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21.发明申请Method of stimulating/sensing brain with combination of intravascularly and non-vascularly delivered leads 有权通过血管内和非血管输送导联组合刺激/感觉脑的方法公开(公告)号：US20050187589A1
公开(公告)日：2005-08-25
申请号：US10783679
申请日：2004-02-20
申请人： Michael Wallace , Robert Garabedian
发明人： Michael Wallace , Robert Garabedian
CPC分类号： A61N1/36025 , A61N1/0529 , A61N1/0531 , A61N1/0534 , A61N1/36017 , A61N1/36064 , A61N1/36067 , A61N1/36082
摘要： A method of treating a neurological disorder in a patient is provided. The method comprises intravascularly delivering a first electrical lead within the head of the patient, and non-vascularly delivering a second electrical lead within the head the patient. The vascular and intravascular leads are placed adjacent brain tissue (e.g., cortical brain tissue or deep brain tissue). Optionally, the method comprises implanting a source of stimulation and/or recorder within the patient's body, and then electrically coupling the proximal ends of the electrical leads to the implanted device. Using the electrical leads, the brain tissue can then be stimulated and/or recorded in order to treat the neurological disorder.
摘要翻译： 提供了治疗患者神经障碍的方法。 该方法包括血管内传递患者头部内的第一电引线，并且在患者的头部内非血管输送第二电引线。 血管和血管内引线被放置在脑组织（例如皮质脑组织或深部脑组织）附近。 可选地，该方法包括在患者体内植入刺激源和/或记录器源，然后将电引线的近端电连接到植入装置。 使用电引线，然后可以刺激和/或记录脑组织以治疗神经障碍。
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22.发明申请Method of intravascularly delivering stimulation leads into direct contact with tissue 失效血管内传递刺激的方法导致与组织的直接接触公开(公告)号：US20050137647A1
公开(公告)日：2005-06-23
申请号：US10744853
申请日：2003-12-22
CPC分类号： A61N1/0529 , A61N1/0531 , A61N1/0534
摘要： A method of treating a disorder in a patient is provided. The method comprises delivering a stimulation lead within a blood vessel, intralumenally puncturing a wall of the blood vessel to create an exit point, and then introducing the stimulation lead through the exit point into direct contact with tissue the stimulation of which treats the disorder. Optionally, the method comprises implanting a source of stimulation within the patient's body, and then electrically coupling the proximal end of the stimulation lead to the implanted stimulation source. Using the stimulation lead, the tissue can then be stimulated in order to treat the disorder.
摘要翻译： 提供了一种治疗患者疾病的方法。 该方法包括在血管内递送刺激引线，腔内穿刺血管的壁以产生出口点，然后将刺激引线通过出口点直接接触组织，其刺激治疗病症。 可选地，该方法包括将刺激源植入患者体内，然后将刺激引线的近端电耦合到植入的刺激源。 使用刺激铅，然后可以刺激组织以治疗该疾病。
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公开(公告)号：US20060041225A1
公开(公告)日：2006-02-23
申请号：US10920735
申请日：2004-08-17
申请人： Michael Wallace , Robert Garabedian
发明人： Michael Wallace , Robert Garabedian
IPC分类号： A61M29/00
CPC分类号： A61M25/10 , A61M25/0141 , A61M25/0147 , A61M2025/0163 , A61M2025/105 , A61M2025/1086
摘要： A targeted drug delivery device is provided. The device comprises an elongated member with proximal and distal ends, a plurality of infusion ports associated with the distal end of the elongated member, and a selector mechanism for selectively placing an introducer port into fluid communication with at least one infusion port. A method for treating tissue is also provided. The method comprises introducing a medical device into the tissue, selecting an region of the tissue to treat, positioning the medical device in proximity to the region, and introducing a medicament through the device to treat only that region.
摘要翻译： 提供了靶向药物递送装置。 该装置包括具有近端和远端的细长构件，与细长构件的远端相关联的多个输注端口以及用于选择性地将引导器端口与至少一个输注端口流体连通的选择器机构。 还提供了一种治疗组织的方法。 该方法包括将医疗装置引入组织中，选择组织的区域以治疗，将医疗装置定位在该区域附近，以及通过该装置引入药物以仅对该区域进行治疗。
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公开(公告)号：US20070135809A1
公开(公告)日：2007-06-14
申请号：US11286257
申请日：2005-11-23
申请人： David Utley , Robert Garabedian , Michael Wallace
发明人： David Utley , Robert Garabedian , Michael Wallace
IPC分类号： A61B18/14
CPC分类号： A61B18/1492 , A61B18/18 , A61B2018/00214 , A61B2018/0022 , A61B2018/00577 , A61B2018/1495 , A61B2018/1807
摘要： Apparatus for treating abnormal mucosa in an alimentary tract are provided. The apparatus include an ablation structure configured to be removably coupled to an endoscope and a deflection mechanism adapted to move the ablation structure with respect to the endoscope and toward a tissue surface.
摘要翻译： 提供了用于治疗消化道异常粘膜的装置。 该装置包括被配置为可移除地联接到内窥镜的消融结构和适于使消融结构相对于内窥镜移动并朝向组织表面的偏转机构。
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公开(公告)号：US20050251238A1
公开(公告)日：2005-11-10
申请号：US10841069
申请日：2004-05-06
申请人： Michael Wallace , Robert Garabedian , John Peckham
发明人： Michael Wallace , Robert Garabedian , John Peckham
CPC分类号： A61N1/057 , A61N1/3787 , A61N2001/0585
摘要： An expandable intravascular medical device is provided. The medical device comprises an expandable tubular body that includes an integrated resilient support structure that forms a plurality of electrically conductive regions to which the lead(s) is coupled. The tubular body further includes at least one electrically insulative element disposed between the conductive regions. In one embodiment, the support structure is skeletal in nature, e.g., it can be formed of a mesh, braid, or coil. The conductive regions can be variously formed by the support structure. For example, the support structure may comprise electrically conductive sub-structures that form the conductive regions. In this case, the sub-structures may be mechanically linked together by the insulative element(s), or they can be directly linked together, and the insulative element(s) can take the form of insulative layer(s) disposed on one or more of the conductive sub-structures. As another example, the support structure can have a conductive core and insulative material disposed over portions of the conductive core. In this case, the exposed core portions form the conductive regions, and the unexposed core portions form the insulative element(s).
摘要翻译： 提供可扩张血管内医疗装置。 医疗装置包括可扩张的管状体，其包括形成多个导电区域的集成的弹性支撑结构，引线与该多个导电区域相连。 管状体还包括设置在导电区域之间的至少一个电绝缘元件。 在一个实施例中，支撑结构本质上是骨架的，例如，其可以由网，编织物或线圈形成。 导电区域可以由支撑结构各种形成。 例如，支撑结构可以包括形成导电区域的导电子结构。 在这种情况下，子结构可以通过绝缘元件机械地连接在一起，或者它们可以直接连接在一起，并且绝缘元件可以采取设置在一个或多个绝缘元件上的绝缘层的形式， 更多的导电子结构。 作为另一示例，支撑结构可以具有设置在导电芯的部分上方的导电芯和绝缘材料。 在这种情况下，露出的芯部形成导电区域，未曝光的芯部形成绝缘元件。
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公开(公告)号：US20050203599A1
公开(公告)日：2005-09-15
申请号：US10799271
申请日：2004-03-12
申请人： Robert Garabedian , Michael Wallace
发明人： Robert Garabedian , Michael Wallace
CPC分类号： A61N1/36071 , A61N1/0551 , A61N1/36017 , A61N1/36021
摘要： A medical kit and method for treating an ailment, such as chronic pain is provided. The kit comprises first and second medical leads, e.g., stimulation leads. Each lead comprises an elongated body and at least one operative element. The first medical lead comprises a coupling mechanism, such as a slot, and the second medical lead comprises a complementary mechanism, such as a rail, that slidably engages the coupling mechanism of the first medical lead. The method may comprise delivering the first medical lead into a patient's body, e.g., into the epidural space of the patient, and delivering the second medical lead into the patient's body by sliding the complementary coupling mechanism of the second medical lead along the coupling mechanism of the first medical lead.
摘要翻译： 提供了用于治疗诸如慢性疼痛之类的疾病的医疗用具和方法。 该试剂盒包括第一和第二医疗引线，例如刺激引线。 每个引线包括细长主体和至少一个操作元件。 第一医疗引线包括诸如槽的联接机构，并且第二医疗引线包括可滑动地接合第一医疗引线的联接机构的互补机构，例如轨道。 该方法可以包括将第一医疗引线输送到患者体内，例如进入患者的硬膜外腔，并且通过沿第二医疗引线的联接机构滑动第二医疗引线的互补联接机构，将第二医疗引线输送到患者体内 第一个医疗领导。
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27.发明申请公开(公告)号：US20070135861A1
公开(公告)日：2007-06-14
申请号：US11627359
申请日：2007-01-25
IPC分类号： A61N1/36
CPC分类号： A61N1/0529 , A61N1/0531 , A61N1/0534
摘要： A method of treating a neurological disorder in a patient is provided. The method comprises intravascularly delivering a stimulation lead within the head of the patient, and placing the stimulation lead adjacent brain tissue (e.g., cortical brain tissue or deep brain tissue), the stimulation of which will treat the neurological disorder. The stimulation lead can be placed into indirect contact with the brain tissue (e.g., through a blood vessel) or indirect contact with the brain tissue (e.g., when placed within the ventricular cavity or by being introduced through an exit point within a vessel wall). Optionally, the method comprises implanting a source of stimulation within the patient's body, and then electrically coupling the proximal end of the stimulation lead, which conveniently extends from the access point within the circulatory system, to the implanted stimulation source. Using the stimulation lead, the brain tissue can then be stimulated in order to treat the neurological disorder.
摘要翻译： 提供了治疗患者神经障碍的方法。 该方法包括血管内递送患者头部内的刺激引线，并将刺激引导线邻近脑组织（例如皮质脑组织或深部脑组织）放置，其刺激将治疗神经障碍。 刺激引线可以与脑组织（例如，通过血管）间接接触或与脑组织间接接触（例如当放置在心室内或通过血管壁内的出口点引入时） 。 可选地，该方法包括将刺激源植入患者体内，然后将刺激引线的近端电连接，其方便地从循环系统内的接入点延伸到植入的刺激源。 使用刺激引线，可以刺激脑组织以治疗神经系统疾病。
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公开(公告)号：US20070118106A1
公开(公告)日：2007-05-24
申请号：US11286444
申请日：2005-11-23
申请人： David Utley , Robert Garabedian , Michael Wallace
发明人： David Utley , Robert Garabedian , Michael Wallace
IPC分类号： A61B18/14
CPC分类号： A61B18/1492 , A61B18/02 , A61B18/1815 , A61B90/50 , A61B2017/00296 , A61B2018/00285 , A61B2018/00482 , A61B2018/046 , A61B2018/1495
摘要： Methods of ablating tissue in an alimentary tract are provided. The methods include advancing an ablation structure into an alimentary tract while supporting the ablation structure with an endoscope. The methods further include a step of moving at least part of the ablation structure with respect to the endoscope and toward a tissue surface, before activating the ablation structure to ablate a tissue surface.
摘要翻译： 提供了在消化道中消融组织的方法。 所述方法包括将消融结构推进消化道，同时用内窥镜支持消融结构。 所述方法还包括在激活消融结构以消融组织表面之前相对于内窥镜移动至少部分消融结构并朝向组织表面的步骤。
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公开(公告)号：US20050203602A1
公开(公告)日：2005-09-15
申请号：US10799270
申请日：2004-03-12
申请人： Michael Wallace , Robert Garabedian , Alex Leynov
发明人： Michael Wallace , Robert Garabedian , Alex Leynov
IPC分类号： A61N1/05
CPC分类号： A61N1/0553 , A61N1/0529 , A61N1/0531 , A61N1/0534 , A61N1/0558
摘要： A medical lead and method of treating a patient are provided. The medical lead comprises an electrically insulative membrane, a resilient spring element associated with the insulative membrane, and at least one electrode associated with the insulative membrane. The spring layer is configured to urge that insulative membrane into an expanded geometry. The medical lead is configured to be collapsed into a compact form for percutaneous delivery into the patient, thereby obviating the need to perform an invasive surgical procedure on the patient. The body formed by these elements, when expanded, can be sized to fit within the epidural space of a patient. The patient can be treated by placing the medical lead into a collapsed state by applying a compressive force to the medical lead, percutaneously delivering the collapsed medical lead into the patient adjacent tissue to be treated, and placing the medical lead into an expanded state by releasing the compressive force. In one preferred method, the stimulation lead is used to stimulate tissue, such as spinal cord tissue.
摘要翻译： 提供医疗用铅和治疗患者的方法。 医用引线包括电绝缘膜，与绝缘膜相关联的弹性弹簧元件，以及与绝缘膜相关联的至少一个电极。 弹簧层构造成将绝缘膜推动成扩展的几何形状。 医疗用引线被构造成塌缩成紧密形式用于经皮输送到患者体内，从而避免了对患者执行侵入性外科手术的需要。 由这些元件形成的身体，当扩张时，其尺寸可以适合于患者的硬膜外腔内。 可以通过向医用引线施加压缩力将医用引线置于折叠状态来将患者放置在患者身体中，将经塌陷的医用导管经皮递送到邻近被治疗组织的患者中，并通过释放将医用引线放入扩张状态 压缩力。 在一种优选的方法中，刺激引线用于刺激组织，例如脊髓组织。
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公开(公告)号：US20050137646A1
公开(公告)日：2005-06-23
申请号：US10744319
申请日：2003-12-22
CPC分类号： A61N1/0529 , A61N1/0531 , A61N1/0534
摘要： A method of treating a neurological disorder in a patient is provided. The method comprises intravascularly delivering a stimulation lead within the head of the patient, and placing the stimulation lead adjacent brain tissue (e.g., cortical brain tissue or deep brain tissue), the stimulation of which will treat the neurological disorder. The stimulation lead can be placed into indirect contact with the brain tissue (e.g., through a blood vessel) or indirect contact with the brain tissue (e.g., when placed within the ventricular cavity or by being introduced through an exit point within a vessel wall). Optionally, the method comprises implanting a source of stimulation within the patient's body, and then electrically coupling the proximal end of the stimulation lead, which conveniently extends from the access point within the circulatory system, to the implanted stimulation source. Using the stimulation lead, the brain tissue can then be stimulated in order to treat the neurological disorder.
摘要翻译： 提供了治疗患者神经障碍的方法。 该方法包括血管内递送患者头部内的刺激引线，并将刺激引导线邻近脑组织（例如皮质脑组织或深部脑组织）放置，其刺激将治疗神经障碍。 刺激引线可以与脑组织（例如，通过血管）间接接触或与脑组织间接接触（例如当放置在心室内或通过血管壁内的出口点引入时） 。 可选地，该方法包括将刺激源植入患者体内，然后将刺激引线的近端电连接，其方便地从循环系统内的接入点延伸到植入的刺激源。 使用刺激引线，可以刺激脑组织以治疗神经系统疾病。
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