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公开(公告)号：US20110144667A1
公开(公告)日：2011-06-16
申请号：US12877919
申请日：2010-09-08
申请人： Anthony Richard Horton , Paul Martakos , Steve A. Herweck , Theodore Karwoski , Joseph F. Ferraro
发明人： Anthony Richard Horton , Paul Martakos , Steve A. Herweck , Theodore Karwoski , Joseph F. Ferraro
IPC分类号： A61B17/08
CPC分类号： A61F2/0063 , A61F2210/0004 , A61F2210/0076 , A61F2220/0008 , A61F2220/0075 , A61F2230/0004 , A61F2250/0018 , A61F2310/00389 , A61K31/20 , A61L31/10 , A61L31/14 , A61L31/148
摘要： A hernia patch supporting tissue in-growth conforms to a tissue wall upon surgical installation and fixation within a patient. The hernia patch can include a base and positioning straps. The base is formed of two layers that are affixed to each other around the perimeter of the patch, for example by stitching. A stabilizing washer is provided between the two layers, and the stitch is provided peripherally around the stabilizing washer, keeping the washer free-floating between the layers. The base, positioning straps, and stabilizing washer are formed of a structure that does not separate the layers of the implant or form a space in the form of a pocket, and promotes more uniform and confluent tissue incorporation or in-growth after implantation. The hernia patch may further include a hydrolysable bioabsorbable cross-linked coating of a fatty acid based material, such as an omega-3 fatty acid based material.
摘要翻译： 支撑组织生长的疝补片在外科手术安装和固定在患者体内时符合组织壁。 疝补片可以包括基部和定位带。 底座由两层相互贴合，例如通过拼接而在贴片的周边彼此固定。 在两层之间设有一个稳定的垫圈，并且在周向围绕稳定垫圈设置线圈，保持垫片在层之间自由浮动。 基部，定位带和稳定垫圈由不分离植入物层或形成袋状空间的结构形成，并且在植入后促进更均匀和汇合的组织结合或生长。 疝补片可以进一步包括基于脂肪酸的材料如ω-3脂肪酸基材料的可水解生物可吸收的交联涂层。
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22.发明申请DRUG DELIVERY COATING FOR USE WITH A MEDICAL DEVICE AND METHODS OF TREATING VASCULAR INJURY 审中-公开用于医疗设备的药物输送涂料和治疗血管损伤的方法公开(公告)号：US20100004738A1
公开(公告)日：2010-01-07
申请号：US11919315
申请日：2006-04-28
IPC分类号： A61F2/82 , A61F2/00 , A61K31/439 , A61M25/00 , A61B17/03
CPC分类号： A61K31/436 , A61L27/54 , A61L29/16 , A61L31/16 , A61L2300/434 , A61L2300/45
摘要： The present inventions provide various embodiments of methods for one or more of treating vascular injury, neointima proliferation and/or local inflammation in a mammal by locally administering therapeutic compound comprising a mTOR targeting compound and a calcineurin inhibitor. In various aspects, the therapeutic compound comprises a bio-absorbable carrier component carrier component at least partially formed of a cellular uptake inhibitor and a cellular uptake enhancer, a mTOR targeting compound and a calcineurin inhibitor. In various aspects, the present invention provides for controlled delivery, which is at least partially characterized by total and relative amounts of a cellular uptake inhibitor and cellular uptake enhancer in a bio-absorbable carrier component.
摘要翻译： 本发明提供了通过局部施用包含mTOR靶向化合物和钙调磷酸酶抑制剂的治疗化合物来治疗哺乳动物血管损伤，新内膜增生和/或局部炎症中的一种或多种的方法的各种实施方案。 在各个方面，治疗化合物包括至少部分由细胞摄取抑制剂和细胞吸收增强剂，mTOR靶向化合物和钙调磷酸酶抑制剂形成的生物可吸收载体组分载体组分。 在各个方面，本发明提供受控递送，其至少部分地表征为生物可吸收载体组分中的细胞摄取抑制剂和细胞摄取增强剂的总量和相对量。
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公开(公告)号：US20080207756A1
公开(公告)日：2008-08-28
申请号：US11711389
申请日：2007-02-27
CPC分类号： A61K31/20
摘要： Exemplary embodiments of the invention provide a dispersing liquid for coating internal body tissues with a bio-absorbable oil, a method of making the dispersing liquid, methods of using the dispersing liquid and a kit for coating internal body tissues using the dispersing liquid. The dispersing liquid includes a suspension of a bio-absorbable oil suspended in a liquid carrier. The invention results in a uniform thin coating of bio-absorbable oil on internal body tissues.
摘要翻译： 本发明的示例性实施方案提供了用生物可吸收油涂覆内部身体组织的分散液，制备分散液的方法，使用分散液的方法和使用分散液涂覆内部身体组织的试剂盒。 分散液包括悬浮在液体载体中的生物可吸收油的悬浮液。 本发明导致生物吸收油在内部身体组织上的均匀薄涂层。
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公开(公告)号：US6042666A
公开(公告)日：2000-03-28
申请号：US105736
申请日：1998-06-26
IPC分类号： A61F2/00 , A61F2/06 , A61F2/10 , A61F2/24 , A61F2/88 , A61L27/16 , A61L27/34 , A61L27/40 , B32B31/00
CPC分类号： A61F2/07 , A61F2/06 , A61L27/16 , A61L27/34 , A61L27/40 , A61F2/105 , A61F2/2412 , A61F2/88 , A61F2002/072 , A61F2240/001
摘要： The wall of a prosthesis has a region which modulates communication through the porosity of the wall. The prosthesis is unitary, but may be assembled in successive bodies which are coalesced, so that the porous microstructure changes distinctly at stages through the thickness dimension of the wall. One embodiment is formed entirely of fluoropolymer, and has at least one surface adapted to support tissue regeneration and ingrowth. The modulation region is a stratum of high water entry pressure that reduces pulsatile hydraulic pressure transmission, or locally alters fluid-born-distribution of biological material through the wall and allows more natural gradients for tissue regeneration and growth in the outer region of the wall.
摘要翻译： 假体的壁具有通过壁的孔隙调节连通的区域。 假体是单一的，但是可以组合成连续的体，其被聚结，使得多孔微结构在阶段通过壁的厚度尺寸明显变化。 一个实施方案完全由氟聚合物形成，并且具有适于支持组织再生和向内生长的至少一个表面。 调制区域是高水入口压力的层次，可降低脉动式液压传递，或局部改变生物材料通过壁的流体出生分布，并允许更多的自然梯度用于组织再生和壁的外部区域的生长。
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公开(公告)号：US6010529A
公开(公告)日：2000-01-04
申请号：US759877
申请日：1996-12-03
CPC分类号： A61F2/07 , A61F2/06 , A61F2/88 , A61L31/04 , A61L31/10 , A61F2/105 , A61F2002/072 , A61F2240/001 , Y10S623/901
摘要： A radially expandable support body is enveloped within a cocoon. In a preferred construction, the support is a stent, and a tube of polymeric material, e.g. polytetrafluoroethylene (PTFE), passes through the interior of the stent body and is turned back upon itself over the stent to form a cuff. The assembly is then heated and the outer layer contacts and coalesces with the inner layer, closely surrounding the stent body within a folded envelope having a continuous and seamless end. In one embodiment, an end portion of the tube is expanded before folding back over the stent. The end portion, which becomes an exterior surface of the finished product, thus acquires a greater degree of porosity. Each end of the central tube may be so expanded, and folded back to seal all surfaces and both ends. The stent body itself may be a ring, or a short series of spaced-apart rings, or a wire or web, or a sheet possessing a number of apertures extending entirely through the sheet. The spaces or apertures are covered over or bridged by both the inner and outer polymer layers. The apertures, which may comprise under five to over eighty percent of the surface area of the stent, constitute regions or a grid of points through which the material is coalesced and continuously bonded, and around which strain is distributed by the support. These points or regions remain tacked together so expansion of the assembly does not delaminate the polymer or create flaps and pockets. In another embodiment, a two tube construction is cuffed and assembled into a similarly unitized and seamless stent. One tube is cuffed back, and the other tube covers the cuffed stent. In this embodiment both the tube thicknesses and porosities may differ substantially. For example the inner porosity may be selected to enhance blood flow or intimal regeneration, and the outer surface may have a porosity to encourage anchoring to external muscle tissue.
摘要翻译： 径向可扩展的支撑体被包围在茧内。 在优选的结构中，支撑件是支架，以及聚合物材料管，例如。 聚四氟乙烯（PTFE）穿过支架主体的内部并在支架上自身转回以形成袖带。 然后将组件加热并且外层与内层接触并聚结，在具有连续和无缝端部的折叠外壳内紧密地围绕支架主体。 在一个实施例中，管的端部在折回到支架之前膨胀。 成为成品的外表面的端部因此获得更大程度的孔隙率。 中心管的每个端部可以如此膨胀，并且被折回以密封所有表面和两端。 支架主体本身可以是一个环，或一系列间隔开的环，或者线或腹板，或者具有完全贯穿片材的多个孔的片。 空间或孔被内聚合物层和外聚合物层覆盖或桥接。 可以包括支架表面积的五到八十成以上的孔构成区域或网格，通过该点或网格将材料聚结并连续地结合，并且通过支撑分布在哪个应变附近。 这些点或区域保持粘合在一起，因此组件的膨胀不会分解聚合物或产生襟翼和口袋。 在另一个实施例中，将双管结构压合并组装成相似的单元化且无缝的支架。 一根管子被套在后面，另一根管子覆盖着袖口支架。 在该实施例中，管的厚度和孔隙度可能基本上不同。 例如，可以选择内部孔隙率以增强血流或内膜再生，并且外表面可以具有孔隙度以促进锚定到外部肌肉组织。
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公开(公告)号：US5397299A
公开(公告)日：1995-03-14
申请号：US817594
申请日：1992-01-07
申请人： Theodore Karwoski , Steve A. Herweck , David Cross
发明人： Theodore Karwoski , Steve A. Herweck , David Cross
IPC分类号： A61M1/00
CPC分类号： A61M1/0001 , A61M1/0013 , A61M1/0015 , A61M1/0056 , A61M2205/3348 , A61M2205/59 , A61M2209/082
摘要： A collection vessel for drainage of body fluids includes a molded body with internal dividers constituting ports, baffles and subchambers, and a face plate that closes the body to form a suction-regulated multi-chamber vessel. The vessel has overpressure and underpressure protection, and resists tipping. The molded body includes a wall structure that enhances its utility for blood collection, monitoring, and reinfusion, and incorporates novel valves, ports, handle and stand.
摘要翻译： 用于排出体液的收集容器包括具有构成端口，挡板和子室的内部分隔件的模制体和封闭主体以形成抽吸多腔室容器的面板。 该船具有超压和欠压保护，并且抵抗倾翻。 成型体包括壁结构，其增强其对采血，监测和再灌注的效用，并且结合新颖的阀，口，手柄和支架。
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公开(公告)号：US5380314A
公开(公告)日：1995-01-10
申请号：US755032
申请日：1991-09-04
IPC分类号： A61M1/00
CPC分类号： A61M1/0001 , A61M1/0015 , A61M1/0056
摘要： Apparatus for blood collection includes a collection bag with a suction inlet, a fluid inlet, and an outlet, and an internal stent that resiliently biases the bag into a fixed shape while moving to modulate abrupt variations in suction level. A gross filter about the outlet is located out of the suction path, eliminating blood damage from drying or cell trauma. Different graduation scales show the true volume of collected fluid under suction conditions during collection and with no suction during reinfusion. Two quick-connects allow in-line connection with a chest drain to provide suction, and mate with each other to close the inlets when the filtered bag is removed for gravity reinfusion. When multiple units are piggy-backed, they fill sequentially and may be removed for reinfusion quickly, with only a single tube reconnection required during surgery.
摘要翻译： 用于采集血液的装置包括具有抽吸入口，流体入口和出口的收集袋，以及内部支架，其在移动时弹性地将袋偏压以调节吸入水平的突然变化。 关于出口的总过滤器位于吸入路径之外，消除了由于干燥或细胞损伤引起的血液损伤。 不同的刻度表示收集过程中抽吸条件下收集的液体的真实体积，并且在再灌注期间没有吸力。 两个快速连接允许与胸部排水管线连接以提供抽吸，并且当过滤的袋子被移除以重力输入时，彼此配合以关闭入口。 当多个单位捎带时，它们依次填充，并且可以快速地移除以进行再灌注，在手术期间仅需要单个管重新连接。
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公开(公告)号：US4988342A
公开(公告)日：1991-01-29
申请号：US255764
申请日：1988-10-11
IPC分类号： A61M1/00
CPC分类号： A61M1/0013 , A61M1/0031 , A61M1/0056 , A61M2205/3348 , A61M2205/59
摘要： A thoracic cavity drainage device includes a first vessel having a plurality of chambers one of which is a regulated drainage chamber, and a separate transfer vessel which receives fluid collected in the drainage chamber of the first vessel. The chambers of both vessels are interconnected in a series by fluid passageways which cooperate to maintain a uniform range of suction in the drainage chamber while preventing passage of water into the drainage chamber and permitting a different level of suction in the transfer vessel. This operation is effective despite relatively large pressure and vacuum impulses caused by stripping of drainage lines, patient coughing, and the like, and despite discrete changes in the physical configuration of the system caused by disconnection of the transfer vessel, connection of the transfer vessel to an infusion line or the opening or closing of fluid lines and ports. A novel transfer vessel empties the drainage device and provides gravity reinfusion of the collected fluids. A mechanism within the transfer vessel provides an effective suction without vacuum connections or pressure regulating adjustments.
摘要翻译： 胸腔引流装置包括具有多个腔室的第一容器，其中一个腔室是受调节的排液室，以及接收收集在第一容器的排液室中的流体的单独转运容器。 两个容器的腔室通过流体通道串联连接，这些通道协作以在排水室中保持均匀的吸力范围，同时防止水进入排水室并允许转移容器中的不同吸力水平。 尽管相当大的压力和排水管线的排出引起的真空冲击，患者咳嗽等，尽管由转移容器的断开引起的系统的物理结构发生离散的变化，但是转移容器连接到 输液管线或流体管线和端口的打开或关闭。 一个新的转移容器排空排水装置，并提供收集的流体的重力回输。 转移容器内的机构提供无需真空连接或压力调节调节的有效吸力。
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公开(公告)号：US4652263A
公开(公告)日：1987-03-24
申请号：US747035
申请日：1985-06-20
IPC分类号： A61F2/06
CPC分类号： A61F2/06 , A61F2002/065
摘要： Disclosed are the product and method for making a macroscopically smooth, microporous, flexible, elastic tubular prosthetic device from a substantially non-elastic woven fabric tube. The method involves axially compressing the substantially non-elastic tube on a tight fitting cylindrical mandrel so that the individual axially oriented threads of the fabric form loops projecting radially outwardly between circumferential threads. The threads are set to return to this loop configuration upon release of tension applied axially to the tube. The exterior of the tube presents an easily deformed, macroscopically smooth surface having a multiplicity of interstices among the threads and among the fibers of the threads into which cells can grow after implantation.
摘要翻译： 公开了用于从基本上非弹性的机织织物管制造宏观平滑，微孔，柔性，弹性的管状假体装置的产品和方法。 该方法包括在紧密配合的圆柱形心轴上轴向压缩基本上非弹性的管，使得织物的各个轴向定向的线形成在圆周螺纹之间径向向外突出的环。 当释放沿轴向施加到管上的张力时，螺纹被设置为返回到该回路结构。 管的外部呈现容易变形的宏观光滑表面，其在螺纹之间以及在植入后细胞能够生长的螺纹的纤维之间具有多个间隙。
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30.发明授权公开(公告)号：US09592324B2
公开(公告)日：2017-03-14
申请号：US11980155
申请日：2007-10-30
CPC分类号： A61L31/14 , A61F2/0063 , A61L31/08
摘要： A barrier layer device is formed of an underlying biocompatible structure having a barrier layer coating that can exhibit anti-inflammatory properties, non-inflammatory properties, and/or adhesion-limiting properties, as well as generate a modulated healing effect on injured tissue. As implemented herein, the barrier layer is a non-polymeric cross-linked gel derived at least in part from a fatty acid compound, and may include a therapeutic agent. The underlying structure can be in the form of a surgical mesh. The barrier device is further provided with reinforced sections or portions to aid with the fastening of the barrier device for implantation purposes and prohibits or substantially reduces the occurrence of excessive stretching and tearing. The barrier device is implantable in a patient for short term or long term applications, and can include controlled release of the therapeutic agent.
摘要翻译： 阻挡层装置由潜在的生物相容性结构形成，该结构具有可显示抗炎性质，非炎症性质和/或粘附限制性质的阻隔层涂层，并且对损伤的组织产生调节的愈合作用。 如本文所实施的，阻挡层是至少部分地由脂肪酸化合物衍生的非聚合交联凝胶，并且可以包括治疗剂。 底层结构可以是手术网的形式。 阻挡装置还设置有加强部分或部分，以帮助阻挡装置紧固以用于植入目的，并且禁止或基本上减少过度拉伸和撕裂的发生。 阻挡装置可植入患者体内以进行短期或长期应用，并且可包括治疗剂的受控释放。
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