-
21.发明申请公开(公告)号：US20100226549A1
公开(公告)日：2010-09-09
申请号：US12722043
申请日：2010-03-11
IPC分类号： G06K9/00
CPC分类号： A61B5/1455 , A61B5/14532 , A61B5/14556 , G01N21/6456 , G01N21/65 , G01N2021/6423
摘要： A spectral image is corrected for optical aberrations. Tissue is exposed to a high-intensity, narrow band of light. The narrow band of light is scattered by at least one analyte in the tissue. Raman signals are optically collected from the scattered light. The Raman signals are directed to a wavelength-separating device. The Raman signals are detected as a function of intensity and wavelength to create the spectral image. The spectral image is corrected for optical aberrations using a software algorithm to spatially reassign intensity. The software may be adapted to use a reference image to make dynamic corrections. Fluorescence signals may also be collected.
摘要翻译： 对光学像差校正光谱图像。 组织暴露于高强度，窄带光。 窄带光被组织中的至少一种分析物散射。 拉曼信号从散射光中被光学收集。 拉曼信号被引导到波长分离装置。 作为强度和波长的函数检测拉曼信号以产生光谱图像。 使用软件算法对光学像差校正光谱图像以空间重新分配强度。 该软件可以适于使用参考图像进行动态校正。 也可以收集荧光信号。
-
公开(公告)号：US20090062632A1
公开(公告)日：2009-03-05
申请号：US11918537
申请日：2006-04-13
申请人： Mihailo V. Rebec
发明人： Mihailo V. Rebec
IPC分类号： A61B5/1455
CPC分类号： G01J3/1256 , A61B5/14532 , A61B5/1455 , A61B5/1495 , A61B5/726 , G01J3/02 , G01J3/0218 , G01J3/0262 , G01J3/0272 , G01J3/10 , G01J3/28 , G01J3/433 , G01J2003/2866 , G01N21/35 , G01N2021/3144 , G01N2021/3185
摘要： A system for determining an analyte concentration in a fluid sample (e.g., glucose) comprises a light source, a detector, and a central processing unit. The detector is adapted to receive spectral information corresponding to light returned from the fluid sample being analyzed and to convert the received spectral information into an electrical signal indicative of the received spectral information. The central processing unit is adapted to compare the electrical signal to an algorithm built upon correlation with the analyte in body fluid. The algorithm is adapted to convert the received spectral information into the analyte concentration in body fluid. Spectral information is delivered from the central processing unit to the light source and used to vary the intensity and timing of the light to improve the accuracy of conversion into analyte concentration.
摘要翻译： 用于确定流体样品（例如葡萄糖）中的分析物浓度的系统包括光源，检测器和中央处理单元。 检测器适于接收对应于正在分析的流体样品返回的光的光谱信息，并将接收到的光谱信息转换为指示所接收的光谱信息的电信号。 中央处理单元适于将电信号与建立在体液中分析物相关的算法进行比较。 该算法适用于将接收到的光谱信息转换成体液中的分析物浓度。 光谱信息从中央处理单元传送到光源，并用于改变光的强度和时间，以提高转换成分析物浓度的准确度。
-
公开(公告)号：US20080154106A1
公开(公告)日：2008-06-26
申请号：US11999634
申请日：2007-12-06
申请人： Mihailo V. Rebec
发明人： Mihailo V. Rebec
IPC分类号： A61B5/1473
CPC分类号： A61B5/201 , A61B5/0002 , A61B5/145 , A61B5/14528 , A61B5/14546 , A61B5/686 , A61B2010/008
摘要： A method of using a diffusion-based, continuous-monitoring system to analyze for a disease or condition includes creating a diffusion channel in an area of skin. The diffusion channel is maintained for a desired duration. The level of the disease marker(s) is continuously monitored for the desired duration via a diffusion-based, continuous-monitoring device. The levels of the at least one disease marker at the area of skin are analyzed to determine if the disease or condition associated with the at least one disease marker is present.
摘要翻译： 使用基于扩散的连续监测系统来分析疾病或病症的方法包括在皮肤区域中产生扩散通道。 扩散通道保持期望的持续时间。 疾病标志物的水平通过基于扩散的连续监测装置连续监测所需的持续时间。 分析皮肤区域上的至少一种疾病标记物的水平，以确定与至少一种疾病标记物相关的疾病或病症是否存在。
-
公开(公告)号：US07299079B2
公开(公告)日：2007-11-20
申请号：US10361895
申请日：2003-02-11
申请人： Mihailo V. Rebec , James E. Smous , Steven D. Brown , Hu-Wei Tan
发明人： Mihailo V. Rebec , James E. Smous , Steven D. Brown , Hu-Wei Tan
IPC分类号： A61B5/00
CPC分类号： A61B5/14532 , A61B5/1455 , A61B5/1495 , A61B5/726 , G01N21/274 , G01N21/359 , G01N2201/067
摘要： A system for determining the concentration of an analyte in at least one body fluid in body tissue, the system comprising an infrared light source, a body tissue interface, a detector, and a central processing unit. The body tissue interface is adapted to contact body tissue and to deliver light from the infrared light source to the contacted body tissue. The detector is adapted to receive spectral information corresponding to infrared light transmitted through the portion of body tissue being analyzed and to convert the received spectral information into an electrical signal indicative of the received spectral information. The central processing unit is adapted to compare the electrical signal to an algorithm built upon correlation with the analyte in body fluid, the algorithm adapted to convert the received spectral information into the concentration of the analyte in at least one body fluid.
摘要翻译： 一种用于确定身体组织中的至少一种体液中的分析物的浓度的系统，所述系统包括红外光源，身体组织界面，检测器和中央处理单元。 身体组织界面适于接触身体组织并将红外光源的光传送到被接触的身体组织。 检测器适于接收对应于通过被分析的身体组织部分透射的红外光的光谱信息，并将接收到的光谱信息转换为指示所接收的光谱信息的电信号。 中央处理单元适于将电信号与建立在体液中与分析物相关的算法进行比较，该算法适于将接收到的光谱信息转换成至少一个体液中分析物的浓度。
-
公开(公告)号：US5208163A
公开(公告)日：1993-05-04
申请号：US803076
申请日：1991-12-06
CPC分类号： B01L3/502753 , G01N33/5302 , B01L2200/0605 , B01L2300/0681 , B01L2300/0825 , B01L2300/0864 , B01L2300/0887 , B01L2400/0406 , Y10S435/81 , Y10S436/807 , Y10T436/255 , Y10T436/2575
摘要： A method for detecting blood analytes with a sample volume as low as 2 microliters in the hematocrit range of 0% to 60%, or higher. This is accomplished by using a diagnostic device comprising a housing with various chambers and compartments for processing the blood. A sample application port in the housing is used to introduce blood into a metering chamber. From the metering chamber, the blood flows to a reaction chamber for analyzing blood analytes. Blood entering the metering chamber flows into a fluid capillary which indicates that an adequate amount of blood has been received in the metering chamber. The reaction compartment includes a reagent and a filter, the latter of which is disposed between the metering chamber and the reagent so that the reagent reacts with the filtered blood.
摘要翻译： 在0％至60％或更高的血细胞比容范围内检测样品体积低至2微升的血液分析物的方法。 这通过使用包括具有用于处理血液的各种室和隔室的壳体的诊断装置来实现。 外壳中的样品应用端口用于将血液引入计量室。 从计量室，血液流到反应室，用于分析血液分析物。 进入计量室的血液流入流体毛细管，这表明在计量腔中已经接收了足够量的血液。 反应室包括试剂和过滤器，其中后者设置在计量室和试剂之间，使得试剂与过滤的血液反应。
-
公开(公告)号：US5147606A
公开(公告)日：1992-09-15
申请号：US563044
申请日：1990-08-06
CPC分类号： G01N33/5302 , B01L3/502753 , B01L2200/0605 , B01L2200/0684 , B01L2300/0681 , B01L2300/0825 , B01L2300/0864 , B01L2300/0887 , B01L2400/0406 , Y10S435/808 , Y10S435/81 , Y10S436/805 , Y10S436/808 , Y10T436/25375
摘要： A diagnostic device detects blood analytes with a sample volume as low as 2 microliters in the hematocrit range of 0% to 60%, or higher. This is accomplished by employing a housing with various chambers and compartments for processing the blood. A sample application port in the housing is used to introduce blood into a metering chamber. From the metering chamber, the blood flows to a reaction chamber for analyzing blood analytes. Blood entering the metering chamber flows into a fluid capillary which indicates that an adequate amount of blood has been received in the metering chamber. The reaction compartment includes a reagent and a filter, the latter of which is disposed between the metering chamber and the reagent so that the reagent reacts with the filtered blood.
-
公开(公告)号：US09649056B2
公开(公告)日：2017-05-16
申请号：US13731007
申请日：2012-12-29
申请人： Mihailo V. Rebec
发明人： Mihailo V. Rebec
IPC分类号： A61B5/1455 , A61B5/1459 , A61B5/145
CPC分类号： A61B5/1459 , A61B5/14532 , A61B2560/0233
摘要： Embodiments provide sensors, such as implantable sensors, and methods of producing such sensors. An implantable sensor may include a base, one or more chambers, and one or more sensor reagents. A membrane may be coupled to the chambers over the sensor reagents. The implantable sensor may be at least partially implanted into the dermis of an animal. One or more of the sensor reagents may emit light or exhibit a color change in response to the presence of a target analyte or reaction product thereof. The response may be detected and analyzed by the user or by a reader device to determine the target analyte concentration.
-
公开(公告)号：US08180422B2
公开(公告)日：2012-05-15
申请号：US11918537
申请日：2006-04-13
申请人： Mihailo V. Rebec
发明人： Mihailo V. Rebec
IPC分类号： A61B5/1455
CPC分类号： G01J3/1256 , A61B5/14532 , A61B5/1455 , A61B5/1495 , A61B5/726 , G01J3/02 , G01J3/0218 , G01J3/0262 , G01J3/0272 , G01J3/10 , G01J3/28 , G01J3/433 , G01J2003/2866 , G01N21/35 , G01N2021/3144 , G01N2021/3185
摘要： A system for determining an analyte concentration in a fluid sample (e.g., glucose) comprises a light source, a detector, and a central processing unit. The detector is adapted to receive spectral information corresponding to light returned from the fluid sample being analyzed and to convert the received spectral information into an electrical signal indicative of the received spectral information. The central processing unit is adapted to compare the electrical signal to an algorithm built upon correlation with the analyte in body fluid. The algorithm is adapted to convert the received spectral information into the analyte concentration in body fluid. Spectral information is delivered from the central processing unit to the light source and used to vary the intensity and timing of the light to improve the accuracy of conversion into analyte concentration.
摘要翻译： 用于确定流体样品（例如葡萄糖）中的分析物浓度的系统包括光源，检测器和中央处理单元。 检测器适于接收对应于正在分析的流体样品返回的光的光谱信息，并将接收到的光谱信息转换为指示所接收的光谱信息的电信号。 中央处理单元适于将电信号与建立在体液中分析物相关的算法进行比较。 该算法适用于将接收到的光谱信息转换成体液中的分析物浓度。 光谱信息从中央处理单元传送到光源，并用于改变光的强度和时间，以提高转换成分析物浓度的准确度。
-
公开(公告)号：US08160666B2
公开(公告)日：2012-04-17
申请号：US11974477
申请日：2007-10-12
申请人： Mihailo V. Rebec , James E. Smous , Steven D. Brown , Hu-Wei Tan
发明人： Mihailo V. Rebec , James E. Smous , Steven D. Brown , Hu-Wei Tan
IPC分类号： A61B5/1455
CPC分类号： A61B5/14532 , A61B5/1455 , A61B5/1495 , A61B5/726 , G01N21/274 , G01N21/359 , G01N2201/067
摘要： A system for determining the concentration of an analyte in at least one body fluid in body tissue comprises an infrared light source, a body tissue interface, a detector, and a central processing unit. The body tissue interface is adapted to contact body tissue and to deliver light from the infrared light source to the contacted body tissue. The detector is adapted to receive spectral information corresponding to infrared light transmitted through the portion of body tissue being analyzed and to convert the received spectral information into an electrical signal indicative of the received spectral information. The central processing unit is adapted to compare the electrical signal to an algorithm built upon correlation with the analyte in body fluid, the algorithm adapted to convert the received spectral information into the concentration of the analyte in at least one body fluid.
摘要翻译： 用于确定身体组织中的至少一种体液中的分析物的浓度的系统包括红外光源，身体组织界面，检测器和中央处理单元。 身体组织界面适于接触身体组织并将红外光源的光传送到被接触的身体组织。 检测器适于接收对应于通过被分析的身体组织部分透射的红外光的光谱信息，并将接收到的光谱信息转换为指示所接收的光谱信息的电信号。 中央处理单元适于将电信号与建立在与体液中的分析物相关的算法上进行比较，该算法适于将接收到的光谱信息转换成至少一个体液中分析物的浓度。
-
30.发明授权公开(公告)号：US07896819B2
公开(公告)日：2011-03-01
申请号：US11665118
申请日：2005-10-20
IPC分类号： A61B5/00
CPC分类号： A61B5/15134 , A61B5/150022 , A61B5/150068 , A61B5/150114 , A61B5/150358 , A61B5/150755 , A61B5/15136
摘要： A method of obtaining a body fluid sample for determining the concentration of an analyte in the body fluid sample comprises applying pressure to the skin of the user. The skin is stretched so as to create a tear in the skin such that the applied pressure causes the body fluid to flow from the tear. The body fluid flowing from the tear is collected. Disclosed is also a pressure member for applying pressure to and stretching skin in preparation for forming a tear in the skin.
摘要翻译： 获得用于确定体液样品中分析物浓度的体液样品的方法包括向使用者的皮肤施加压力。 皮肤被拉伸以在皮肤中产生撕裂，使得所施加的压力导致体液从泪液流出。 收集从泪液流出的体液。 还公开了用于对皮肤施加压力并拉伸皮肤以准备在皮肤中形成泪液的压力构件。
-
-
-
-
-
-
-
-
-
搜索结果
41 条记录 (耗时 0.022 秒)
