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    VACCINE PHARMACEUTICAL COMPOSITION FOR TRANSDERMAL ADMINISTRATION
    21.
    发明申请
    VACCINE PHARMACEUTICAL COMPOSITION FOR TRANSDERMAL ADMINISTRATION 有权

    公开(公告)号：US20170216431A1

    公开(公告)日：2017-08-03

    申请号：US15514868

    申请日：2015-10-01

    Applicant: NITTO DENKO CORPORATION

    Inventor： Takuya SHISHIDO ,  Daisuke ASARI ,  Kyohei MATSUSHITA ,  Katsuyuki OKUBO ,  Mitsuhiko HORI

    IPC: A61K39/39 ,  A61K39/02 ,  A61K39/00 ,  A61K9/70

    Abstract: The present invention provides a vaccine pharmaceutical composition for transdermal administration which is safe, usable as a prophylactic or therapeutic agent for cancer or infectious diseases, and capable of safely and effectively inducing a systemic immune response. It can be administered to a human or animal skin, the vaccine pharmaceutical composition including: a lipopolysaccharide or its salt derived from at least one gram-negative bacterium such as Serratia, Lelercia, Rahnella, Acidicaldus, Acidiphilium, Acidisphaera, Acidocella, Acidomonas, Asaia, Belnapia, Craurococcus, Gluconacetobacter, Gluconobacter, Kozakia, Leahibacter, Muricoccus, Neoasaia, Oleomonas, Paracraurococcus, Rhodopila, Roseococcus, Rubritepida, Saccharibacter, Stella, Swaminathania, Teichococcus, Zavarzinia, Pseudomonas, Achromobacter, Bacillus, Methanoculleus, Methanosarcina, Clostridium, Micrococcus, Flavobacterium, Pantoea, Acetobacter, Zymomonas, Xanthomonas, and Enterobacter, as an immunostimulant; and at least one antigen, the vaccine pharmaceutical composition having a mass ratio between the immunostimulant and the antigen, the total mass of the immunostimulant/the total mass of the antigen, of 0.002 to 500.

    INJECTABLE VACCINE COMPOSITION
    22.
    发明申请
    INJECTABLE VACCINE COMPOSITION 有权
    可注射的疫苗组合物

    公开(公告)号：US20160287697A1

    公开(公告)日：2016-10-06

    申请号：US14916807

    申请日：2014-10-02

    Applicant: NITTO DENKO CORPORATION

    Inventor： Kyohei MATSUSHITA ,  Masahiro FUKASAKA ,  Arimichi OKAZAKI ,  Eiji KIYOTOH ,  Katsuyuki OKUBO ,  Daisuke ASARI ,  Mitsuhiko HORI

    IPC: A61K39/39 ,  A61K9/00

    CPC classification number: A61K39/39 ,  A61K9/0019 ,  A61K39/00 ,  A61K2039/55572

    Abstract: The present invention aims at providing an injectable vaccine composition that is safe, useful as a prophylactic or therapeutic agent for cancers or infectious diseases, and capable of inducing the systemic immune response safely and effectively. The present invention is an injectable vaccine composition to be administered by injection to a human being or an animal, containing: at least one antigen, and as an adjuvant, a lipopolysaccharide derived from at least one gram negative bacterium selected from the group consisting of Serratia, Leclercia, Rahnella, Acidicaldus, Acidiphilium, Acidisphaera, Acidocella, Acidomonas, Asaia, Belnapia, Craurococcus, Gluconacetobacter, Gluconobacter, Kozakia, Leahibacter, Muricoccus, Neoasaia, Oleomonas, Paracraurococcus, Rhodopila, Roseococcus, Rubritepida, Saccharibacter, Stella, Swaminathania, Teichococcus, Zavarzinia, Pseudomonas, Achromobacter, Bacillus, Methanoculleus, Methanosarcina, Clostridium, Micrococcus, Flavobacterium, Pantoea, Acetobacter, Zymomonas, Xanthomonas, and Enterobacter, or a salt thereof.

    Abstract translation: 本发明的目的在于提供一种安全有效的可用作癌症或感染性疾病的预防或治疗剂并且能够安全有效地诱导全身免疫应答的可注射疫苗组合物。 本发明是通过注射给人或动物施用的可注射疫苗组合物，其包含至少一种抗原和佐剂，衍生自至少一种革兰氏阴性细菌的脂多糖，所述至少一种阴性细菌选自沙雷氏菌属 ，Leclercia，Rahnella，Acidicaldus，Acidiphilium，Acidisphaera，Acidocella，Acidomonas，Asaia，Belnapia，Craurococcus，Gluconacetobacter，Gluconobacter，Kozakia，Leahibacter，Muricoccus，Neoasaia，Oleomonas，Paracraurococcus，Rhodopila，Roseococcus，Rubritepida，Saccharibacter，Stella，Swaminathania，Teichococcus ，Zavarzinia，假单胞菌属，无色杆菌属，芽孢杆菌属，甲烷球菌属，甲烷球菌属，梭菌属，微球菌属，黄杆菌属，泛菌属，醋杆菌属，发酵单胞菌属，黄单胞菌属，肠杆菌属或其盐。

    ORAL FILM-FORM BASE AND PREPARATION
    25.
    发明申请
    ORAL FILM-FORM BASE AND PREPARATION 审中-公开
    口腔膜形式和准备

    公开(公告)号：US20130177605A1

    公开(公告)日：2013-07-11

    申请号：US13737255

    申请日：2013-01-09

    Applicant: NITTO DENKO CORPORATION

    Inventor： Daisuke ASARI ,  Mitsuhiko HORI ,  Takuya SHISHIDO

    IPC: A61K9/46

    CPC classification number: A61K9/0007 ,  A61K9/006 ,  A61K47/02

    Abstract: The present invention provides an oral film-form base which has a rapid dissolution profile in the mouth and sufficient film strength, and gives an improved taking property by foaming in the mouth. The oral film-form base includes an edible polymer soluble both in water and in an organic solvent having a solubility parameter of 9.7 or higher, a foaming agent, and an auxiliary foaming agent, wherein the foaming agent is foamable in the presence of water, and the foaming agent and the auxiliary foaming agent each are insoluble in the organic solvent, have an average particle size of 0.1 to 60 μm, and are included in particle states.

    Abstract translation: 本发明提供一种在口中具有快速溶出曲线并具有足够的膜强度的口腔膜形式的底物，并通过在口中发泡获得改进的吸收性能。 口腔膜型基质包括可溶于水和可溶性参数为9.7以上的有机溶剂中的可食用聚合物，发泡剂和辅助发泡剂，其中发泡剂在水的存在下是可发泡的， 发泡剂和辅助发泡剂各自不溶于有机溶剂，平均粒径为0.1〜60μm，并且以颗粒状态包含。

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