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公开(公告)号:US20200061281A1
公开(公告)日:2020-02-27
申请号:US16317903
申请日:2017-07-18
发明人: David DESOUZA , Daniel J. RUBERY, Jr. , Dennis M. TREU , Mark T. WYETH , Jerome JAMES , Garrett D. CASEY , James M. BRUGGER , William J. SCHNELL , Jeffrey H. BURBANK , Goetz FRIEDERICHS
摘要: The disclosed subject matter relates to extracorporeal blood processing or other processing of fluids. Volumetric fluid balance, a required element of many such processes, may be achieved with multiple pumps or other proportioning or balancing devices which are to some extent independent of each other. This need may arise in treatments that involve multiple fluids. Safe and secure mechanisms to ensure fluid balance in such systems are described.
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公开(公告)号:US20200009308A1
公开(公告)日:2020-01-09
申请号:US16575482
申请日:2019-09-19
发明人: Goetz FRIEDERICHS , William K. WEIGEL , Dennis M. TREU , Jeffrey H. BURBANK , James M. BRUGGER , Keith David J. WHEELER , Scott W. NEWELL
摘要: A medicament preparation system, according to an embodiment, includes a water purification module and a medicament proportioning module. The system is configured to allow convenient and safe use in a home environment or a critical care environment as well as others affording safety, reliability, and a compact form factor.
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公开(公告)号:US20190275226A1
公开(公告)日:2019-09-12
申请号:US16423214
申请日:2019-05-28
发明人: Jeffrey H. BURBANK , Dennis M. TREU , Goetz FRIEDERICHS , Brian C. GREEN , Christopher S. MCDOWELL , James M. BRUGGER
摘要: A fluid preparation system has a sealed sterilized fluid circuit with a sealed sterilized container with a conductivity sensor in communication with an interior of said container. Further, at least one sealed connector is adapted for adding fluid to said container, and at least one sealed connector is adapted for removing fluid from said container. The conductivity sensor is contained in a test line in communication with said interior and is adapted to be connected to a source of suction thereby to draw a sample of contents of said container. Furthermore, the test line may have a check valve to prevent ingress of contaminants into said container, and the sealed connector is adapted for adding fluid to said container and may have an inline sterile filter. Furthermore, the system may have a controller that controls pumping actuators.
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公开(公告)号:US20150374895A1
公开(公告)日:2015-12-31
申请号:US14762831
申请日:2014-01-24
CPC分类号: A61M1/1656 , A61M1/1664 , A61M1/1666 , A61M1/1672 , C02F1/001 , C02F1/283 , C02F1/32 , C02F1/42 , C02F1/441 , C02F2001/427 , C02F2101/12 , C02F2103/026 , C02F2209/003 , C02F2209/02 , C02F2209/05 , C02F2209/29 , C02F2209/445
摘要: A water purification component, which may be integrated in a medicament production plant and/or a blood treatment system, removes chloramine and other chlorine compounds and deionizes water. The deionization is selected to be effective for providing product water whose resistivity is sufficiently high to allow chloramine to be detected in the product water if the chloramine removal filtration fails. This allows a chloramine removal filter to be changed based on a predicted exhaustion schedule with the safety of automatic chloramine breakthrough provided.
摘要翻译: 可以集成在药物生产设备和/或血液处理系统中的水净化组分可除去氯胺和其他氯化合物并使水去离子。 选择去离子电极对于提供电阻率足够高的产品水是有效的,以便如果氯胺除去过滤失败,则可以在产品水中检测到氯胺。 这允许基于预测的耗尽时间表改变氯胺去除过滤器,并提供自动氯胺突破的安全性。
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公开(公告)号:US20230293794A1
公开(公告)日:2023-09-21
申请号:US18200666
申请日:2023-05-23
发明人: Orlando SOTO , Joseph RAUSA , James M. BRUGGER , William J. SCHNELL , Goetz FRIEDERICHS , Jeffrey H. BURBANK , Joseph E. TURK, JR. , Scott W. NEWELL , Amanda WOZNIAK
IPC分类号: A61M1/16
CPC分类号: A61M1/1668 , A61M1/1666 , A61M1/1605 , A61M1/1601 , A61M2205/3368 , A61M2205/3317 , A61M2205/12 , A61M5/14228
摘要: A conductivity measurement device includes first and second conductivity measurement flow channels positioned in a fluid circuit and fluidly linked for fluid flow between the first and second conductivity measurement flow channels. A controller having a current source connected to the first and second conductivity channels applies alternating voltages at frequencies that are different, each being respective to one of the first and second conductivity cells.
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公开(公告)号:US20230201431A1
公开(公告)日:2023-06-29
申请号:US17922207
申请日:2021-06-23
发明人: Goetz FRIEDERICHS
IPC分类号: A61M1/14
摘要: A method of reducing leakage current from a patient to a ground potential through an applied part of a medical device includes defining a maximum permissible leakage current Amax from the patient to the ground potential when the patient is energized to an electric potential V and supplying the medical device with water having a resistivity value ρ through a fluid line having a length L and an inner diameter ID. The value of L and ID is selected to cause the fluid conduit filled with water of resistivity ρ to have a resistance of R high enough to maintain the leakage current from the patient to the ground potential below Amax.
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公开(公告)号:US20230191015A1
公开(公告)日:2023-06-22
申请号:US18107136
申请日:2023-02-08
发明人: David DESOUZA , Daniel Joseph RUBERY, JR. , Dennis M. TREU , Mark T. WYETH , Jerome JAMES , Garrett D. CASEY , James M. BRUGGER , William J. SCHNELL , Jeffrey H. BURBANK , Goetz FRIEDERICHS
CPC分类号: A61M1/3663 , A61M1/1601 , A61M1/1647 , A61M1/3607 , A61M2205/3334 , A61M2205/3393
摘要: The disclosed subject matter relates to extracorporeal blood processing or other processing of fluids. Volumetric fluid balance, a required element of many such processes, may be achieved with multiple pumps or other proportioning or balancing devices which are to some extent independent of each other. This need may arise in treatments that involve multiple fluids. Safe and secure mechanisms to ensure fluid balance in such systems are described.
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公开(公告)号:US20220296796A1
公开(公告)日:2022-09-22
申请号:US17696546
申请日:2022-03-16
发明人: Goetz FRIEDERICHS , Gregory YANTZ
IPC分类号: A61M1/28 , A61M60/279 , A61J1/10
摘要: A system for preparing a medicament for use by a medicament user includes a proportioning machine with a controller and pumping and clamping actuators to engage a fluid circuit having pumping and clamping portions that engage with respective actuators of the proportioning machine. The fluid circuit includes a mixing container that is initially empty and later filled with a concentrated medicament from a concentrate container. The proportioning machine is configured to receive purified water and to mix it with the concentrated medicament to produce a medicament and to output the medicament to a medicament consumer in such a way that to the medicament consumer the medicament appears to be provided from a bag of medicament.
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公开(公告)号:US20220296792A1
公开(公告)日:2022-09-22
申请号:US17837405
申请日:2022-06-10
发明人: James M. BRUGGER , Jeffrey H. BURBANK , Goetz FRIEDERICHS , Scott W. NEWELL , William J. SCHNELL , Orlando SOTO
摘要: A medicament preparation system includes a disposable cartridge with a flow path. Various sensors may be placed on the cartridge to measure qualities of the fluid flowing through the flow path. The sensors are placed in precise locations using various approaches that make manufacturing of the cartridge efficient and repeatable. A drain line that is susceptible to fouling may be preattached and various approaches are used to remove or reduce the fouling. An elastomeric contact can also be present in the medical preparation system and used in a conductivity measurement subsystem.
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公开(公告)号:US20220241478A1
公开(公告)日:2022-08-04
申请号:US17612747
申请日:2020-05-21
发明人: Goetz FRIEDERICHS , Kevin HUGHES
摘要: A system for mixing a batch of medicament has a pump actuator, control valve actuators, a source of concentrate, and a purified water source, all connected by a fluid circuit. A controller controls various control valves to open fluid channels from the source of concentrate and from the purified water source to connect a junction of the fluid circuit to the concentrate container and the purified water source. The controller also controls the pump actuator and a water pump to flow water and concentrate through the junction into a mixing container, such that the mixture of the concentrate and the water requires additional dilution to form a ready-to-use medicament. The controller samples the mixture and calculate an additional quantity of water to add based on the sampling.
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