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    Instrumentation to Facilitate Access into the Intervertebral Disc Space and Introduction of Materials Therein
    21.
    发明申请
    Instrumentation to Facilitate Access into the Intervertebral Disc Space and Introduction of Materials Therein 审中-公开
    便于进入椎间盘空间的仪器和其中的材料引入

    公开(公告)号：US20090099660A1

    公开(公告)日：2009-04-16

    申请号：US11869991

    申请日：2007-10-10

    申请人： Jeffrey L. Scifert ,  Scott D. Boden

    发明人： Jeffrey L. Scifert ,  Scott D. Boden

    IPC分类号： A61F2/44 ,  A61B17/00 ,  A61F5/00 ,  A61B1/00 ,  A61B17/58 ,  A61B19/00

    CPC分类号： A61B17/025 ,  A61B6/505 ,  A61B17/1604 ,  A61B17/1671 ,  A61B2017/00539 ,  A61B2017/0256 ,  A61F2/4455 ,  A61F2/4611 ,  A61F2002/444

    摘要： Methods for facilitating access to the intervertebral disc to deliver materials for disc repair are disclosed. The methods may be used to replace or augment nucleus pulposus as well as to perform interbody fusion procedures. These methods include providing access to the intervertebral disc space by drilling a channel through a vertebral bone, optionally accessing the intervertebral disc space to at least partially remove the disc tissue through the channel in the vertebrae; delivering a disc repairing material to the intervertebral disc space and back-filling the channel in the vertebrae with a channel sealing material. The methods may further comprise distracting the intervertebral height and inserting a restrictor into the channel in the vertebrae. Kits for practicing these methods are also disclosed.

    摘要翻译： 公开了便于进入椎间盘以输送用于椎间盘修复的材料的方法。 该方法可用于替代或增加髓核以及进行体内融合程序。 这些方法包括：通过穿过椎骨钻通道，提供对椎间盘空间的通路，任选地进入椎间盘空间以至少部分地通过椎骨中的通道去除椎间盘组织; 将椎间盘修复材料递送到椎间盘间隙，并用通道密封材料对椎骨中的通道回填。 所述方法还可以包括使椎间高度分散并将节流器插入椎骨的通道中。 还披露了用于实施这些方法的套件。

    Flowable carrier matrix
    24.
    发明申请
    Flowable carrier matrix 有权
    可流动载体矩阵

    公开(公告)号：US20080038351A1

    公开(公告)日：2008-02-14

    申请号：US11504363

    申请日：2006-08-14

    申请人： Neal Beals ,  Jeffrey L. Scifert ,  Scott D. Boden

    发明人： Neal Beals ,  Jeffrey L. Scifert ,  Scott D. Boden

    IPC分类号： A61K38/18 ,  A61K9/14

    CPC分类号： A61K9/0024 ,  A61K9/0085 ,  A61K38/177 ,  A61K38/1774 ,  A61K38/18 ,  A61K38/1825 ,  A61K38/1841 ,  A61K38/1858 ,  A61K38/1866 ,  A61K38/1875 ,  A61K38/19 ,  A61K38/30 ,  A61K47/42 ,  A61L27/24 ,  A61L27/54 ,  A61L27/56 ,  A61L2300/414

    摘要： A carrier matrix may be delivered to a target position within a patient in a minimally invasive manner by first cutting a collagen sponge sheet into a plurality of relatively small pieces. These pieces are sized so that, when wet, they are capable of flowing through a cannula and/or reduced-diameter syringe tip. The pieces are placed into a syringe and wetted, say with a morphogenic solution, and optionally mixed with a bulking material, which is similarly sized to fit through the cannula. The thoroughly mixed and wetted product forms a viscous aggregate which may then be injected into the patient at the target site.

    摘要翻译： 通过首先将胶原海绵片切割成多个相对小的片，可以以微创方式将载体基质递送到患者体内的目标位置。 这些件的尺寸使得在潮湿时它们能够流过套管和/或减小直径的针头。 将片放置在注射器中并用形态发生溶液润湿，并且可选地与填充材料混合，膨胀材料的尺寸类似于穿过套管。 充分混合和润湿的产品形成粘性聚集体，然后可以在目标部位将其注入患者体内。

    Bone mineralization proteins, DNA, vectors, expression systems
    25.
    发明授权
    Bone mineralization proteins, DNA, vectors, expression systems 失效
    骨矿化蛋白，DNA，载体，表达系统

    公开(公告)号：US06300127B1

    公开(公告)日：2001-10-09

    申请号：US09124238

    申请日：1998-07-29

    申请人： Gregory A. Hair ,  Scott D. Boden

    发明人： Gregory A. Hair ,  Scott D. Boden

    IPC分类号： C12N500

    CPC分类号： C07K14/51 ,  A61K48/00 ,  C07K14/47 ,  C12N2799/021

    摘要： The present invention is directed to isolated nucleic acid molecules that encode LIM mineralization protein, or LMP. The invention further provides vectors comprising nucleotide sequences that encode LMP, as well as host cells comprising those vectors. Moreover, the present invention relates to methods of inducing bone formation by transfecting osteogenic precursor cells with an isolated nucleic acid molecule comprising a nucleotide sequence encoding LIM mineralization protein. The transfection may occur ex vivo or in vivo by direct injection of virus or naked plasmid DNA. In a particular embodiment, the invention provides a method of fusing a spine by transfecting osteogenic precursor cells with an isolated nucleic acid molecule having a nucleotide sequence encoding LIM mineralization protein, admixing the transfected osteogenic precursor cells with a matrix and contacting the matrix with the spine. Finally, the invention relates to methods for inducing systemic bone formation by stable transfection of host cells with the vectors of the invention.

    摘要翻译： 本发明涉及编码LIM矿化蛋白或LMP的分离的核酸分子。 本发明还提供了包含编码LMP的核苷酸序列的载体以及包含这些载体的宿主细胞。 此外，本发明涉及通过用包含编码LIM矿化蛋白的核苷酸序列的分离的核酸分子转染成骨前体细胞诱导骨形成的方法。 转染可以通过直接注射病毒或裸体质粒DNA离体或体内发生。 在一个具体实施方案中，本发明提供了一种通过用具有编码LIM矿化蛋白的核苷酸序列的分离的核酸分子转染成骨前体细胞来融合脊柱的方法，将转染的成骨前体细胞与基质混合并使基质与脊柱 。 最后，本发明涉及通过用本发明的载体稳定转染宿主细胞诱导全身骨形成的方法。

    Percutaneous delivery system for treatment of osteonecrosis of the hip and methods of use thereof
    29.
    发明授权
    Percutaneous delivery system for treatment of osteonecrosis of the hip and methods of use thereof 有权
    用于治疗髋关节骨坏死的经皮递送系统及其使用方法

    公开(公告)号：US08092452B2

    公开(公告)日：2012-01-10

    申请号：US11751321

    申请日：2007-05-21

    申请人： Stephen D. Stamps ,  Scott D. Boden ,  James S. Marotta

    发明人： Stephen D. Stamps ,  Scott D. Boden ,  James S. Marotta

    IPC分类号： A61B17/56

    CPC分类号： A61M31/002

    摘要： Systems, methods, and carriers for percutaneous delivery of growth factors to treat osteonecrosis in the hip and other locations are disclosed. A rolled carrier comprising a biphasic ceramic rolled by a collagen sponge, and carrying a growth factor, are inserted via a delivery tube or cannula into a pre-formed hole in bone without overstuffing of the carrier or growth factor.

    摘要翻译： 公开了用于经皮递送生长因子以治疗髋部和其他位置的骨坏死的系统，方法和载体。 包括由胶原海绵滚动并携带生长因子的双相陶瓷的滚动载体通过输送管或插管插入到骨中的预先形成的孔中，而不会过载载体或生长因子。