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21.发明申请公开(公告)号：US20200330644A1
公开(公告)日：2020-10-22
申请号：US16756214
申请日：2018-10-16
Inventor： Luke Alexander MacQueen , Kevin Kit Parker , Kwanwoo Shin , Giho Choi
Abstract: Some embodiments provide method of forming a three-dimensional tissue scaffold that includes extruding a bioink material through a nozzle onto a support while moving the nozzle relative to the support or moving the support relative to the nozzle to form a three-dimensional structure of the bioink material. The bioink material includes a plurality of polymeric fibers, each polymeric fiber having a diameter on a range of 0.1 μm to 20 μm, and each polymeric fiber comprising one or more biocompatible polymers, and a carrier. The method also includes cross-linking or heat fusing at least some of plurality of polymeric fibers in the three-dimensional structure of the bioink material.
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公开(公告)号：US10725021B2
公开(公告)日：2020-07-28
申请号：US15693565
申请日：2017-09-01
Applicant: President and Fellows of Harvard College
Inventor： Kevin Kit Parker , Josue A. Goss , Anna Grosberg , Patrick W. Alford , Adam W. Feinberg , Ashutosh Agarwal , Megan Laura McCain , Johan Ulrik Lind
IPC: G01N33/50
Abstract: The present invention provides high throughput assays for identifying compounds that modulate a contractile function, as well as devices suitable for use in these assays.
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公开(公告)号：US10518107B2
公开(公告)日：2019-12-31
申请号：US14261693
申请日：2014-04-25
Applicant: President and Fellows of Harvard College
Inventor： Kevin Kit Parker
Abstract: Photosensitive cardiac rhythm modulation structures and systems are described. A genetically-engineered tissue comprising a population of pacing cells expressing a photosensitive membrane transport mechanism that is responsive to light of a particular wavelength(s) combined with one or more of a light source, a power generator, and a sensor provides pacemaker and/or defibrillator function to a subject. The systems further provide in vitro model systems for electrophysiological studies.
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公开(公告)号：US20180209957A1
公开(公告)日：2018-07-26
申请号：US15693565
申请日：2017-09-01
Applicant: President and Fellows of Harvard College
Inventor： Kevin Kit Parker , Josue A. Goss , Anna Grosberg , Patrick W. Alford , Adam W. Feinberg , Ashutosh Agarwal , Megan Laura McCain , Johan Ulrik Lind
IPC: G01N33/50
CPC classification number: G01N33/5008 , G01N33/5088 , G01N2500/04 , G01N2500/10
Abstract: The present invention provides high throughput assays for identifying compounds that modulate a contractile function, as well as devices suitable for use in these assays.
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公开(公告)号：US20180008093A1
公开(公告)日：2018-01-11
申请号：US15544270
申请日：2016-01-26
Applicant: President and Fellows of Harvard College
Inventor： Kevin Kit Parker , Alexander Peyton Nesmith , Joseph A. Festa , Michel Maalouly , Elizabeth Olayinka Ogunbiyi
IPC: A47J37/07
CPC classification number: A47J37/0754 , A47J37/0704 , A47J37/0786
Abstract: Devices, systems, and computer-readable medium are provided for a barbecue smoker device. A barbecue smoker device is provided, that includes a multi-wall container, a food platform, a heat source, an air vent at the top of the barbecue smoker device, an air flow control mechanism at the lower portion of the barbecue smoker device, and a plurality of sensors coupled to the barbecue smoker device. The barbeque smoker device may include a control device for automated control of the air flow control mechanism. A system for remotely controlling a barbecue smoker device is provided, where the system includes a barbecue smoker device including a processor and a display unit, a mobile device in wireless communication with the barbecue smoker device, and the mobile device displaying a graphical user interface that is configured to receive input from a user causing a configuration change in the barbecue smoker device.
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Patent Agency Ranking
公开(公告)号：US09857356B2
公开(公告)日：2018-01-02
申请号：US14362287
申请日：2012-12-10
Applicant: President and Fellows of Harvard College
Inventor： Kevin Kit Parker , Josue Adrian Goss , Anna Grosberg , Patrick W. Alford , Adam W. Feinberg , Ashutosh Agarwal , Megan Laura McCain , Johan Ulrik Lind
IPC: G01N33/50
CPC classification number: G01N33/5008 , G01N33/5088 , G01N2500/04 , G01N2500/10
Abstract: The present invention provides high throughput assays for identifying compounds that modulate a contractile function, as well as devices suitable for these assays.
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公开(公告)号：US20170370908A1
公开(公告)日：2017-12-28
申请号：US15536310
申请日：2015-12-17
Applicant: President and Fellows of Harvard College
Inventor： Stephanie Dauth , Josue A. Goss , Thomas Grevesse , Ben Meir Maoz , Kevin Kit Parker
CPC classification number: G01N33/5058 , B01L3/5027 , C12N5/0062 , C12N5/0697 , C12N2502/081 , C12N2502/086 , C12N2502/28
Abstract: Exemplary embodiments provide in vitro brain models, such as in vitro models of a neurovascular unit or a functionally connected trineural pathway, and systems, devices and methods of use thereof. The present invention provides in vitro brain models, systems, devices and methods that mimic in vivo conditions to, for example, determine the effect of a test compound, such as a drug candidate or a toxin, on various biological responses, such as for example, cell viability, cell growth, migration, differentiation and maintenance of cell phenotype, metabolic activity, structural remodeling and tissue level pre-stress, a neural activity, such as an electrophysiological activity.
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28.发明申请System and Method for Determining Quality of Stem Cell Derived Cardiac Myocytes 审中-公开确定干细胞来源的心肌细胞质量的系统和方法公开(公告)号：US20160203262A1
公开(公告)日：2016-07-14
申请号：US14913925
申请日：2014-08-21
Applicant: President and Fellows of Harvard College
Inventor： Sean Paul Sheehy , Francesco Pasqualini , Kevin Kit Parker
CPC classification number: G01N33/5073 , G01N33/5005 , G01N33/5091 , G16B40/00
Abstract: The present invention relates to a system and method for calculating a quality index of a differentiated cell. To calculate the quality index, the present invention measures a differentiated cell by at least one metric, calculates a strictly standardized mean difference between the differentiated cell and a targeted cell, and calculates a mean squared error versus the target cell to define a value that represents the total difference between the differentiated cell and targeted cell based on the at least one measured metric.
Abstract translation: 本发明涉及一种用于计算分化细胞的质量指数的系统和方法。 为了计算质量指标，本发明通过至少一个度量来测量分化的细胞，计算分化细胞与目标细胞之间的严格标准化的平均差异，并计算相对于靶细胞的均方差，以定义表示 基于所述至少一个测量度量的所述分化细胞和靶细胞之间的总差异。
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公开(公告)号：US20160000886A1
公开(公告)日：2016-01-07
申请号：US14768846
申请日：2014-02-21
Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
Inventor： Kevin Kit Parker , Johan Ulrik Lind , David A. Weitz , Nichlaus J. Carroll , Alireza Abbaspourrad
CPC classification number: A61K38/465 , A61K9/0019 , A61K9/113 , A61K9/1273 , A61K47/34 , A61K47/42 , C12Y301/01008
Abstract: The present invention provides nano structured active therapeutic vehicles which include a biodegradable polymeric fiber and/or thread comprising a porous particle which encapsulates an active agent. The vehicles of the present invention may be used to provide sustained release of the active agent to a subject.
Abstract translation: 本发明提供纳米结构的活性治疗载体，其包括可生物降解的聚合物纤维和/或线，其包含封装活性剂的多孔颗粒。 本发明的载体可用于向受试者提供活性剂的持续释放。
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公开(公告)号：US20150253307A1
公开(公告)日：2015-09-10
申请号：US14429826
申请日：2013-09-20
Applicant: Kevin PARKER , PRESIDENT AND FELLOWS OF HARVARD COLLEGE
Inventor： Kevin Kit Parker , Mohammad Reza Badrossamay , Ashutosh Agarwal
CPC classification number: G01N33/5082 , C12N5/0657 , C12N5/0658 , C12N5/0661 , C12N5/0697 , C12N2513/00 , C12N2533/30 , G01N33/5061
Abstract: The present invention provides devices, constructs, and methods of use of polymeric fiber-scaffolded engineered tissues and assays for identifying compounds that modulate a contractile function, using such devices and constructs.
Abstract translation: 本发明提供使用聚合物纤维支架工程组织的装置，构建体和方法以及使用这种装置和结构识别调节收缩功能的化合物的测定法。
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