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公开(公告)号：US5932701A
公开(公告)日：1999-08-03
申请号：US978458
申请日：1997-11-25
申请人： Michael Terence Black , Jason Craig Fedon , John Edward Hodgson , David Justin Charles Knowles , Michael Arthur Lonetto , Anna Lisa Kosmatka , Richard Oakley Nicholas , Leslie Marie Palmer , Lisa Kathleen Shilling , Robert King Stodola , Richard Lloyd Warren
发明人： Michael Terence Black , Jason Craig Fedon , John Edward Hodgson , David Justin Charles Knowles , Michael Arthur Lonetto , Anna Lisa Kosmatka , Richard Oakley Nicholas , Leslie Marie Palmer , Lisa Kathleen Shilling , Robert King Stodola , Richard Lloyd Warren
IPC分类号： C12N15/09 , A61K38/00 , A61K39/00 , A61K39/09 , A61K39/395 , A61K45/00 , A61K48/00 , A61P9/00 , A61P11/00 , A61P25/00 , A61P27/02 , A61P27/16 , A61P31/04 , A61P43/00 , C07K14/315 , C07K16/12 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/10 , C12N9/12 , C12N9/78 , C12N9/80 , C12P21/02 , C12P21/08 , C12Q1/02 , C12Q1/68 , C12R1/46 , C07K1/00 , C07K14/00 , C07K17/00
CPC分类号： C12N9/1077 , C07K14/3156 , C12N9/1205 , C12N9/78 , C12N9/80 , C12Y207/01002 , A61K38/00 , A61K39/00 , C07K2319/00
摘要： The invention provides ribA polypeptides and polynucleotides encoding ribA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ribA polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供ribA多肽和编码ribA多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用ribA多肽筛选抗菌化合物的方法。
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公开(公告)号：US06171835B2
公开(公告)日：2001-01-09
申请号：US09385288
申请日：1999-08-30
申请人： Michael Terence Black , Jason Craig Fedon , John Edward Hodgson , David Justin Charles Knowles , Michael Arthur Lonetto , Anna Lisa Kosmatka , Richard Oakley Nicholas , Leslie Marie Palmer , Lisa Kathleen Shilling , Robert King Stodola , Richard Lloyd Warren
发明人： Michael Terence Black , Jason Craig Fedon , John Edward Hodgson , David Justin Charles Knowles , Michael Arthur Lonetto , Anna Lisa Kosmatka , Richard Oakley Nicholas , Leslie Marie Palmer , Lisa Kathleen Shilling , Robert King Stodola , Richard Lloyd Warren
IPC分类号： C12N900
CPC分类号： C12N9/1085 , A61K38/00 , A61K39/00 , C07K14/3156 , C12Y205/01009
摘要： The invention provides ribH polypeptides and polynucleotides encoding ribH polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ribH polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供ribH多肽和编码ribH多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用ribH多肽筛选抗菌化合物的方法。
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公开(公告)号：US06251652B1
公开(公告)日：2001-06-26
申请号：US09238555
申请日：1999-01-28
申请人： Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Raymond Winfield Reichard , Richard Oakley Nicholas , Martin Karl Russel Burnham , Jamie M Pratt , Martin Rosenberg , Judith M Ward , Michael Arthur Lonetto , Patrick Vernon Warren
发明人： Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Raymond Winfield Reichard , Richard Oakley Nicholas , Martin Karl Russel Burnham , Jamie M Pratt , Martin Rosenberg , Judith M Ward , Michael Arthur Lonetto , Patrick Vernon Warren
IPC分类号： C12N988
CPC分类号： C12N9/0006 , A61K38/00 , A61K39/00 , C07K14/31 , C07K2319/00 , C12N9/00 , C12N9/1205 , C12N9/88 , Y10S435/883
摘要： The invention provides yitJ polypeptides and DNA (RNA) encoding yitJ polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing yitJ polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供了yitJ多肽和编码yitJ多肽的DNA（RNA），以及通过重组技术产生此类多肽的方法。 还提供了利用yitJ多肽筛选抗菌化合物的方法。
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公开(公告)号：US6020159A
公开(公告)日：2000-02-01
申请号：US910501
申请日：1997-08-04
申请人： Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Raymond Winfield Reichard , Richard O Nicholas , Martin Karl Russel Burnham , Martin Rosenberg , Julie M Pratt , Judith M Ward , Michael Arthur Lonetto , Patrick Vernon Warren
发明人： Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Raymond Winfield Reichard , Richard O Nicholas , Martin Karl Russel Burnham , Martin Rosenberg , Julie M Pratt , Judith M Ward , Michael Arthur Lonetto , Patrick Vernon Warren
IPC分类号： C12N15/09 , A61K38/00 , A61K38/43 , A61K39/00 , A61K39/085 , A61K39/395 , A61P31/04 , C07K14/31 , C07K16/12 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/00 , C12N9/04 , C12N9/12 , C12N9/88 , C12N15/00 , C12N15/60 , C12R1/445 , C12P21/06 , C07H17/00
CPC分类号： C12N9/1205 , C07K14/31 , C12N9/00 , C12N9/0006 , C12N9/88 , A61K38/00 , A61K39/00
摘要： The invention provides 3-DEHYDROQUINATE SYNTHASE polypeptides and DNA (RNA) encoding 3-DEHYDROQUINATE SYNTHASE polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing 3-DEHYDROQUINATE SYNTHASE polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供了3-脱水氨基酸合成酶多肽和编码3-脱水氨基酸合成酶多肽的DNA（RNA）和通过重组技术产生这种多肽的方法。 还提供了利用3-脱氢氨基酸合成酶多肽筛选抗菌化合物的方法。
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公开(公告)号：US5882891A
公开(公告)日：1999-03-16
申请号：US898779
申请日：1997-07-23
申请人： Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Raymond Winfield Reichard , Richard Oakly Nicholas , Martin Karl Russel Burnham , Julie M Pratt , Martin Rosenberg , Judith M Ward , Michael Arthur Lonetto , Patrick Vernon Warren
发明人： Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Raymond Winfield Reichard , Richard Oakly Nicholas , Martin Karl Russel Burnham , Julie M Pratt , Martin Rosenberg , Judith M Ward , Michael Arthur Lonetto , Patrick Vernon Warren
IPC分类号： G01N33/50 , A61K38/00 , A61K39/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P31/04 , A61P37/00 , C07K14/31 , C07K16/12 , C12N1/21 , C12N9/78 , C12N15/09 , C12N15/31 , C12N15/11 , C12N1/20 , C12N15/63
CPC分类号： C07K16/1275 , C07K14/31 , C12N9/78 , C12Y305/04025 , A61K2039/51 , A61K38/00 , A61K39/00
摘要： The invention provides Ferrichrome transport ATP-Binding Protein polypeptides and DNA (RNA) encoding Ferrichrome transport ATP-Binding Protein polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing Ferrichrome transport ATP-Binding Protein polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供了Ferrichrome转运ATP结合蛋白多肽和编码Ferrichrome转运ATP结合蛋白多肽的DNA（RNA）和通过重组技术产生此类多肽的方法。 还提供了利用Ferrichrome转运ATP结合蛋白多肽筛选抗菌化合物的方法。
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公开(公告)号：US06232292B1
公开(公告)日：2001-05-15
申请号：US09398550
申请日：1999-09-17
申请人： Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Raymond Winfield Reichard , Richard O Nicholas , Martin Karl Russel Burnham , Julie M. Pratt , Martin Rosenberg , Judith M Ward , Michael Arthur Lonetto , Patrick Vernon Warren
发明人： Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Raymond Winfield Reichard , Richard O Nicholas , Martin Karl Russel Burnham , Julie M. Pratt , Martin Rosenberg , Judith M Ward , Michael Arthur Lonetto , Patrick Vernon Warren
IPC分类号： C07K1400
CPC分类号： C12N9/1205 , A61K38/00 , A61K39/00 , C07K14/31 , C12N9/00 , C12N9/0006 , C12N9/88
摘要： The invention provides 3-DEHYDROQUINATE SYNTHASE polypeptides and DNA (RNA) encoding 3-DEHYDROQUINATE SYNTHASE polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing 3-DEHYDROQUINATE SYNTHASE polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供了3-脱水氨基酸合成酶多肽和编码3-脱水氨基酸合成酶多肽的DNA（RNA）和通过重组技术产生这种多肽的方法。 还提供了利用3-脱氢氨基酸合成酶多肽筛选抗菌化合物的方法。
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公开(公告)号：US06348582B1
公开(公告)日：2002-02-19
申请号：US08936165
申请日：1997-09-23
申请人： Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Raymond Winfield Reichard , Richard O Nicholas , Martin Karl Russel Burnham , Julie M Pratt , Martin Rosenberg , Judith M Ward , Michael Arthur Lonetto
发明人： Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Raymond Winfield Reichard , Richard O Nicholas , Martin Karl Russel Burnham , Julie M Pratt , Martin Rosenberg , Judith M Ward , Michael Arthur Lonetto
IPC分类号： C07H2100
CPC分类号： C12N9/0006 , A61K38/00 , A61K39/00 , C07K14/31 , C07K2319/00 , C12N9/00 , C12N9/1205 , C12N9/88 , Y10S435/883
摘要： The invention provides novel polypeptides and polynucleotides encoding such polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing such polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供了编码这种多肽的新型多肽和多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用这些多肽筛选抗菌化合物的方法。
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公开(公告)号：US06264955B1
公开(公告)日：2001-07-24
申请号：US09224502
申请日：1998-12-31
申请人： Julie M Pratt , Martin Rosenberg , Judith M Ward , Michael Arthur Lonetto , Patrick Vernon Warren , Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Raymond Winfield Reichard , Richard O Nicholas , Martin Karl Russel Burnham
发明人： Julie M Pratt , Martin Rosenberg , Judith M Ward , Michael Arthur Lonetto , Patrick Vernon Warren , Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Raymond Winfield Reichard , Richard O Nicholas , Martin Karl Russel Burnham
IPC分类号： A61K3902
CPC分类号： C07K16/1275 , A61K38/00 , A61K39/00 , A61K2039/51 , C07K14/31 , C12N9/78 , C12Y305/04025
摘要： The invention provides Ferrichrome transport ATP-Binding Protein polypeptides and DNA (RNA) encoding Ferrichrome transport ATP-Binding Protein polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing Ferrichrome transport ATP-Binding Protein polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供了Ferrichrome转运ATP结合蛋白多肽和编码Ferrichrome转运ATP结合蛋白多肽的DNA（RNA）和通过重组技术产生此类多肽的方法。 还提供了利用Ferrichrome转运ATP结合蛋白多肽筛选抗菌化合物的方法。
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公开(公告)号：US6107071A
公开(公告)日：2000-08-22
申请号：US910505
申请日：1997-08-04
申请人： Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Raymond Winfield Reichard , Richard O Nicholas , Martin Karl Russel Burnham , Julie M Pratt , Martin Rosenberg , Judith M Ward , Michael Arthur Lonetto , Patrick Vernon Warren
发明人： Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Raymond Winfield Reichard , Richard O Nicholas , Martin Karl Russel Burnham , Julie M Pratt , Martin Rosenberg , Judith M Ward , Michael Arthur Lonetto , Patrick Vernon Warren
IPC分类号： G01N33/50 , A61K31/70 , A61K38/00 , A61K38/04 , A61K38/44 , A61K38/55 , A61K39/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P31/04 , A61P35/00 , A61P37/00 , A61P37/04 , A61P43/00 , C07K14/31 , C07K16/12 , C12N1/00 , C12N1/21 , C12N9/00 , C12N9/04 , C12N9/12 , C12N9/14 , C12N9/88 , C12N15/00 , C12N15/09 , C12N15/31 , C12N15/53 , C12N15/54 , C12P21/02 , C12P21/08 , C12Q1/02 , C12Q1/68 , C12R1/19 , C12R1/44 , C12R1/445 , G01N33/15 , G01N33/53 , G01N33/569 , G01N33/573 , C07H21/04 , C12N1/20
CPC分类号： C12N9/0006 , C07K14/31 , C12N9/00 , C12N9/1205 , C12N9/88 , A61K38/00 , A61K39/00 , C07K2319/00 , Y10S435/883
摘要： The invention provides histidinol dehydrogenase polypeptides and DNA (RNA) encoding histidinol dehydrogenase polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing histidinol dehydrogenase polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供组氨醇脱氢酶多肽和编码组氨醇脱氢酶多肽的DNA（RNA），以及通过重组技术产生此类多肽的方法。 还提供了利用组氨醇脱氢酶多肽筛选抗菌化合物的方法。
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公开(公告)号：US06252044B1
公开(公告)日：2001-06-26
申请号：US08977555
申请日：1997-11-25
申请人： Michael Terance Black , Lisa Kathleen Shilling , Robert King Stodola , Richard Lloyd Warren , Anna Lisa Kosmatka , Richard Oakley Nicholas , Leslie Marie Palmer , Michael Arthur Lonetto , Jason Craig Fedon , John Edward Hodgson , David Justin Charles Knowles
发明人： Michael Terance Black , Lisa Kathleen Shilling , Robert King Stodola , Richard Lloyd Warren , Anna Lisa Kosmatka , Richard Oakley Nicholas , Leslie Marie Palmer , Michael Arthur Lonetto , Jason Craig Fedon , John Edward Hodgson , David Justin Charles Knowles
IPC分类号： C07K100
CPC分类号： C12N9/1085 , A61K38/00 , A61K39/00 , C07K14/3156 , C12N9/1205 , C12N9/78 , C12Y205/01009 , C12Y207/01002
摘要： The invention provides ribB polypeptides and polynucleotides encoding ribB polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ribB polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供ribB多肽和编码ribB多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用ribB多肽筛选抗菌化合物的方法。
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