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公开(公告)号：US20110282451A1
公开(公告)日：2011-11-17
申请号：US12922953
申请日：2009-03-17
申请人： Sune Lund Sporring , Ole Olsen , Tom Løgstrup Andersen , Povl Brøndsted , Mischa Nelis , Roelof Marissen
发明人： Sune Lund Sporring , Ole Olsen , Tom Løgstrup Andersen , Povl Brøndsted , Mischa Nelis , Roelof Marissen
CPC分类号： A61F2/30907 , A61F2/30965 , A61F2/36 , A61F2/38 , A61F2/40 , A61F2/42 , A61F2002/30014 , A61F2002/30448 , A61F2002/30909 , A61F2002/30914 , A61F2220/005 , A61F2250/0018 , A61L27/443 , A61L27/446 , A61L27/48 , A61L2430/24 , Y10T29/49826 , Y10T428/24942 , C08L33/04
摘要： A biocompatible medical component comprising•a hybrid fabric comprising i. at least one type of second fibre, and ii. at least one type of first fibre, and•a structural component, wherein the Young's modulus of said second fibre is at least 125% of the Young's modulus of the first fiber.
摘要翻译： 一种生物相容性医疗部件，包括：混合织物，其包含i。 至少一种类型的第二纤维，和ii。 至少一种类型的第一纤维和•结构组分，其中所述第二纤维的杨氏模量为第一纤维的杨氏模量的至少125％。
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公开(公告)号：US20110044994A1
公开(公告)日：2011-02-24
申请号：US12726245
申请日：2010-03-17
申请人： Po-Ying Chan-Hui , Steven Frey , Ole Olsen , Jennifer Mitcham , Matthew Moyle , Sanjay K. Phogat , Dennis R. Burton , Laura Marjorie Walker , Pascal Raymond Georges Poignard , Wayne Koff , Melissa Danielle De Jean De St. Marcel Simek-Lemos
发明人： Po-Ying Chan-Hui , Steven Frey , Ole Olsen , Jennifer Mitcham , Matthew Moyle , Sanjay K. Phogat , Dennis R. Burton , Laura Marjorie Walker , Pascal Raymond Georges Poignard , Wayne Koff , Melissa Danielle De Jean De St. Marcel Simek-Lemos
IPC分类号： A61K39/42 , C07K16/10 , C07K16/00 , C07H21/04 , C12N15/63 , C12N5/10 , A61K39/395 , A61K39/21 , A61P31/18
CPC分类号： C07K16/1045 , A61K39/21 , A61K2039/505 , C07K16/1063 , C07K2317/56 , C07K2317/565 , C07K2317/76
摘要： The invention provides a method for obtaining a broadly neutralizing antibody (bNab), including screening memory B cell cultures from a donor PBMC sample for neutralization activity against a plurality of HIV-1 species, cloning a memory B cell that exhibits broad neutralization activity; and rescuing a monoclonal antibody from that memory B cell culture. The resultant monoclonal antibodies are characterized by their ability to selectively bind epitopes from the Env proteins in native or monomeric form, as well as to inhibit infection of HIV-1 species from a plurality of clades. Compositions containing human monoclonal anti-HIV antibodies used for prophylaxis, diagnosis and treatment of HIV infection are provided. Methods for generating such antibodies by immunization using epitopes from conserved regions within the variable loops of gp120 are provided. Immunogens for generating anti-HIV1 bNAbs are also provided. Furthermore, methods for vaccination using suitable epitopes are provided.
摘要翻译： 本发明提供了一种获得广泛中和抗体（bNab）的方法，包括筛选来自供体PBMC样品的记忆B细胞培养物，以抵抗多种HIV-1物质的中和活性，克隆显示广泛中和活性的记忆B细胞; 并从该记忆B细胞培养物中拯救单克隆抗体。 所得单克隆抗体的特征在于它们以天然或单体形式选择性地结合来自Env蛋白的表位的能力，以及抑制HIV-1物种从多个进化枝的感染。 提供了含有用于预防，诊断和治疗HIV感染的人单克隆抗HIV抗体的组合物。 提供了通过使用来自gp120的可变环内的保守区域的表位进行免疫来产生这种抗体的方法。 还提供了产生抗艾滋病毒1型免疫球蛋白的免疫原。 此外，提供了使用合适表位的疫苗接种方法。
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公开(公告)号：US20100178295A1
公开(公告)日：2010-07-15
申请号：US12726297
申请日：2010-03-17
申请人： Andres Grandea, III , Gordon King , Thomas Cox , Ole Olsen , Jennifer Mitcham , Matthew Moyle
发明人： Andres Grandea, III , Gordon King , Thomas Cox , Ole Olsen , Jennifer Mitcham , Matthew Moyle
IPC分类号： A61K39/395 , C07K16/10 , A61P31/16
CPC分类号： C07K16/1018 , A61K2039/505 , C07K14/005 , C07K2317/21 , C07K2317/32 , C07K2317/34 , C12N2760/16122 , G01N33/56983
摘要： The present invention provides novel human anti-influenza antibodies and related compositions and methods. These antibodies are used in the diagnosis and treatment of influenza infection.
摘要翻译： 本发明提供新的人类抗流感抗体及相关组合物和方法。 这些抗体用于流感感染的诊断和治疗。
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公开(公告)号：US20090029000A1
公开(公告)日：2009-01-29
申请号：US10598779
申请日：2005-03-09
申请人： Klaus Breddam , Ole Olsen , Birgitte Skadhauge , Finn Lok , Soren Knudsen , Lene Molskov Bech
发明人： Klaus Breddam , Ole Olsen , Birgitte Skadhauge , Finn Lok , Soren Knudsen , Lene Molskov Bech
CPC分类号： C12C1/18 , A01H5/10 , C12C5/004 , C12C7/04 , C12C7/047 , C12C11/003 , C12C12/00 , C12N9/0069 , C12N15/8242 , C12N15/8243
摘要： According to the invention, there is provided null-LOX-1 barley and plant products produced thereof, such as malt manufactured by using barley kernels defective in synthesis of the fatty acid-converting enzyme lipoxygenase-1. Said enzyme accounts for the principal activity related to conversion of linoleic acid into 9-hydroperoxy octadecadienoic acid, a lipoxygenase pathway metabolite, which-through further enzymatic or spontaneous reactions may lead to the appearance of trans-2-nonenal. The invention enables brewers to produce a beer devoid of detectable trans-2-nonenal-specific off flavors, even after prolonged storage of the beverage.
摘要翻译： 根据本发明，提供了无效LOX-1大麦及其生产的植物产品，例如通过使用缺乏合成脂肪酸转化酶脂氧合酶-1的大麦籽粒制备的麦芽。 所述酶涉及与亚油酸转化为9-氢过氧十八碳二烯酸（脂氧合酶途径代谢物）相关的主要活性，其通过进一步的酶促或自发反应可导致反式-2-壬烯醛的出现。 本发明使酿造商能够生产没有可检测的反式-2-壬烯醛特异性异味的啤酒，甚至在长时间储存饮料之后。
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公开(公告)号：US20080010693A1
公开(公告)日：2008-01-10
申请号：US11111663
申请日：2005-04-21
申请人： Egon Persson , Ole Olsen
发明人： Egon Persson , Ole Olsen
IPC分类号： A01K67/027 , A01H5/00 , C07H21/00 , C12N15/63 , C12N15/82 , C12N5/06 , C12N5/08 , C12N5/10 , C12P21/00
CPC分类号： C07K14/745 , A61K38/00
摘要： The present invention relates to novel human coagulation Factor VIIa variants having coagulant activity as well as polynucleotide constructs encoding such variants, vectors and host cells comprising and expressing the polynucleotide, pharmaceutical compositions, uses and methods of treatment.
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公开(公告)号：US20050204437A1
公开(公告)日：2005-09-15
申请号：US10800200
申请日：2004-03-11
申请人： Klaus Breddam , Ole Olsen , Birgitte Skadhauge , Finn Lok , Soren Knudsen , Lene Bech
发明人： Klaus Breddam , Ole Olsen , Birgitte Skadhauge , Finn Lok , Soren Knudsen , Lene Bech
CPC分类号： C12C1/18 , A01H5/10 , C12C5/004 , C12C7/04 , C12C7/047 , C12C11/003 , C12C12/00 , C12N9/0069 , C12N15/8242 , C12N15/8243
摘要： According to the invention, there is provided null-LOX-1 barley and plant products produced thereof, such as malt manufactured by using barley kernels defective in synthesis of the fatty acid-converting enzyme lipoxygenase-1. Said enzyme accounts for the principal activity related to conversion of linoleic acid into 9-hydroperoxy octadecadienoic acid, a lipoxygenase pathway metabolite, which—through further enzymatic or spontaneous reactions—may lead to the appearance of trans-2-nonenal. The invention enables brewers to produce a beer devoid of detectable trans-2-nonenal-specific off-flavors, even after prolonged storage of the beverage.
摘要翻译： 根据本发明，提供了无效LOX-1大麦及其生产的植物产品，例如通过使用缺乏合成脂肪酸转化酶脂氧合酶-1的大麦籽粒制备的麦芽。 所述酶涉及与将亚油酸转化为9-氢过氧十八碳二烯酸（脂氧合酶途径代谢物）相关的主要活性，其通过进一步的酶促或自发反应可能导致反式-2-壬烯醛的出现。 本发明使酿造商能够生产没有可检测的反式-2-壬烯醛特异性异味的啤酒，即使在饮料长期储存之后。
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公开(公告)号：US08916160B2
公开(公告)日：2014-12-23
申请号：US13372870
申请日：2012-02-14
申请人： Andres G. Grandea, III , Gordon King , Thomas C. Cox , Ole Olsen , Jennifer Mitcham , Matthew Moyle , Phil Hammond
发明人： Andres G. Grandea, III , Gordon King , Thomas C. Cox , Ole Olsen , Jennifer Mitcham , Matthew Moyle , Phil Hammond
IPC分类号： A61K39/00 , A61K39/42 , A61K39/145 , G01N33/569 , C07K16/10
CPC分类号： C07K16/1018 , A61K39/42 , A61K45/06 , A61K2039/505 , A61K2039/507 , C07K2317/21 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/565 , C07K2317/76 , G01N33/54306 , G01N33/56983 , G01N2333/11
摘要： The present invention provides compositions, vaccines, and methods for diagnosing, treating, and preventing influenza infection using a combination of antibodies raised against the influenza hemagglutinin and the matrix 2 ectodomain polypeptides.
摘要翻译： 本发明提供使用针对流感血凝素和基质2胞外域多肽产生的抗体的组合来诊断，治疗和预防流感感染的组合物，疫苗和方法。
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公开(公告)号：US20120315277A1
公开(公告)日：2012-12-13
申请号：US13418923
申请日：2012-03-13
申请人： Andres G. Grandea, III , Gordon King , Thomas C. Cox , Ole Olsen , Jennifer Mitcham , Matthew Moyle , Phil Hammond
发明人： Andres G. Grandea, III , Gordon King , Thomas C. Cox , Ole Olsen , Jennifer Mitcham , Matthew Moyle , Phil Hammond
CPC分类号： A61K31/215 , A61K39/42 , A61K2039/505 , A61K2039/507 , C07K16/1018 , C07K2317/21 , C07K2317/34 , C07K2317/565 , C07K2317/732 , C07K2317/734 , C07K2317/92 , A61K2300/00
摘要： The present invention provides novel human anti-influenza antibodies and related compositions and methods. These antibodies are used in the diagnosis and treatment of influenza infection.
摘要翻译： 本发明提供新的人类抗流感抗体及相关组合物和方法。 这些抗体用于流感感染的诊断和治疗。
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29.发明授权公开(公告)号：US08268309B2
公开(公告)日：2012-09-18
申请号：US13109632
申请日：2011-05-17
申请人： Ole Olsen
发明人： Ole Olsen
IPC分类号： A61K39/395 , A61K39/00
CPC分类号： C07K16/088 , A61K39/42 , A61K45/06 , A61K2039/505 , C07K2317/21 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/56994 , G01N2333/045
摘要： The present invention provides novel anti-cytomegalovirus antibodies and related compositions and methods. These antibodies may be used in the diagnosis, prevention, and treatment of cytomegalovirus infection.
摘要翻译： 本发明提供新型抗巨细胞病毒抗体及相关组合物和方法。 这些抗体可用于巨细胞病毒感染的诊断，预防和治疗。
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公开(公告)号：US08057796B2
公开(公告)日：2011-11-15
申请号：US12269781
申请日：2008-11-12
申请人： Andres Grandea, III , Gordon King , Thomas Cox , Ole Olsen , Jennifer Mitcham , Matthew Moyle
发明人： Andres Grandea, III , Gordon King , Thomas Cox , Ole Olsen , Jennifer Mitcham , Matthew Moyle
CPC分类号： C07K16/1018 , A61K2039/505 , C07K14/005 , C07K2317/21 , C07K2317/32 , C07K2317/34 , C12N2760/16122 , G01N33/56983
摘要： The present invention provides novel human anti-influenza antibodies and related compositions and methods. These antibodies are used in the diagnosis and treatment of influenza infection.
摘要翻译： 本发明提供新的人类抗流感抗体及相关组合物和方法。 这些抗体用于流感感染的诊断和治疗。
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