公开(公告)号：US20140377169A1

公开(公告)日：2014-12-25

申请号：US13921217

申请日：2013-06-19

申请人： Ming-Hsin Li ,  Shu-Pei Chiu ,  Chih-Hsien Chang ,  Te-Wei Lee

发明人： Ming-Hsin Li ,  Shu-Pei Chiu ,  Chih-Hsien Chang ,  Te-Wei Lee

IPC分类号： B01J19/00 ,  A61K51/12

CPC分类号： B01J19/004 ,  A61K51/1234 ,  C07B59/001

摘要： An automated synthesis device to produce Re-188-BMEDA solution including: a plurality of reagent vials, three-way solenoid valves, gel filtration columns and micro pumps, and a reaction vial, a product vial, a temporary storage vial, a filter membrane, and a waste vial, wherein the plurality of reagent vials include first reagent vial and second reagent vials being connected to the reaction vial through first micro pump, the third reagent vial and fourth reagent vial being connected to the reaction vial through second micro pump, fifth reagent vial being connected to the reaction vial through third micro pump, and sixth reagent vial being connected to the temporary storage vial through fourth micro pump, wherein the reaction vial is connected to the plurality of gel filtration columns through the micro-pump, respectively. The automated synthesis device is operable with program to upgrade yield and avoid contamination.

摘要翻译： 一种用于生产Re-188-BMEDA溶液的自动化合成装置，包括：多个试剂瓶，三通电磁阀，凝胶过滤柱和微型泵，以及反应瓶，产品小瓶，临时储存小瓶，过滤膜 以及废物小瓶，其中所述多个试剂小瓶包括通过第一微泵连接到所述反应小瓶的第一试剂小瓶和第二试剂小瓶，所述第三试剂小瓶和第四试剂小瓶通过第二微泵连接到所述反应小瓶， 第五试剂小瓶通过第三微泵连接到反应小瓶，第六试剂小瓶通过第四微泵连接到临时存储小瓶，其中反应小瓶分别通过微型泵连接到多个凝胶过滤柱 。 自动合成装置可与程序一起操作，以提高产量并避免污染。

公开(公告)号：US08894860B2

公开(公告)日：2014-11-25

申请号：US12963263

申请日：2010-12-08

申请人： Ming-Hsin Li ,  Jin-Jenn Lin ,  Ther-Jen Ting ,  I-Lea Dai

发明人： Ming-Hsin Li ,  Jin-Jenn Lin ,  Ther-Jen Ting ,  I-Lea Dai

IPC分类号： B01D15/36 ,  B01D15/04 ,  B01D15/08 ,  G21F5/00 ,  G21G1/00

CPC分类号： B01D15/361 ,  G21G1/0005 ,  G21G2001/0021

摘要： A Gallium-68 (Ga-68) radioisotope generator includes a generating column and a citrate eluent. The generating column is at least partially filled with an ion-exchange resin with glucamine groups to absorb germanium-68 (Ge-68) and Ga-68 radioisotopes. The citrate eluent is added into the generating column to desorb the Ga-68 radioisotope and form an eluent containing the Ga-68 radioisotope in the form of Ga-68 citrate. A method for generating Ga-68 radioisotope is also disclosed.

摘要翻译： 镓68（Ga-68）放射性同位素发生器包括产生柱和柠檬酸盐洗脱液。 生成塔至少部分地填充有具有葡糖胺基团的离子交换树脂以吸收锗-68（Ge-68）和Ga-68放射性同位素。 将柠檬酸盐洗脱液加入产生塔中以解吸Ga-68放射性同位素，形成含有Ga-68柠檬酸盐形式的Ga-68放射性同位素的洗脱液。 还公开了一种生成Ga-68放射性同位素的方法。

公开(公告)号：US11202577B2

公开(公告)日：2021-12-21

申请号：US16664946

申请日：2019-10-28

申请人： Ming-Hsin Li ,  Kai-Hung Cheng ,  Shih-Wei Lo

发明人： Ming-Hsin Li ,  Kai-Hung Cheng ,  Shih-Wei Lo

IPC分类号： A61B5/0205 ,  A61B5/029 ,  A61B5/00 ,  A61B5/021 ,  A61B5/024 ,  A61B5/369

摘要： A system and method for monitoring cardiovascular and brain functions in combination with a physiological detection device, which uses a smart wearable device to detect physiological data such as heart rate and pulse pressure of a user, and transmits the physiological data to an arithmetic function. An electronic device in which a preset function and a calculation formula are built in, and the physiological data can be converted into corresponding determination parameters to monitor the possibility and risk of cardiovascular diseases and neurodegenerative diseases.

公开(公告)号：US09266084B2

公开(公告)日：2016-02-23

申请号：US13916599

申请日：2013-06-13

申请人： Ming-Hsin Li ,  Hsin-Han Hsieh

发明人： Ming-Hsin Li ,  Hsin-Han Hsieh

IPC分类号： A61K51/00 ,  A61M36/14 ,  B01J19/00 ,  A61K51/08 ,  C07B59/00

CPC分类号： B01J19/0053 ,  A61K51/083 ,  C07B59/00

摘要： The invention provides an automatic synthesizer apparatus and method for producing radiopharmaceutical tumor imaging agent Gallium-68-DOTATATE with one button control process to effectively isolate the medication in vials from the contamination of environment and manual operations, saving the costs of investment in production with alleviation of the critical standard required for the environmental equipments to be used for production.

摘要翻译： 本发明提供一种用于制造放射性药物肿瘤成像剂Gallium-68-DOTATATE的自动合成装置和方法，其具有一个按钮控制过程，以有效地将小瓶中的药物与环境污染和手动操作隔离，从而节省了生产投资的成本，减轻了 环境设备用于生产所需的关键标准。

公开(公告)号：US20140378830A1

公开(公告)日：2014-12-25

申请号：US13925806

申请日：2013-06-24

申请人： Ming-Hsin Li

发明人： Ming-Hsin Li

IPC分类号： A61B6/00 ,  A61B6/03

CPC分类号： A61B6/501 ,  A61B5/055 ,  A61B5/4064 ,  A61B6/037 ,  A61B6/486 ,  G01R33/4806

摘要： A method for stimulating a brain to form a cognitive reaction image is provided, which includes administrating 11C-isotope labeled glucose to a test recipient closing eyes, exposing the test recipient to visual stimulus, auditory stimulus and cognitive stimulus, respectively, and then monitoring the test recipient by a brain imaging device and collecting brain imaging data to compare variation between actions of the administrated 11C-isotope labeled glucose in the test recipient's brain before and after the test recipient being exposed to the stimulus. The brain images in correspondence with the brain reacting to the visual, auditory and cognitive stimuli are obtained by detecting the metabolic process of the 11C-isotope labeled glucose in brain.

摘要翻译： 提供了一种刺激大脑形成认知反应图像的方法，其包括将11C同位素标记的葡萄糖施用于接受闭合眼睛的测试受体，分别将测试受体暴露于视觉刺激，听觉刺激和认知刺激，然后监测 通过脑成像装置测试受体，并收集脑成像数据，以比较测试受体暴露于刺激之前和之后给予的11C同位素标记的葡萄糖在受试者的大脑中的作用之间的变化。 通过检测大脑中11C同位素标记的葡萄糖的代谢过程，获得与大脑对视觉，听觉和认知刺激反应的大脑图像。

公开(公告)号：US08347925B2

公开(公告)日：2013-01-08

申请号：US12543507

申请日：2009-08-19

申请人： Ming-Hsin Li

发明人： Ming-Hsin Li

IPC分类号： B65B1/04

CPC分类号： B65B3/003

摘要： An automatic radiopharmaceuticals filling machine mainly comprises a main unit with an activation mechanism to perform three-dimensional reciprocal movement. The activation mechanism has a lateral slider that can be activated to move reciprocally along lateral X-axis. On the lateral slider, there is a vertical slider that can extend perpendicularly and move reciprocally along lateral Y-axis. An injection needle is located on the vertical slider and can be activated to move reciprocally along Z-axis perpendicular to the lateral slider. A syringe rack is located in the moving range of the injection needle to accommodate a plural number of syringes, on each of which there is an injection hole. A drug pump has an inlet and an outlet. The inlet connects to a high-dose radiopharmaceuticals drug bottle. The outlet connects to the injection needle. The drug pump withdraws the radiopharmaceuticals from the drug bottle to the injection needle and allows the front end of the injection needle activated to go through the injection hole into the syringe and fill the radiopharmaceuticals into the syringe.

摘要翻译： 一种自动放射性药物灌装机主要包括具有执行三维往复运动的激活机构的主单元。 激活机构具有可以被激活以沿着横向X轴往复运动的横向滑块。 在横向滑动器上，有一个垂直滑动件可以垂直延伸并沿横向Y轴往复运动。 注射针位于垂直滑块上，可以被激活以沿着与轴向滑动件垂直的Z轴往复运动。 注射器架位于注射针的移动范围内，以容纳多个注射器，每个注射器都具有注射孔。 药泵具有入口和出口。 入口连接到高剂量放射性药物药瓶。 出口连接到注射针。 药物泵将放射性药物从药瓶抽出到注射针上，并且允许注射针的前端被激活以通过注射孔进入注射器并将放射性药物填充到注射器中。

公开(公告)号：US08181677B2

公开(公告)日：2012-05-22

申请号：US11868540

申请日：2007-10-08

申请人： Ming-Hsin Li ,  Wuu-Jyh Lin ,  Tain-Shi Zen

发明人： Ming-Hsin Li ,  Wuu-Jyh Lin ,  Tain-Shi Zen

IPC分类号： B67C3/00

CPC分类号： A61J1/2096 ,  B65B3/003 ,  G21G1/0005

摘要： An automated dispenser for radiopharmaceuticals is mainly for a platform to have a moving mechanism being able to move three-dimensionally back and forth, a syringe holder and a bottle holder. The syringe holder is for holding a plural number of syringes. The bottle holder has a reverse drug bottle. The moving mechanism has a syringe clamp rotatable around a horizontal axis and a syringe driving mechanism. The syringe clamp is activated to hold a syringe and move it to where the syringe needle is inserted to the drug bottle. The syringe driving mechanism and the syringe clamp are simultaneously associated with the syringe for drug-withdrawing action.

摘要翻译： 用于放射性药物的自动分配器主要用于具有能够三维来回移动的移动机构的平台，注射器保持器和瓶保持器。 注射器支架用于容纳多个注射器。 瓶架有一个反向药瓶。 移动机构具有可绕水平轴线旋转的注射器夹具和注射器驱动机构。 注射器夹具被启动以保持注射器并将其移动到注射器针头插入药瓶的位置。 注射器驱动机构和注射器夹具同时与注射器相关联用于吸药动作。

公开(公告)号：US06867441B1

公开(公告)日：2005-03-15

申请号：US10681656

申请日：2003-10-08

申请人： Chao-Hsiang Yang ,  Charles Chen ,  Wesley Lin ,  Harry Chuang ,  Ming-Hsin Li ,  Jeng-Long Huang

发明人： Chao-Hsiang Yang ,  Charles Chen ,  Wesley Lin ,  Harry Chuang ,  Ming-Hsin Li ,  Jeng-Long Huang

IPC分类号： H01L23/525 ,  H01L23/58 ,  H01L27/10

CPC分类号： H01L23/585 ,  H01L23/5258 ,  H01L2924/0002 ,  H01L2924/00

摘要： A fuse structure for a semiconductor device on a substrate includes a fuse having an electrically conductive fuse line of a standard fuse length formed in an electrically conductive layer disposed over the substrate, and a pair of electrically conductive, inwardly bent interconnects formed in a first plurality of electrically conductive layers disposed over the substrate, below the electrically conductive layer in which the fuse line is formed. The inwardly bent interconnects couple the fuse line to a circuit area of the substrate disposed under the fuse line. The fuse structure may further include a protective guard ring formed around the fuse. The guard ring includes a second plurality of electrically conductive interconnects.

摘要翻译： 用于衬底上的半导体器件的熔丝结构包括具有形成在设置在衬底上的导电层中的标准熔丝长度的导电熔丝线的熔丝，以及形成在第一组中的一对导电的向内弯曲的互连 的导电层设置在衬底上方，形成有熔丝线的导电层之下。 向内弯曲的互连将熔丝线耦合到设置在熔丝线下方的衬底的电路区域。 熔丝结构还可以包括围绕熔丝形成的保护保护环。 保护环包括第二多个导电互连。

公开(公告)号：US20150374859A1

公开(公告)日：2015-12-31

申请号：US14315318

申请日：2014-06-25

申请人： Ming-Hsin Li

发明人： Ming-Hsin Li

IPC分类号： A61K51/04 ,  C07B59/00

CPC分类号： C07B59/001 ,  A61K51/0482 ,  A61K51/0497 ,  C07B59/002 ,  C07B2200/05 ,  C07C237/42 ,  C07D257/00

摘要： A synthesis method of labeling histone deacetylase inhibitor (HDAC inhibitors) SC027 with Gallium-67 or Gallium-68 radionuclide, wherein a labeled precursor DOTA-SC027 which comprises DOTA-NHS-ester (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid-N-hydroxysuccinimide-ester) and HDACi-SC027 is prepared for the synthesis to label HDACi-SC027 with Gallium-67 or Gallium-68 radionuclide for producing imaging tracers for tracking the HDACi.

摘要翻译： 使用镓-67或镓-69放射性核素标记组蛋白脱乙酰酶抑制剂（HDAC抑制剂）SC027的合成方法，其中包含DOTA-NHS-酯（1,4,7,10-四氮杂环十二烷-1）的标记前体DOTA-SC027， 4,7,10-四乙酸-N-羟基琥珀酰亚胺酯）和HDACi-SC027用于合成以用镓-67或镓-69放射性核素标记HDACi-SC027，用于产生用于跟踪HDACi的成像示踪剂。

公开(公告)号：US20150033828A1

公开(公告)日：2015-02-05

申请号：US13956375

申请日：2013-08-01

申请人： Ming-Hsin Li ,  Shu-Pei Chiu ,  Chih-Hsien Chang ,  Te-Wei Lee

发明人： Ming-Hsin Li ,  Shu-Pei Chiu ,  Chih-Hsien Chang ,  Te-Wei Lee

IPC分类号： G01N15/08

CPC分类号： B01D65/102 ,  B01D65/10 ,  G01M3/06

摘要： An automated test apparatus for risk and integrity testing for pharmaceutical filtration membranes, including at least the following components: a liquid injection inlet, a pump, a fluid pressure gauge, a gas pressure gauge, a plurality of solenoid valves, a plurality of membranes, a gas pressure regulator valve, a pharmaceutical product bottle, and a bubble generation bottle. The automated test apparatus of the present invention is controlled by computer software in connection with an automatic pharmaceutical synthesis apparatus for automated testing. In use of the automated test apparatus of the present invention, it needs only to start the operating system of the automated test apparatus for membrane risk and integrity test after the completion of the automatic pharmaceutical synthesis. The membrane risk and integrity test can be accomplished in a short time by measuring pressures of gas and liquid with pressure gauges deposed online concurrently.

摘要翻译： 一种用于药物过滤膜的风险和完整性测试的自动测试装置，包括至少以下组件：液体注射入口，泵，流体压力计，气体压力计，多个电磁阀，多个膜， 气体压力调节阀，药品瓶和气泡生成瓶。 本发明的自动测试装置由计算机软件与用于自动化测试的自动药物合成装置有关。 在使用本发明的自动测试装置时，仅需要在自动药物合成完成之后启动用于膜风险和完整性测试的自动测试装置的操作系统。 薄膜风险和完整性测试可以在短时间内通过测量气体和液体的压力同时在线排出的压力计来完成。