公开(公告)号：US20120003270A1

公开(公告)日：2012-01-05

申请号：US13056608

申请日：2009-07-30

Applicant: Alan James Husband ,  Michael James ,  Naresh Kumar

Inventor： Alan James Husband ,  Michael James ,  Naresh Kumar

IPC: A61K31/352 ,  C07D405/10 ,  A61K31/4025 ,  C12N5/071 ,  A61P35/02 ,  A61P9/00 ,  A61P37/02 ,  A61P39/06 ,  C07D311/58 ,  A61P35/00

CPC classification number: A61K31/353 ,  C07D311/04

Abstract: The present invention relates to 6-substituted isoflavonoid compounds and compositions comprising same. The invention further relates to the use of 6-substituted isoflavonoid compounds for the treatment of various diseases and conditions.

Abstract translation: 本发明涉及6-取代的异黄酮化合物及其组合物。 本发明还涉及6-取代异黄酮化合物用于治疗各种疾病和病症的用途。

公开(公告)号：US20110166088A1

公开(公告)日：2011-07-07

申请号：US13000561

申请日：2009-06-25

Applicant: Jitendra A. Sattigeri ,  Naresh Kumar ,  Ajay Yadav ,  Lalima Sharma ,  Ian A. Cliffe ,  Shibu B. Varughese ,  Shaikh Rizwan Shabbir ,  V. Samuel Raj ,  Dilip J. Upadhyay ,  Pradip K. Bhatnager

Inventor： Jitendra A. Sattigeri ,  Naresh Kumar ,  Ajay Yadav ,  Lalima Sharma ,  Ian A. Cliffe ,  Shibu B. Varughese ,  Shaikh Rizwan Shabbir ,  V. Samuel Raj ,  Dilip J. Upadhyay ,  Pradip K. Bhatnager

IPC: A61K31/7068 ,  C07D417/14 ,  C07D413/14 ,  C07H17/02 ,  A61K31/444 ,  A61K31/4439 ,  A61K31/496 ,  A61K31/5355 ,  A61K31/513 ,  A61K31/506 ,  A61P31/04

CPC classification number: C07D417/14 ,  C07D417/04 ,  C07D493/04

Abstract: The present invention provides Gyrase B and/or Topoisomerase IV par E inhibitors, which can be used as antibacterial agents. Compounds disclosed herein can be used for treating or preventing conditions caused by or contributed by gram positive, gram negative and anaerobic bacteria, more particularly against, for example, Staphylococci, Streptococci, Enterococci, Haemophilus, Pseudomonas spp., Acenetobacter spp., Moraxalla spp., Chlamydia spp., Mycoplasma spp., Legionella spp., Ktycobacterium spp., Helicobacter, Clostridium spp., Bacteroides spp., Corynebacterium, Bacillus spp., Enterobactericeae,’ (E. coli, Klebsiella spp., Proteus spp., etc.) or any combination thereof. Also provided, are processes for preparing compounds disclosed herein, pharmaceutical compositions containing compounds disclosed herein, and methods of treating bacterial infections. (Formula)

Abstract translation: 本发明提供可用作抗菌剂的促旋酶B和/或拓扑异构酶IV对E抑制剂。 本文公开的化合物可用于治疗或预防由革兰氏阳性，革兰氏阴性和厌氧细菌引起的或由其贡献的病症，更具体地针对例如葡萄球菌，链球菌，肠球菌，嗜血杆菌，假单胞菌属，醋酸杆菌属，莫氏假单胞菌 ，衣原体属（Chlamydia spp。），支原体属（Mycoplasma spp。），军团菌属（Legionella spp。），科分枝杆菌属（Ktycobacterium spp。），幽门螺杆菌属（Helicobacter），梭菌属（Clostridium spp。），拟杆菌属（Bacteroides spp。），棒杆菌属（Corynebacterium），芽孢杆菌属（Bacillus spp。），肠杆菌属（Enterobactersisae），（E.coli，Klebsiella spp。，Proteus spp。 等等）或其任何组合。 还提供了制备本文公开的化合物的方法，含有本文公开的化合物的药物组合物，以及治疗细菌感染的方法。 （式）

公开(公告)号：US20100168197A1

公开(公告)日：2010-07-01

申请号：US12528987

申请日：2008-02-27

Applicant: Naresh Kumar ,  Jaskiran Kaur ,  Shelly Aeron ,  Abhijit Ray ,  Suman Gupta ,  Shivani Malhotra ,  Raj Kumar Shirumalla

Inventor： Naresh Kumar ,  Jaskiran Kaur ,  Shelly Aeron ,  Abhijit Ray ,  Suman Gupta ,  Shivani Malhotra ,  Raj Kumar Shirumalla

IPC: A61K31/4164 ,  C07D233/54

CPC classification number: C07D235/08 ,  C07D233/54 ,  C07D409/06

Abstract: This present invention generally relates to muscarinic receptor antagonists, which are useful, among other uses, for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. The invention also relates to the process for the preparation of disclosed compounds, pharmaceutical compositions containing the disclosed compounds, and the methods for treating diseases mediated through muscarinic receptors.

Abstract translation: 本发明一般涉及毒蕈碱受体拮抗剂，其可用于治疗通过毒蕈碱受体介导的呼吸，泌尿和胃肠系统的各种疾病，以及其它用途。 本发明还涉及制备所公开的化合物的方法，含有所公开的化合物的药物组合物，以及用于治疗通过毒蕈碱受体介导的疾病的方法。

公开(公告)号：US20090319596A1

公开(公告)日：2009-12-24

申请号：US12141203

申请日：2008-06-18

Applicant: Naresh Kumar ,  Robert Perry

Inventor： Naresh Kumar ,  Robert Perry

IPC: G06F15/16

CPC classification number: H04L12/14 ,  G06F11/2033 ,  G06F11/2038 ,  G06F11/2041 ,  H04L12/1403 ,  H04L69/40 ,  H04M15/70 ,  H04M15/74 ,  H04M2215/70 ,  H04M2215/709

Abstract: A determination is made whether a first application server of a group of N application servers, N being at least two, is a coordinator of the group. Responsive to determining that the first application server is the coordinator of the group, a connection to a billing system is established, via a terminal server, by the first application server. A determination is made whether a second application server of the group of N application servers is the coordinator of the group. Responsive to determining that the second application server is not the coordinator of the group, a periodic check is made whether the second application server of the group of N application servers is the coordinator of the group. The second application server may later be determined to be the coordinator of the group, when the first server experiences difficulty. Once it is determined that the second application server now is the coordinator of the group, a connection is established to the billing system, via the terminal server, by the second application server.

Abstract translation: 确定一组N个应用服务器的第一应用服务器是否为该组的协调器，N至少为两个。 响应于确定第一应用服务器是该组的协调器，通过终端服务器由第一应用服务器建立与计费系统的连接。 确定N个应用服务器组的第二应用服务器是否是该组的协调器。 响应于确定第二应用服务器不是组的协调器，定期检查N个应用服务器组中的第二应用服务器是否是该组的协调器。 当第一服务器遇到困难时，可以将第二应用服务器确定为该组的协调器。 一旦确定第二应用服务器现在是组的协调器，则通过第二应用服务器经由终端服务器向计费系统建立连接。

公开(公告)号：US07544708B2

公开(公告)日：2009-06-09

申请号：US10520572

申请日：2003-04-11

Applicant: Mohammad Salman ,  Anita Mehta ,  Pakala Kumara Savithru Sarma ,  Shankar Jayram Shetty ,  Sankaranarayanan Dharmarajan ,  Naresh Kumar ,  Arundutt Vishwanatham Silamkoti ,  Anita Chugh

Inventor： Mohammad Salman ,  Anita Mehta ,  Pakala Kumara Savithru Sarma ,  Shankar Jayram Shetty ,  Sankaranarayanan Dharmarajan ,  Naresh Kumar ,  Arundutt Vishwanatham Silamkoti ,  Anita Chugh

IPC: A61K31/40 ,  C07D209/44

CPC classification number: C07D401/12 ,  C07D209/52 ,  C07D403/12 ,  C07D413/12 ,  C07D417/12

Abstract: This invention generally relates to muscarinic receptor antagonists which are useful, among other uses, for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. Specifically, the invention relates to derivatives of azabicyclo compounds, including, for example, 6-substituted azabicyclo[3.1.0] hexanes, and 2,4,6-trisubstituted derivatives. The invention also relates to pharmaceutical compositions containing the compounds and the methods of treating the diseases mediated through muscarinic receptors.

Abstract translation: 本发明一般涉及毒蕈碱受体拮抗剂，其可用于治疗通过毒蕈碱受体介导的呼吸，泌尿和胃肠系统的各种疾病，以及其它用途。 具体地，本发明涉及氮杂双环化合物的衍生物，包括例如6-取代的氮杂双环[3.1.0]己烷和2,4,6-三取代的衍生物。 本发明还涉及含有化合物的药物组合物和通过毒蕈碱受体介导的疾病的治疗方法。

公开(公告)号：US20080306140A1

公开(公告)日：2008-12-11

申请号：US11909538

申请日：2006-03-24

Applicant: Andrew Heaton ,  Naresh Kumar

Inventor： Andrew Heaton ,  Naresh Kumar

IPC: A61K31/352 ,  C07D311/78 ,  C12N5/00 ,  A61P35/00 ,  A61P29/00 ,  A61P9/00

CPC classification number: C07D493/04

Abstract: Novel compounds based on phenyl-substituted naphtho[1,2-g]chrysene compounds (A) are described. The compounds are obtainable by dimerisation of 3-phenylchroman (isoflavonoid) ring systems (B). Methods of synthesis of the novel dimeric compounds, compositions containing same and use of the dimers as therapeutic agents are also described.

Abstract translation: 描述了基于苯基取代萘并[1,2-g]化合物（A）的新型化合物。 该化合物可通过3-苯基苯并二氢吡喃（异黄酮）环体系（B）的二聚得到。 还描述了新型二聚化合物的合成方法，含有它们的组合物和二聚体作为治疗剂的用途。

公开(公告)号：US20080167373A1

公开(公告)日：2008-07-10

申请号：US12051392

申请日：2008-03-19

Applicant: Roger Read ,  Naresh Kumar

Inventor： Roger Read ,  Naresh Kumar

IPC: A01N43/08 ,  C07D307/26 ,  A01P1/00 ,  C08G59/00

CPC classification number: C08F20/00 ,  A01N43/08 ,  C07D307/58 ,  C08F24/00

Abstract: The present invention relates to the side chain functionalization of fimbrolides (halogenated 3-alkyl-5-methylene-2(5H)-furanones) and their synthetic analogues, that yields fimbrolides substituted with a halogen, an oxygen or a nitrogen functionality in the alkyl chain, especially fimbrolide alcohols, caboxylate and sulfinate and sulfonate esters, ethers, aldehydes, ketones, acids, amides, nitro derivatives, hydrophobic, hydrophilic and fluorophilic alkyl derivatives and polymers.

Abstract translation: 本发明涉及福滨龙（卤代3-烷基-5-亚甲基-2（5 H） - 呋喃酮）及其合成类似物的侧链官能化，其产生在卤素，氧或氮官能团中被取代的菲莫拉林 烷基链，特别是曲芬洛尔醇，卡波西铵和亚磺酸盐和磺酸酯，醚，醛，酮，酸，酰胺，硝基衍生物，疏水性，亲水性和氟性烷基衍生物和聚合物。

公开(公告)号：US20060287380A1

公开(公告)日：2006-12-21

申请号：US10552455

申请日：2004-01-07

Applicant: Mohammad Salman ,  Anita Mehta ,  Pakata Sarma ,  Naresh Kumar ,  Sankaranarayanan Dharmarajan ,  Kirandeep Kaur ,  Anita Chugh

Inventor： Mohammad Salman ,  Anita Mehta ,  Pakata Sarma ,  Naresh Kumar ,  Sankaranarayanan Dharmarajan ,  Kirandeep Kaur ,  Anita Chugh

IPC: A61K31/4035 ,  C07D403/02

CPC classification number: C07D209/52 ,  C07D403/06

Abstract: This invention generally relates to muscarinic receptor antagonists of formula (I) which are useful, among other uses for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. The invention also relates to pharmaceutical compositions containing the compounds of the present invention and the methods of treating the diseases mediated through muscarinic receptors.

Abstract translation: 本发明一般涉及式（I）的毒蕈碱受体拮抗剂，其可用于治疗通过毒蕈碱受体介导的呼吸，泌尿和胃肠系统的各种疾病的其它用途。 本发明还涉及含有本发明化合物的药物组合物和通过毒蕈碱受体介导的疾病的治疗方法。

公开(公告)号：US20060217564A1

公开(公告)日：2006-09-28

申请号：US11442369

申请日：2006-05-25

Applicant: Andrew Heaton ,  Naresh Kumar

Inventor： Andrew Heaton ,  Naresh Kumar

IPC: C07D311/02

CPC classification number: C07D311/56 ,  C07D311/36 ,  C07D311/38

Abstract: Methods for the hydrogenation of isoflavones are described which provide access to workable quantities of isoflavan-4-ols, isoflav-3-enes, and isoflavans. The isoflavone derivatives can be obtained in high purity and in near quantitative yields whilst employing pharmaceutically acceptable reagents and solvents.

Abstract translation: 描述了异黄酮氢化方法，其提供了可使用量的异黄烷-4-醇，异氟烷-3-烯和异构体。 异黄酮衍生物可以以高纯度和接近定量的产率获得，同时使用药学上可接受的试剂和溶剂。

公开(公告)号：US20060173042A1

公开(公告)日：2006-08-03

申请号：US10538956

申请日：2003-12-15

Applicant: Mukesh Sharma ,  Chandra Khanduri ,  Naresh Kumar

Inventor： Mukesh Sharma ,  Chandra Khanduri ,  Naresh Kumar

IPC: A61K31/445 ,  C07D211/34 ,  C07C59/76

CPC classification number: C07D211/22 ,  C07C51/16 ,  C07C57/46

Abstract: The present invention relates to a process for the preparation of cyclopropyl keto a,a-dimethylphenyl acetic acid of structural Formula I, and to the use of this compound as an intermediate for the preparation of an antihistamine, fexofenadine.

Abstract translation: 本发明涉及一种制备结构式I的环丙基酮a，α-二甲基苯基乙酸的方法，以及该化合物作为制备抗组胺药非索非那定的中间体的用途。