公开(公告)号：US20140094903A1

公开(公告)日：2014-04-03

申请号：US13319007

申请日：2010-05-04

Applicant: Eran Miller ,  Oz Cabiri ,  Yossi Gross ,  Amir Gross ,  Tal Reich

Inventor： Eran Miller ,  Oz Cabiri ,  Yossi Gross ,  Amir Gross ,  Tal Reich

IPC: A61F2/24

CPC classification number: A61F2/2427 ,  A61B17/0401 ,  A61B2017/00243 ,  A61B2017/0409 ,  A61B2017/0414 ,  A61B2017/0441 ,  A61B2017/0464 ,  A61B2017/0496 ,  A61B2017/0649 ,  A61B2017/12095 ,  A61F2/2457 ,  A61F2/2466 ,  A61F2/2487

Abstract: Apparatus is provided, including first and second longitudinal members coupled at respective first portions thereof to tissue surrounding the ventricle. The first portion of at least the first longitudinal member is coupled to a tissue anchor, and respective second portions of the first and second longitudinal members are coupled to respective first and second leaflets of a cardiac valve. The longitudinal members are arranged with respect to the tissue anchor and the portion of tissue surrounding the ventricle in a manner which facilitates adjustment of a degree of tension of the first and second longitudinal members to draw the first and second leaflets together. A longitudinal-member-coupling device is coupled to the first and second longitudinal members, and is advanceable toward a ventricular surface of the first and second leaflets, and responsively to draw together the first and second longitudinal members. Other applications are also described.

Abstract translation: 提供了包括在其相应的第一部分处耦合到围绕心室的组织的第一和第二纵向构件的装置。 至少第一纵向构件的第一部分联接到组织锚，并且第一和第二纵向构件的相应的第二部分联接到心脏瓣膜的相应的第一和第二小叶。 纵向构件以便于调整第一和第二纵向构件的张力程度以将第一和第二传单牵引在一起的方式相对于组织锚和围绕心室的组织的部分布置。 纵向构件联接装置联接到第一和第二纵向构件，并且可朝向第一和第二小叶的心室表面前进，并且响应地将第一和第二纵向构件汇合在一起。 还描述了其它应用。

公开(公告)号：US20130304034A1

公开(公告)日：2013-11-14

申请号：US13470319

申请日：2012-05-13

Applicant: Oz Cabiri

Inventor： Oz Cabiri

IPC: A61M25/00

CPC classification number: A61M25/0147 ,  A61B1/00078 ,  A61B1/00135 ,  A61M25/0138 ,  A61M2025/0161

Abstract: A steering tool including an internal tube disposed inside an external tube, the internal and external tubes being arranged for longitudinal axial movement relative to one another, wherein a distal end of the internal tube is fixedly joined to a distal end of the external tube, and at least one of the internal and external tubes is slotted near the distal end thereof, and wherein the longitudinal axial movement causes bending of the distal ends of the tubes.

公开(公告)号：US08353956B2

公开(公告)日：2013-01-15

申请号：US12706868

申请日：2010-02-17

Applicant: Eran Miller ,  Amir Gross ,  Oz Cabiri ,  Iftah Beinart ,  Aviram Baum

Inventor： Eran Miller ,  Amir Gross ,  Oz Cabiri ,  Iftah Beinart ,  Aviram Baum

IPC: A61F2/24

CPC classification number: A61F2/2448 ,  A61F2/2442 ,  A61F2210/0014 ,  A61F2250/0004 ,  A61F2250/0007

Abstract: Apparatus is provided, including a locking mechanism, an implant, and a flexible strip within the implant having a plurality of recesses. A perimeter of the strip shortens and expands when the first end of the strip is advanced bidirectionally with respect to a second end of the strip. The locking mechanism includes a moveable recess-engaging portion, a mechanical support removably coupled to the recess-engaging portion, and a force applicator which maintains the recess-engaging portion in a position in which the recess-engaging portion is not disposed in any of the recesses. Upon decoupling of the mechanical support from the recess-engaging portion, the force applicator restricts motion of the plurality of recesses of the strip with respect to the second end of the strip, by facilitating positioning of the recess-engaging portion in one of the plurality of recesses. Other embodiments are also described.

Abstract translation: 提供了包括锁定机构，植入物和在植入体内的具有多个凹部的柔性条带的装置。 当带的第一端相对于带的第二端双向前进时，带的周边缩短并膨胀。 锁定机构包括可移动的凹入接合部分，可移除地联接到凹部接合部分的机械支撑件，以及将凹部接合部分保持在凹部接合部分不设置在凹部接合部分中的任一个 凹槽。 在机械支撑件与凹陷接合部分分离时，力施加器通过促进凹部接合部分在多个部分之一中的定位来限制条带的多个凹部相对于条带的第二端的运动 的凹陷。 还描述了其它实施例。

公开(公告)号：US08348898B2

公开(公告)日：2013-01-08

申请号：US12689249

申请日：2010-01-19

Applicant: Oz Cabiri

Inventor： Oz Cabiri

IPC: A61M5/20

CPC classification number: A61M5/2033 ,  A61M5/142 ,  A61M5/14248 ,  A61M5/158 ,  A61M5/1626 ,  A61M5/3204 ,  A61M5/322 ,  A61M5/3287 ,  A61M2005/14252 ,  A61M2005/1585 ,  A61M2005/206 ,  A61M2005/2073

Abstract: A needle assembly adapted for fluid communication with a vial containing a substance to be delivered to a subject, the needle assembly including a needle held in a needle holder, the needle holder confined to move in a housing, and an activation mechanism for activating delivery of the substance through the needle, the activation mechanism including a safety latch that initially impedes movement of the needle holder, wherein when the safety latch is placed on the subject, the safety latch moves to a position that permits moving the needle holder to cause the needle to protrude outwards of the housing to pierce the subject to allow administration of the substance to the subject, characterized by a biasing device arranged to apply a biasing force on the needle to cause the needle to protrude outwards of the housing to pierce the subject, and needle release apparatus including a needle arrestor that initially blocks movement of the biasing device and which releases the biasing device when the safety latch moves to the position that permits moving the needle holder to cause the needle to protrude outwards of the housing.

Abstract translation: 一种针组件，其适于与包含要递送到被检体的物质的小瓶流体连通，所述针组件包括保持在针保持器中的针，所述针保持器限定在壳体中移动，以及用于激活输送的活动机构 所述物质通过所述针，所述致动机构包括最初阻止所述针保持器的运动的安全闩锁，其中当所述安全闩锁被放置在所述被检体上时，所述安全闩锁移动到允许移动所述针架以使所述针头 突出到所述壳体的外部以刺穿所述物体以允许所述物质对所述物体施用，其特征在于，偏置装置被布置成在所述针上施加偏置力以使所述针向所述壳体的外部突出以刺穿所述被检体，并且 针头释放装置包括针止动器，其最初阻止偏置装置的移动并且当该位置释放偏置装置时 安全闩锁移动到允许移动针架以使针突出到壳体外侧的位置。

公开(公告)号：US08277502B2

公开(公告)日：2012-10-02

申请号：US12608316

申请日：2009-10-29

Applicant: Eran Miller ,  Oz Cabiri

Inventor： Eran Miller ,  Oz Cabiri

IPC: A61F2/06

CPC classification number: A61F2/2445 ,  A61B17/0401 ,  A61B17/064 ,  A61B17/068 ,  A61B2017/00243 ,  A61B2017/0409 ,  A61B2017/0414 ,  A61B2017/0427 ,  A61B2017/0441 ,  A61B2017/0448 ,  A61B2017/0464 ,  A61B2017/0647 ,  A61B2017/0649 ,  A61F2/2466

Abstract: A method is provided, including coupling, to a first portion of tissue of a patient, a distal tissue coupling element of a tissue anchor. The tissue anchor further includes (a) an implant -coupling element, and (b) a cord, which is removably coupled to the implant-coupling element. The method comprises advancing an implant over the cord until the implant reaches and is coupled to the implant-coupling element. The method further includes restraining the implant from separating from the implant-coupling element, with an implant-restraining element of the implant-coupling element. Other applications are also described.

Abstract translation: 提供了一种方法，包括将患者的组织的第一部分联接到组织锚的远侧组织连接元件。 组织锚固件还包括（a）植入物耦合元件，和（b）绳索，其可移除地联接到植入物联接元件。 该方法包括使植入物在绳索上推进，直到植入物到达和连接到植入物联接元件。 该方法还包括通过注入耦合元件的植入物限制元件来限制植入物与注入耦合元件分离。 还描述了其它应用。

公开(公告)号：US08157769B2

公开(公告)日：2012-04-17

申请号：US12559563

申请日：2009-09-15

Applicant: Oz Cabiri

Inventor： Oz Cabiri

IPC: A61M1/00

CPC classification number: A61M5/1456 ,  A61M5/14248 ,  A61M5/158 ,  A61M5/162 ,  A61M2005/14268 ,  A61M2005/14573

Abstract: A cartridge insertion assembly including apparatus with a pathway formed therein, a cartridge insertable into the pathway, the cartridge including a cartridge coupling element connectable to an activation mechanism disposed in the apparatus operative to cause a substance contained in the cartridge to be metered out of the cartridge, and a door pivoted to the apparatus that includes a door coupling element arranged with respect to the cartridge such that when the door is in a fully closed position, the door coupling element couples the cartridge coupling element with a coupling element of the activation mechanism.

Abstract translation: 一种墨盒插入组件，包括具有形成在其中的路径的装置，可插入路径中的盒，所述盒包括可连接到设置在所述装置中的启动机构的盒联接元件，所述启动机构可操作以将包含在所述盒中的物质计量出 盒和一个转动到该装置的门，该门包括相对于盒布置的门联接元件，使得当门处于完全关闭位置时，门联接元件将盒联接元件与启动机构的联接元件 。

公开(公告)号：US20110301698A1

公开(公告)日：2011-12-08

申请号：US12795192

申请日：2010-06-07

Applicant: Eran MILLER ,  Oz Cabiri

Inventor： Eran MILLER ,  Oz Cabiri

IPC: A61F2/24

CPC classification number: A61B17/0401 ,  A61B2017/00243 ,  A61B2017/0441 ,  A61B2017/0464 ,  A61B2017/0496 ,  A61F2/2442 ,  A61F2/2454 ,  A61F2/2457

Abstract: A method is provided including coupling a tissue-engaging element to a first portion of cardiac tissue of a heart of a patient and advancing toward the tissue-engaging element an adjustment mechanism along at least one guide member that is removably coupled to the tissue-engaging element. The adjustment mechanism engages a first portion of a first flexible longitudinal member. A second portion of the first flexible longitudinal member is coupled to a second portion of cardiac tissue. Following the coupling of the second portion of the first flexible longitudinal member to the second portion of cardiac tissue, the adjustment mechanism is slid further along the guide member and coupled to the tissue-engaging element. Using the adjustment mechanism, a length of the first flexible longitudinal member is adjusted between the first and second portions of cardiac tissue. Other applications are also described.

Abstract translation: 提供了一种方法，包括将组织接合元件耦合到患者心脏的心脏组织的第一部分并且沿着至少一个引导构件向着组织接合元件推进调节机构，所述至少一个引导构件可移除地联接到组织接合 元件。 调节机构接合第一柔性纵向构件的第一部分。 第一柔性纵向构件的第二部分联接到心脏组织的第二部分。 在第一柔性纵向构件的第二部分与心脏组织的第二部分的联接之后，调节机构沿着引导构件进一步滑动并联接到组织接合元件。 使用调节机构，在心脏组织的第一和第二部分之间调节第一柔性纵向构件的长度。 还描述了其它应用。

公开(公告)号：US20110288635A1

公开(公告)日：2011-11-24

申请号：US12785717

申请日：2010-05-24

Applicant: Eran MILLER ,  Oz Cabiri

Inventor： Eran MILLER ,  Oz Cabiri

IPC: A61F2/24 ,  A61B17/04

CPC classification number: A61B17/0401 ,  A61B17/0482 ,  A61B2017/0409 ,  A61B2017/0414 ,  A61B2017/0441 ,  A61B2017/0496 ,  A61F2/2457

Abstract: Apparatus is provided, including an artificial-chordeae-tendineae-adjustment mechanism and at least one primary artificial chordea tendinea coupled at a distal portion thereof to the artificial-chordeae-tendineae-adjustment mechanism. A degree of tension of the at least one primary artificial chordea tendinea is adjustable by the artificial-chordeae-tendineae-adjustment mechanism. One or more loops are coupled at a proximal portion of the at least one primary artificial chordea tendinea. The one or more loops are configured to facilitate suturing of the one or more loops to respective portions of a leaflet of an atrioventricular valve of a patient. Other applications are also described.

Abstract translation: 提供了装置，其包括人造腱 - 腱索调节机构和在其远端部分与人造腱 - 腱调节机构联接的至少一个初级人造腱索。 所述至少一个原发性人造大戟属植物的张力可以通过人造腱 - 腱调节机制来调节。 一个或多个环在所述至少一个原始人造大戟属的近端部分联接。 一个或多个环被构造成便于将一个或多个环缝合到患者的房室瓣的小叶的相应部分。 还描述了其它应用。

公开(公告)号：US07967795B1

公开(公告)日：2011-06-28

申请号：US12689250

申请日：2010-01-19

Applicant: Oz Cabiri

Inventor： Oz Cabiri

IPC: A61M1/00

CPC classification number: A61M5/14566 ,  A61M5/1452 ,  A61M5/1456 ,  A61M5/2425 ,  A61M2005/14506

Abstract: A cartridge interface assembly including a driving plunger including an outer shaft, and a driver including an inner shaft, the inner shaft mating with an intermediate shaft, the intermediate shaft mating with the outer shaft, so that the shafts are movable telescopically with respect to one another, wherein rotation of the driver causes the driving plunger to advance in a direction away from the driver.

Abstract translation: 一种盒式接口组件，其包括包括外轴的驱动柱塞和包括内轴的驱动器，与中间轴配合的内轴，与外轴配合的中间轴，使得轴相对于一个轴可伸缩地运动 另一个，其中驾驶员的旋转使得驱动柱塞沿远离驾驶员的方向前进。

公开(公告)号：US07947013B2

公开(公告)日：2011-05-24

申请号：US10596971

申请日：2005-01-03

Applicant: Oz Cabiri ,  Yossi Gross ,  Boris Degtiar ,  Eran Shor

Inventor： Oz Cabiri ,  Yossi Gross ,  Boris Degtiar ,  Eran Shor

IPC: A61M29/00

CPC classification number: A61M25/0122 ,  A61B1/00082 ,  A61B1/00096 ,  A61B1/00154 ,  A61B1/00181 ,  A61B1/015 ,  A61B1/05 ,  A61B1/31

Abstract: Apparatus (10) is provided for use with a biologically-compatible-fluid pressure source (16), the apparatus (10) including an elongate carrier (26), adapted to be inserted through a proximal opening (18) of a body lumen (20), and a piston head (30) coupled to a distal portion of the carrier (26). The piston head (30) is adapted to form a pressure seal with a wall of the lumen (20) after the carrier (26) has been inserted into the lumen (20), and to be advanced distally through the body lumen (20) in response to pressure from the fluid pressure source (16). The apparatus (10) is configured to facilitate distal advancement of the piston head (30) by facilitating passage of fluid out of the lumen (20) from a site within the lumen (20) distal to the piston head (30). The apparatus (10) additionally includes an optical system (32), coupled to the carrier (26) in a vicinity of the distal portion, the optical system (32) having distal and proximal ends. The optical system (32) includes an image sensor (232), positioned at the proximal end of the optical system (32); an optical member (234) having distal and proximal ends, and shaped so as to define a lateral surface, at least a distal portion of which is curved, configured to provide omnidirectional lateral viewing; and a convex mirror (240), coupled to the distal end of the optical member (234), wherein the optical member (234) and the mirror (240) have respective rotational shapes about a common rotation axis.

Abstract translation: 设备（10）被提供用于与生物相​​容流体压力源（16）一起使用，所述设备（10）包括细长载体（26），其适于插入通过体腔的近端开口（18） 20）和联接到所述载体（26）的远端部分的活塞头（30）。 活塞头（30）适于在载体（26）已被插入内腔（20）之后与腔（20）的壁形成压力密封，并且通过体腔（20）向远侧推进， 响应于来自流体压力源（16）的压力。 设备（10）被配置为通过促使流体从腔（20）远离活塞头（30）的内​​腔（20）内的部位流出，从而促进活塞头（30）的远端前进。 所述装置（10）还包括光学系统（32），所述光学系统（32）在所述远端部分附近联接到所述载体（26），所述光学系统（32）具有远端和近端。 光学系统（32）包括位于光学系统（32）的近端处的图像传感器（232）; 光学构件（234），其具有远端和近端，并且成形为限定侧表面，至少其远端部分是弯曲的，构造成提供全方位的横向观察; 以及耦合到所述光学构件（234）的远端的凸面镜（240），其中所述光学构件（234）和所述反射镜（240）围绕公共旋转轴线具有相应的旋转形状。