Albumin fusion proteins
    23.
    发明授权
    Albumin fusion proteins 有权
    白蛋白融合蛋白

    公开(公告)号:US08143026B2

    公开(公告)日:2012-03-27

    申请号:US12534585

    申请日:2009-08-03

    摘要: The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells. Additionally the present invention encompasses pharmaceutical compositions comprising albumin fusion proteins and methods of treating, preventing, or ameliorating diseases, disorders or conditions using albumin fusion proteins of the invention.

    摘要翻译: 本发明包括白蛋白融合蛋白。 编码本发明的白蛋白融合蛋白的核酸分子也包括在本发明中,载体含有这些核酸,用这些核酸载体转化的宿主细胞,以及制备本发明的白蛋白融合蛋白并使用这些核酸的方法 酸,载体和/或宿主细胞。 另外,本发明包括包含白蛋白融合蛋白的药物组合物以及使用本发明的白蛋白融合蛋白来治疗,预防或改善疾病,病症或病症的方法。

    Human transcription factor IIA
    26.
    发明授权
    Human transcription factor IIA 失效
    人转录因子IIA

    公开(公告)号:US5652117A

    公开(公告)日:1997-07-29

    申请号:US411635

    申请日:1995-04-11

    摘要: The small (.gamma.) subunit of human Transcription Factor IIA and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques. Also disclosed are methods for utilizing such polypeptide for regulating gene-specific and global transcription. Antagonists against such polypeptide and their use to inhibit transcription are also disclosed.

    摘要翻译: PCT No.PCT / US94 / 10644 Sec。 371日期1995年04月11日 102(e)日期1995年4月11日PCT 1994年9月20日PCT PCT。 公开号WO96 / 09311 日期1996年3月28日编码这种多肽的人转录因子IIA和DNA(RNA)的小(γ)亚基和通过重组技术产生这种多肽的方法。 还公开了利用这种多肽调节基因特异性和全局转录的方法。 还公开了抗这种多肽的拮抗剂及其抑制转录的用途。

    Method of identifying a binding partner to a cytokine receptor common gamma chain like polypeptide
    27.
    发明授权
    Method of identifying a binding partner to a cytokine receptor common gamma chain like polypeptide 有权
    鉴定细胞因子受体常见的γ链如多肽的结合配偶体的方法

    公开(公告)号:US07816091B2

    公开(公告)日:2010-10-19

    申请号:US12358097

    申请日:2009-01-22

    IPC分类号: G01N33/53 C07K14/00

    摘要: The present invention relates to a novel human gene encoding a polypeptide which is a member of the Cytokine Receptor family. More specifically, the present invention relates to a polynucleotide encoding a novel human polypeptide named Cytokine Receptor Common Gamma Chain Like, or “CRCGCL.” This invention also relates to CRCGCL polypeptides, as well as vectors, host cells, antibodies directed to CRCGCL polypeptides, and the recombinant methods for producing the same. Also provided are diagnostic methods for detecting disorders related to the immune system, and therapeutic methods for treating diagnosing, detecting, and/or preventing such disorders. The invention further relates to screening methods for identifying agonists and antagonists of CRCGCL activity.

    摘要翻译: 本发明涉及编码作为细胞因子受体家族成员的多肽的新型人基因。 更具体地,本发明涉及编码称为细胞因子受体通用γ链或类似于“CRCGCL”的新型人多肽的多核苷酸。本发明还涉及CRCGCL多肽,以及载体,宿主细胞,针对CRCGCL多肽的抗体, 及其制备方法。 还提供了用于检测与免疫系统相关的疾病的诊断方法,以及用于治疗诊断,检测和/或预防这种疾病的治疗方法。 本发明还涉及用于鉴定CRCGCL活性的激动剂和拮抗剂的筛选方法。

    Cytokine receptor common gamma chain like
    28.
    发明授权
    Cytokine receptor common gamma chain like 有权
    细胞因子受体常见γ链

    公开(公告)号:US06844170B1

    公开(公告)日:2005-01-18

    申请号:US09263626

    申请日:1999-03-05

    CPC分类号: C07K14/715

    摘要: The present invention relates to a novel human protein called Cytokine Receptor Common Gamma Chain Like, and isolated polynucleotides encoding this protein. Also provided are vectors, host cells, antibodies, and recombinant methods for producing this human protein. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to this novel human protein.

    摘要翻译: 本发明涉及称为细胞因子受体通用γ链的新型人类蛋白质,以及编码该蛋白质的分离的多核苷酸。 还提供了用于产生该人蛋白质的载体,宿主细胞,抗体和重组方法。 本发明还涉及用于诊断和治疗与该新型人蛋白相关的疾病的诊断和治疗方法。