit time value based on a cardiac electrogram signal received from the electrodes and at least one of the signal received from the optical sensor and the subcutaneous tissue impedance signal. The processing circuitry may further compare the current tissue oxygen saturation value, current tissue impedance value, and current pulse transit time value to corresponding baseline values, and determine the heart failure status of the patient based on the comparison.

    SENSING FOR HEART FAILURE MANAGEMENT
    25.
    发明申请
    SENSING FOR HEART FAILURE MANAGEMENT 审中-公开

    公开(公告)号：US20190336076A1

    公开(公告)日：2019-11-07

    申请号：US15969369

    申请日：2018-05-02

    Applicant: Medtronic, Inc.

    Inventor： Jonathan L. Kuhn ,  James K. Carney ,  Vinod Sharma ,  Shantanu Sarkar ,  Todd M. Zielinski ,  Tommy D. Bennett

    IPC: A61B5/00 ,  A61B5/0205 ,  A61B5/042 ,  A61B5/07 ,  A61B5/1455 ,  A61B5/1459

    Abstract: In some examples, determining a heart failure status includes using an implantable medical device configured for subcutaneous implantation and comprising a plurality of electrodes and an optical sensor. Processing circuitry of a system comprising the device may determine, for a patient, a current tissue oxygen saturation value based on a signal received from the at least one optical sensor, a current tissue impedance value based on a subcutaneous tissue impedance signal received from the electrodes, and a current pulse transit time value based on a cardiac electrogram signal received from the electrodes and at least one of the signal received from the optical sensor and the subcutaneous tissue impedance signal. The processing circuitry may further compare the current tissue oxygen saturation value, current tissue impedance value, and current pulse transit time value to corresponding baseline values, and determine the heart failure status of the patient based on the comparison.

    CARDIAC RESYNCHRONIZATION THERAPY OPTIMIZATION BASED ON INTRACARDIAC IMPEDANCE
    27.
    发明申请
    CARDIAC RESYNCHRONIZATION THERAPY OPTIMIZATION BASED ON INTRACARDIAC IMPEDANCE 有权
    基于内皮抑素的心脏再生治疗优化

    公开(公告)号：US20150202436A1

    公开(公告)日：2015-07-23

    申请号：US14158516

    申请日：2014-01-17

    Applicant: Medtronic, Inc.

    Inventor： Todd M. Zielinski ,  Yong Kyun Cho ,  Douglas Hettrick ,  Xusheng Zhang

    IPC: A61N1/368 ,  A61N1/365

    CPC classification number: A61N1/368 ,  A61N1/36521 ,  A61N1/3682

    Abstract: Methods and/or devices used in delivering cardiac resynchronization therapy based on a plurality of device parameters (e.g., A-V delay, V-V delay, etc.) are optimized by setting a device parameter based on selection data. The selection data may be acquired by acquiring temporal fiducial points (e.g., heart sounds) associated with at least a part of a systolic portion of at least one cardiac cycle and/or temporal fiducial points associated with at least a part of a diastolic portion of the at least one cardiac cycle for each of a plurality of electrode vector configurations, and extracting measurements from the intracardiac impedance signal acquired for each of a plurality of electrode vector configurations based on the temporal fiducial points. The acquired selection data may be scored and used to optimize the device parameter.

    Abstract translation: 通过基于选择数据设置设备参数来优化基于多个设备参数（例如，A-V延迟，V-V延迟等）递送心脏再同步治疗的方法和/或设备。 选择数据可以通过获取与至少一个心动周期的收缩期部分的至少一部分相关联的时间基准点（例如，心音）和/或与至少一个心动周期的舒张部分的至少一部分相关联的时间基准点来获取 所述至少一个心脏周期用于多个电极向量配置中的每一个，并且基于所述时间基准点从针对多个电极向量配置中的每一个获取的心脏内阻抗信号提取测量值。 可以对所获取的选择数据进行评分并用于优化设备参数。

    MULTI-FREQUENCY IMPEDANCE MONITORING SYSTEM
    28.
    发明申请
    MULTI-FREQUENCY IMPEDANCE MONITORING SYSTEM 有权
    多频阻抗监测系统

    公开(公告)号：US20140288455A1

    公开(公告)日：2014-09-25

    申请号：US14294877

    申请日：2014-06-03

    Applicant: Medtronic, Inc.

    Inventor： Todd M. Zielinski ,  Douglas A. Hettrick ,  Shantanu Sarkar

    IPC: A61B5/08

    CPC classification number: A61B5/0809 ,  A61B5/053 ,  A61B5/0538 ,  A61B5/4869 ,  A61B5/686 ,  A61B5/7257 ,  A61N1/36521

    Abstract: A system and method is provided to measure intrathoracic complex impedance and to identify and indicate disease conditions based on the impedance measurements. Multiple impedance vectors may be taken into account, and an optimal vector may be selected to provide the most useful impedance measurement for the identification and indication of disease conditions.

    Abstract translation: 提供了一种系统和方法来测量胸腔内复合阻抗，并根据阻抗测量来识别和指示疾病状况。 可以考虑多个阻抗矢量，并且可以选择最佳矢量以提供用于疾病状况的识别和指示的最有用的阻抗测量。

    USE OF THORACIC AND EXTRA-THORACIC IMPEDANCE FOR DIAGNOSTIC MONITORING
    29.
    发明申请
    USE OF THORACIC AND EXTRA-THORACIC IMPEDANCE FOR DIAGNOSTIC MONITORING 有权
    用于诊断监测的THORACIC和超声阻抗的使用

    公开(公告)号：US20140148867A1

    公开(公告)日：2014-05-29

    申请号：US13686359

    申请日：2012-11-27

    Applicant: MEDTRONIC, INC.

    Inventor： Todd M. Zielinski ,  Douglas A. Hettrick ,  Yong K. Cho ,  Eduardo N. Warman ,  Paul A. Sobotka

    IPC: A61N1/365 ,  A61M27/00

    CPC classification number: A61N1/36507 ,  A61B5/0537 ,  A61B5/085 ,  A61M27/00 ,  A61N1/3627 ,  A61N1/36521

    Abstract: A medical device and associated method for delivery of a cardiac therapy that includes determining a first impedance signal along a thoracic electrode vector extending within a portion of a thoracic cavity, determining a second impedance signal along an extra-thoracic electrode vector extending outside the thoracic cavity, comparing first amplitude measurements corresponding to the first impedance signals and second amplitude measurements corresponding to the second impedance signals, comparing first slope measurements corresponding to the first impedance signals and second slope measurements corresponding to the second impedance signals, and determining delivery of the cardiac therapy in response to the comparing.

    Abstract translation: 一种用于递送心脏疗法的医疗装置和相关联的方法，其包括沿着在胸腔的一部分内延伸的胸部电极矢量确定第一阻抗信号，沿着延伸到胸腔外部的胸外电极矢量确定第二阻抗信号 比较对应于第一阻抗信号的第一振幅测量值和对应于第二阻抗信号的第二振幅测量值，比较对应于第一阻抗信号的第一斜率测量值和对应于第二阻抗信号的第二斜率测量值，以及确定心脏治疗 响应比较。

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